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Pharmaceutical Grade Reducing Fat Mass Chemicals Sr9011 SR-9011 1379686-29-9

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Pharmaceutical Grade Reducing Fat Mass Chemicals Sr9011 SR-9011 1379686-29-9
 
SR9011 Basic Info:
 
Product Name: SR9011
Synonyms: 3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)-N-pentylpyrrolidine-1-carboxamide
CAS No: 1379686-29-9
Molucelar Formula: C23H31ClN4O3S
Molucelar Weight: 479.03524
Solubility: DMSO up to 100 mM
 
Sr9011 Description:
 
SR9011 is a trifunctional methacrylate monomer that provides exceptional adhesion to metal substrates.
SR9011 is recommended for use in peroxide cured coatings, sealants, and PVC-based plastisols. Usage levels of 5% to 10% by weight are recommended.
 
SR9011 is a potent and specific synthetic REV-ERB agonist that binds to REV ERB α with an EC50 ~790 nM and REV-ERB-β with EC50 ~560 nM. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.
 
Sr9011 Application:
 
In vitro: SR9011 was used at 5-10 μM concentration in vitro and in cellular assays.
In vivo: IP administration of SR9011 was used at 100 mg/kg once or twice per day for 12-30 days in different mouse models.
 

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Tacrolimus FK-506 Pharmaceutical Intermediates Organ Transplant 104987-11-3

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Tacrolimus FK-506 Pharmaceutical Intermediates Organ Transplant  104987-11-3
 
Tacrolimus Basic info: 
 
Product Name: Tacrolimus
Synonyms: Tacrolimus;Fr900506;Prograf;Tsukubaenolide;FK-506;
CAS: 104987-11-3
MF: C44H69NO12
MW: 804.02
Purity: 99%
Melting Point: 113-115°C
Boiling Point: 871.7 °C at 760 mmHg
Solubility: DMSO: >3 mg/mL
Appearance: White Crystalline Powder
Storage temp.: −20°C
Storage: Store in a cool, dry place. Do not store in direct sunlight. Store in a tightly closed container.
Product Categories: Active Pharmaceutical Ingredients;Immunosuppressant.;Intermediates & Fine Chemicals;Pharmaceuticals;API;Chiral Reagents;Fujimycin, Prograf;antibiotic;Inhibitors.
Usage: FK-506 (Tacrolimus) is a macrolide immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system.
 
Tacrolimus Application: 
 
L Immunosuppression following transplantation It has similar immunosuppressive properties to ciclosporin, but is much more potent. Immunosuppression with tacrolimus was associated with a significantly lower rate of acute rejection compared with ciclosporin-based immunosuppression (30.7% vs 46.4%) in one study. Clinical outcome is better with tacrolimus than with ciclosporin during the first year of liver transplantation. Long term outcome has not been improved to the same extent. Tacrolimus is normally prescribed as part of a post-transplant cocktail including steroids, mycophenolate and IL-2 receptor inhibitors. Dosages are titrated to target blood levels. Typical starting doses for once daily tacrolimus are 0.15-0.20 mg/kg body weight.
 
Tacrolimus Interactions:
 
Also like cyclosporin it has a wide range of interactions, including that with grapefruit which increases plasma-tacrolimus concentration. Several of the newer class of antifungals, especially of the azole class (fluconazole, posaconazole) also increase drug levels by competing for degradative enzymes.
 
Ulcerative colitis: 
In recent years, tacrolimus has been used to suppress the inflammation associated with ulcerative colitis, a form of inflammatory bowel disease. Although almost exclusively used in trial cases only, tacrolimus has shown to be significantly effective in the suppression of outbreaks of UC.
 
Tacrolimus Dermatological Use: 
 
As an ointment, tacrolimus is used in the treatment of eczema, in particular atopic dermatitis. It suppresses inflammation in a similar way to steroids, and is equally as effective as a mid-potency steroid. An important advantage of tacrolimus is that, unlike steroids, it does not cause skin thinning (atrophy), or other steroid related side-effects.
 
It is applied on the active lesions until they heal off, but may also be used continuously in low doses (twice a week), and applied to the thinner skin over the face and eyelids[citation needed]. Clinical trials of up to one year have been conducted. Recently it has also been used to treat segmental vitiligo in children, especially in areas on the face.
 

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tert-Butyl ((1R,2R,5S)-5-(dimethylcarbamoyl)-2-hydroxycyclohexyl)carbamate 99%

Shanghai Ansion Pharma Technology Co.,Ltd

www.ansionpharma.com

ann.xu@ansionpharma.com

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(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid 99%

Shanghai Ansion Pharma Technology Co.,Ltd

www.ansionpharma.com

ann.xu@ansionpharma.com

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(S)-3-((S)-5-(4-fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one 99%

Ansion pharma is a factory providing pharmaceutical intermediate and custom synthesis service. 
 
More products infomation, pls contact us: ann.xu@ansionpharma.com; www.ansionpharma.com

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3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine 99%

Shanghai Ansion Pharma Technology Co.,Ltd

www.ansionpharma.com

ann.xu@ansionpharma.com

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6-(5-((2-(Methylsulfonyl)ethylamino)methyl)furan-2-yl)quinazolin-4(3h)-one 99%

Ansion pharma is a factory providing pharmaceutical intermediate and custom synthesis service. 
 
