Hormone drugs used in treating deficient hormone levels in body, thyroid problems, ovulation

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Oral Anabolic Steroids Powder 7-Keto DHEA Acetate CAS 1449-61-2

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Oral Anabolic Steroids Powder 7-Keto DHEA Acetate CAS 1449-61-2
 
7-Keto-DHEA Acetate Basic Info.:
 
Product Name: Androst-5-en-3-ol-7,17-dione acetate
Synonyms: 10,13-dimethyl-7,17-dioxo-2,3,4,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthren-3-yl acetate;7-KETO-DHEA;7-OXO-DEHYDROEPIANDROSTERONE ACETATE;7,17-dioxoandrost-5-en-3-yl acetate;androst-5-en-3-ol-7,17-dione acetate;3-BETA-ACETOXYANDROST-5-ENE-7,17-DIONE;3BETA-ACETOXY-17A-OXO-ANDROST-5-ENE-7,17-DIONE;3-ACETYL-7-KETO-DHEA
CAS: 1449-61-2
MF: C21H28O4
MW: 344.44
EINECS: N/A
Product Categories: Pharmaceutical Raw Materials;steroids
 
Description And Applications Of 7-Keto-DHEA Acetate:
 
7-keto-DHEA is a by-product of dehydroepiandrosterone (DHEA), a chemical that is formed in the body. 
DHEA is a "parent hormone" produced by glands near thekidneys. But unlike DHEA, 7-keto-DHEA is not converted to steroid hormones such as androgen and estrogen. Taking 7-keto-DHEA by mouth or applying it to the skindoes not increase the level of steroid hormones in the blood.
 
7-keto-DHEA might promote weight loss by speeding up the body's metabolism.
7-Keto is marketed as a dietary supplement with the implication that it may accelerate weight loss, increase metabolism, enhance memory, or prevent age-related changes. When used in a topical (skin lotion) product 7-Keto caused long-lasting changes in the body's levels of testosterone, epitestosterone, estradiol, and other steroid hormones. Researchers have raised concern that supplements may trigger positive tests for performance-enhancing drugs.
 

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Oral Finasteride / Proscar Steroids Powder For Hairloss Treatment 98319-26-7

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Oral Finasteride / Proscar Steroids Powder For Hairloss Treatment 98319-26-7
 
Finasteride Basic Info.
 
Product Name: Finasteride
Synonyms: Finasteride;Proscar;Prostide;
CAS: 98319-26-7
Molecular Formula: C23H36N2O2
Molecular Weight: 372.5441
Assay: 99%
Appearance: White or off-white crystal powder
Density: 1.066g/cm3
Boiling Point: 576.61°C at 760 mmHg
Flash Point: 177.448°C
Vapour Pressure: 0mmHg at 25°C
Usage: It is 5 alpha - reductase inhibitor that can inhibit testosterone to convert into DHT. Also used for the treatment of Hyperplasia of prostate. Finasteride is a 4-- aza-steroid compound which is a specific inhibitor of the metabolism of testosterone within dihydro testosterone become stronger during the cell type-II enzyme 5a-reductase. The enlarged prostate called benign prostatic hyperplasia or prostate depends on the conversion of testosterone to dihydro-testosterone.
 
Finasteride Description:
 
Finasteride is a popular anti-androgen medication manufactured by Merck most commonly known as either Proscar or Propecia. Based on the progesterone skeleton, Finasteride belongs to a class of medications known as 5alpha-reductase inhibitors and as such is used for the treatment revolving around type 2 5-AR based occurrences.
 
This is important for performance enhancers as DHT based anabolic steroids have specific side-effects that may occur that can largely be remedied with the use of a 5-AR inhibitor such as Finasteride. As a type 2 5-AR inhibitor Finasteride was designed for the purpose of treating hair-loss, prostate enlargement, as well as prostate cancer.
 
Finasteride is very common among those who supplement with anabolic steroids yet fear hair-loss but there are important things you need to understand before you consider Finasteride use. As an androgen suppressor Finasteride can seriously inhibit the gains made while on cycle, severely and on that basis it is not highly recommended for on-cycle hair preservation.
 
