API intermediates - suppliers, manufacturers, exporters

chemical-categories

Bortezomib

Bortezomib (originally PS-341 and marketed as Velcade by Millennium Pharmaceuticals) is the first therapeutic proteasome inhibitor to be tested in humans. Cardiovascular safety pharmacology studies in monkeys show that lethal IV doses are associated with decreases in blood pressure, increases in heart rate, increases in contractility, and ultimately terminal hypotension. In monkeys, doses of 3.0 mg/m2 and greater (approximately twice the recommended clinical dose) resulted in progressive hypotension starting at 1 hour and progressing to death by 12 to 14 hours following drug administration.

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Cisplatin

Cisplatin is a chemotherapy drug. It is used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas, and germ cell tumors. It was the first member of a class of platinum-containing anti-cancer drugs, which now also includes carboplatin and oxaliplatin.

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Dapagliflozin

Dapagliflozin is an experimental drug being studied as a potential treatment for type 1 and 2 diabetes. Although dapagliflozin's method of action would operate on either type of diabetes or other conditions resulting in hyperglycemia, the current clinical trials specifically exclude participants with Type 1 diabetes.

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Docetaxel

Docetaxel is a clinically well-established anti-mitotic chemotherapy medication. It is a semi-synthetic, second-generation taxane, with anti-neoplastic application for the treatment of breast, ovarian, and non-small cell lung cancer. Docetaxel is a taxoid antineoplastic agent. It promotes the assembly of microtubules from tubulin dimers and stabilizes microtubules by preventing depolymerization. Docetaxel interferes with the normal function of microtubule growth, which results in cell- cycle arrest at the G2/M phase and cell death. Docetaxel does not block disassembly of interphase microtubules and so does not prevent entry into the mitotic cycle, but does block mitosis by inhibiting mitotic spindle assembly. Docetaxel is mainly metabolized in the liver by the cytochrome P450 CYP3A4 and CYP3A5 subfamilies of isoenzymes.

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Dolutegravir Sodium

Dolutegravir Sodium is the sodium salt form of dolutegravir, an orally bioavailable integrase strand-transfer inhibitor (INSTI), with activity against human immunodeficiency virus type 1 (HIV-1) infection.

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FLURBIPROFEN AXETIL HPS 99%

[1,1'-Biphenyl]-4-acetic acid, 2-fluoro-a-methyl-, 1
[1,1'-Biphenyl]-4-acetic acid, 2-fluoro-a-methyl-, 1-(acetyloxy)ethyl ester
-(acetyloxy)ethyl ester

 

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MDL72274(HCl) LAB GRADE

MDL-72274 HCl CAS 85278-24-6 is selective and potent inhibitors of SSAO for treatment of Parkinson diseases. MDL-72974 is a potent (IC50 = 10(-9) M) inhibitor of both MAO-B and SSAO, with 190-fold lower affinity for MAO-A. In clinical studies, oral doses as low as 100 micrograms produced substantial inhibition of platelet MAO-B. One or 4 mg MDL-72274 HCl given daily for 28 days to 40 Parkinson's patients treated with L-dopa produced statistically significant reductions in the Unified Parkinson's Disease Rating Scale. MAO-B inhibitors, such as MDL 72974A and L-deprenyl, offer the potential of being neuroprotective in Parkinson's Disease and other neurogenerative disorders

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Medical Salicylic acid USP 99.0-100.5%

Medical Salicylic Acid

 

Annual output: 4000 MT

Chemical name: Benzoic acid,-2hydroxcy

Molecular formula: C7H6O3

CAS: 69-72-7

Molecular weight: 138.12

EINECS: 200-712-3

HS Code29182110

Structure formula:

Standard: BP/USP/EP/CP/JP

Physical and Chemical Properties: White crystal or crystal powders, and sweets first and then hot, no chemical changes in the air. Atmospherically sublimation temperature over 76oC.Easily to decarboxylate and change into phenol and dioxide when heated atmospherically, and its aqueous solution appears acid reaction, becomes purple with FeCL3.Slightly dissolves in water but dissolves in boiling water easily. Dissolves in the ethanol or ether and slightly soluble in chloroform.

Specification:

Appearance: White crystal or crystal powders

Clarity and color of solution: Meet the requirement.

Loss of drying: ≤0.5%

Sulfate ash: ≤0.1%

Assay: 99.0-100.5%

Moisture: ≤0.40%

Heavy metals: ≤20ppm

Sulfate: ≤200ppm

M.P.: ≥158oC

Phenol: ≤0.10%

Usage: Medicine of disinfection and antiseptic for dissolving skin cutin hyperplasia and skin mould infection.

 

Packing:

25kg / kraft bag or fibre drum

25kg / package with paper or polyethylene bag inside

1 MT = 40 Packages

Packing size: 50*80cm / kraft bag; 36*40 cm / fibre drum

Capacity / 20"FCL:

Without pallet: 20 MT / 800 Bag , 1.6CBM/MT;  15 MT / 600 Drum, 2.1CBM / MT

with pallet: 18 MT / 720 Bag , 11 .25MT / 450 Drum

Our company may produce and pack according to customer's requirement.

 

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Medical Salicylic acid USP 90-104%

Aspirin (Acetyl Salicylic Acid)

Annual output: 3300 MT

Chemical name: Benzoic acid, 2-(acetyloxyl)-Salicylic acid acetate

Alias: Aspirin, Acetylsalicylic acid, 2-(Acetyloxy)benzoic acid, Acetol 

Molecular formula: C9H8O4

CAS: 50-78-2

Molecular weight: 180.2

EINECS No.: 200-064-1

HS Code: 29182210

Structure formula:

Quality Standard: BP/USP/EP/CP/JP

Physical and Chemical Properties: White crystal or crystalline powder,with acid taste and is stable in dry air,slowly hydrolyze into salicylic acid and acetic anhydride.Its solution shows and acid reaction.Sparingly soluble in alcohol,chloroform or ether,slightly soluble in water or absolute ether,it dissolves in alkali hydroxide or alkali carbonate solution and decomposes at the same time.

Specification:

Assay: 99.50-101.0%

Clarity and color of solution: Clear and colorless

Heavy metals: ≤20ppm

Free salicylic acid: ≤500ppm

Sulfate: ≤0.1%

Loss of drying: ≤0.5%

Addition Material: ≤0.1%

Appearance: white crystal or crystalline powder.

Usage: This product is an antipyretic ant rheumatic that is used to allay fever, headache, arthralgia, acticerheumatism, and rheumatoid arthritis. Toothache and dysmenorrhea and as raw material for making anti-carcinogen.

 

Packing:

25kg / kraft bag or fibre drum

25kg / package with paper or polyethylene bag inside

1 MT = 40 Packages

Packing size: 50*80cm / kraft bag;  36*40 cm / fibre drum

Capacity / 20"FCL:

without pallet: 20 MT / 800 Bag , 1.6CBM/MT;  15 MT / 600 Drum, 2.1CBM / MT

with pallet: 18 MT / 720 Bag , 11 .25MT / 450 Drum

Our company may produce and pack according to customer's requirement.

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