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Amisulpride is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder. In small doses it is also used to treat depression.
Simvastatin is a derivative of lovastatin and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (hydroxymethylglutaryl COA reductases), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL receptors, it increases breakdown of LDL cholesterol. The 6-membered lactone ring of simvastatin is hydrolyzed in vivo to generate mevinolinic acid, an active metabolite structurally similar to HMG-CoA (hydroxymethylglutaryl CoA). Once hydrolyzed, simvastatin competes with HMG-CoA for HMG-CoA reductase, a hepatic microsomal enzyme. Interference with the activity of this enzyme reduces the quantity of mevalonic acid, a precursor of cholesterol.
Bicalutamide is an oral non-steroidal anti-androgen used in the treatment of prostate cancer and hirsutism. Bicalutamide acts as a pure anti-androgen by binding to the androgen receptor (AR) and preventing the activation of the AR and subsequent upregulation of androgen responsive genes by androgenic hormones. Bicalutamide is indicated for the treatment of stage D2 metastatic prostate cancer in combination with a luteinizing hormone-releasing hormone analogue or as a monotherapy. It has also been used in clinical trials for ovarian cancer. It has also been used in combination with castration. Bicalutamide is currently tested for treatment of andogen receptor positive metastatic breast cancer.
Posaconazole is a triazole antifungal drug. It is used to treat invasive infections by Candida species, Mucor, and Aspergillus species in severely immunocompromised patients. There is also limited clinical evidence for its utility in treatment of invasive disease caused by Fusarium species (fusariosis).
Dapagliflozin is an experimental drug being studied as a potential treatment for type 1 and 2 diabetes. Although dapagliflozin's method of action would operate on either type of diabetes or other conditions resulting in hyperglycemia, the current clinical trials specifically exclude participants with Type 1 diabetes.
Ammonium lactate is the ammonium salt of lactic acid, which is a natural acid produced by the fermentation of lactose (milk sugar). It is produced commercially from the bacterial fermentation of carbohydrates and molasses. Ammonium lactate acts as a preservative, acidity regulator, and anti-microbial agent which is highly effective against bacteria, fungi, and yeast.
Cutamesine CAS 165377-44-6, also known as SA-4503 and AGY94806, is a sigma-1 receptor agonist under development for recovery enhancement after acute ischemic stroke. Cutamesine protects against retinal cell death in vitro and in vivo by the agonistic effect of sigma-1 receptor. Therefore, sigma-1 receptor may have a potential as a therapeutic target in retinal diseases mediated by photoreceptor degeneration.
Amlodipine Besylate is a dihydropyridine calcium channel blocker and used as an antianginal and antihypertensive. Amlodipine Besylate is a prescription medication not FDA approved for veterinary use. Amlodipine Besylate is used to treat certain high blood pressure especially in cats with kidney disease. Amlodipine Besylate is used in cats for the treatment of systemic hypertension (high blood pressure).
Dolutegravir Sodium is the sodium salt form of dolutegravir, an orally bioavailable integrase strand-transfer inhibitor (INSTI), with activity against human immunodeficiency virus type 1 (HIV-1) infection.
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