Finasteride Applications:
 
Propecia (finasteride) is used to treat male pattern baldness (androgenic alopecia) in men. Oral use though will reduce DHT levels systemically, which may adversely affect training and sex drive.
 
It is also used in combination with doxazosin in the treatment of benign prostatic hyperplasia (BPH).] Finasteride is an orally active testosterone Type II 5-alpha reductase inhibitor, inhibiting the enzyme that converts testosterone to dihydrotestosterone (DHT).
Topically (on the scalp itself) it is of some effect in minimizing further hair loss. In combination with Nizoral and spironolactone (which smells awful, by the way) it can actually reverse loss moderately.
 
For use in cycles with testosterone, I don't think it is bad at all. One simply doesn't want less DHT than normal. As the amount of testosterone in the system increases, the amount of finasteride needed to keep levels down to normal increases. I consider 5 mg/day reasonable at the gram per week level, and proportionally less at lower dosages of testosterone.
 

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Oral or Injection Trenbolones Steroids 6-Bronmandrostenedione For Gain Muscle 38632-00-7

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Oral or Injection Trenbolones Steroids 6-Bronmandrostenedione For Gain Muscle 38632-00-7
 
6-Bronmandrostenedione Basic Info.:
 
Product Name: 6-Bronmandrostenedione
Synonyms: (6b)-6-Bromoandrost-4-ene-3,17-dione; (6beta)-6-bromoandrost-4-ene-3,17-dione; 6-Bromoandrost-4-ene-3,17-dione
CAS RN.: 38632-00-7
Molecular Weight: 365.3046
Molecular Formula: C19H25BrO2
Density: 1.35g/cm3
Boiling Point(ºC): 467°C at 760 mmHg
Flash Point(ºC): 100.3°C
refractive_index: 1.577
Chemical Properties: Pale Yellow Solid
Usage: 6-Bronmandrostenedione analog, an aromatase inhibitor.
 
6-Bronmandrostenedione Description:
 
6-Bromodione is a fast acting competitive inhibitor of the aromatase enzyme. It works by binding to the aromatase enzyme to prevent it from aromatizing androgens. This is not a permanent binding and later acts to normalize aromatase (and thus estrogen levels) as hormone production returns to normal. It specifically targets aromatase and does not act as a central anti-androgen like some other post cycle products can. This means that your libido and mood will not be negatively affected.
 
6-Bronmandrostenedione Application:
 
6-beta-Bromodione works in a similar way but has an irreversible and permanent effect. This works well to mediate the excess aromatase that was produced while on cycle, while the alpha isomer works to normalize the natural levels. The goal is again to transition into normal production levels for all hormones affected by the anabolic cycle.
 

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Palmitoyl Tetrapeptide-7

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Pentadecapeptide Bpc 157 Human Growth Hormone Supplements Peptide Peptide Drum 137525-51-0

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Pentadecapeptide Bpc 157 Human Growth Hormone Supplements Peptide Peptide Drum 137525-51-0
 
Pentadecapeptide Bpc 157 Basic Info.
 
Product Name: Pentadecapeptide Bpc 157
Alias: Booly Protection Compound 15, Pentadecapeptide, BPC 157;
Sequence: Gly-Glu-Pro-Pro-Pro-Gly- Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val 
CAS: 137525-51-0 
MF: C62H98N16O22 
MW: 1419.53552 
Purity: 99% 
Specification: 2mg/vial 
Appearance: White Lyophilized Powder 
Standard: USP 
Certification: SGS 
Method of Analysis: HPLC 
Storage: Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18°C. Upon reconstitution of the peptide it should be stored at 4°C between 2-21 days and for future use below -18°C. 
 
Pentadecapeptide Bpc 157 Description:
 
Pentadecapeptide BPC 157, composed of 15 amino acids, is a partial sequence of body protection
compound (BPC) Pentadecapeptide BPC 157, composed of 15 amino acids, is a partial sequence 
of body protection compound (BPC) that is discovered in and isolated from human gastric juice.
The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, 
cell survival, and cell migration
 
Stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W. 1419) may be the new drug stable in human gastric juice, effective both in the upper and lower GI tract, and free of side effects.
 
