Cardiovascular drugs used in cardiovascular diseases treatment heart attack, stroke, hypertension



Mexiletine belongs to the Class IB anti-arrhythmic group of medicines. It is used to treat arrhythmias within the heart, or seriously irregular heartbeats. It slows conduction in the heart and makes the heart tissue less sensitive. Mexiletine has little or no effect at slower heart rates, and more effects at faster heart rates. It shortens the action potential duration, reduces refractoriness, and decreases Vmax in partially depolarized cells with fast response action potentials. Mexiletine either does not change the action potential duration, or decreases the action potential duration.

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Midodrine is an ethanolamine derivative that is an adrenergic alpha agonist. It is used as a vasoconstrictor agent in the treatment of hypotension.

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Milrinone is a phosphodiesterase 3 inhibitor. It is a synthetic dimethylxanthine derivative structurally related to theophylline and caffeine. It potentiates the effect of cyclic adenosine monophosphate (cAMP). Milrinone also enhances contraction of the left ventricle by increasing Ca2+-ATPase activity on the cardiac sarcoplasmic reticulum. It has positive inotropic, vasodilating and minimal chronotropic effects. It is used in the management of heart failure only when conventional treatment with vasodilators and diuretics has proven insufficient.

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Minoxidil is an antihypertensive vasodilator medication which also slows or stops hair loss and promotes hair regrowth.It is an orally effective direct acting peripheral vasodilator that reduces elevated systolic and diastolic blood pressure by decreasing peripheral vascular resistance. Minoxidil is also used topically to treat androgenetic alopecia.It is thought to promote the survival of human dermal papillary cells (DPCs) or hair cells by activating both extracellular signal-regulated kinase (ERK) and Akt and by preventing cell death by increasing the ratio of BCl-2/Bax. Minoxidil may stimulate the growth of human hairs by prolonging anagen through these proliferative and anti-apoptotic effects on DPCs. Minoxidil, when used as a vasodilator, acts by opening adenosine triphosphate-sensitive potassium channels in vascular smooth muscle cells.

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Nebivolol is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and, in Europe, also for left ventricular failure.It is highly cardioselective under certain circumstances.Nebivolol lowers blood pressure (BP) by reducing peripheral vascular resistance, and significantly increases stroke volume with preservation of cardiac output.

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Nesiritide is used to improve breathing in people with congestive heart failure (CHF).

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Nif-Ten is a combination containing two medicines: the beta-blocker atenolol and the calcium-channel blocker nifedipine, which are provided in one capsule. Nif-Ten is used to treat high blood pressure (hypertension) and/or angina. It interferes with the action of the nervous system on the heart and reduces the rate and force of heart muscle contraction and lowers blood pressure.

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Nitroglycerin is a explosive liquid obtained by nitrating glycerol. Since the 1860s, it has been used as an active ingredient in the manufacture of explosives, specifically dynamite, and as such is employed in the construction and demolition industries. Similarly, since the 1880s, it has been used by the military as an active ingredient, and a gelatinizer for nitrocellulose, in some solid propellants, such as Cordite and Ballistite. It is also used medically as a vasodilator to treat heart conditions, such as angina and chronic heart failure. It is one of the oldest and most useful drugs for treating heart disease by shortening or even preventing attacks of angina pectoris.

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Norfenefrine is a cardiac stimulant.

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Omarigliptin 98%


Omarigliptin (MK-3102);



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Omarigliptin (MK-3102) is an oral hypoglycemic agent. It is administered orally once a week, being able to produce sustained DPP-4 inhibition with a new mechanism of lowering blood sugar. 

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