Anticancer drugs used in treating malignancies cells in human body

Antineoplastics-agents

AZD-9291 mesylate

Name AZD-9291 mesylate
Synonyms N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide methanesulfonate (1:1)
Molecular Formula C28H33N7O2.CH4O3S
Molecular Weight 595.71
CAS Registry Number 1421373-66-1

  

 

AZD9291 1421373-65-0
N1-[2-(Dimethylamino)ethyl]-5-methoxy-N1-methyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-1,2,4-benzenetriamine 1421372-66-8

 

 

 

For the non-small cell lung cancer (non - small cell lung cancer) for the treatment of epidermal growth factor receptor (EGFR) T790M mutation or to other EGFR inhibitors.

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Altretamine

Altretamine is an anti-neoplastic agent.It also acts as a chemosterilant for male houseflies and other insects.It is used to treat refractory ovarian cancer.It can be useful as salvage therapy.

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Amsacrine

Amsacrine derivative that is a potent intercalating antineoplastic agent. It is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors. It is frequently used in combination with other antineoplastic agents in chemotherapy protocols. It produces consistent but acceptable myelosuppression and cardiotoxic effects.

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Aprepitant

Name mk 0869
Synonyms Aprepitant; 5-[2(R)-[1(R)-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)morpholin-4-ylmethyl]-3,4-dihydro-2H-1,2,4-triazol-3-one
Molecular Formula C23H21F7N4O3
Molecular Weight 534.43
CAS Registry Number 170729-80-3 (221350-96-5)

Aprepitant is a neurokinin-1 (NK-1) receptor antagonist and belongs to the treating agents of vomiting during chemotherapy of cancer.

 

 

(R)-4-Benzyl-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)morpholin-3-one 287930-75-0
(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride 171482-05-6
(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine 4-methylbenzenesulfonate

200000-59-5
Methyl 2-(2-chloro-1-iminoethyl)hydrazinecarboxylate 155742-64-6
3-(Chloromethyl)-1H-1,2,4-triazol-5(4H)-one          252742-72-6
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethan-1-ol     127852-28-2

 

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Arctigenin

Arctigenin is a lignan found in certain plants of the Asteraceae , including the Greater burdock. It has shown antiviral and anticancer effects. It is the aglycone of arctiin.

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Clofarabine

Clofarabine is a purine nucleoside antimetabolite.It is FDA-approved for treating a type of leukaemia called relapsed or refractory acute lymphoblastic leukaemia (ALL) in children.Clofarabine is a purine nucleoside antimetabolite that differs from other puring nucleoside analogs by the presence of a chlorine in the purine ring and a flourine in the ribose moiety. Clofarabine seems to interfere with the growth of cancer cells, which are eventually destroyed.Clofarabine is metabolized intracellularly to the active 5'-monophosphate metabolite by deoxycytidine kinase and 5'-triphosphate metabolite by mono- and di-phospho-kinases.

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Dacarbazine

Dacarbazine is an antineoplastic chemotherapy drug used in the treatment of various cancers, among them malignant melanoma, Hodgkin lymphoma, sarcoma, and islet cell carcinoma of the pancreas. It is a member of the class of alkylating agents, which destroy cancer cells by adding an alkyl group to its DNA.

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Docetaxel

Docetaxel is a clinically well-established anti-mitotic chemotherapy medication. It is a semi-synthetic, second-generation taxane, with anti-neoplastic application for the treatment of breast, ovarian, and non-small cell lung cancer. Docetaxel is a taxoid antineoplastic agent. It promotes the assembly of microtubules from tubulin dimers and stabilizes microtubules by preventing depolymerization. Docetaxel interferes with the normal function of microtubule growth, which results in cell- cycle arrest at the G2/M phase and cell death. Docetaxel does not block disassembly of interphase microtubules and so does not prevent entry into the mitotic cycle, but does block mitosis by inhibiting mitotic spindle assembly. Docetaxel is mainly metabolized in the liver by the cytochrome P450 CYP3A4 and CYP3A5 subfamilies of isoenzymes.

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Estramustine

Estramustine is a chemotherapy agent used to treat prostate cancer. It is a derivative of estrogen with a nitrogen mustard-carbamate ester moiety that makes it a alkylating antineoplastic agent similar to mechlorethamine, with estrogen-induced specificity.

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Etoposide

Etoposide is an anti-cancer agent. It inhibits the enzyme topoisomerase II, which unwinds DNA, and by doing so causes DNA strands to break. Cancer cells are less able to repair this damage than healthy cells. It is used as a form of chemotherapy for cancers such as Ewing's sarcoma, lung cancer, testicular cancer, lymphoma, non-lymphocytic leukemia, and glioblastoma multiforme. It is often given in combination with other drugs. It is also sometimes used in a conditioning regimen prior to a bone marrow or blood stem cell transplant.

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