BPC 157, in addition to an antiulcer effect efficient in therapy of inflammatory bowel disease (IBD)(PL 14736) so far only tested in clinical phase II, has a very safe profile, and exhibited a particular wound healing effect. It also has shown to interact with the NO-saystem, providing endothelium protection and angiogenic effect, even in severely impaired conditions (i.e., it stimulated expression of early growth response 1 gene responsible for cytokine and factor generation and early extracellular matrix (collagen) formation (but also its repressor nerve factor 1- A binding protein-2)), important to counteract severe complications of advanced and poorly controlled IBD. Hopefully, the lessons from animal studies, particularly advanced intestinal anastomosis healing, reversed short bowel syndrome and fistula healing indicate BPC 157s high significance in further IBD therapy. Also, this supportive evidence (i.e., no toxic effect, limit test negative, LD1 not achieved, no side effect in trials) may counteract the problems commonly exercised in the use of peptidergic agents, particularly those used on a long-term basis
 
Pentadecapeptide Bpc 157 Application:
 
1. BPC 157 has a strong anti-inflammatory activity in both acute and chronic inflammation models. In fact, preliminary results in clinical trials suggest that BPC 157 may become an important therapeutic tool for the treatment of inflammatory bowel disease.
 
2. BPC 157 was shown to accelerate wound healing and to have a marked angiogenic effect. In addition, it significantly facilitates the healing of bone fracture in rats. This peptide also exhibits an osteogenic effect significantly improving the healing of segmental bone defect. BPC 157 accelerates the healing of transected rat Achilles tendon and transected rat quadriceps muscle.
 
3. FITC-phalloidin staining was able to demonstrate that BPC 157 induces F-actin formation in fibroblasts. Likewise, Western blot analysis was able to detect the production and activation of paxillin and FAK proteins. The western blot analysis also showed that BPC 157 increases the extent of phosphorylation of paxillin and FAK proteins without affecting the amounts produced.
 

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Peptides 170851-70-4 Weight Loss Steroids Ipamorelin For Muscle Gain

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Peptides 170851-70-4 Weight Loss Steroids Ipamorelin For Muscle Gain
 
Ipamorelin Basic Info.:
 
Product Name: Ipamorelin
Synonyms: IpoMarelin;IpaMorelin Acetate;Aib-His-D-2-Nal-D-Phe-Lys-NH2
Unit Size: 2 mg/vial
Unit Quantity: 1 Vial
CAS NO.: 170851-70-4
Molecular Formula: C38H49N9O5
Molecular Weight: 711.85
Sequence: H-Aib-His-D-2-Nal-D-Phe-Lys-NH2
Appearance: White Powder
Purity: 98.49%
Identity (ESI-MS) 711.85±0.5
Source Chemical Synthesis
Storage: Stable at room temperature for 90 days,however it should be stored in a freezer below -8°C for any extended period of time. After reconstituting Ipamorelin should be refrigerated at temperatures not to exceed 36°F.
 
Ipamorelin Description:
 
Ipamorelin is a fascinating new muscle building discovery that is getting a lot of attention in the bodybuilding world. It is a synthetic peptide that has powerful Growth Hormon releasing properties. And these GH releasing properties are what is of interest to athletes and bodybuilders since they can make a tremendous difference in the amount of muscle you can grow and how quickly you burn fat.
 
Ipamorelin is a penta-peptide. (Aib-His-D-2-Nal-D- Phe-Lys-NH2) And, the strength it displays may very well make regular old Growth Hormon (GH) obsolete. But what athletes and bodybuilders really want to know is what is this wonder peptide capable of doing, how is it used, and how does it compare to the other GHRP peptides?
 
Athletes are taking Ipamorelin in a 200mcg -300mcg dosage, two or three times daily, using a tiny insulin needle to inject. They usually start with the lower dose since side effects can include headaches or what feels like a head-rush. Ipamorelin can be taken at anytime but taking it about 30-45 minutes before a workout would seem ideal because of the pulse in Growth Hormon (GH) it creates allowing for maximum growth.
 
Studies on the effects of Ipamorelin on bone growth, body weight, and GH release showed some interesting conclusions.In one experiment, various doses were administered over the course of 15 days to test the group's reactions.
 
