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Minoxidil is an antihypertensive vasodilator medication which also slows or stops hair loss and promotes hair regrowth.It is an orally effective direct acting peripheral vasodilator that reduces elevated systolic and diastolic blood pressure by decreasing peripheral vascular resistance. Minoxidil is also used topically to treat androgenetic alopecia.It is thought to promote the survival of human dermal papillary cells (DPCs) or hair cells by activating both extracellular signal-regulated kinase (ERK) and Akt and by preventing cell death by increasing the ratio of BCl-2/Bax. Minoxidil may stimulate the growth of human hairs by prolonging anagen through these proliferative and anti-apoptotic effects on DPCs. Minoxidil, when used as a vasodilator, acts by opening adenosine triphosphate-sensitive potassium channels in vascular smooth muscle cells.
Nebivolol is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and, in Europe, also for left ventricular failure.It is highly cardioselective under certain circumstances.Nebivolol lowers blood pressure (BP) by reducing peripheral vascular resistance, and significantly increases stroke volume with preservation of cardiac output.
Practolol is a selective beta blocker that has been used in the emergency treatment of cardiac arrhythmias. It reduce the effect of excitemen or physical exertion on heart rate and force of contraction and dilation of blood vessels. It is no longer used as it is highly toxic despite the similarity of its chemical formula to propanolol. The use of practolol has been referred to as the practolol disaster and is considered the worst medical blunders since thalidomide.
Quinidine, a hydantoin anticonvulsant, is used alone or with phenobarbital or other anticonvulsants to manage tonic-clonic seizures, psychomotor seizures, neuropathic pain syndromes including diabetic neuropathy, digitalis-induced cardiac arrhythmias, and cardiac arrhythmias associated with QT-interval prolongation. Quinidine sulfate is used in the treatment of atrial fibrillation in the horse.
Tenoretic is for the treatment of hypertension. It combines the antihypertensive activity of two agents: a β1-selective (cardioselective) hydrophilic blocking agent (atenolol, Tenormin) and a monosulfonamyl diuretic (chlorthalidone).
Tocainide is a primary amine analog of lidocaine with antiarrhythmic properties useful in the treatment of ventricular arrhythmias. Tocainide acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. Tocainide binds preferentially to the inactive state of the sodium channels.
Valsartan is an angiotensin II receptor antagonist with particularly high affinity for the type I (AT1) angiotensin receptor. It is a prescription medicine that has been licensed to treat several conditions related to the heart and blood vessels.Valsartan is an angiotensin-receptor blocker (ARB) that may be used to treat a variety of cardiac conditions including hypertension, diabetic nephropathy and heart failure. Valsartan lowers blood pressure by antagonizing the renin-angiotensin-aldosterone system.Valsartan may be used to treat hypertension, isolated systolic hypertension, left ventricular hypertrophy and diabetic nephropathy. It may also be used as an alternative agent for the treatment of heart failure, systolic dysfunction, myocardial infarction and coronary artery disease.
Amiodarone is an antiarrhythmic agent used for various types of tachyarrhythmias, both ventricular and supraventricular arrhythmias. Discovered in 1961, it was not approved for use in the United States until 1985. Despite relatively common side-effects, it is used in arrhythmias that are otherwise difficult to treat with medication. Related newer compounds, such as dronedarone, have lower efficacy but a reduced rate of side-effects.
Arbutamine is a synthetic catecholamine with positive chronotropic and inotropic properties.It is used to elicit acute cardiovascular responses, similar to those produced by exercise, in order to aid in diagnosing the presence or absence of coronary artery disease (CAD) in patients who cannot exercise adequately.
Benazepril belongs to the class of medications called ACE inhibitors. It is the prescription medication used in dogs and cats for the treatment of heart failure, high blood pressure, and some forms of kidney disease. It works by relaxing blood vessels and reducing the workload of the heart. Benazepril may be used in addition to diuretics (water pills) known as thiazide diuretics.
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