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Tadalafil

Tadalafil is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) for the treatment of pulmonary arterial hypertension. It initially was developed by the biotechnology company ICOS. The most common side effects when using tadalafil are headache, indigestion, back pain, muscle aches, flushing, and stuffy or runny nose. These side effects reflect the ability of PDE5 inhibition to vasodilate (cause blood vessels to widen) and usually go away after a few hours. Back pain and muscle aches can occur 12 to 24 hours after taking the drug, and the symptom usually disappears after 48 hours.

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Tasisulam

Tasisulam is an acyl-sulfonamide with potential antineoplastic activity. Selectively toxic towards tumor cells, tasisulam appears to induce tumor cell apoptosis by a mitochondrial-targeted mechanism involving the loss of mitochondrial membrane potential and induction of reactive oxygen species (ROS). In combination with an angiogenesis inhibitor, this agent may exhibit synergistic antiangiogenic activity. Tasisulam has been used in trials studying the treatment and basic science of Melanoma, Lymphoma, Solid Tumors, Breast Cancer, and Ovarian Cancer, among others.

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Thymidine

Thymidine is a chemical compound, more precisely a pyrimidine deoxynucleoside.It is the DNA nucleoside T, which pairs with deoxyadenosine (A) in double-stranded DNA.It can be phosphorylated with one, two or three phosphoric acid groups, creating respectively deoxythymidine mono,di or triphosphate.It is non-toxic and as part of one of the four nucleotides in DNA it is a naturally occurring compound that exists in all living organisms and DNA viruses.

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