Roger Yonchien Tsien key pioneer of calcium imaging, developed various dyes

Roger Yonchien Tsien – discoverer of green fluorescent protein

Article on Roger Yonchien Tsien

Biography & Contributions

Roger Yonchien Tsien is Chinese American biochemist boron on February 01, 1952. He is a professor at the Department of Chemistry and Biochemistry, University of California, San Diego. He was awarded the 2008 Nobel Prize in chemistry "for his discovery and development of the green fluorescent protein (GFP).

Awards & Prizes

Tsien was got many awards and prizes like Javits Neuroscience Investigator Award in the year of 1989, Young Scientist Award and W. Alden Spencer Award in the year of 1991, Artois-Baillet-Latour Health Prize and Gairdner Foundation International Award, Basic Research Prize in the year of 1995, Pearse Prize in the year of 2000, Christian B. Anfinsen Award,Heineken Prize and Max Delbruck Medal in the year of 2002.

Wolf Prize in Medicine, Keio Medical Science Prize, Perl Prize in Neuroscience in the year of 2004, J.Allyn Taylor International Prize in Medicine in the year of 2005, ABRF [Association of Bimolecular Resource Facilities] Award, Lewis S. Rosenstiel Award in the year of 2006, BioPharma Leadership Award in the year of 2007,Nobel Prize in Chemistry in the year of 2008, E.B. Wilson Medal, Lifetime Innovation Award,Molecular Imaging Achievement Award in the year of 2009,General President Gold Medal, Spiers Memorial Award in the year of 2010.

Tsien is renowned for revolutionizing the fields of cell biology and neurobiology by discovering genetically programmable fluorescent tags, thereby Tsien and his colleagues developed FlAsH-EDT2 is a biochemical method for specific covalent labeling inside live cells. He also developed fluorescent indicators of calcium ions and other ions important in biological processes.

Tsien is a key pioneer of calcium imaging and well known for developing various dyes. He has studied and genetically modified Green Fluorescent Protein (GFP), the ‘glowing proteins’. Tsien engineered colorful and fluorescent dyes that have allowed cellular biologists and neurobiologists to follow the flow and behavior of molecules.

Calcium Imaging

Tsien is a key pioneer of calcium imaging and well known for developing various dyes which become fluorescent in the presence of particular ions such as calcium. One such dye, Fura-2, is widely used to track the movement of calcium within cells. Indo-1, another popular calcium indicator, was also developed by Tsien's group in 1985. He has also developed fluorescent indicators for other bio-relevant ions. Aequorin is also a useful tool to indicate calcium level inside cells.

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