Anticancer drugs used in treating malignancies cells in human body

chemical-categories

Ledipasvir

Name Ledipasvir
Synonyms GS 588
Molecular Formula C49H54F2N8O6
Molecular Weight 889.00
CAS Registry Number 1256388-51-8

 

 

 

1-(7-Bromo-9,9-difluoro-9H-fluoren-2-yl)-2-chloroethanone 1378387-81-5
(1R,3S,4S)-3-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]-2-azabicyclo[2.2.1]heptane-2-carboxylic acid 1,1-dimethylethyl ester 1256387-87-7
(1R,3S,4S)-3-(6-Bromo-1H-benzimidazol-2-yl)-2-azabicyclo[2.2.1]heptane-2-carboxylic acid 1,1-dimethylethyl ester 1256387-74-2
(1R,3S,4S)-2-(tert-Butoxycarbonyl)-2-azabicyclo[2.2.1]heptane-3-carboxylic acid 291775-59-2
(S)-2-((Methoxycarbonyl)amino)-3-methylbutanoic acid 74761-42-5
(6S)-6-[5-[7-[2-(1R,3S,4S)-2-Azabicyclo[2.2.1]hept-3-yl-1H-benzimidazol-6-yl]-9,9-difluoro-9H-fluoren-2-yl]-1H-imidazol-2-yl]-5-azaspiro[2.4]heptane hydrochloride (1:4) 1499193-67-7
ledipasvir interMediate 1441670-89-8
ledipasvir interMediate 1441673-92-2

 

 

A benzimidazole derivative that is used in combination with sofosbuvir (under the trade name Harvoni) for the treatment of chronic hepatitis C genotype 1 infection.

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Mafosfamide

Mafosfamide is an oxazaphosphorine alkylating agent under investigation as a chemotherapeutic. Several Phase I trials have been completed.

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Minoxidil 98%

Name

Minoxidil

Synonyms

2,4-Diamino-6-piperidino-pyrimidine-3-oxide; 6-(1-Piperidinyl)-2,4-pyrimidinediamine-3-oxide; Loniten; Regain; Rogaine

Molecular Formula

C9H15N5O

Molecular Weight

209.25

CAS Registry Number

38304-91-5 (16317-69-4)

White to off-white powder

Loss on drying≤0.5%

Assay:98,5-101 %

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Mitoxantrone

Mitoxantrone is an anthracenedione antineoplastic agent. It is used in the treatment of certain types of cancer, mostly metastatic breast cancer, acute myeloid leukemia, and non-Hodgkin's lymphoma. It is also used to treat multiple sclerosis.

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Nimustine

Nimustine is a nitrosourea alkylating agent. It is used as antineoplastic agents. The drug has also been used in combination with other antineoplastic agents or with radiotherapy for the treatment of various neoplasms.

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Paclitaxel

Paclitaxel is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. Paclitaxel is classified as a "plant alkaloid," a "taxane" and an "antimicrotubule agent."

Paclitaxel Injection is used for treatment of breast, ovarian, lung, bladder, prostate, melanoma, esophageal, as well as other types of solid tumor cancers. It has also been used in Kaposi's sarcoma.

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Palbociclib

Name

Palbociclib
Synonyms 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(piperazin-1-yl)pyridin-2-yl]amino]-8H-pyrido[2,3-d]pyrimidin-7-one; PD 0332991
Molecular Formula C24H29N7O2
Molecular Weight 447.53
CAS Registry Number 571190-30-2

 

 

 

6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one 1016636-76-2
tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate 571188-59-5

 

A new drug for the treatment of breast cancer

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Picoplatin

Picoplatin is a cytotoxic platinum compound in clinical development by Poniard Pharmaceuticals for the treatment of patients with solid tumors. In Phase I and Phase II clinical trials, picoplatin demonstrated activity in a variety of solid tumors, including lung, ovarian, colorectal and hormone-refractory prostate cancer. However, in Phase III trials, picoplatin failed to hit its primary endpoint for advanced small cell lung cancer. Hopes are now pinned on its use for metastatic colorectal cancer.

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Procarbazine

Procarbazine is an antineoplastic chemotherapy drug for the treatment of Hodgkin's lymphoma and certain brain cancers. It is a member of a group of medicines called alkylating agents. It gained FDA Approved in July 1969. The drug is metabolized and activated in the liver. It also inhibits MAO thus increasing the effects of sympathomimetics, TCAs, and tyramine.

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Sorafenib

Sorafenib is a drug approved for the treatment of primary kidney cancer and advanced primary liver cancer.

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