Biography & contributions
Lloyd Conover [Lloyd Hillyard Conover] is born on June 13, 1923. Lloyd is inducted into the National inventors of hall of fame for his great invention of broad spectrum antibiotic called tetracycline.
Lloyd made this tetracycline by chemically modifying a naturally produced drug. Lloyd specifically, was able to produce tetracycline by dischlorinating another broad spectrum antibiotic Aureomycin by catalytic reduction.
Facts about tetracycline
Tetracyclines were discovered in the 1940s and exhibited activity against a wide range of microorganisms. The term "tetracycline" is also used to denote the four-ring system of this compound. It is classified as bacterial protein synthesis inhibitor. Tetracycline is commonly used to treat acne, rosacea. It is also used to produce several semisynthetic derivatives, which together are known as the tetracycline antibiotics.
Tetracycline molecules comprise a linear fused tetracyclic nucleus, to which a variety of functional groups are attached. Structural components which are important for antibacterial activity among the tetracyclines are maintenance of the linear fused tetracycle, naturally occurring (α) stereochemical configurations at the 4a, 12a (A-B ring junction), and 4 (dimethylamino group) positions, and conservation of the keto-enol system (positions 11, 12, and 12a) in proximity to the phenolic D ring.
Facts about chlortetracycline / aureomycin
Chlortetracycline is belongs to member of tetracycline family and veterinary medicine. Commercial name for chlortetracycline is aureomycin. Chlortetracycline was discovered in the year of 1945 by Benjamin Minge Duggar. Chlortetracycline can be used to prevent, control, and treat animal health problems.
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