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(R)-tert-butyl (4-cyano-2,3-dihydro-1H-inden-1-yl)carbamate 99%

Ansion pharma is a factory providing pharmaceutical intermediate and custom synthesis service. 
 
More products infomation, pls contact us: ann.xu@ansionpharma.com; www.ansionpharma.com

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3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester 99%

Shanghai Ansion Pharma Technology Co.,Ltd

www.ansionpharma.com

ann.xu@ansionpharma.com

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High Quality Anti-Estrogen Steroids Raloxifene HCl 82640-04-8

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High Quality Anti-Estrogen Steroids Raloxifene HCl 82640-04-8 
 
Raloxifene HCL Basic Info.:
 
Product Name: Raloxifene Hydrochloride
Synonyms: Raloxifene HCL;Raloxifene Hydrochloride;Ly156758;Piperidin;Keoxifene;Keoxifene Hydrochloride;Ly 139481;AKOS 92138
CAS: 82640-04-8
MF: C28H28ClNO4S
MW: 510.04
Melting Point: 250-253°C
Storage Temp.: -20°C Freezer
Solubility DMSO: 28 mg/mL, soluble
Chemical Properties: Light-Yellow Solid
Assay: 99%
Grade: Pharmaceutical Grade
Product Categories: Active Pharmaceutical Ingredients;Raloxifene;Intracellular receptor;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Pharmaceutical intermediate;API;Inhibitors;antifungal
Usage: amino acid, nutrient, Labeled Raloxifene, intended for use as an internal standard for the quantification of Raloxifene by GC- or LC-mass spectrometry.A nonsteroidal, selective estrogen receptor modulator (SERM). Antiosteoporotic.
 
Product Description:
 
Raloxifene HCL(marketed as Evista) is an oral selective estrogen receptor modulator (SERM) that has estrogenic actions on bone and anti-estrogenic actions on the uterus and breast. It is used in the prevention of osteoporosis in postmenopausal women and to reduce the risk of invasive breast cancer in postmenopausal women with osteoporosis and in postmenopausal women at high risk for invasive breast cancer.
 
This drug is different from hormones (including estrogens and progestins). It works by acting like estrogen (as a selective estrogen receptor modulator or SERM) in some parts of the body. Raloxifene HCL helps to preserve bone mass, but it does not affect the breast and uterus like estrogen or relieve symptoms of menopause such as hot flashes.
 
Raloxifene HCL is indicated for the treatment and prevention of osteoporosis in postmenopausal women. It is also used for reduction of risk and treatment of invasive breast cancer, and it also reduces breast density.For either osteoporosis treatment or prevention, supplemental calcium and/or vitamin D should be added to the diet if daily intake is inadequate.
 
Raloxifene HCL is used to prevent and treat bone loss (osteoporosis) in women after menopause. Maintaining strong bones by slowing bone loss helps to reduce the risk of fractures.
 
Raloxifene HCL may also lower the chance of getting a certain type of breast cancer (invasive) in women after menopause.
 

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Lidocaine HCL 73-78-9 Natural Procaine Lidocaine Hydrochloride

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Lidocaine HCL 73-78-9 Natural Procaine Lidocaine Hydrochloride
 
Lidocaine HCL Basic Info.:
 
Product name: Lidocaine HCl
Alias: Lidocaine Hydrochloride
CAS No.: 73-78-9
Molecular Formula: C14H23ClN2O
Molecular Weight: 270.8
EINECS: 200-803-8
Appearance: White crystalline powder
Melting point: 80-82°C
Usage: To enhance the growing of man genitals.
 
Product Description Of Lidocaine HCL:
 
Lidocaine, as a local anesthetic, is characterized by a rapid onset of action and intermediate duration of efficacy. Therefore, lidocaine is suitable for infiltration, block and surface anesthesia. Longer-acting substances such as bupivacaine are sometimes given preference for subdural and epidural anesthesias. Lidocaine, on the other hand, has the advantage of a rapid onset of action. It can stop Epinephrine  vasoconstricts arteries form bleeding, and it can also delays the resorption of lidocaine, almost doubling the duration of anaesthesia. For surface anesthesia several formulations are available that can be used e. G. For endoscopies, before intubations etc. Buffering the pH of lidocaine makes local freezing less painful. Lidocaine drops can be used on the eyes for short ophthalmic procedures.
 
