API intermediates - suppliers, manufacturers, exporters

API

CK-636

cas 442632-72-6

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Acitretin

Acitretin is a second generation retinoid. It is a metabolite of etretinate.It is taken orally, and is typically used for psoriasis.Acitretin works by inhibiting the excessive cell growth and keratinisation (process by which skin cells become thickened due to the deposition of a protein within them) seen in psoriasis. It therefore reduces the thickening of the skin, plaque formation and scaling.

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Acteoside

?Product Name? Acteoside ?CAS Number? 61276-17-3 ?Del. CAS Number? 22323-52-0, 27625-92-9 ?Synonyms? Acteoside; Kusaginin; Russetinol; Stereospermin; Verbascoside; TJC 160; NSC 603831 ?????? ?????????????????????? ?Chemical Name? ?-D-Glucopyranoside, 2-(3,4-dihydroxyphenyl)ethyl 3-O-(6-deoxy-?-L-mannopyranosyl)-, 4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate] ?Chemical Formula? C29H36O15 ?Molecular Weight? 624.59 ?Chemotaxonomic Group?Phenolic Compounds

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Adapalene

Adapalene is a third-generation topical retinoid.It is primarily used in the treatment of mild-moderate acne and is also used to treat keratosis pilaris as well as other skin conditions,topical treatment of comedo, papular and pustular acne (acne vulgaris) of the face, chest or back.Adapalene in small concentrations is a moderator of cellular differentiation, keratinization, and inflammatory processes. It has both exfoliating and anti-inflammatory effects.

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Cisplatin

Cisplatin is a chemotherapy drug. It is used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas, and germ cell tumors. It was the first member of a class of platinum-containing anti-cancer drugs, which now also includes carboplatin and oxaliplatin.

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Docetaxel

Docetaxel is a clinically well-established anti-mitotic chemotherapy medication. It is a semi-synthetic, second-generation taxane, with anti-neoplastic application for the treatment of breast, ovarian, and non-small cell lung cancer. Docetaxel is a taxoid antineoplastic agent. It promotes the assembly of microtubules from tubulin dimers and stabilizes microtubules by preventing depolymerization. Docetaxel interferes with the normal function of microtubule growth, which results in cell- cycle arrest at the G2/M phase and cell death. Docetaxel does not block disassembly of interphase microtubules and so does not prevent entry into the mitotic cycle, but does block mitosis by inhibiting mitotic spindle assembly. Docetaxel is mainly metabolized in the liver by the cytochrome P450 CYP3A4 and CYP3A5 subfamilies of isoenzymes.

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Amiodarone

Amiodarone is an antiarrhythmic agent used for various types of tachyarrhythmias, both ventricular and supraventricular arrhythmias. Discovered in 1961, it was not approved for use in the United States until 1985. Despite relatively common side-effects, it is used in arrhythmias that are otherwise difficult to treat with medication. Related newer compounds, such as dronedarone, have lower efficacy but a reduced rate of side-effects.

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Bortezomib

Bortezomib (originally PS-341 and marketed as Velcade by Millennium Pharmaceuticals) is the first therapeutic proteasome inhibitor to be tested in humans. Cardiovascular safety pharmacology studies in monkeys show that lethal IV doses are associated with decreases in blood pressure, increases in heart rate, increases in contractility, and ultimately terminal hypotension. In monkeys, doses of 3.0 mg/m2 and greater (approximately twice the recommended clinical dose) resulted in progressive hypotension starting at 1 hour and progressing to death by 12 to 14 hours following drug administration.

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