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Sarms Powder Steroids Pirfenidone 53179-13-8 Anti Fibrosis

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Sarms Powder Steroids Pirfenidone 53179-13-8 Anti Fibrosis 
 
Pirfenidone Basic information
 
Product Name: Pirfenidone
Synonyms: 5-methyl-1-phenyl-2(1h)-pyridon;amr-69;PIRFENIDONE;5-METHYL-1-PHENYL-1H-PYRIDIN-2-ONE;5-METHYL-1-PHENYL-2(1H)-PYRIDINONE;5-METHYL-1-PHENYL-2-(1H)-PYRIDONE;5-Methyl-N-phenyl-2-1H-pyridone;Pirfenidone also see 5-Methyl-1-Phenyl-2(1H)-Pyridinone
CAS: 53179-13-8
MF: C12H11NO
MW: 185.22
EINECS: N/A
Melting point: 96-97°C
Storage temp.: Store at RT
Solubility: DMSO: ≥10 mg/mL, Soluble
Chemical Properties: Off-White Solid
Usage: Pirfenidone has demonstrated activity in multiple fibrotic conditions, including those of the lung, kidney and liver
Product Categories: Aromatics Compounds;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Cytokine signaling;Inhibitors.
 
Pirfenidone Description:
 
Pirfenidone (INN, BAN) is an anti-fibrotic drug for the treatment of idiopathic pulmonary fibrosis (IPF). It works by reducing lung fibrosis through downregulation of the production of growth factors and procollagens I and II.
 
It is a drug developed by several companies worldwide, including InterMune Inc. (now part of Roche), Shionogi Ltd., and GNI Group Ltd. In 2008, it was first approved in Japan for the treatment of IPF after clinical trials, under the trade name of Pirespa by Shionogi & Co. In October 2010, the Indian Company Cipla launched it as Pirfenex. In 2011, it was approved for use in Europe for IPF; it was approved in Canada in 2012 ; and was approved in the United States in October 2014 under the same name. In September 2011, the Chinese State Food and Drug Administration provided GNI Group Ltd with new drug approval of pirfenidone in China, and later manufacture approval in 2013 under the trade name of Etuary.
 
In 2014 it was approved in Mexico under the name KitosCell LP, indicated for pulmonary fibrosis and liver fibrosis.There is also a topical form created for the treatment of abnormal wound healing processes.
 
Pirfenidone Application:
 
In vitro, pirfenidone can inhibit the uterine flesh tumour cells and leiomyoma cells proliferation. Pirfenidone can inhibit the TGF - beta - 1 inducing fibroblast collagen formation. Inhibition of PDGF, FGF and TGF - beta - 1 inducing fibroblast proliferation. In hamster model, pirfenidone, taken by mouth, that can the prevention and treatment of pulmonary fibrosis . Pirfenidone can prevent the sclerosing peritonitis in rats induced by chemical, can also be keloid grafting for the treatment of nude mice. Pirfenidone 0.01 1 mg/ml can suppress the matrix and dose dependent manner serum stimulate uterine fibroids and leiomyoma cell DNA synthesis, the compound has no cytotoxic effect, has no effect on collagen mRNA level also. Pirfenidone in hamster pulmonary fibrosis model can reduce the disease before the collagen I mRNA level enhancement, reduce the level of the lung hydroxyproline and malondialadehyde and lung preserved ammonia acyl hydroxylase activity.
 

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High Purity Dutasteride Avodart For Bodybuilding 164656-23-9

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Plant Extract Whitening Cosmetic Arbutin Arbutoside 497-76-7

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Plant Extract Whitening Cosmetic Arbutin Arbutoside 497-76-7
 
Arbutin Basic information
 
Product Name: Arbutin
Synonyms: 4-hydroxyphenyl-beta-d-glucopyranosid; Arbutin; Arbutoside
CAS: 497-76-7
MF: C12H16O7
MW: 272.25
EINECS: 207-850-3
Melting point: 195-198 °C
Alpha: -64 º (c=3)
Refractive index: -65.5 ° (C=4, H2O)
Storage temp.: 2-8°C
Solubility: H2O: 50 mg/mL hot, clear
Water Solubility: 10-15 g/100 mL at 20 ºC
Sensitive: Hygroscopic
Merck: 14,773
BRN : 89673
Stability: Stable. Hygroscopic - store under dry nitrogen.
Chemical Properties: Crystalline powder
Uses: Diuretic and anti-infective drugs of urinary system. Color photographic developing stabilizer. Whitening, anti-freckle, hair care in cosmetics.
Product Categories: Biochemistry;Glucose;Glycosides;Sugars;Natural Plant Extract;Herb extract;chemical reagent;pharmaceutical intermediate;phytochemical;standardized herbal extract;Uva, Ursi, p-Arbutin, Hydroquinone β-D-glucopyranoside;natural product;Inhibitors.
 