There was a distinct and dose-dependent effect on body weight gain however, the treatment group did not show a change in total IGF-I levels. Nor did the treatment group produce serum markers of bone development. For example, the number of cells in the wide portion of the tibia (the shinbone) did not change significantly. This is a good thing because it suggests muscle growth with less potential for deformity of bone or cartilage.
 
Ipamorelin in theory may increase Acetylchloine or Cortisol when used in higher dosages. However, and increase in Acetylchloine or Cortisol is even more likely with GHRP-2 and GHRP-6. In fact, in the case of Ipamorelin, there was little to no rise in Acetylcholine and Cortisol blood plasma levels even at injections more than 200 times higher than the effective dosage for comparable GH release.
 
Ipamorelin Applications:
 
Ipamorelin is a selective growth hormon secretagogue and agonist of the ghrelin receptor. In pentobarbital anaesthetised rats, ipamorelin released GH with a potency and efficacy comparable to GHRP-6 (ED50 = 80±42 nmol/kg and Emax = 1545±250 ng GH/ml vs 115±36nmol/kg and 1167±120ng GH/ml). In conscious swine, ipamorelin released GH with an ED50 = 2.3±0.03 nmol/kg and an Emax = 65±0.2 ng GH/ml plasma. Again, this was very similar to GHRP-6 (ED50 = 3.9±1.4 nmol/kg and Emax = 74±7ng GH/ml plasma). GHRP-2 displayed higher potency but lower efficacy (ED50 = 0.6 nmol/kg and Emax = 56±6 ng GH/ml plasma). The specificity for GH release was studied in swine.
 

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Peptides Alarelin Acetate For Ovulation And Endmometriosis 79561-22-1

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Peptides Alarelin Acetate For Ovulation And Endmometriosis 79561-22-1 
 
Alarelin Acetate Basic Info.:
 
Product Name: Alarelin Acetate
Synonyms: Des-Gly10,[D-Ala6]-Lh-Rh Ethylamide Acetate Salt.
CAS: 79561-22-1
MF: C56H78N16O12
MW: 1167.32
Storage temp.: −20°C
Form: Powder
Product Categories: Amino Acid Derivatives;Peptide;LH-RH;LH-RHPeptides for Cell Biology;Neuropeptides;Releasing Factors;API.
 
Alarelin Acetate (79561-22-1) Description:
 
Alarelin acetate is a gondatrophin releasing hormone. Natural forms of alarelin found in animals are used to induce ovulation. Synthetic versions of this product are created using an LH-RH antagonist which is commonly set in larger doses than the natural LH-RH that is typically found in the rat hypophyseal stimulation or the gondatoropin secretions in induced ovulation or in vitro.
 
This chemical is the acetate form of the natural hypothalamic peptide which is used by an animal’s body to release LH and FSH from the pituitary gland. The peptide alarelin acetate has a single non-glycosylated polypeptide structure that is made up of nine amino acids. This has a molecular mass of 1167.3.
 
Alarelin is commonly used in research settings both to better understand this peptide’s effects on an animal’s body and to induce conditions that may assist with reproductive research. Samples of this chemical intended for research settings are typically stable for around three weeks at room temperature, and will need to be stored at temperatures below -18 degrees Celsius for long term use.
 
Most versions of this chemical are shipped as a lyophilized powder that can be reconstituted at a sterile temperature. This chemical may remain stable for up to three weeks at room temperature if it is kept sealed when it is not in use. If this product will be used for long periods of time is should be kept in a freezer with a waterproof sea.
 
If the mixture has already been reconstituted it can be kept at 40 degrees Celsius for 2-7 days but should be kept at -180 degrees Celsius for longer periods of time. Do not continually refreeze and thaw the product.
 

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Peptides Carbetocin Acetate Contracting Uterus Control Bleeding 37025-55-1

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Peptides Carbetocin Acetate Contracting Uterus Control Bleeding 37025-55-1
 
Carbetocin Acetate Basic Info.:
 
Product Name: Carbetocin Acetate
Synonyms: (Butyryl1,Tyr(Me)2)-1-Carbaoxytocin Trifluoroacetate Salt;Carbetocin;Carbetocin Trifluoroacetate Salt;
CAS: 37025-55-1
MF: C45H69N11O12S
MW: 988.17
EINECS: 253-312-6
Storage temp.: -15°C
Product Categories: Peptide;Vasopressin and Oxytocin receptor;Intermediates & Fine Chemicals;Pharmaceuticals;Other APIs
Usage: An obstetric drug used to control postpartum hemorrhaging.
 
