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LY2157299 analytical pure 0.999

LY2157299 is a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM in a cell-free assay.

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Cortisol

Cortisol is a hormone that belongs to a family of steroid hormones known as glucocorticoids. It’s secreted by the adrenal cortex, which is located in your adrenal glands that sit atop your kidneys. Cortisol is the main glucocorticoid in humans.Cortisol is a life sustaining adrenal hormone essential to the maintenance of homeostasis. Called “the stress hormone,” cortisol influences, regulates or modulates many of the changes that occur in the body in response to stress.Cortisol levels normally fluctuate throughout the day and night in a circadian rhythm that peaks at about 8 AM and reaches it lowest around 4 AM. While it is vital to health for the adrenals to secret more cortisol in response to stress, it is also very important that bodily functions and cortisol levels return to normal following a stressful event.Cortisol is produced in the human body by the adrenal gland in the zona fasciculata,the second of three layers comprising the adrenal cortex.Cortisol prevents the release of substances in the body that cause inflammation. It is used to treat conditions resulting from over activity of the B-cell-mediated antibody response.Cortisol plays an important role in glycogenolysis, the breaking down of glycogen to glucose-1-phosphate and glucose, in liver and muscle tissue. Glycogenolysis is stimulated by epinephrine and/or norepinephrine. Cortisol facilitates the activation of glycogen phosphorylase, which is necessary for epinephrine to have an effect on glycogenolysis.Cortisol is released in response to stress, sparing available glucose for the brain, generating new energy from stored reserves, and diverting energy from low-priority activities (such as the immune system) in order to survive immediate threats or prepare for the exertion of rising to a new day.

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Estrogen

Estrogen is the general name for a group of hormone compounds. It is the main sex hormone in women and is essential to the menstrual cycle.It is also an essential part of a woman’s reproductive process. Estrogen regulates the menstrual cycle and prepares the uterus for pregnancy by enriching and thickening the endometrium.Estrogen is manufactured mostly in the ovaries, by developing egg follicles. It is also produced by the corpus luteum in the ovaries, as well as by the placenta.Estrogens are used as part of some oral contraceptives, in estrogen replacement therapy for postmenopausal women, and in hormone replacement therapy for trans women.

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Androstenol

Androstenol is a steroidal pheromone and neurosteroid in humans and other mammals, notably pigs.It possesses a characteristic musk-like odor.In humans and boars, androstenol is biosynthesized in the testes.Androstenol may also be synthesized in the adrenal glands and the ovaries in humans.In addition, androstenol may be synthesized in the human nasal mucosa from androstenone, and likely also from androstadienol and androstadienone in this area.It has been proposed that this action may mediate the pheromone effects of androstenol.In animals, androstenol has been found to produce anxiolytic-like, antidepressant-like, and anticonvulsant effects.Androstenol has also been found to modify the behavioral and social responses of humans. In addition, androstenol has been found to decrease luteinizing hormone (LH) pulse frequency during the follicular phase of the human menstrual cycle.

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Androstenone

Androstenone is a steroid-like pheromone. It is found in boar's saliva, celery cytoplasm,and truffle fungus.Androstenone was the first mammalian pheromone to be identified. It is found in high concentrations in the saliva of male pigs, and, when inhaled by a female pig that is in heat, results in the female assuming the mating stance.

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Geranic Acid

Geranic Acid is a pheromone used by some organisms. It is a double bond isomer of nerolic acid.

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Meta-Topolin

Meta-Topolin is an aromatic cytokinin. It was first isolated from poplar leaves. Its name is derived from “topol”, the Czech word for poplar.Meta-Topolin did not improve shoot proliferation, however, positively influences growth and quality of shoots.

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Angiotensin I

Angiotensin I is an N-terminal decapeptide produced when renin acts on angiotensinogen. Angiotensin I is the precursor of angiotensin II.

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Angiotensin II

Angiotensin II acts as an endocrine, autocrine / paracrine, and intracrine hormone. Angiotensin II increases blood pressure by stimulating the Gq protein in vascular smooth muscle cells.

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