Product Description:
 
Alpha-Arbutin is a synthetic compound derived from natural plant sources. It is a water-soluble, white powder that remains stable in a pH range between 3.5 to 6.5. According to Lotion Crafters, a company offering skin care products, a 1 percent solution in clinical tests resulted in faster and better skin lightening after testing against other products for one month. Epidermal melanin biosynthesis, the effects of melanin on the skin, is blocked by Alpha-Arbutin; it reportedly works best when used for a period of two to three months.
 
Application:
 
1. Cosmetic industry:
Alpha Arbutin protect the skin against damage caused by free radicals Alpha Arbutin is a skin whitening agent which is very popular in Japan and Asian countries for skin de-pigmentation, Alpha Arbutin inhibits the formation of melanin pigment by inhibiting Tyrosinase activity. Alpha Arbutin is very safe skin agent for external use which does not have toxicity, stimulation, unpleasant odor or side effect such as Hydroqinone.The encapsulation of Alpha Arbutin constitute a delivery system to potentialize the effect in time.
 
2. Medical industry:
Back in the 18th century, Alpha Arbutin was first used in medical areas as an anti-inflammatory and antibacterial agent. Alpha Arbutin was used particularly for cystitis, urethritis and pyelitis. These uses still until today where natural medicine uses only natural ingredients to treat any disease. Also Alpha Arbutin may be used to repress the virulence of bacterial pathogens and to prevent contaminating bacteria, Alpha Arbutin is also used for treating allergic inflammation of the skin.
 
Function :
 
1.Alpha arbutin will relieve and dispell chloasma, melanin, acne ect;
2. Alpha arbutin has good effects of sterilization and relieving cough;
3. It used to alleviate pain of burn and scald,enhancing immune fuction;
4.It can promote skin elasticity, retaining skin moisture and slowing down aging skin;
5.It has function of restraining the activity of tyrosinase; preventing the formation of melanin.
 

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Purity 99% Female Hormone Chlormadinone Acetate CAS 302-22-7

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Purity 99% Female Hormone Chlormadinone Acetate CAS 302-22-7
 
Chlormadinone Acetate Basic Info.:
 
Product Name: Chlormadinone Acetate
CAS: 302-22-7
MF: C23H29ClO4
MW: 404.93
EINECS: 206-118-0
Mp: 212°C
Storage temp: -20°C Freezer
Appearance: Crystalline Solid
 
Chlormadinone Acetate Description:
 
Chlormadinone acetate (CMA) is a derivative of progesterone (17-acetoxy-6-chloro-4,6-pregnadiene-3,20-dione), first synthesized in 1961 and is used as an orally effective progestogen in hormone replacement therapy (HRT), and in combination with ethinyl estradiol (EE) in contraception since 1999. Chlormadinone acetate has a strong progestogenic effect about one-third higher than that of progesterone and may vary depending on the previous effect of an estrogen, i.e., estrogens may promote the formation of progesterone receptors and proliferation of the endometrium. Like progesterone, it is anti-estrogenic and has no partial androgenic effect (at the doses used for contraception and HRT). In contrast to progesterone, it has a slight glucocorticoid effect, a pronounced anti-androgenic effect and no anti-mineralocorticoid effect. No pregnancy-maintaining effect of CMA has been demonstrated in humans.
 
The anti-androgenic effect of CMA is presumed to be the result of both its binding to androgen receptors competitively inhibiting the effect of endogenous testosterone and dihydrotestosterone and the competitive inhibition of 5-reductase. In this respect, dosing of CMA is crucial; agonistic effects are observed when doses are increased from those optimal for an antagonistic effect.
 
