Cardiovascular drugs used in cardiovascular diseases treatment heart attack, stroke, hypertension

chemical-categories

Rosuvastatin

Rosuvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reducuase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Rosuvastatin belongs to a class of medications called statins and is used to reduce plasma cholesterol levels and prevent cardiovascular disease. It is used as an adjunct to dietary therapy to treat primary hypercholesterolemia (heterozygous familial and nonfamilial), mixed dyslipidemia and hypertriglyceridemia and it also indicated for homozygous familial hypercholesterolemia as an adjunct to other lipid-lowering therapies or when other such therapies are not available. It is also used to lower total cholesterol, low density lipoprotein-cholesterol (LDL-C), apolipoprotein B (apoB), non-high density lipoprotein-cholesterol (non-HDL-C), and trigleride (TG) plasma concentrations while increasing HDL-C concentrations.

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Sitagliptin phosphate

Sitagliptin phosphate[654671-78-0]

CAS: 654671-78-0
MF: C16H15F6N5O.H3PO4
MW: 505.31

 

 

 

Sitagliptin phosphate is dipeptidyl peptidase Ⅳ(DDP-4) inhibitor class of drugs developed by the German Merck company and firstly obtained the US Food and Drug Administration approval for the treatment of type 2 diabetes, is a new antidiabetic drug, can improve the body's own ability to reduce high blood glucose levels, and the relatively increase naturally occurring incretin by inhibiting the activity of this enzyme, including the levels of glucagon-like peptide 1 and glucose-dependent insulinotropic peptide, thereby triggering the pancreas to improve insulin production and stop glucose production in liver, and ultimately reduce the clinical effect of blood glucose concentration. Features of this product is to stimulate insulin secretion, at the same time can alleviate hunger, but does not make weight gain, and also cannot happen hypoglycemia and edema, is not suitable for use in diabetic patients with poor glycemic control and often developed hypoglycemia.

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Tenoretic

Tenoretic is for the treatment of hypertension. It combines the antihypertensive activity of two agents: a β1-selective (cardioselective) hydrophilic blocking agent (atenolol, Tenormin) and a monosulfonamyl diuretic (chlorthalidone).

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Testosterone Enanthate

Testosterone Enanthate is one of the oldest forms of testosterone ever made available and is further by-in-large the most popular and commonly used testosterone. Testosterone enanthate heals the damaged cells of the body, thanks to the fact that it increases the activity of satellite cells that promotes healing. Testosterone enanthate has the ability to guard your body against coronary heart disease that comes because of bad cholesterol, by reducing bad cholesterol. Testosterone enanthate is popular among athletes and bodybuilders because promotes protein synthesis leading to muscle hypertrophy and muscle hyperplasia, the two different but equally important processes in muscle growth.

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Ticagrelor

Ticagrelor is an oral antiplatelet treatment for acute coronary syndromes (ACS) in a new chemical class called cyclopentyltriazolopyrimidines (CPTPs). Ticagrelor works by preventing the formation of new blood clots and maintaining blood flow in the body to help reduce a patient's risk of another cardiovascular event (called atherothrombotic events) such as a heart attack or cardiovascular death. Ticagrelor is the first reversibly-binding oral adenosine diphosphate (ADP) receptor antagonist. Ticagrelor is extensively metabolized in humans with approximately 27% of the dose excreted as the parent compound.

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Ticagrelor 99%

Name Ticagrelor
Synonyms AR-C 126532XX; AZD 6140; (1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-1,2-cyclopentanediol
Molecular Formula C23H28F2N6O4S
Molecular Weight 522.57
CAS Registry Number 274693-27-5

 

 

 

2-(((3aR,4S,6R,6aS)-6-Amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol (2R,3R)-2,3-dihydroxysuccinate 376608-65-0
(3aR,4S,6R,6aS)-6-Amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-ol 155899-66-4
2-(((3aR,4S,6R,6aS)-6-Amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol 274693-55-9
(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (R)-2-hydroxy-2-phenylacetate 376608-71-8
(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 220352-38-5
(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride 1156491-10-9
4,6-Dichloro-2-(propylthio)pyrimidin-5-amine 145783-15-9
4,6-Dichloro-5-nitro-2-(propylthio)pyrimidine 145783-14-8

 

 

Ticagrelor, a new platelet aggregation inhibitor successfully developed by AstraZeneca (U.S.), is the world’s first reversible combination orally-administered P2Y12 adenosine diphosphate receptor antagonist.
It is used to reduce cardiovascular death and heart attacks in patients with acute coronary syndrome (ACS.) Rapid onset after oral administration, and can effectively improve symptoms of patients with ACS. Thienopyridin

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Tocainide

Tocainide is a primary amine analog of lidocaine with antiarrhythmic properties useful in the treatment of ventricular arrhythmias. Tocainide acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. Tocainide binds preferentially to the inactive state of the sodium channels.

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Trelagliptin succinate

Name Trelagliptin succinate
Synonyms SYR 111472 succinate; SYR 472
Molecular Formula C18H20FN5O2.C4H6O4
Molecular Weight 475.47
CAS Registry Number

1029877-94-8

 

 

 

Trelagliptin 865759-25-7
2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile 865759-24-6
3-Methyl-6-chlorouracil 4318-56-3
2-CYANO-5-FLUOROBENZYL BROMIDE 421552-12-7
(R)-(-)-3-Aminopiperidine dihydrochloride 334618-23-4

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Tribenoside

Tribenoside is a vasoprotective. Induction of hypersensitivity has been reported.

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Troxerutin

Troxerutin is a flavonol, a type of flavonoid. It is more accurately a hydroxyethylrutoside. It can be isolated from Sophora japonica, the japanese pagoda tree. It is used as a vasoprotective.

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