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o,p'-DDD

Mitotane, or o,p'-DDD, is an antineoplastic medication used in the treatment of adrenocortical carcinoma. It is an isomer of DDD and is a derivative of DDT.[2] Its main use is in those patients who have persistent disease despite surgical resection, those who are not surgical candidates, or those who have metastatic disease. It has been produced by Bristol Myers Squibb SpA but it is marketed as an orphan drug due to the small number of patients in need of it. A 2007 study of 177 patients shows a significant increase in the recurrence-free interval after radical surgery followed by Mitotane when compared to surgery alone. Mitotane alters steroid peripheral metabolism, directly suppresses the adrenal cortex and alters cortisone metabolism leading to hypocortisolism. Side effects as reporte

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o,p'-DDE

DDT was the first of the chlorinated insecticides, it was originally prepared in 1873. The use of DDT increased enormously after WW II because of its effectivenessagainst mosquitoes and lice. DDT and it’s main metabolite DDE, have been found to be toxic to animals, cause birth defects and it’s known to be an endocrine disruptor (EDC). The use of DDT has been banned in the US since 1973, although it’s still used in other parts of the world.

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o,p'-DDT

DDT (from its trivial name, dichlorodiphenyltrichloroethane) is one of the most well-known synthetic pesticides. It is a chemical with a long, unique, and controversial history.First synthesized in 1874, DDT's insecticidal properties were not discovered until 1939, and it was used with great success in the second half of World War II to control malaria and typhus among civilians and troops. The Swiss chemist Paul Hermann Müller was awarded the Nobel Prize in Physiology or Medicine in 1948 "for his discovery of the high efficiency of DDT as a contact poison against several arthropods."[2] After the war, DDT was used as an agricultural insecticide, and soon its production and use skyrocketed.

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p-Cymene

Cymene, or p-cymene, is a naturally occurring aromatic organic compound. It is classified as a hydrocarbon related to a monoterpene. Its structure consists of a benzene ring para-substituted with a methyl group and an isopropyl group. It is insoluble in water, but miscible with ethanol and ether. Cymene is a constituent of a number of essential oils, most commonly the oil of cumin and thyme Cymene is a common ligand for ruthenium.

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