Chlormadinone acetate has a strong anti-gonadotropic effect, through negative feedback on gonadotropin secretion, and has been used for more than 20 years alone for contraception in arterial risk patients. The clinical and metabolic tolerability of CMA has been demonstrated in numerous clinical studies with duration of treatment of up to 2.5 years.
The more recent application of CMA as an oral contraceptive in combination with EE (Neo Eunomin, Belara) has proven highly successful, with studies reporting excellent contraceptive efficacy, high tolerability and adherence due to a good side effect profile and positive effects on preexisting dysmenorrhea, skin and hair conditions.
 
Chlormadinone Acetate Application:
 
Chlormadinone acetate (CMA) is a derivative of naturally secreted progesterone that shows high affinity and activity at the progesterone receptor. It has an anti-estrogenic effect and, in contrast to natural progesterone, shows moderate anti-androgenic properties. CMA acts by blocking androgen receptors in target organs and by reducing the activity of skin 5alpha-reductase. It suppresses gonadotropin secretion and thereby reduces ovarian and adrenal androgen production. CMA shows high contraceptive efficacy by inhibiting ovulation due to its ability to suppress or disrupt endogenous gonadotropin secretion and, by this, inhibits follicular growth and maturation. In addition, it suppresses endometrial thickness and increases the viscosity of cervical mucus.
 

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Raw Medical Material Powder Priligy / Dapoxetine 119356-77-3

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Raw Medical Material Powder Priligy / Dapoxetine 119356-77-3
 
Dapoxetine Basic Info:
 
Product Name: Dapoxetine 
Synonyms: Priligy;Dapoxetine;Dapoxetine hydrochloride;Dapoxetine base;D-Dapoxetine HCL
CAS: 119356-77-3
MF: C21H23NO.ClH
MW: 341.88
EINECS: N/A
Purity: 99%
Appearance: White powder, odorless, slightly sweet, soluble in water and alcohol.
Product Categories: Erectile Dysfunction;API;Dapoxetine hydrochloride
  
Dapoxetine Description:
 
Premature ejaculation (PE) is the most common male sexual dysfunction. Dapoxetine hydrochloride, belonging to a class of drugs known as selective serotonin reuptake inhibitors or, was the first drug originally approved for the on-demand treatment of men with PE. We aimed to compare the intravaginal ejaculatory latency time (IELT), patient-reported global impression of change (PGIC), and adverse effect (AE) incidence associated with the use of dapoxetine (30 mg and 60 mg) versus placebo, and evaluate the differences in administering 60 mg versus 30 mg as on-demand medical oral therapy for the treatment of PE via a literature review and meta-analysis. Relevant randomized controlled trials (RCTs) were identified from PubMed, EMBASE, and Cochrane Central Register of Controlled Trials (Cochrane Library) databases. Ultimately, a total of seven RCTs with 8039 patients were included. Our meta-analysis demonstrated that dapoxetine (in the 30 mg and 60 mg subgroup) resulted in significantly higher IELT, PGIC, and AE incidence relative to the placebo, with higher proportions observed for 60 mg versus 30 mg of dapoxetine administration. The most common AEs were mild and tolerable. We conclude that dapoxetine (particularly the 60 mg dosage) may be considered a safe and effective drug for patients with PE.
 
Dapoxetine Application:
 
Dapoxetine hydrochloride is a drug that is used to treat premature ejaculation in men. It is available by prescription and is taken orally, prior to sexual intercourse. The drug belongs to the class called serotonin reuptake inhibitors (SSRIs), which have mainly been used to treat depression.
 
Sexual dysfunction, including premature ejaculation, is an extremely common condition worldwide. The cause of premature ejaculation has not been fully elucidated, but may include both psychological and physiological factors. Premature ejaculation refers to a short ejaculation time, which can affect the satisfaction of both partners during sexual intercourse.
 

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Yk11 Sarm Myostatin Inhibitor Yk-11 For Athletes 431579-34-9

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Yk11 Sarm Myostatin Inhibitor Yk-11 For Athletes 431579-34-9
 
YK-11 Basic Info.
 
