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Sustanon 250 USP 99%

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Tacrolimus FK-506 Pharmaceutical Intermediates Organ Transplant 104987-11-3

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Tacrolimus FK-506 Pharmaceutical Intermediates Organ Transplant  104987-11-3
 
Tacrolimus Basic info: 
 
Product Name: Tacrolimus
Synonyms: Tacrolimus;Fr900506;Prograf;Tsukubaenolide;FK-506;
CAS: 104987-11-3
MF: C44H69NO12
MW: 804.02
Purity: 99%
Melting Point: 113-115°C
Boiling Point: 871.7 °C at 760 mmHg
Solubility: DMSO: >3 mg/mL
Appearance: White Crystalline Powder
Storage temp.: −20°C
Storage: Store in a cool, dry place. Do not store in direct sunlight. Store in a tightly closed container.
Product Categories: Active Pharmaceutical Ingredients;Immunosuppressant.;Intermediates & Fine Chemicals;Pharmaceuticals;API;Chiral Reagents;Fujimycin, Prograf;antibiotic;Inhibitors.
Usage: FK-506 (Tacrolimus) is a macrolide immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system.
 
Tacrolimus Application: 
 
L Immunosuppression following transplantation It has similar immunosuppressive properties to ciclosporin, but is much more potent. Immunosuppression with tacrolimus was associated with a significantly lower rate of acute rejection compared with ciclosporin-based immunosuppression (30.7% vs 46.4%) in one study. Clinical outcome is better with tacrolimus than with ciclosporin during the first year of liver transplantation. Long term outcome has not been improved to the same extent. Tacrolimus is normally prescribed as part of a post-transplant cocktail including steroids, mycophenolate and IL-2 receptor inhibitors. Dosages are titrated to target blood levels. Typical starting doses for once daily tacrolimus are 0.15-0.20 mg/kg body weight.
 
Tacrolimus Interactions:
 
Also like cyclosporin it has a wide range of interactions, including that with grapefruit which increases plasma-tacrolimus concentration. Several of the newer class of antifungals, especially of the azole class (fluconazole, posaconazole) also increase drug levels by competing for degradative enzymes.
 
Ulcerative colitis: 
In recent years, tacrolimus has been used to suppress the inflammation associated with ulcerative colitis, a form of inflammatory bowel disease. Although almost exclusively used in trial cases only, tacrolimus has shown to be significantly effective in the suppression of outbreaks of UC.
 
Tacrolimus Dermatological Use: 
 
As an ointment, tacrolimus is used in the treatment of eczema, in particular atopic dermatitis. It suppresses inflammation in a similar way to steroids, and is equally as effective as a mid-potency steroid. An important advantage of tacrolimus is that, unlike steroids, it does not cause skin thinning (atrophy), or other steroid related side-effects.
 
It is applied on the active lesions until they heal off, but may also be used continuously in low doses (twice a week), and applied to the thinner skin over the face and eyelids[citation needed]. Clinical trials of up to one year have been conducted. Recently it has also been used to treat segmental vitiligo in children, especially in areas on the face.
 

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Teriparatide Acetate

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Tesamorelin Anabolic Androgenic Steroids Tesamorelin Intramuscular Injection 218949-48-5

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Tesamorelin Anabolic Androgenic Steroids Tesamorelin Intramuscular Injection 218949-48-5
 
Tesamorelin Basic Info.:
 
Product Name: Tesamorelin
Unit Size: 2 mg/vial 
Unit Quantity: 1 Vial 
C6H9O-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2
CAS: 218949-48-5
Molecular Formula: C211H366N72O67S1
Molecular Weight: 5135.89
Appearance: white powder
Purity (HPLC): ≥99.00%
Packing: According to every customer's requirement.
 
Tesamorelin Description:
 
Tesamorelin is a synthetic peptide consisting of all 44 amino acids of hGRF with the addition of a trans-3-Hexenoic acid group.Tesamorelin (also known as Egrifta) is a synthetic form of growth-hormone-releasing hormone which is used in the treatment of HIV-associated lipodystrophy.tendon fibroblasts in a dose-dependent manner as revealed by transwell filter migration assay. BPC 157 also dose dependently accelerated the spreading of tendon fibroblasts on culture dishes. The F-actin formation as detected by FITC-phalloidin staining was induced in BPC 157-treated fibroblasts. The protein expression and activation of FAK and paxillin were determined by Western blot analysis, and the phosphorylation levels of both FAK and paxillin were dose dependently increased by BPC 157 while the total amounts of protein was unaltered. In conclusion, BPC 157 promotes the ex vivo outgrowth of tendon fibroblasts from tendon explants, cell survival under stress, and the in vitro migration of tendon fibroblasts, which is likely mediated by the activation of the FAK-paxillin pathway.
 
