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White Crystal Pharmaceutical Intermediates Hydrochloride Procaine HCL For Pain Relief 51-05-8
Procaine HCL Basic Info.:
Product Name: Procaine Hydrochloride (Procaine HCL)
Synonyms: Aminocaine;Anadolor;Anesthesol;Anestil;Atoxicocaine;Bernocaine
CAS: 51-05-8
MF: C13H21ClN2O2
MW: 272.77
EINECS: 200-077-2
Melting point: 155-156 °C(lit.)
Boiling point: 195-196°C 17mm
Fp: 195-196°C/17mm
storage temp.: room temp
Water Solubility: soluble
Sensitive: Air Sensitive
Merck: 14,7757
Stability: Stable. Incompatible with strong oxidizing agents.
Chemical Properties: White crystalline powder
Product Categories: Pharmaceutical;Sodium channel;APIS;Anesthetics;Pharmaceutical intermediate
Usage: Local anesthesic;Na+ channel blocker;Procaine is a local anesthetic of the amino ester group that is primarily used as a topical anesthetic. Procaine is also used to control the pain of intramuscular injection of penicillin as well as in dentistry;Non Caine local anesthetic.
Procaine HCL Product description:
Procaine HCl is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. It acts mainly by being a sodium channel blocker. Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.
Procaine HCl is indicated for the production of local or regional analgesia and anesthesia by local infiltration and peripheral nerve block techniques.
The routes of administration and concentrations are: For local infiltration use 0.25% to 0.5% (via dilution) and for peripheral nerve blocks use 0.5% (via dilution), 1%, and 2%. (See DOSAGE AND ADMINISTRATION for additional information. )
Procaine HCL Application:
Procaine HCl is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, in some regions procaine is referred to generically . It acts mainly by being a sodium channel blocker. Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.
Procaine HCl is indicated for the production of local or regional analgesia and anesthesia by local infiltration and peripheral nerve block techniques.
Application of procaine leads to the depression of neuronal activity. The depression causes the nervous system to become hypersensitive producing restlessness and shaking, leading to minor to severe convulsions. Studies on animals have shown the use of procaine LED to the increase of dopamine and serotonin levels in the brain. Other issues may occur because of varying individual tolerance to procaine dosage. Nervousness and dizziness can arise from the excitation of the central nervous system, which may lead to respiratory failure if overdosed. Procaine may also induce weakening of the myocardium leading to cardiac arrest.
Procaine can also cause allergic reactions causing the individuals to have problems with breathing, rashes, and swelling. Allergic reactions to procaine are usually not in response to procaine itself, but to its metabolite PABA. About one in 3000 people have an atypical form of pseudocholinesterase, [citation needed] which does not hydrolyze ester anesthetics such as procaine, resulting in a prolonged period of high levels of the anesthetic in the blood and increased toxicity.
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