Lidocaine HCL Applications:
 
Topical lidocaine has been shown in some patients to relieve the pain of postherpetic neuralgia (a complication of shingles), though there is not enough study evidence to recommend it as a first-line treatment. IV lidocaine also has uses as a temporary fix for tinnitus. Although not completely curing the disorder, it has been shown to reduce the effects by around two thirds.
Lidocaine hydrochloride injection administered intravenously or intramuscularly, is specifically indicated in the acute management of ventricular arrhythmias such as those occurring in relation to acute myocardial infarction, or during cardiac manipulation, such as cardiac surgery.
 

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Male Enhancement 4-Androstenedione 63-05-8 For Muscle Building

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Male Enhancement 4-Androstenedione 63-05-8 For Muscle Building
 
Androstenedione Basic Info.
 
Product Name: Androstenedione
Synonyms: 4-Androstenedione;4AD;3,17-Dioxoandrost-4-Ene;delta-(sup4)-Androsten-3,17-dione;delta(Sup4)-Androstene-3,17-dione;delta4-androsten-3,17-dione;delta-4-androstenedione;SKF 2170;skf2170;4-AD
CAS: 63-05-8
MF: C19H26O2
MW: 286.41
EINECS: 200-554-5
Purity: 98.88%
Manufacturer: Kafen
Characters: Near white crystalline powder, soluble in ethanol, insoluble in water
 
Androstenedione Applications:
 
Testo-ster-one precursor and metabolite with androgenic activity. Controlled substance (anabolic steroid); Simplified hormone drugs, from the testis or urine extracted with the role of a male hormone steroids, norethisterone, testosterone propionate in the middle body, is widely used in small rheumatoid arthritis, diuretic, and a variety of contraceptive to control infectious inflammation.
 
Androstenedione Description:
 
4-Androstenedione can be synthesized in one of two ways. The primary pathway involves conversion of 17-hydroxypregnenolone to dehydroepiandrosterone by way of 17,20-lyase, with subsequent conversion of dehydroepiandrosterone to 4-Androstenedione via the enzyme 3-β-hydroxysteroid dehydrogenase. The secondary pathway involves conversion of 17-hydroxyprogesterone, most often a precursor to cortisol, to 4-androstenedione directly by way of 17,20-lyase. Thus, 17,20-lyase is required for the synthesis of 4-androstenedione, whether immediately or one step removed.  
 
The production of adrenal 4-Androstenedione is governed by ACTH, whereas production of gonadal 4-Androstenedione is under control by gonadotropins. In premenopausal women, the adrenal glands and ovaries each produce about half of the total 4-androstenedione(about 3 mg/day). After menopause, 4-androstenedione production is about halved, due primarily to the reduction of the steroid secreted by the ovary. Nevertheless, 4-androstenedione is the principal steroid produced by the postmenopausal.
 

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Manufacturer Terlipressin Acetate With High Quality 14636-12-5

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Manufacturer Terlipressin Acetate With High Quality 14636-12-5
 
Terlipressin Acetate Basic Info.:
 
Product Name: Terlipressin Acetate
Synonyms: Terlipressin;Terlipressin Acetate;Terilipressin;
CAS: 14636-12-5
MF: C52H74N16O15S2
MW: 1227.37
EINECS: 238-680-8
Product Categories: Amino Acid Derivatives;Peptide;hormones
Usage: Terlipressin is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. Terlipressin is used norepinephrine-resistant septic shock and hepatorenal syndrome. Terlipressin is also used in the treatment of acute variceal bleeding.
 
Terlipressin Acetate Pharmacological Effects:
 
Terlipressin is a novel long-acting synthetic vasopressin reagent,its chemical name is three glycyl lysine vasopressin, it is a prodrug, itself has no activity ,in vivo  , it removes three glycyl residues in its N-terminus by aminopeptidase, and slowly "releases" the active lysine vasopressin. It is this "slow release" mechanism that makes it maintain the smooth muscle contraction up to 10 hours after a single administration, whereas the same dose of vasopressin, it can maintain its activity for 20-40 minutes. On the other hand,because of the slow digestion,  lysine vasopressin in the circulation cannot reach toxic levels, and usage of  terlipressin is safer.
Pharmacological effect of terlipressin is splanchnic vascular smooth muscle contraction, and reduction of visceral blood flow (such as reducing blood flow in the mesentery, spleen, uterus, etc.), thereby reducing portal vein blood flow,and reducing portal pressure, on the other hand it may also reduce plasma renin concentration, thereby increasing the renal blood flow in patients with hepatorenal syndrome, to improve kidney function, and increase urine output. Terlipressin is currently the only drug which is able to increase mortality in patients with esophageal varices bleeding , it is previously mainly used in clinical for the treatment of variceal bleeding, in addition,terlipressin now has also been successfully used for liver and kidney integrated syndrome and refractory shock, it is also likely to play a useful role in the cardiopulmonary resuscitation . Compared with vasopressin, it has a lasting effect, and it does not cause dangerous complications, including promoting  fibrinolysis and severe complications in the cardiovascular systems, and the use of it is simple (available intravenous injection), it is more suitable for rescue and treatment of emergent and critical  patients.
 