Tesamorelin Applications:
 
1. Triptorelin raises testosterone levels by causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). 
 
2. Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty,estrogen-dependent conditions (such as endometriosis or uterine fibroids), and in assisted reproduction.
 

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Testosterone Decanoate USP 99%

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USP 99% Raw Steroids Powder Anabolic Testosterone Decanoate 5721-91-5
 
Testosterone Decanoate Basic Info.:
 
Product Name: Testosterone Decanoate (Test D)
Synonyms: Test D;Testosterone Decanoate;4-Androsten-17Beta-Ol-3-One Decanoate
CAS: 5721-91-5
Molecular Formula: C29H46O3
Molecular Weight: 442.68
EINECS: 227-226-4
Specification: 200mg/ml
Packing: foil bag or tin
Appearance: yellowish liquids
Usage: Pharmaceutical material
 
Testosterone Decanoate Description:
 
Testosterone decanoate is a steroid hormone from the androgen and is found in mammals and other vertebrates, testosterone decanoate is primarily secreted in the tests of mails and the ovaries of female, although small amount are also secreted by the adrenal glands, testosterone decanoate is the principle male sex hormone and an anabolic steroid.
 
Testosterone decanoate plays a key role in the development of male reproductive tissue such as the testis and prostates. In addition, testosterone decanoate is essential for health and well-being as well as the prevention of osteoporosis, testosterone decanoate is conserved through most vertebrates, although fish make a slightly difference.
 
Testosterone Decanoate Applications:
 
Testosterone decanoate is commonly used in intramuscular injection solution, the oil absorption is slow, function is strong and durable, can maintain time for just a few days.Testosterone propionate can promote the development of male organs and secondary sex characteristic, promote protein synthesis and bone formation, estrogen, inhibit the growth of endometrium and ovary and pituitary function. Used for testosterone, cryptorchidism, male hypogonadism, gynecological diseases, such as menorrhagia, uterine fibroids, senile osteoporosis and aplastic anemia.
 

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Testosterone Undecanoate USP 99%

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Anabolic Steroid Hormone Testosterone Undecanoate For Muscle Buildng 5949-44-0
 
Testosterone Undecanoate Basic Info.
 
Product Name: Testosterone Undecanoate
Alias: Test U;Testosterone Undecanoate;Andriol
CAS No.: 5949-44-0
Purity: 99%
MF: C30H48O3
MW: 456.7
Einecs No.: 227-712-65000
MOQ(minimum order quantity): 10gram
Standard: Enterprise Standard
Appearance: White powder, Odourless.
Usage: Can be used as pharmaceutical material. Its main function is to promote metabolism. Anabolic effects include growth of muscle mass and strength, increased bone density and strength, and stimulation of linear growth and bone maturation.
 
Testosterone Undecanoate Description:
 
Testosterone undecanoate or testosterone undecylate is an ester of testosterone which is used for the treatment of male hypogonadism, and is currently under research for use as a male contraceptive, testosterone undecanoate is sold and distributed under the brand names Andriol, understor, nebido, pantestone, restandol.
 
Testosterone Undecanoate Applications:
 
Testosterone undecanoate or testosterone undecylate is an ester of testosterone which is used for the treatment of male hypogonadism, and is currently under research for use as a male contraceptive, testosterone undecanoate is sold and distributed under the brand names Andriol, understor, nebido, pantestone, restandol.
 
Andriol is a version of the anabolic steroid testosterone undecanoatedeveloped by the pharmaceutical company organon, testosterone is said to enter the body as a fat through the lymphatic system, experience from user indicates that in dose of less than 240mg per day, effects are negligible, except at every onset of use, while even in higher dose, effects are still minimal, testosterone undecanoate is therefor thought that most of the steroid is somehow not making it into the blood stream.
 
Testosterone undecanoate or testosterone undecylate is an ester of testosterone. This hormone is used in androgen replacement therapy primarily for the treatment of male hypogonadism, and is currently under research for use as a male contraceptive.
 

