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Desomorphine

Desomorphine is an opiate analogue invented in 1932 in the United States, that is a derivative of morphine, where the 6-hydroxy group has been removed and the 7,8 double bond has been saturated. It has sedative and analgesic effects, and is around 10 times more potent than morphine. It was described as having a fast onset and a short duration of action, with relatively little nausea or respiratory depression compared to equivalent doses of morphine. This drug has attracted recent attention in Russia due to an upsurge in clandestine production, presumably due to its relatively simple synthesis from codeine. It is prepared from α-chlorocodide, which is itself obtained by reacting thionyl chloride with codeine. By catalytic reduction, α-chlorocodide gives dihydrodesoxycodeine, which yields desomorphine on demethylation.

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Detomidine

Detomidine is an imidazole derivative and &alpha2-adrenergic agonist, used as a large animal sedative, primarily used in horses. It is usually available as the salt detomidine hydrochloride. It is a prescription medication.Detomidine is a poor premedication when using Ketamine as an anesthetic in horses.Detomidine is a potent sedative, especially with butorphanol, acting within 5 minutes and lasting 90-180 minutes.

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Detomidine Hydrochloride

Detomodine hydrochloride is a sedative with analgesic properties. Detomidine hydrochloride is used to calm excitable horses and to provide relief from abdominal pain, facilitating procedures such as bronchoscopy, bronchoalveolar lavage, nasogastric intubation, nonreproductive rectal palpations, and suturing skin lacerations. It is also approved for use as a local infiltration anesthetic for castration.

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Devapamil

Devapamil is a calcium channel blocker.

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Dexamethasone

Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs.It is a glucocorticoid anti-inflammatory agent.It regulates T cell survival, growth, and differentiation and Inhibits the induction of nitric oxide synthase.It acts as an anti-inflammatory and immunosuppressant.It is also used to treat difficult ear infections, especially in dogs. It can also be combined with trichlormethiazide to treat horses with swelling of distal limbs and general bruising.Dexamethasone is used in transvenous screw-in cardiac pacing leads to minimize the inflammatory response of the myocardium,used as a direct chemotherapeutic agent in certain hematological malignancies, especially in the treatment of multiple myeloma.

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Dexamethasone Sodium Phosphate

Dexamethasone Sodium Phosphate is a systemic corticosteroid. It induces apoptosis and inhibits sodium phosphate symporter. It is used in the treatment of emetic effects of cancer therapy and epicondylitis, to treat eye inflammation caused by infections, injury, surgery, or other conditions. Dexamethasone Sodium Phosphate suppresses the inflammatory response to a variety of agents and it probably delays or slows healing.

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Dexanabinol

Dexanabinol is a synthetic cannabinoid derivative, which is the "unnatural" enantiomer of the potent cannabinoid agonist HU-210. Unlike other cannabinoid derivatives, it does not act as a cannabinoid receptor agonist, but instead has NMDA antagonist effects. It therefore does not produce cannabis-like effects, but is anticonvulsant and neuroprotective, and is widely used in scientific research as well as currently being studied for practical applications such as treatment of head injury or stroke. However, in clinical trials it was shown to be safe, but not more efficacious than placebo.

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Dexketoprofen

Dexketoprofen is a non-steroidal anti-inflammatory drug. It is also known as an NSAID. It is used to relieve short-term pain, such as muscular pain, dental pain, and dysmenorrhoea. Dexketoprofen works by blocking a substance in the body called cyclo-oxygenase, which is involved in the production of certain irritant chemicals in response to injury and some conditions.

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Dexloxiglumide

Dexloxiglumide is a drug which acts as a cholecystokinin antagonist, selective for the CCKA subtype. It inhibits gastrointestinal motility and reduces gastric secretions, and despite older selective CCKA antagonists such as lorglumide and devazepide having only limited success in trials and ultimately never making it into clinical use. It is being investigated as a potential treatment for a variety of gastrointestinal problems including irritable bowel syndrome, dyspepsia, constipation and pancreatitis, and has moderate success so far although trials are still ongoing.

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Dexmedetomidine

Dexmedetomidine is a sedative medication used by intensive care units and anesthetists. It is relatively unique in its ability to provide sedation without causing respiratory depression. It is the dextrorotatory S-enantiomer of medetomidine.

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