Cardiovascular drugs used in cardiovascular diseases treatment heart attack, stroke, hypertension

chemical-categories

Lisinopril

Lisinopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). Lisinopril may be used to treat hypertension and symptomatic congestive heart failure, to improve survival in certain individuals following myocardial infarction, and to prevent progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy.

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Mexiletine

Mexiletine belongs to the Class IB anti-arrhythmic group of medicines. It is used to treat arrhythmias within the heart, or seriously irregular heartbeats. It slows conduction in the heart and makes the heart tissue less sensitive. Mexiletine has little or no effect at slower heart rates, and more effects at faster heart rates. It shortens the action potential duration, reduces refractoriness, and decreases Vmax in partially depolarized cells with fast response action potentials. Mexiletine either does not change the action potential duration, or decreases the action potential duration.

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Nesiritide

Nesiritide is used to improve breathing in people with congestive heart failure (CHF).

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Peruvoside

Peruvoside is a cardiac glycoside for heart failure. It is derived from Thevetia neriifolia.

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Ticagrelor

Ticagrelor is an oral antiplatelet treatment for acute coronary syndromes (ACS) in a new chemical class called cyclopentyltriazolopyrimidines (CPTPs). Ticagrelor works by preventing the formation of new blood clots and maintaining blood flow in the body to help reduce a patient's risk of another cardiovascular event (called atherothrombotic events) such as a heart attack or cardiovascular death. Ticagrelor is the first reversibly-binding oral adenosine diphosphate (ADP) receptor antagonist. Ticagrelor is extensively metabolized in humans with approximately 27% of the dose excreted as the parent compound.

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Troxerutin

Troxerutin is a flavonol, a type of flavonoid. It is more accurately a hydroxyethylrutoside. It can be isolated from Sophora japonica, the japanese pagoda tree. It is used as a vasoprotective.

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Zestoretic

Zestoretic combines an angiotensin converting enzyme inhibitor, lisinopril, and a diuretic, hydrochlorothiazide. It was sustained for at least 24 hours. Zestoretic is indicated for the treatment of hypertension.

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Alprostadil

Alprostadil (prostaglandin E1) is produced endogenously to relax vascular smooth muscle and cause vasodilation. In adult males, the vasodilatory effects of alprostadil on the cavernosal arteries and the trabecular smooth muscle of the corpora cavernosa result in rapid arteriolar inflow and expansion of the lacunar spaces within the corpora. In infants, it is used for palliative, not definitive, therapy to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in neonates who have congenital heart defects and who depend upon the patent ductus for survival. In adults, it is used for the treatment of erectile dysfunction due to neurogenic, vasculogenic, psychogenic, or mixed etiology. Alprostadil causes vasodilation by means of a direct effect on vascular and ductus arteriosus smooth muscle, preventing or reversing the functional closure of the ductus arteriosus that occurs shortly after birth. Alprostadil must be infused continuously because it is very rapidly metabolized.

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Ambrisentan

Ambrisentan is a drug indicated for use in the treatment of pulmonary hypertension. It functions as an endothelin receptor antagonist, and is selective for the type A endothelin receptor. Ambrisentan is indicated for the treatment of pulmonary arterial hypertension in patients with WHO class II or III symptoms to improve exercise capacity and delay clinical worsening.

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Anacetrapib

Anacetrapib is a CETP inhibitor being developed to treat hypercholesterolemia and prevent cardiovascular disease.

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