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Cirazoline is a nonselective agonist of the alpha-1 adrenergic receptor, and an antagonist to the alpha-2 adrenergic receptor. It is believed that this combination of properties could make cirazoline an effective vasoconstricting agent. It has also been shown to decrease food intake in rats, purportedly through activation of alpha 1-adrenoceptors in the paraventricular nucleus in the hypothalamus of the brain.


Conhydrine is a poisonous alkaloid found in poison hemlock in small quantities. This oxygenated alkaloid was isolated by Wertheim.

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