Product Name: YK11/ YK-11
Full Name: (17a,20E)-17,20-[(1-Methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna- 4,20-diene-21-carboxylic Acid Methyl Ester
Synonyms: (17a,20E)-17,20-[(1-Methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna- 4,20-diene-21-carboxylic Acid Methyl Ester;YK11 ((17α,20E)-17,20-[(1-methoxyethylidene)bis-(oxy)]-3-oxo-
CAS: 431579-34-9; 366508-78-3 
Standard: In-house Standard
Appearance: White powder
Purity: 98.6 %
Shelf life: 2 years
Dosage: Daily dosage of YK11 is 4 mg once a day for hardcore users max 8 mg
 
YK-11 Description:
 
S.A.R.M. "YK-11" is one of the most powerful S.A.R.M.S (Selective Androgen Receptor Modulator) on the market today. It is used to achieve Anabolic Steroid type results, but without the negative side effects and legality issues.
This particular SARM "YK-11" is for helping the user Gain Lean Muscle Tissue and Lose Fat simultaneously.  
Taking a Moderate dose (4mg - 8mg per day, 2 to 4 capsules per day) of "YK-11" the user can expect to get a more Aesthetic Physique (Lean, Hard and Strong).
Taking a Large dose (18mg - 22mg per day, 9 to 11 capsules) of "YK-11" the user will experience Gaining More Muscle Tissue and maintaining Extreme Muscle Fullness (The "Pumped" Look) 24/7. This is attributed to the abilities of "YK-11" inducing the muscle cells to produce more Follistatin (even more than DHT Steroids), which helps inhibit the production of Myostatin (Myostatin - limits muscle growth). This S.A.R.M. has the potential for being as good as Testosterone in term of Muscle Strengthening, but without the negative side effects.
 
YK-11 Introduction:   
 
YK11 attaches itself to the AR (androgen receptor), but only inducts methods that lead to the traditional side effects of androgens such as growth of body hair and prostate and enhanced aggression - to a restricted degree. 
Kanno tested C2C12 muscle cells and not lab animals or humans. It has been discovered that muscle cells produce more anabolic factors if exposed to 500 nmol (nanomoles) YK11 than if you expose the same muscle cells to 500 nmol DHT.
YK11 induces muscle cells to make more follistatin (more than DHT does) - a strong myostatin inhibitor. 
 
YK-11 Functions:
 
Sarm YK-11 is a powerful SARM supplement promoting massive lean muscle gains which is a great benefit for those wanting to have an aesthetic and shredded physique!
 

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99% Purity Peptide Triptorelin For Muscle Building 57773-63-4

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99% Purity Peptide Triptorelin For Muscle Building 57773-63-4
 
Triptorelin Basic Info.
 
Product Name: Triptorelin
Synonyms: PGLU-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH2;PYROGLU-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY NH2;PYR-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH2;PYR-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH2 PAMOATE SALT;Triptorelin Pamoate;Triptorelin Acetate;Triptorelin Amide;Triptorelin, [Dtrp6]-Lh-Rh, Amide
CAS: 57773-63-4
MF: C64H82N18O13
MW: 1311.45
Usage: promoting ovulation
 
Description Of Triptorelin:
 
Triptorelin is a gonadotropin-releasing hormone agonist (GnRH agonist) used as the acetate or pamoate salts.
 
Triptorelin raises testosterone levels by causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Like other GnRH agonists.
 
triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, estrogen-dependent conditions (such as endometriosis or uterine fibroids), and in assisted reproduction.
 
Application Of Triptorelin:
 
Triptorelin is used to treat advanced prostate cancer in men. It is not a cure. Mosttypes of prostate cancer need the male hormone testosterone to grow and spread.
 
Triptorelin works by reducing the amount of testosterone that the body makes. This effect helps slow or stop the growth of cancer cells and helps relieve symptoms such as painful/difficult urination.
 
This medication is similar to a natural substance made by the body (luteinizing hormone releasing hormone-LHRH). 
 
Dosage And Suggestion:
 
Triptorelin injection comes as a powder to be mixed with sterile water and injected into the muscle of either buttock by a doctor or nurse in a medical office or clinic.
 

