Victor Grignard engineered dichloroethyl sulfide for use as chemical weaponry - WorldOfChemicals

Victor Grignard – developer of Grignard reagent

Article on Victor Grignard

Biography & Contributions

Victor Grignard was a chemist and Nobel laureate born on May 06, 1871 – died on December 13, 1935. Grignard was the developer of Grignard reaction in the chemistry field. Grignard shared the Cahours prize in the year of 1901, Berthelot medal in the year of 1902, Prix Jecker in the year of 1905, Lavoisier medal and Nobel Prize in the year of 1912.

Grignard's had done first investigations on ethyl b-isopropylacetobutyrate, stereoisomeric diisopropylbutenedicarboxylic acids and studies of branched unsaturated hydrocarbons. He used the agents to prepare and study the more exotic alcohols, ketones, keto-esters, nitriles and terpene compounds and he developed a method for the synthesis of fulvenes.

Grignard has also been concerned with work on the constitution of unsaturated compounds by quantitative ozonization, condensation of aldehydes and ketones, ketone splitting of tertiary alcohols, the cracking of hydrocarbons in presence of aluminium chloride and catalytic hydrogenation and dehydrogenation processes under reduced pressures. He engineered Phosgene and dichloroethyl sulfide (mustard gas) for use as chemical weaponry.

Grignard Reaction

Grignard Reaction is an organometallic chemical reaction in which alkyl, vinyl, or aryl-magnesium halides (Grignard reagents) add to a carbonyl group in an aldehyde or ketone. Grignard Reaction is an important tool for the formation of carbon-carbon bonds. The reaction of an organic halide with magnesium is not a Grignard reaction, but provides a Grignard reagent.

The Grignard reagent functions as a nucleophile, attacking the electrophilic carbon atom that is present within the polar bond of a carbonyl group. The addition of the Grignard reagent to the carbonyl typically proceeds through a six-membered ring transition state.


Phosgene is a valued industrial reagent and building block in synthesis of pharmaceuticals and other organic compounds. In low concentrations, its odor resembles freshly cut hay or grass. It is one of the simplest acid chlorides, being formally derived from carbonic acid.

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