Anticancer drugs used in treating malignancies cells in human body

chemical-categories

Dacarbazine

Dacarbazine is an antineoplastic chemotherapy drug used in the treatment of various cancers, among them malignant melanoma, Hodgkin lymphoma, sarcoma, and islet cell carcinoma of the pancreas. It is a member of the class of alkylating agents, which destroy cancer cells by adding an alkyl group to its DNA.

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Mafosfamide

Mafosfamide is an oxazaphosphorine alkylating agent under investigation as a chemotherapeutic. Several Phase I trials have been completed.

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Aprepitant

Name mk 0869
Synonyms Aprepitant; 5-[2(R)-[1(R)-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)morpholin-4-ylmethyl]-3,4-dihydro-2H-1,2,4-triazol-3-one
Molecular Formula C23H21F7N4O3
Molecular Weight 534.43
CAS Registry Number 170729-80-3 (221350-96-5)

Aprepitant is a neurokinin-1 (NK-1) receptor antagonist and belongs to the treating agents of vomiting during chemotherapy of cancer.

 

 

(R)-4-Benzyl-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)morpholin-3-one 287930-75-0
(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride 171482-05-6
(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine 4-methylbenzenesulfonate

200000-59-5
Methyl 2-(2-chloro-1-iminoethyl)hydrazinecarboxylate 155742-64-6
3-(Chloromethyl)-1H-1,2,4-triazol-5(4H)-one          252742-72-6
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethan-1-ol     127852-28-2

 

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Estramustine

Estramustine is a chemotherapy agent used to treat prostate cancer. It is a derivative of estrogen with a nitrogen mustard-carbamate ester moiety that makes it a alkylating antineoplastic agent similar to mechlorethamine, with estrogen-induced specificity.

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Ledipasvir

Name Ledipasvir
Synonyms GS 588
Molecular Formula C49H54F2N8O6
Molecular Weight 889.00
CAS Registry Number 1256388-51-8

 

 

 

1-(7-Bromo-9,9-difluoro-9H-fluoren-2-yl)-2-chloroethanone 1378387-81-5
(1R,3S,4S)-3-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]-2-azabicyclo[2.2.1]heptane-2-carboxylic acid 1,1-dimethylethyl ester 1256387-87-7
(1R,3S,4S)-3-(6-Bromo-1H-benzimidazol-2-yl)-2-azabicyclo[2.2.1]heptane-2-carboxylic acid 1,1-dimethylethyl ester 1256387-74-2
(1R,3S,4S)-2-(tert-Butoxycarbonyl)-2-azabicyclo[2.2.1]heptane-3-carboxylic acid 291775-59-2
(S)-2-((Methoxycarbonyl)amino)-3-methylbutanoic acid 74761-42-5
(6S)-6-[5-[7-[2-(1R,3S,4S)-2-Azabicyclo[2.2.1]hept-3-yl-1H-benzimidazol-6-yl]-9,9-difluoro-9H-fluoren-2-yl]-1H-imidazol-2-yl]-5-azaspiro[2.4]heptane hydrochloride (1:4) 1499193-67-7
ledipasvir interMediate 1441670-89-8
ledipasvir interMediate 1441673-92-2

 

 

A benzimidazole derivative that is used in combination with sofosbuvir (under the trade name Harvoni) for the treatment of chronic hepatitis C genotype 1 infection.

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Mitoxantrone

Mitoxantrone is an anthracenedione antineoplastic agent. It is used in the treatment of certain types of cancer, mostly metastatic breast cancer, acute myeloid leukemia, and non-Hodgkin's lymphoma. It is also used to treat multiple sclerosis.

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Procarbazine

Procarbazine is an antineoplastic chemotherapy drug for the treatment of Hodgkin's lymphoma and certain brain cancers. It is a member of a group of medicines called alkylating agents. It gained FDA Approved in July 1969. The drug is metabolized and activated in the liver. It also inhibits MAO thus increasing the effects of sympathomimetics, TCAs, and tyramine.

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Streptozocin

Streptozocin is a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. It is used in medicine for treating certain cancers of the Islets of Langerhans and used in medical research to produce an animal model for Type 1 diabetes.It is an antibiotic that is produced by Stretomyces achromogenes.It is known to inhibit DNA synthesis, interfere with biochemical reactions of NAD and NADH, and inhibit some enzymes involved in gluconeogenesis. Its activity appears to occur as a result of formation of methylcarbonium ions, which alkylate or bind with many intracellular molecular structures including nucleic acids. Its cytotoxic action is probably due to cross-linking of strands of DNA, resulting in inhibition of DNA synthesis.

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Trofosfamide

Trofosfamide is a nitrogen mustard alkylating agent.It is an orally bioavailable oxazaphosphorine prodrug with antineoplastic activity.It is metabolized predominantly to the cyclophosphamide analogue ifosfamide (IFO), which is then metabolized by liver cytochrome P450s to the active isophosphoramide mustard (IPM).

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Paclitaxel

Paclitaxel is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. Paclitaxel is classified as a "plant alkaloid," a "taxane" and an "antimicrotubule agent."

Paclitaxel Injection is used for treatment of breast, ovarian, lung, bladder, prostate, melanoma, esophageal, as well as other types of solid tumor cancers. It has also been used in Kaposi's sarcoma.

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