Cardiovascular drugs used in cardiovascular diseases treatment heart attack, stroke, hypertension

chemical-categories

Candoxatril

Candoxatril is only found in individuals that have used or taken this drug. It is the orally-active prodrug of candoxatrilat (UK-73967), the active enantiomer of candoxatrilat (UK-69578), a potent neutral endopeptidase (NEP) inhibitor used in the treatment of chronic heart failure.Neutral endopeptidase inhibitors such as Candoxatril have a dual mechanism of action. They inhibit two metalloprotease enzymes, neutral endopeptidase and ACE, resulting in an increased availability of natriuretic peptides that exhibit vasodilatory effects and, possibly, tissue protective effects.

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Cicletanine

Cicletanine is a furopyridine low-ceiling diuretic drug, usually used in the treatment of hypertension. It appears to be more potent in salt-sensitive hypertension.

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Clobenfurol

Clobenfurol is belongs to the class of vasodilators used in cardiac diseases.

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Deslanoside

Deslanoside is a cardiac glycoside from the leaves of Digitalis lanata. Deslanoside is a cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. Deslanoside inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations. Deslanoside also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential.

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Epinephrine

Epinephrine is a hormone and neurotransmitter.It increases heart rate, contracts blood vessels, dilates air passages and participates in the fight-or-flight response of the sympathetic nervous system.It is indicated for intravenous injection in treatment of acute hypersensitivity, treatment of acute asthmatic attacks to relieve bronchospasm, and treatment and prophylaxis of cardiac arrest and attacks of transitory atrioventricular heart block with syncopal seizures (Stokes-Adams Syndrome).It stimulates both the alpha- and beta- adrenergic systems, causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels.

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Hexobendine

Hexobendine is a vasodilator that acts as an adenosine reuptake inhibitor.

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Metaraminol

Metaraminol is a potent sympathomimetic amine used in the prevention and treatment of hypotension due to hemorrhage, spinal anesthesia, and shock associated with brain damage due to trauma or tumor. Metaraminol is also used in the treatment of priapism. It is an adrenergic agonist that acts predominantly at alpha adrenergic receptors and also stimulates the release of norepinephrine. It acts by increasing the force of the heart's pumping action as well as constricting peripheral blood vessels.

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Methoxamine

Methoxamine is a potent sympathomimetic amine that increases both systolic and diastolic blood pressure. It is an &aplha;1-adrenergic receptor agonist. It is indicated for prevention and treatment of the acute hypotensive state occurring with spinal anesthesia. It is also indicated as adjunctive treatment of hypotension due to hemorrhage, reactions to medications, surgical complications, and shock associated with brain damage due to trauma or tumor. It has little if any direct effect on the central nervous system. It acts by increasing the force of the heart's pumping action as well as constricting peripheral blood vessels.

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Phentermine

Phentermine is a psychostimulant drug of the phenethylamine class, with pharmacology similar to amphetamine. It is used medically as an appetite suppressant. Phentermine is used together with diet and exercise to treat obesity (overweight) in people with risk factors such as high blood pressure, high cholesterol, or diabetes. It is a central nervous system stimulant and sympathomimetic with actions and uses similar to those of dextroamphetamine. Phentermine is an amphetamine that stimulates neurons to release or maintain high levels of a particular group of neurotransmitters known as catecholamines. High levels of these catecholamines tend to suppress hunger signals and appetite. The drug seems to inhibit reuptake of noradrenaline, dopamine, and seratonin through inhibition or reversal of the reuptake transporters. It may also inhibit MAO enzymes leaving more neurotransmitter available at the synapse. Phentermine (through catecholamine elevation) may also indirectly affect leptin levels in the brain.

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Prenalterol

Prenalterol is a cardiac stimulant which acts as a β1-adrenergic agonist.

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