Cardiovascular drugs used in cardiovascular diseases treatment heart attack, stroke, hypertension


Heparin Sodium USP 95%

Heparin Sodium is the sodium salt of sulfated glycosaminoglycans and is present as a mixture of heterogeneous molecules varying in molecular weights that work against different factors of the blood clotting spectrum. It is obtained from porcine intestinal mucosa.Heparin Sodium is composed of polymers of alternating derivatives of α-D-glucosamido (N-sulfated, O-sulfated, or N-acetylated) and O-sulfated uronic acid (α-L-iduronic acid or β-D-glucuronic acid). The component activities of the mixture are in ratios corresponding to the USP specification. These components have the property of prolonging the clotting time of blood. This occurs mainly through the formation of a complexity of each component with the plasma proteins antithrombin and heparin cofactor II to potentiate the inactivation of thrombin (factor IIa). Other coagulation proteases in the clotting sequence, such as activated factor X (factor Xa), are also inhibited.

Heparin Sodium is a naturally-occurring anticoagulant used for anticoagulation for Cardiovascular Disease.Heparin Sodium Salt is widely used as an injectable anticoagulant. It can also be used to form an inner anticoagulant surface on various experimental and medical devices such as test tubes and renal dialysis machines.

Heparin sodium, is a kind of acid mucopolysaccharides an anti clotting drug, on a number of links in coagulation process to intervene, prolonged clotting time and thrombin time. And the application range is not limited to in vivo, in vitro threw a good anticoagulant effect, by fibrin, inhibiting platelet aggregation.

Heparin Sodium also can be used in cosmetic industry. Heparin sodium can be used as a hair tonic, nourishing cream acne products, eye cream, cosmetics raw materials. It can be added to the nutritional cream, eye cream, acne products and hair agent and other cosmetics to increase skin vascular permeability, improve the role of local vascular circulation, promote the supply of skin nutrition and the excretion of metabolic waste,Health care and skin care.

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Hexobendine is a vasodilator that acts as an adenosine reuptake inhibitor.

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Hidrosmin is a flavone, a type of flavonoid. It is a vasoprotective.

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ISIS-APOA is an antisense drug we designed to reduce apolipoprotein(a) in the liver to offer a direct approach for reducing Lp(a), an independent risk factor for cardiovascular disease.

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ISIS-APOCIII is an antisense drug we designed to reduce apolipoprotein C-III, or apoC-III, protein production and lower triglycerides. ApoC-III regulates triglyceride metabolism in the blood and is an independent cardiovascular risk factor. Humans who do not produce apoC-III have lower levels of triglycerides and lower instances of cardiovascular disease.

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ISIS-CRP is an antisense drug that targets CRP, a protein produced in the liver. CRP levels increase dramatically during inflammatory disorders, and scientists have linked excessive amounts of CRP to coronary artery disease. Furthermore, a growing body of evidence from clinical trials implicates CRP in cardiovascular disease progression.

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ISIS-FXI is an antisense drug we designed to treat clotting disorders. It targets Factor XI, a clotting factor produced in the liver that is an important component of the coagulation pathway.

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Ibutilide Fumrtate

Ibutilide fumarate is an antiarrhythmic drug. It prolongs action potential duration in isolated adult cardiac myocytes and increases both atrial and ventricular refractoriness.

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Irbesartan is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. It is also used for the treatment of hypertension, as well as diabetic nephropathy with an elevated serum creatinine and proteinuria (>300 mg/day) in patients with type 2 diabetes and hypertension. Irbesartan is also used as a second line agent in the treatment of congestive heart failure.

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Isosorbide Dinitrate

Isosorbide Dinitrate is a moderate to long acting oral organic nitrate used for the relief and prophylactic management of angina pectoris. It relaxes the vascular smooth muscle and consequent dilatation of peripheral arteries and veins. It is also used as a direct vasodilator to treat congestive heart failure. It relaxes blood vessels, increasing the blood and oxygen supply to heart. It relieves the pain you can get with angina. Isosorbide dinitrate can also help to prevent pain before activities that can cause an attack.

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