Antiparasitic drugs highly effective, safe, cost effective drugs used in parasitic diseases treatment

chemical-categories

Mefloquine

Mefloquine belongs to the class of medications called antimalarials. It is used to treat and prevent malaria infections caused by certain types of parasites.Mefloquine is a 4-methanolquinine antimalarial which acts as a blood schizontocide. It is active against most Plasmodium species and is used both as prophylaxis and treatment against malaria.It is used for the treatment of mild to moderate acute malaria caused by Mefloquineuine-susceptible strains of Plasmodium falciparum (both chloroquine-susceptible and resistant strains) or by Plasmodium vivax,and also for the prophylaxis of Plasmodium falciparum and Plasmodium vivax malaria infections, including prophylaxis of chloroquine-resistant strains of Plasmodium falciparum.

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Metronidazole

Metronidazole is a nitroimidazole antibiotic medication used particularly for anaerobic bacteria and protozoa.It is also amebicide.It is also used as a gel preparation in the treatment of the dermatological conditions such as rosacea and fungating tumours,used to treat infections of Giardia in dogs, cats, and other companion animals.It is also used to treat enteric (gi) and systemic infections.

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Nonactin

Nonactin is a member of a family of naturally occurring cyclic ionophores known as the macrotetrolide antibiotics. Nonactin is known for its ability to form complexes with alkali cations, most notably potassium and sodium.Nonactin has been reported to specifically inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. It is able to uncouple the oxidative phosphorylation of mitochondria of rat liver in a low concentration, and can also carry cations across biological and artificial membranes.

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Paclitaxel USP 98.5%

Paclitaxel:33069-62-4

White crystalline powder, odorless

Specific rotation:-49.0 ?-55o

Related substance≤2.0%

Loss on drying≤1.0%

Water≤4.0%

Residue on ignition≤0.2%

Residual Solvents

Dichloromethane≤0.06%

Heptane≤0.5%

Ethyl acetate≤0.5%

Acetone≤0.5%

Ether≤0.5%

Heavy metals≤20ppm

Microbial limits?0.4 USP/mg

Bacterial endotoxins?100 CFU/g

Assay(HPLC):97.0~102.0%

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Pentamidine

Pentamidine is an antimicrobial medication given for prevention and treatment of Pneumocystis pneumonia (PCP) caused by Pneumocystis jirovecii, a severe interstitial type of pneumonia often seen in patients with HIV infection.It is used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. It interferes with nuclear metabolism producing inhibition of the synthesis of DNA, RNA, phospholipids, and proteins.

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Primaquine

Primaquine is a medication used in the treatment of malaria and Pneumocystis pneumonia. It is a member of the 8-aminoquinoline group of drugs that includes tafenoquine and pamaquine.It is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria.It may be acting by generating reactive oxygen species or by interfering with the electron transport in the parasite.

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Pyrimethamine

Pyrimethamine is a medication used for protozoal infections. It is commonly used as an antimalarial drug, and is also used, in combination with sulfadiazine, in the treatment of Toxoplasma gondii infections in immunocompromised patients, such as HIV-positive individuals.Pyrimethamine inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis and cell multiplication. This leads to failure of nuclear division at the time of schizont formation in erythrocytes and liver.

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Quinine

Quinine is a natural white crystalline alkaloid having antipyretic,antimalarial, analgesic (painkilling), anti-inflammatory properties and a bitter taste. It is a stereoisomer of quinidine which, unlike quinine, is an anti-arrhythmic. Quinine contains two major fused-ring systems: the aromatic quinoline and the bicyclic quinuclidine.Quinine is used parenterally to treat life-threatening infections caused by chloroquine-resistant Plasmodium falciparum malaria. Quinine acts as a blood schizonticide although it also has gametocytocidal activity against P. vivax and P. malariae.

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Rafoxanide

Rafoxanide is a salicylanilide used as an antiparasitic agent.

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Sotagliflozin

Name

Sotagliflozin

Synonyms

LP 802034; LX 4211; (5S)-Methyl 5-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-thio-beta-L-xylopyranoside

Molecular Formula

C21H25ClO5S

Molecular Weight

424.94

CAS Registry Number

1018899-04-1

SGLT1 / SGLT2 double inhibitor

New drugs for the treatment of diabetes

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