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duloxetine hcl 99%

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Shanghai Ansion pharma Technology Co.,Ltd
www.ansionpharma.com
ann.xu@ansionpharma.com

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Atorvastatin Calcium

* CAS No.: 134523-03-8 * IUPAC Name: 7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid, Calcium salt * Molecular weight: 558.64 g/mol * Chemical Formula: C33H34FN2O5 * Assay/Purity: NLT 98% * Description: White solid * Category: Blood cholesterol lowering agent * Indications: Primary uses of atorvastatin are for the treatment of dyslipidemia and the prevention of cardiovascular disease.

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Bethanechol Chloride

Bethanechol chloride, a cholinergic agent, is a synthetic ester which is structurally and pharmacologically related to acetylcholine. Bethanechol chloride is indicated for the treatment of acute postoperative and postpartum nonobstructive (functional) urinary retention, and neurogenic atony of the urinary bladder with retention.

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Dicloxacillin Sodium

Dicloxacillin Sodium is an oral semisynthetic isoxazolyl antistaphylococcal penicillin. It is stable against penicillinase.It is active against many of the penicillinase-producing strains of Staphylococcus aureus, and is used mainly in the treatment of infections caused by these organisms. It is the most active of the isoxazolyl antistaphylococcal penicillins. It is used to skin and soft-tissue infections, bone and joint infections, and urinary and respiratory tract infections.

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Fluconazole USP >99%

Fluconazole USP and BP grades available

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Isavuconazonium 99%

Shanghai Ansion Pharma Technology Co.,Ltd
www.ansionpharma.com
ann.xu@ansionpharma.com

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L-Citrulline USP 99%

Product: L-Citrulline

Cas No.: 372-75-8

Molecular Formular: C6H13N3O3
Molecular Weight: 175.19

Conforms to: AJI92

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RAF265 Technical 90%

RAF265 (CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM, and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM.

in vitro: RAF265 inhibits C-Raf, wild type B-Raf and mutant (V600E) B-Raf. RAF265 effectively block phosphorylation of Raf's downstream substrates MEK and ERK in cells and also kill melanoma and colorectal cancer cell lines harboring B-Raf mutations independent of PTEN mutation status. Raf kinase inhibition by RAF265 in mutant B-Raf melanoma cell lines causes cell cycle arrest and induces apoptosis, mimicking the effect of Raf RNAi in these cells. RAF265 also potently inhibits the phosphorylation of VEGFR2 and proliferation of VEGF-stimulated hMVEC [1]. In HT29 and MDAMB231 cells, RAF265 shows inhibitory activity with IC20 of 1 to 3 μM and IC50 of 5 to 10 μM, respectively. While RAF265 leads to a significant decrease in clonogenic survival in all tested cell lines, which means that RAF265 induces a dominant effect on clonogenic survival. Addition of RAF265 to RAD001 in HCT116 cells could lead to moderately decreased AKT, S6 protein, and 4EBP1 phosphorylation [2]. Raf265 markedly reduces the protein level of Bcl-2 and great inhibitory in CM- and NCI-H727 cells, while having no effect on the TRAIL susceptibility of BON1 and GOT1 cells [3].

in vivo: AF265 shows 71% to 72% TVI% (tumor volume inhibition percentage) in HCT116 xenografts at 12 mg/kg. While the combination of RAF265 and RAD001 shows enhanced antitumor activity with increased T10 (time to achieve a relative tumor volume of 10 times the initial tumor volume) and tumor growth delay. The combination of RAD001 and RAF265 also significantly enhances the activation of caspase-3 in HCT116 and MDAMB231 but not in A549 xenografts [2]. RAF265 inhibits FDG (2-deoxy-2-[18F]fluoro-d-glucose) accumulation and decreases the tumor volumes in A375M xenografts by orally dosed of 100 mg/kg [4].

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Rocuronium Bromide

Those products patented are for laboratory analytical/research purpose only, not offered for sale in countries where the sales of sunch products constitutes patent infringement, otherwise the following liability is at buyer’s rick.

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Vecuronium bromide

Those products patented are for laboratory analytical/research purpose only, not offered for sale in countries where the sales of sunch products constitutes patent infringement, otherwise the following liability is at buyer’s rick.

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