Terlipressin Acetate Mechanism of Action:
 
Terlipressin, a synthetic triglycyl-lysine derivative of vasopressin, is a inactive prodrug. It has pressor and antidiuretic effects. Following IV injection, lysine vasopressin are released following the enzymatic cleavage of 3 glycyl moieties.
Duration: 4-6 hr.
 

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White Ghrp-2 Human Growth Hormone For Bodybuilding 158861-67-7

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White Ghrp-2 Human Growth Hormone For Bodybuilding 158861-67-7
 
GHRP 2 Basic Info.:
 
Product name: GHRP-2 (GHRP-2 Acetate )
Synonym: Pralmorelin; GHRP2; D-Alanyl-3-(2-naphthalenyl)-D-alanyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide; GHRP 2; 
CAS: 158861-67-7
MF: C45H55N9O6
MW: 817.9749
Purity: 98%
Appearance: White powder
Density: 1.27g/cm3
Boiling point: 1265.3°C at 760 mmHg
Flashing point: 719°C
Function: To stimulate GH secretion, appetite, and to gain weight
 
GHRP 2 Description:
 
GHRP-2 is a synthetic agonist of ghrelin, the newly-discovered gut peptide which binds to the GH secretagogue receptor. Ghrelin has two major effects, stimulating both GH secretion and appetite/meal initiation. GHRP-2 has been extensively studied for its utility as a GHS. Since the test subjects body will end up producing more GH this way, fat will be reduced while lean muscle mass is increased. Along with this, IGF-1 levels will increase, as well, along with the different hypothalamus functions.
 
GHRP 2 Application:
 
GHRP-2 basically acts exactly like ghrelin. It can induce food consumption just like ghrelin and stimulate GH secretion, too. When infused, GHRP-2 makes the GH levels in the body increase a lot and it can induce cell cAMP secretion the way that GRF tends to, as well.
GHRP-2 as a Growth Hormone Secretagogue
 
GHRP-2 has been studied extensively for its utility as a growth hormone secretagogue (GHS). Scientists have discovered that the Growth Hormone Releasing Peptide-2 increases the natural production of growth hormone (GH). In the early 90’s, one of the most famous studies was performed and later published in 1997 in the Journal of Endocrinology and Metabolism. This study further exemplifies the theory that growth hormone releasing peptides (including Ipamorelin and GHRP-6) could help hormone deficient adults and children. Ever since these major scientific studies, GHRP-2 has been widely produced. With other scientific labs confirming the results from their studies, GHRP-2 can in fact work for those who lack the ability to make adequate human growth.
 

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99% High Purity Prohormones Steroids Raw Powder Estriol 50-27-1

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99% High Purity Prohormones Steroids Raw Powder Estriol 50-27-1
 
Estriol Basic Info.:
 
Product Name: Estriol
CAS No.: 50-27-1
Formula: C18H24O3
Molecular Weight: 288.39
EINECS: 200-022-2
Density: 1.255 g/cm3
Melting Point: 280-282 °C(lit. )
Boiling Point: 469 °C at 760 mmHg
Flash Point: 220.8 °C
Purity: 99%
Appearance: White crystalline powder
 
Estriol Description:
 
Estradiol, or more precisely, 17β-estradiol, is a human sex hormone and steroid, and the primary female sex hormone. It is named for and is important in the regulation of the estrous and menstrual female reproductive cycles. Estradiol is essential for the development and maintenance of female reproductive tissues but it also has important effects in many other tissues including bone. While estrogen levels in men are lower compared to women, estrogens have essential functions in men as well. Estradiol is found in most vertebrates as well as many crustaceans, insects, fish, and other animal species.
 
Estradiol or oestradiol (American or British English usages), derives from estra-, Gk. οστρο? (oistros, literally meaning "verve or inspiration") and -diol, a chemical name and suffix indicating that this form of steroid and sex hormone is a type of alcohol bearing two hydroxyl groups.
 
Estradiol is produced especially within the follicles of female ovaries, but also in other endocrine (i.e., hormone-producing) and non-endocrine tissues (e.g., including fat, liver, adrenal, breast, and neural tissues). Estradiol is biosynthesized from progesterone (arrived at in two steps from cholesterol, via intermediate pregnenolone). One principle pathway then converts progesterone to its 17-hydroxy-derivative, and then to androstenedione via sequential cytochrome P450-catalyzed oxidations.Action of aromatase on this dione generates estrone, and action of a dehydrogenase on this gives the title compound, 17β-estradiol.
 
