Proton Pump Inhibitors used in relieving symptoms acid reflux ulcers



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Ilaprazole is a proton pump inhibitor used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer.

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Omeprazole a highly effective inhibitor of gastric acid secretion used in the therapy of stomach ulcers and zollinger-ellison syndrome. It inhibits the H(+)-K(+)-ATPase (H(+)-K(+)-exchanging ATPase) in the proton pump of gastric parietal cells by functioning as proton pump inhibitor.Omeprazole overdose include confusion, drowsiness, blurred vision, tachycardia, nausea, diaphoresis, flushing, headache, and dry mouth.

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Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It belongs to a class of antisecretory compounds.It is a prodrug in the acid environment of the parietal cells it turns into active sulphenamide form.It is used for the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use.Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.

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Esomeprazole is a proton pump inhibitor which is used in the treatment of dyspepsia, peptic ulcer disease, gastroesophageal reflux disease and Zollinger-Ellison syndrome. It is the S-enantiomer of omeprazole. It is a proton pump inhibitor which reduces acid secretion through inhibition of ATPase in gastric parietal cells.Esomeprazole is combined with the antibiotics clarithromycin and amoxicillin in the 7-14 day eradication triple therapy for Helicobacter pylori.

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Lansoprazole is a proton-pump inhibitor (PPI) which inhibits the stomach's production of gastric acids. It is a racemic 1:1 mixture of the enantiomers dexlansoprazole (Dexilant, formerly named Kapidex) and levolansoprazole. Lansoprazole is used to treat gastric ulcers caused by a family of pain relievers known as nonsteroidal anti-inflammatory drugs (NSAIDs), and to reduce the risk of gastric ulcers for people who are taking NSAIDs. It is also used to treat conditions associated with the over-production of stomach acid, including Zollinger-Ellison syndrome.

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Pantoprazole is a proton pump inhibitor drug used for short-term treatment of Zollinger-Ellison syndrome,erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.It is a substituted benzimidazole indicated for the short-term treatment in the healing and symptomatic relief of erosive esophagitis. It is a proton pump inhibitor (PPI) that suppresses the final step in gastric acid production.

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Tenatoprazole is a proton pump inhibitor indicated for the treatment of reflux oesophagitis and peptic ulcer. It is an imidazopyridine derivative and has an imidazopyridine ring in place of the benzimidazole moiety found in other proton pump inhibitors. It is activated slowly and its inhibition is said to be resistant to reversal. Tenatoprazole has an extended plasma half-life which makes it more effective in the treatment of nocturnal acid breakthrough than esomeprazole.Tenatoprazole is a prodrug of the proton pump inhibitor (PPI) class, which is converted to the active sulfenamide or sulfenic acid by acid in the secretory canaliculus of the stimulated parietal cell of the stomach.

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Dexlansoprazole is a proton pump inhibitor.It is an R-enantiomer of lansoprazole.It decreases acid production by turning off many of the acid pumps in the stomach, thus helping to protect the esophagus from acidic reflux so that esophageal inflammation can heal.It is used to treat the symptoms of GERD, allow the esophagus to heal, and prevent further damage to the esophagus.

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