Cardiovascular drugs used in cardiovascular diseases treatment heart attack, stroke, hypertension

chemical-categories

Nitroglycerin

Nitroglycerin is a explosive liquid obtained by nitrating glycerol. Since the 1860s, it has been used as an active ingredient in the manufacture of explosives, specifically dynamite, and as such is employed in the construction and demolition industries. Similarly, since the 1880s, it has been used by the military as an active ingredient, and a gelatinizer for nitrocellulose, in some solid propellants, such as Cordite and Ballistite. It is also used medically as a vasodilator to treat heart conditions, such as angina and chronic heart failure. It is one of the oldest and most useful drugs for treating heart disease by shortening or even preventing attacks of angina pectoris.

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Phenylephrine

Phenylephrine is a sympathomimetic amine that acts predominantly on α-adrenergic receptors. Phenylephrine is now the most common over-the-counter (OTC) decongestant. It is mainly used to treat nasal congestion, but may also be useful in treating hypotension and shock, hypotension during spinal anaesthesia, prolongation of spinal anaesthesia, paroxysmal supraventricular tachycardia, symptomatic relief of external or internal hemorrhoids, and to increase blood pressure as an aid in the diagnosis of heart murmurs. Parenteral administration of phenylephrine causes a rise in systolic and diastolic pressures, a slight decrease in cardiac output, and a considerable increase in peripheral resistance. Phenylephrine also causes pulmonary vessel constriction and subsequent increase in pulmonary arterial pressure.

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Acetyldigitoxin

Acetyldigitoxin is a cardiac glycoside. It is an acetyl derivative of digitoxin. Acetyldigitoxin binds to a site on the extracellular aspect of the α-subunit of the Na+/K+ ATPase pump in the membranes of heart cells (myocytes). This causes an increase in the level of sodium ions in the myocytes, which then leads to a rise in the level of calcium ions. Increased amounts of Ca2+ are then stored in the sarcoplasmic reticulum and released by each action potential, which is unchanged by acetyldigitoxin. Acetyldigitoxin also increases vagal activity via its central action on the central nervous system, thus decreasing the conduction of electrical impulses through the AV node. This is important for its clinical use in different arrhythmias.

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Ticagrelor 99%

Name Ticagrelor
Synonyms AR-C 126532XX; AZD 6140; (1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-1,2-cyclopentanediol
Molecular Formula C23H28F2N6O4S
Molecular Weight 522.57
CAS Registry Number 274693-27-5

 

 

 

2-(((3aR,4S,6R,6aS)-6-Amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol (2R,3R)-2,3-dihydroxysuccinate 376608-65-0
(3aR,4S,6R,6aS)-6-Amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-ol 155899-66-4
2-(((3aR,4S,6R,6aS)-6-Amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol 274693-55-9
(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (R)-2-hydroxy-2-phenylacetate 376608-71-8
(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 220352-38-5
(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride 1156491-10-9
4,6-Dichloro-2-(propylthio)pyrimidin-5-amine 145783-15-9
4,6-Dichloro-5-nitro-2-(propylthio)pyrimidine 145783-14-8

 

 

Ticagrelor, a new platelet aggregation inhibitor successfully developed by AstraZeneca (U.S.), is the world’s first reversible combination orally-administered P2Y12 adenosine diphosphate receptor antagonist.
It is used to reduce cardiovascular death and heart attacks in patients with acute coronary syndrome (ACS.) Rapid onset after oral administration, and can effectively improve symptoms of patients with ACS. Thienopyridin

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Benzyl Nicotinate

Benzyl Nicotinate is a clear, yellowish to brownish yellow or slightly reddish oily liquid with characteristics Odour. Benzyl Nicotinate is used as a vasodilator and used to reduce the plasma cholesterol.

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Omarigliptin 98%

Name

Omarigliptin (MK-3102);

 

(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-amine

Molecular Formula

C17H20F2N4O3S

Molecular Weight

398.43

CAS Registry Number

1226781-44-7

Omarigliptin (MK-3102) is an oral hypoglycemic agent. It is administered orally once a week, being able to produce sustained DPP-4 inhibition with a new mechanism of lowering blood sugar. 

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Bretylium Tosylate

Bretylium Tosylate is used for prophylaxis and treatment of ventricular fibrillation,treatment of life-threatening ventricular arrhythmia that has failed to respond to first-line antiarrhythmic agents.

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Ibutilide Fumrtate

Ibutilide fumarate is an antiarrhythmic drug. It prolongs action potential duration in isolated adult cardiac myocytes and increases both atrial and ventricular refractoriness.

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posaconazole 98%

Name Posaconazole
Synonyms 4-[4-[4-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one
Molecular Formula C37H42F2N8O4
Molecular Weight 700.78
CAS Registry Number 171228-49-2

 

 

((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate 149809-43-8
1-((2S,3S)-2-(Benzyloxy)pentan-3-yl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one

184177-83-1

 

Posaconazole (posaconazole) is derived from itraconazole. It is currently subject to III phase clinical trials. Its pharmacological effects are similar with azoles, but compared with itraconazole, it has a stronger inhibitory effect on the C14 demethylation of steroid, especially for Aspergillus.

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Atorvastatin Calcium

Atorvastatin Calcium is a selective, competitive HMG-CoA reductase inhibitor. It is primarily used to lower cholesterol and triglycerides in patients with hypercholesterolemia and mixed dyslipidemia, and may also be used for homozygous familial hypercholesterolemia. It is a selective, competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase.

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