Carbetocin Acetate it is used to control bleeding after giving birth. Like oxytocin, it causes contraction of the uterus.
 

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Pharmaceutical Grade Raw Material Chitosan CAS 9012-76-4 For Food

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Pharmaceutical Grade Raw Material Chitosan CAS 9012-76-4 For Food
 
Chitosan Basic information
 
Product Name: Chitosan
Synonyms: POLY(BETA-(1,4)-2-AMINO-2-DEOXY-D-GLUCOSE);POLY(BETA-(1,4)-D-GLUCOSAMINE);POLY(D-GLUCOSAMINE);POLY-(1,4-BETA-D-GLUCOPYRANOSAMINE);POLY-[1->4]-BETA-D-GLUCOSAMINE;BETA-(1,4)-2-AMINO-2-DEOXY-D-GLUCOSE;DEACETYLATED CHITIN;CHITOSAN
CAS: 9012-76-4
MF: C6H11NO4X2
MW: 161.16
EINECS: 222-311-2
Storage temp.: room temp
Solubility: dilute aqueous acid (pH <6.5).: soluble
Stability: Stable. Incompatible with strong oxidizing agents.
Chemical Properties: faintly beige solid  (Coarse ground flakes and powder)
Product Categories: Miscellaneous Natural Products;Biochemistry;Polysaccharides;Sugars;Nutritional Supplements;Dextrins、Sugar & Carbohydrates;Activity Other;Carbohydrate adjuvants;Carbohydrates A-C;Chitosan and Chitin;Activity;and Substrates;Biochemicals and Reagents;Carbohydrates;Carbohydrates A to Z;Cell Culture;Chitosan;Enzyme Substrates;Enzymes;Inhibitors;Materials Science;Natural Polymers;Polymer Science;Polymers;Polysaccharide;Vaccine Adjuvants;Vaccine Production;Oligosaccharide,Biostimulate
Usage: Claimed to have the ability to retain fats and cholesterol in the stomach.
Properties: This product is non-toxic, odorless, off-white or slight yellow powder, and soluble in acid, insoluble in water and base or normal organic solutions.
 
Chitosan Description:
 
Chitosan is a linear polysaccharide composed of randomly distributed β-(1-4)-linked D-glucosamine (deacetylated unit) and N-acetyl-D-glucosamine (acetylated unit). It is made by treating shrimp and other crustacean shells with the alkali sodium hydroxide.
 
Chitosan has a number of commercial and possible biomedical uses. It can be used in agriculture as a seed treatment and biopesticide, helping plants to fight off fungal infections. In winemaking it can be used as a fining agent, also helping to prevent spoilage. In industry, it can be used in a self-healing polyurethane paint coating. In medicine, it may be useful in bandages to reduce bleeding and as an antibacterial agent; it can also be used to help deliver drugs through the skin.
 
More controversially, chitosan has been asserted to have use in limiting fat absorption, which would make it useful for dieting, but there is evidence against this.
 
Other uses of chitosan that have been researched include use as a soluble dietary fiber.
 
Chitosan is extracted from chitin, insoluble in water but soluble in dilute acid and absorbed by human body. As the firdt derivate, it's chemical constitution is macromolecule alkalescent polysaccharide polymer with cation. It has peculiar physical, chemical properties and bioactive function.
 
Chitosan is listed as follows:
A. High Density Chitosan
B. High Viscosity Chitosan
C. Industrial Grade Chitosan
D. Food Grade Chitosan
E. Medical Grade Chitosan
F. Low Molecular Weight Chitosan
G. Aroxymethyl Chitosan
H. Chitosan Oligosaccharide
 
Chitosan Applications:
 
1)Food Field:
Used as food additives, thickeners, preservatives fruits and vegetables, fruit juice clarifying agent, forming agent, adsorbent, and health food.
2)Medicine, health care products field:
As the chitosan non-toxic,has anti-bacterial, anti-inflammatory, hemostatic, and immune function, can be used as artificial skin, self-absorption of surgical sutures, medical dressing Branch, bone, tissue engineering scaffolds, enhance liver function, improve digestive function, blood fat, lowering blood sugar, inhibiting tumor metastasis, and adsorption and complexation of heavy metals and can be excreted, and so on, was vigorously applied to health food and drug additives.
3)Environmental protection field:
Chitosan and its derivatives is a good flocculant for wastewater treatment and metal recovery from metal-containing waste water; in textile field: as a mordant, health care fabric, sizing agents, printing and dyeing
4).Agricultural field:
As growth promoters, bio-pesticides, feed additives, seeds, etc.
5)Field of tobacco
Tobacco sheet used as adhesives, low-tar filter and so on.
 
