Paul Greengard Neuroscientist Discovered Biochemical Action of Dopamine

Paul Greengard – discoverer of biochemical action of dopamine

Article on Paul Greengard

Biography & contributions


Paul Greengard is born on December 11, 1925

Greengard is an American neuroscientist and Nobel laureate

Greengard founded the Pearl Meister Greengard Prize

In 1991 he got NAS Award in the Neurosciences

In 2000 Greengard Nobel Prize for Physiology or Medicine

He worked on dopamine and other neurotransmitters function

Greengard showed that there is protein phosphorylation chemical reaction involved in synaptic transmission which occurs in nervous system


Facts about dopamine


Dopamine is neurotransmitter in the brain that plays vital roles in a variety of different behaviors.

The major behaviors dopamine affects are

  • Movement
  • Cognition
  • Pleasure
  • Motivation


Dopamine is an essential component of the basal ganglia motor loop

It acts as the neurotransmitter responsible for controlling the exchange of information from one brain area to another

Dopamine also helps regulate movement and emotional responses, and it enables us not only to see rewards, but to take action to move toward them.

Dopamine deficiency results in Parkinson's disease, and people with low dopamine activity may be more prone to addiction.


Functions of dopamine


Dopamine is also used as medication.

It acts on the sympathetic nervous system.

Dopamine can leads to increased heart rate and blood pressure.

Dopamine cannot cross the blood-brain barrier, so dopamine given as a drug does not directly affect the central nervous system.


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