Edward Adelbert Doisy Discovered Vitamin k Responsible For Blood clotting, Bone Health

Edward Adelbert Doisy - discoverer of vit-k chemical structure

Article on Edward Adelbert Doisy

Biography & contributions

Edward Adelbert Doisy, American biochemist and Nobel laureate born on November 13, 1893 – died on October 23, 1986. Doisy is known for discovery of chemical nature of vitamin K and its chemical structure, isolating and determining the structure of chemical substances that affect the body. Doisy also had done various research works on antibiotics, insulin, and female hormones.

He and his associates isolated hormones like Estrogen, Estriol, and Estradiol. Doisy shared the 1943 Nobel Prize in physiology or medicine with Danish researcher Henrik Carl Peter Dam.

Vitamin K

Vitamin K is belongs to fat-soluble vitamin. It is vital vitamin which is responsible for blood clotting or coagulation and also helps in improving bone health.

It is of two types

Vitamin K1 – It is synthesized by plants, and is found in highest amounts in green leafy vegetables because it is directly involved in photosynthesis. It is active in animals and may perform the classic functions of vitamin K in animals, including its activity in the production of blood clotting proteins.

Vitamin K2 – It is the main storage form in animals.


Natural estrogens are responsible for female sexual development and play an essential role in fertility, pregnancy, and lactation.

Estrogens are a group of steroid hormones that control the development and maintenance of an individual’s feminine characteristics. Natural estrogens exist in men as well as women, and are found in higher amounts in women, especially in those of reproductive age.Estrogen imbalances can create a variety of disorders, both sexual and nonsexual. Sigma-Aldrich products support research on estrogens and their effects on the body.

The primary molecule that begins the synthesis of estrogen is cholesterol.

Estrogen rich fruits include

  • Tomatoes
  • Apples
  • Cherries
  • Plums
  • Pomegranate
  • Papaya
  • Rhubarb
  • Soybeans


Estriol is synthesized in the body from estrone, estradiol, and androstenedione. Estriol is a major urinary estrogen. During pregnancy, large amount of estriol is produced by the placenta.Estriol has been found to provide some of the protection without the risks associated with stronger estrogens.

Estriol is a weak estrogen capable of exerting either antagonistic or agonistic effects depending on dosage size and schedule, or whether it is given alone or in conjunction with a stronger estrogen such as estradiol. It has been shown to be clinically effective for the treatment of menopausally related symptoms such as hot flashes, insomnia, and poor memory.


Estradiol is a sex hormone. Estradiol is the predominant sex hormone present in females. It is also present in males. In females it is only produced 3 out of 30 days of the cycle. It represents the major estrogen in humans.

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