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99.72% Purity Anesthetic Pharma Raw Powder Lidocaine 137-58-6

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99.72% Purity Anesthetic Pharma Raw Powder Lidocaine 137-58-6
 
Lidocaine Basic Info.:
 
Product Name: Lidocaine
CAS No.: 137-58-6
Molecular Formula: C14H22N2O
Molecular Weight: 234.34 g/mol
EINECS: 205-302-8
Density: 1.026 g/cm3
Melting Point: 66-69 °C
Boiling Point: 350.8 °C at 760 mmHg
Flash Point: 166 °C
Application: It is a common local anesthetic and antiarrhythmic drug.
Solubility: Soluble in water
 
Lidocaine Descroptions: 
 
Lidocaine Hydrochloride Injection, USP is indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks, when the accepted procedures for these techniques as described in standard textbooks are observed.
 
Lidocaine Application and Function:
 
A- For block anesthesia and epidural anesthesia.
B- Also used for ventricular arrhythmias caused by myocardial infarction, digitalism, glucantime poisoning, surgery and so on. Such as ventricular tachycardia, frequent ventricular premature beat, ventricular fibrillation.
C- As painkillers of injection in the medicament.
D- Also used in suppository and ointment preparation, etc.
 

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Antiandrogen 427-51-0 Cyproterone Acetate For Prostate Cancer

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Antiandrogen 427-51-0 Cyproterone Acetate For Prostate Cancer
 
Cyproterone Acetate Basic Info.:
 
Product Name: Cyproterone acetate
CAS: 427-51-0
MF: C24H29ClO4
MW: 416.94
EINECS: 207-048-3
Melting Point: 200-201°C
Boiling Point: 525.9oC at 760 mmHg
Flash Point: 177.6°C
Storage Temp.: 2-8°C
Appearance: Crystalline Solid
Manufacturer: Kafen
Product Categories: Antibiotics;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals;Intracellular receptor;Steroid and Hormone;VETRANAL;Hormone Drugs.
Usage: The free alcohol is an anti-androgen; The acetate is both an anti-androgen and a progestogen. Combined with estrogen it is used in the treatment of acne. 
 
Cyproterone Acetate Description:
 
Cyproterone acetate (INN, USAN, BAN, JAN), sometimes abbreviated asnCPA, and sold under brand names such as Androcur and Cyprostat, isna synthetic steroidal antiandrogen drug with additional progestogennand antigonadotropic.
The main therapeutic indications ofncyproterone acetate are prostate cancer, benign prostaticnhyperplasia, priapism, hypersexuality (e.g., as a form of chemicalncastration), and other conditions in which androgen actionnmaintains the disease process.
 
Cyproterone Acetate Application:
 
CPA has been in use as an antiandrogen since 1964, and was the first antiandrogen introduced for clinical use.It is widely used throughout Europe, and is also used in Canada, Mexico, and other countries. It is not FDA-approved for use in the United States.
due to concerns about hepatotoxicity;medroxyprogesterone acetate has been used in this country instead.CPA has been approved for the treatment of prostate cancer, precocious puberty, androgen-related dermatological conditions (such as acne, seborrhea, hirsutism, and androgenic alopecia), and to reduce sex drive in sex offenders.
Combination formulations of CPA with ethinyl estradiol (a formulation sometimes referred to as co-cyprindiol) have been available as contraceptives since 1997.Other uses of CPA include the treatment of benign prostatic hyperplasia, priapism, hypersexuality, paraphilias, hot flashes, and hyperandrogenism in women. In addition, with the exception of the United States (where CPA is not available and spironolactone is generally employed instead), CPA is widely used as a component of hormone replacement therapy.
 

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Dexmedetomidine HCl 145108-58-3 Dexmedetomidine Hydrochloride

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Dexmedetomidine HCl 145108-58-3 Dexmedetomidine Hydrochloride
 
Dexedetomidine HCL Basic Info.:
 
Product Name: Dexedetomidine HCL
Synonyms: Dexmedetomidine HCL;Dexmedetomidine Hydrochloride;Demedetomidine HCL;Dexmedetomidine(Pilot);
CAS: 145108-58-3
MF: C13H17ClN2
MW: 236.74048
EINECS: N/A
Purity: >99%
Appearance: White or off-White Crystalline Powder
Product Categories: Inhibitors
 
Dexedetomidine HCL Function:
 
For the treatment of various types of schizophrenia.
Can also improve with emotional symptoms, reduce the recurrence of schizophrenia.
 

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