Chemistry Research Paper: “Microwave mediated combinatorial synthesis of 1-aryl-3, 4-diaroylpyrazoles from 3-arylsydnones and 1,2-diaroylacetylenes”

Research Paper

“Microwave mediated combinatorial synthesis of 1-aryl-3, 4-diaroylpyrazoles from 3-arylsydnones and 1,2-diaroylacetylenes”

Published On:
16-12-2007
Journal:
Indian journal of heterocyclic chemistry
Publisher:
Indian journal of heterocyclic chemistry
DOI:
nil
Volume:
16
Issue:
2007
Page:
413-414

Pyrazoles remains of great interest due to the wide applications of such heterocycles in the pharmaceutical and agrochemical industry. Pyrazole derivatives have a long history of application in agrochemicals and pharmaceutical industry as herbicides and active pharmaceuticals. A systematic investigation of this class of heterocyclic lead revealed that, pyrazole containing pharmacoactive agents play important role in medicinal chemistry. The prevalence of pyrazole cores in heterocyclic lead. Among the family of heterocycles, nitrogen containing heterocycles especially pyrazoles is an important class of heterocyclic compound and its derivatives are reported to have the broad spectrum of biological activities such as anti-inflammatory , herbicidal , antitumour and antiviral activities . Microwave mediated combitional synthesis of 1,aroyl-3,4-diaroyl -pyrazoles was achieved. The synthesis involves the [3 2] dipolar cycloaddition of 3-arylsydnones and 1.2-diaroyl acetyelenes. The process proceeds smoothly in moderate to excellent yields.




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