Estriol Application:
 
Hormonal contraception:
A chemical derivative of estradiol, ethinyl estradiol with maximum dosage 200 µg, is a major component of hormonal contraceptive devices. Combined forms of hormonal contraception contain ethinyl estradiol and a progestin, which both contribute to the inhibition of GnRH, LH, and FSH, which accounts for the ability of these birth control methods to prevent ovulation and thus prevent pregnancy. Other types of hormonal birth control contain only progestins and no ethinyl estradiol.
 
Hormone replacement therapy:
If severe side effects of low levels of estradiol in a woman's blood are experienced (commonly at the beginning of menopause or after oophorectomy), hormone replacement therapy may be prescribed. Such therapy is usually combined with a progestin to reduce the risk of endometrial cancer.
 
Estrogen therapy may be used in treatment of infertility in women when there is a need to develop sperm-friendly cervical mucus or an appropriate uterine lining. This is often prescribed in combination with clomifene.
 
Estrogen therapy can also be used to treat advanced prostate cancer, as well as to relieve symptoms of breast cancer.
Not all products are available worldwide. Estradiol is also part of conjugated estrogen preparations, such as Premarin, though it is not the major ingredient. (Premarin consists of a large number of estrogen derivatives. As the name indicates, it comes from pregnant mares' urine.
 
Hormone replacement therapy in transgender women:
Main article: Hormone replacement therapy (male-to-female)
Estrogen therapy is also used as part of the hormone replacement therapy for trans women. Either oral or transdermal estradiol is used in higher concentrations during initial treatment and transition; estradiol is continued in lower doses to maintain female-level hormones following gender reassignment surgery.
 
Estriol Blocking Estrogens:
Inducing a state of hypoestrogenism may be beneficial in certain situations where estrogens are contributing to unwanted effects, e.g., certain forms of breast cancer, gynecomastia, premature closure of epiphyses, and inhibiting feminization in female-to-male transsexual hormone treatment. Estrogen levels can be reduced by inhibiting production using gonadotropin-releasing factor agonists (GnRH agonists) or blocking the aromatase enzyme using an aromatase inhibitor, or with an estrogen receptor antagonist.
 

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N6-(2-Methylthioethyl)-2-(3,3,3-trifluoropropylthio)adenosine 99%

Shanghai Ansion Pharma Technology Co.,Ltd

www.ansionpharma.com

ann.xu@ansionpharma.com

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Oral Anabolic Steroids Powder 7-Keto DHEA Acetate CAS 1449-61-2

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Oral Anabolic Steroids Powder 7-Keto DHEA Acetate CAS 1449-61-2
 
7-Keto-DHEA Acetate Basic Info.:
 
Product Name: Androst-5-en-3-ol-7,17-dione acetate
Synonyms: 10,13-dimethyl-7,17-dioxo-2,3,4,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthren-3-yl acetate;7-KETO-DHEA;7-OXO-DEHYDROEPIANDROSTERONE ACETATE;7,17-dioxoandrost-5-en-3-yl acetate;androst-5-en-3-ol-7,17-dione acetate;3-BETA-ACETOXYANDROST-5-ENE-7,17-DIONE;3BETA-ACETOXY-17A-OXO-ANDROST-5-ENE-7,17-DIONE;3-ACETYL-7-KETO-DHEA
CAS: 1449-61-2
MF: C21H28O4
MW: 344.44
EINECS: N/A
Product Categories: Pharmaceutical Raw Materials;steroids
 
Description And Applications Of 7-Keto-DHEA Acetate:
 
7-keto-DHEA is a by-product of dehydroepiandrosterone (DHEA), a chemical that is formed in the body. 
DHEA is a "parent hormone" produced by glands near thekidneys. But unlike DHEA, 7-keto-DHEA is not converted to steroid hormones such as androgen and estrogen. Taking 7-keto-DHEA by mouth or applying it to the skindoes not increase the level of steroid hormones in the blood.
 
7-keto-DHEA might promote weight loss by speeding up the body's metabolism.
7-Keto is marketed as a dietary supplement with the implication that it may accelerate weight loss, increase metabolism, enhance memory, or prevent age-related changes. When used in a topical (skin lotion) product 7-Keto caused long-lasting changes in the body's levels of testosterone, epitestosterone, estradiol, and other steroid hormones. Researchers have raised concern that supplements may trigger positive tests for performance-enhancing drugs.
 

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