Chitosan is refined from deacetylation of chitin which is extracted from deep-sea Alaska crab cods. As the only basic polysaccharide among natural polysaccharides, this product has many physical and chemical characteristics and physiological activities. Precisely, this product can control cholesterol, inhibit bacterial activity, prevent and control high blood pressure, absorb and excrete heavy metals, maintain humidity and strengthen immunity. In food industry, this product can be used as antibacterial agent, fruit and vegetable preservative and antioxidant. There are many special functional groups in molecular chain, so the chitosan can be manufactured into many products according to different reactions on functional groups, such as acylation, sulfation and oxidation, grafting and crosslinking, hydroxyethylation and hydroxymethylation. These products can be used in many fields, including medicine, food, chemical, cosmetic, water treatment, metal extraction and recovery, biochemical and biomedical engineering. There are many types of chitosan, including GS-chitosan oligosaccharide, high density type, special molecular weight type, medical/food / industrial grade type, water soluble type and specialized type.
Chitosan can inhibit growth and reproduction of fungi, bacteria, and virus. When this product is used as coating preservation, it can inhibit respiratory metabolism and water loss of fruits and vegetables, thus slowing their aging process of organization and structure and effectively extending their postharvest life. This product can also be used as antioxidant. In heating process, free iron ions are released from meat hemoglobin and they form chelates with chitosan, thus their catalytic activity is inhibited.
 
Chitosan Usage:
 
Agricultural and horticultural use
The agricultural and horticultural uses for chitosan, primarily for plant defense and yield increase, are based on how this glucosamine polymer influences the biochemistry and molecular biology of the plant cell. The cellular targets are the plasma membrane and nuclear chromatin. Subsequent changes occur in cell membranes, chromatin, DNA, calcium, MAP Kinase, oxidative burst, reactive oxygen species, callose pathogenesis-related (PR) genes and phytoalexins.
 
Natural biocontrol and elicitor
In agriculture, chitosan is used primarily as a natural seed treatment and plant growth enhancer, and as an ecologically friendly biopesticide substance that boosts the innate ability of plants to defend themselves against fungal infections. The natural biocontrol active ingredients, chitin/chitosan, are found in the shells of crustaceans, such as lobsters, crabs, and shrimp, and many other organisms, including insects and fungi. It is one of the most abundant biodegradable materials in the world.
 

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Pharmaceutical Grade Reducing Fat Mass Chemicals Sr9011 SR-9011 1379686-29-9

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Pharmaceutical Grade Reducing Fat Mass Chemicals Sr9011 SR-9011 1379686-29-9
 
SR9011 Basic Info:
 
Product Name: SR9011
Synonyms: 3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)-N-pentylpyrrolidine-1-carboxamide
CAS No: 1379686-29-9
Molucelar Formula: C23H31ClN4O3S
Molucelar Weight: 479.03524
Solubility: DMSO up to 100 mM
 
Sr9011 Description:
 
SR9011 is a trifunctional methacrylate monomer that provides exceptional adhesion to metal substrates.
SR9011 is recommended for use in peroxide cured coatings, sealants, and PVC-based plastisols. Usage levels of 5% to 10% by weight are recommended.
 
SR9011 is a potent and specific synthetic REV-ERB agonist that binds to REV ERB α with an EC50 ~790 nM and REV-ERB-β with EC50 ~560 nM. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.
 
Sr9011 Application:
 
In vitro: SR9011 was used at 5-10 μM concentration in vitro and in cellular assays.
In vivo: IP administration of SR9011 was used at 100 mg/kg once or twice per day for 12-30 days in different mouse models.
 

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