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Tetrafluoroterephthalonitrile Technical 98%

Product Name: Tetrafluoroterephthalonitrile
Cas No: 1835-49-0
Synonyms:
1,4-Dicyano-2,3,5,6-tetrafluorobenzene;1,4-Dicyanotetrafluorobenzene;2,3,5,6-tetrafluoro-4-benzenedicarbonitrile;Diamond 2031;diamond2031;Terephthalonitrile, tetrafluoro-;tetrafluoroterephthalodinitrile;2,3,5,6-TETRAFLUORO TEREPHTHALONITRILE
Molecular Formula: C8F4N2
Molecular Weight: 200.09
Appearance
White crystalline solid
Assay
>=98%
HNMR,COA,GC are available.
 
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Thioxanthen-9-one

manufacture of Thioxanthen-9-one(492-22-8)

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Thymosin Alpha1 Acetate

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Thyroid Hormone L-Liothyronine Powders 6893-02-3

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Thyroid Hormone L-Liothyronine Powders 6893-02-3
 
L-Liothyronine Basic Info.
 
Product Name: L-Liothyronine
Synonyms: T3;O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine;Cytomel;L-Liothyronine
CAS: 6893-02-3
MF: C15H12I3NO4
MW: 650.97
EINECS: 229-999-3
Purity: 99%
Melting point: 234-238 °C(lit.)
Alpha: 23°(c=2 in ethanol)
Storage temp.: −20°C
Chemical Properties: Off-White Solid
Product Categories: Amino Acids & Derivatives;Intermediates & Fine Chemicals;Labeling and Diagnostics Reagents;Pharmaceuticals;Inhibitors;Stable Isotopes.
Usage: One of the hormones produced by the thyroid gland that is involved in the maintenance of metabolic homeostasis. Also produced in peripheral tissues as the active metabolite of Thyroxine.
 
L-Liothyronine Description :
 
Triiodothyronine, also known as T3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate.
 
Production of T3 and its prohormone thyroxine (T4) is activated by thyroid-stimulating hormone (TSH), which is released from the pituitary gland. This pathway is regulated via a closed-loop feedback process: Elevated concentrations of T3, and T4 in the blood plasma inhibit the production of TSH in the pituitary gland. As concentrations of these hormones decrease, the pituitary gland increases production of TSH, and by these processes, a feedback control system is set up to regulate the amount of thyroid hormones that are in the bloodstream.
 
As the true hormone, the effects of T3 on target tissues are roughly four times more potent than those of T4.Of the thyroid hormone that is produced, just about 20% is T3, whereas 80% is produced as T4. Roughly 85% of the circulating T3 is later formed in the thyroid by removal of the iodine atom from the carbon atom number five of the outer ring of T4. In any case, the concentration of T3 in the human blood plasma is about one-fortieth that of T4. This is observed in fact because of the short half-life of T3, which is only 2.5 days.This compares with the half-life of T4, which is about 6.5 days.
 
L-Liothyronine Application:
 
High Purity Liothyronine sodium/Cytomel T3/3,3',5´╝Źtriiodothyronine sodium/CAS No: 55-06-1 200-223-5 Weight Loss Powders
Liothyronine is the most potent form of thyroid hormone. Chemically, it is nearly identical to triiodothyronine (T3). As such, it acts on the body to increase the basal metabolic rate, affect protein synthesis and increase the body's sensitivity to catecholamines (such as adrenaline) by permissiveness. The thyroid hormones are essential to proper development and differentiation of all cells of the human body. These hormones also regulate protein, fat, and carbohydrate metabolism, affecting how human cells use energetic compounds.
In comparison to levothyroxine (T4), liothyronine has a faster onset of action as well as a shorter biological half-life, which may be due to less plasma protein binding to thyroxine-binding globulin and transthyretin.
 
Physicians can use this instead of or in addition to levothyroxine (T4) for patients undergoing thyroid withdrawal. When a patient has thyroid cancer or Graves' disease, ablation therapy with radioactive iodine can be used to remove any trace thyroid tissue. For 131I therapy to be effective, the trace thyroid tissue must be avid to iodine. The best method is to starve the tissue of iodine but this can lead to hypothyroid symptoms for the patient. Withdrawal from levothyroxine can be done but it takes six weeks of withdrawal for the remaining thyroid tissue to be completely starved. Six weeks is needed owing to levothyroxine's long half life. Six weeks can be inconvenient for the patient and delay treatment. Liothyronine instead can be taken and withdrawn from for two weeks to starve the thyroid tissue. This is much safer and more convenient than levothyroxine.
 

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