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Camptothecin

Camptothecin was isolated from the bark and stem of Camptotheca acuminata. Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor cell death. Camptothecin demonstrated strong anticancer activity in preliminary clinical trials but also low solubility and adverse drug reaction. Camptothecin is believed to be a potent topoisomerase inhibitor that interferes with the essential function of topoisomerase in DNA replication. Camptothecin binds to the topoisomerase I and DNA complex (the covalent complex) resulting in a ternary complex, and thereby stabilizing it.

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Cannabivarin

Cannabivarin is a non-psychoactive cannabinoid found in minor amounts in the hemp plant Cannabis sativa. It is an analog of cannabinol with the side chain shortened by two CH2 groups. It is an oxidation product of tetrahydrocannabivarin.

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Carnauba wax

Carnauba, also called Brazil wax and palm wax, is a wax of the leaves of the palm, Copernicia prunifera, a plant native to and grown only in the northeastern Brazilian states of Piaui, Ceara, and Rio Grande do Norte.

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