More products infomation, pls contact us: ann.xu@ansionpharma.com; www.ansionpharma.com

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9-Bromo-3-(2-Bromo Acetyl)-10,11-Dihydro-5H-dibenzo(c,g) Chromen-8(9H)-one 99%

Shanghai Ansion Pharma Technology Co.,Ltd
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ann.xu@ansionpharma.com

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99% High Quality Anesthetic CAS 61-12-1 Dibucaine Hydrochloride Dibucaine HCl

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99% High Quality Anesthetic CAS 61-12-1 Dibucaine Hydrochloride Dibucaine HCl
 
Dibucaine HCL Basic Info.:
 
Product Name: Dibucaine hydrochloride
Dibucaine hydrochloride Synonyms: 2-butoxy-n-(2-(diethylamino)ethyl)-4-quinolinecarboxamidmonohydrochlorid;butoxycinchoninicaciddiethylethylenediamidehydrochloride;c3225
CAS: 61-12-1
MF: C20H30ClN3O2
MW: 379.92
EINECS: 200-498-1
Product Categories: Heterocycles;Intermediates & Fine Chemicals;PharmaceuticalsDibucaine hydrochloride  Chemical Properties:whitepowder Dibucaine hydrochloride  Usage Anesthetic (local).
 
Dibucaine HCL Description:
 
Dibucaine hydrochloride is a local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted. The drug blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade.
 
In combination sodium dibucaine hydrochloride is administered to dogs to induce rapid, humane, painless euthanasia. The euthanasia solution is toxic to wildlife. Euthanized animals must be properly disposed of by deep burial, incineration or other method in compliance with state and local laws.
 
Dibucaine HCL Applications:
 
Spinal anesthesia (high, low, saddle block) and topically to produce surface anesthesia. Eye: To anesthetize conjunctiva and cornea prior to superficial procedures (including tonometry, gonioscopy, removal of foreign bodies or sutures, corneal scraping).
 
Nose and Throat: To abolish laryngeal and esophageal reflexes prior to bronchoscopy, esophagoscopy.
Skin: To relieve pruritus, pain, burning.
 

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Body Building Anabolic Sarms LGD-4033 Purity 99% Sarms Ligandrol 1165910-22-4

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Body Building Anabolic Sarms LGD-4033 Purity 99% Sarms Ligandrol 1165910-22-4
 
LGD-4033 Basic Info.:
 
Product Name: LGD-4033
Synonyms: LGD-4033;LGD4033;Ligandrol;
CAS: 118237-47-0
MF: C20H16ClN5O2
MW: 393.826
Purity: 99.5%(HPLC)
Apprarance: White crystalline powder.
 
LGD-4033 Product Description:
 
LGD-4033 is a selective androgen receptor modulator (SARMS), and a novel non-steroidal oral SARM that binds to AR with high affinity (Ki of ~1 nM) and selectivity. It’s in a class of androgen receptor (AR) ligands that is tissue selective, developed to treat muscle wasting associated with cancer, acute and chronic illness and age-related muscle loss. LGD-4033 is expected to produce the therapeutic benefits of testosterone with improved safety, tolerability and patient acceptance due to tissue-selective mechanism of action and an oral route of administration.
 
LGD-4033, a novel nonsteroidal, oral selective androgen receptor modulator, binds to the androgen receptor with high affinity and selectivity. It demonstrates anabolic activity in muscles, anti-resorptive and anabolic activity in bones and a robust selectivity for muscle and bone versus prostate and sebaceous glands. LGD-4033 has recently completed a Phase I Multiple Ascending Dose study in healthy volunteers. This randomized, double-blind, placebo-controlled Phase I study established the safety and tolerability up to doses of 22 mg per day.
 
LGD-4033 Application:
 
LGD is still fairly new (3-5 years), but the results have been very similar in studies and logs. LGD-4033 has undergone several recent studies and trials to find the best and safest way to use it. From these trials, the results have shown increases in lean body mass and decreases in body fat. There is also a significant increase in strength, well being, as well as healing possibilities.
 
LGD has shown the most ability of any SARM to put on size that could be considered a bulk. This will, of course, be dependent upon the diet used. Users that have experienced more than 10lb. increases, and have had a significant increase in calorie intake. The possibility of this type of size is present with LGD use. A recommend dosage for this type of goal would be 5-10 mg day for 8 weeks.
 
LGD seems to shine with this method. Many have seen an increase in lean body mass and a decrease in body fat. LGD seems to work the best with this method. Ran in conjunction with other SARMS, like cardarine (GW-501516), will only increase the likelihood of a stronger recomp. Recommended doses for recomping would be 5-8 mg a day for 8 weeks.
 
LGD can be used to cut as well. It will shine more-so if ran in conjunction with SARMS S-4 and Cardarine (GW-501516). This would be similar to a SARMS triple stack that is normally ran with Ostarine, except there is a possibility of more size being put on while cutting. A good dose for this method would be 3-5 mg a day for 8 weeks.
 

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