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98% Purity Aicar 2627-69-2 Sarms White Solid Raw Material

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98% Purity Aicar 2627-69-2 Sarms White Solid Raw Material
 
Aicar Basic Info:
 
Product Name: Aicar
CAS: 2627-69-2
MF: C9H14N4O5
MW: 258.23
EINECS: 220-097-5
Assay: 99%
Product Categories: Carbohydrates & Derivatives;Nucleotides;Protein Kinase;Cardiovascular;
Chemical Properties: White or off-white solid
 
Product Description Of Aicar:
 
Aicar is a peptide whose technical name is 5-Aminoimidazole-4-carboxamide ribonucleotide.
It can also be known as AICA ribonucleotide, ZMP, or Acadesine. It is an intermediate contained in the generation of inosine monophosphate. It primarily functions as an AMP-activated protein kinase agonist, meaning that it has the ability to promote the operation of nutrient stores for energy production. It has a molecular mass of 338.211, and it has a molecular formula of C9H15N4O8P.
 
Aicar is an adenosine analog that selectively activates AMP-activated protein kinase (AMPK). AMPK regulates lipid and glucose metabolism to maintain cellular energy homeostasis (Hardie and Carling).
 
Aicar can play a hand in boosting these processes because it contains the ability to penetrate cardiac
cells and block the production of enzymes tied to regulating glucose intake and energy expulsion. With these regulatory enzymes inhibited, the affected cells can in turn boost the amount of glucose that can be received, and it can also increase its level of energy conversion. Additionally, the peptide’s presence has been determined to aid in lowering programmed cell death, a process that is also known as apoptosis.
 
Aicar Application:
 
Glucose uptake stimulant; AMPK activator.AICAR is a nucleoside analogue that is able to enter
nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP
breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential
in myocardial ischemia. Cardioprotective.
 
Aicar is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.
Biological Activity Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes.
 
Aicar is a peptide whose technical name is 5-Aminoimidazole-4-carboxamide ribonucleotide. It can also be known as AICA ribonucleotide, ZMP, or Acadesine. It is an intermediate contained in the generation of inosine monophosphate. It primarily functions as an AMP-activated protein kinase agonist, meaning that it has the ability to promote the operation of nutrient stores for energy production. It has a molecular mass of 338.211, and it has a molecular formula of C9H15N4O8P.
 
Aicar Function:
 
Aicar is an adenosine analog that selectively activates AMP-activated protein kinase (AMPK). AMPK regulates lipid and glucose metabolism to maintain cellular energy homeostasis (Hardie and Carling).
 
Aicar can play a hand in boosting these processes because it contains the ability to penetrate cardiac cells and block the production of enzymes tied to regulating glucose intake and energy expulsion. With these regulatory enzymes inhibited, the affected cells can in turn boost the amount of glucose that can be received, and it can also increase its level of energy conversion. Additionally, the peptide's presence has been determined to aid in lowering programmed cell death, a process that is also known as apoptosis.
 

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99% Active Pharmaceutical Ingredient Lorcaserin CAS 616202-92-7

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99% Active Pharmaceutical Ingredient Lorcaserin CAS 616202-92-7
 
Lorcaserin Basic Info.:
 
Product name: Lorcaserin
CAS No.: 616202-92-7
M.F.: C11H14ClN
M.W.: 195.6886
Purity: 99.5%
Appearance: White crystal
Use: Medicine reducing weight and antidepressants.
 
Product Description Of Lorcaserin: 
 
The U.S. Food and Drug Administration approved Belviq (lorcaserin hydrochloride), as an addition to a reduced-calorie diet and exercise, for chronic weight management.
lorcaserin (Belviq) works by activating the serotonin 2C receptor in the brain. Activation of this receptor may help a person eat less and feel full after eating smaller amounts of food.
 
Lorcaserin Superiority: 
 
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99% Antiestrogen Steroid Hormones Toremifene Citrate For Cancer Patients 89778-27-8

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99% Antiestrogen Steroid Hormones Toremifene Citrate For Cancer Patients 89778-27-8

Toremifene Citrate Basic Info.

Product Name: Toremifene Citrate

Synonyms: FC 1157a; Fareston; NK 622; NSC 613680

CAS: 89778-27-8

Molecular Formula: C32H36ClNO8

Molecular Weight: 598.08

Melting point: 160-162°C

Boiling point: 146-148C

Density: 1,045g/cm

Refractive index: 1,416-1,418

Storage temp.: -20°C Freezer

Appearance: White or almost white powder

Toremifene Citrate Descriptions:

Fareston will display both estrogen antagonist / agonist properties in the body. This puts Fareston in the same category as Nolvadex and Clomid, the two most popular drugs in Farestons category. FARESTON is an estrogen agonist/antagonist indicated for the treatment of metastatic breast cancer in postmenopausal women with estrogen-receptor positive or unknown tumors.

Toremifene administration for a period of 3 months in men with idiopathic oligozoospermia is associated with significant improvements of sperm count, motility, and morphology, mediated by increased gonadotropin secretion and possibly a direct beneficial effect of toremifene on the testes. The above findings are also indicative of a better testicular exocrine (improved sperm parameters) response to treatment in men whose partners achieved pregnancy compared with those who did not. Further randomized, placebo-controlled trials should be conducted to determine whether this particular selective estrogen receptor modulator can be useful as an initial approach in men with oligozoospermia.

Toremifene Citrate Applications:

Toremifene Citrate improved lipid profiles, particularly as an enhancer of high density lipoprotein cholesterol. it improved low density lipoprotein cholesterol levels.Both fareston and tamoxifen selective estrogen receptor modulators and equivalent treatments for metastatic breast cancer.No significant differences were found between treatment with either tamoxifen or fareston Treatment of HR-positive patients with either tamoxifen or toremifene is appropriate.In treating idiopathic oligozoospermia, tamoxifen and fareston are roughly equally effective but raloxifene is not.The antiestrogenic effects of SERMs at the hypothalamic level result in a statistically significant increase of gonadotropin levels, which is more marked for tamoxifen and fareston compared with raloxifene.

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99% Benzocaine Hydrochloride Local Anesthetic Agents Benzocaine HCL 23239-88-5

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99% Benzocaine Hydrochloride Local Anesthetic Agents Benzocaine HCL 23239-88-5
 
Benzocaine HCL Basic Info.:
 
Product Name: Benzocaine HCL
Synonyms: Ethyl 4-Aminobenzoate Hydrochloride;Benzocaine Hcl;Benzocaine Hydrochloride;Benzocaine Hydrochl;
CAS: 23239-88-5
MF: C9H11NO2.ClH
MW: 201.65
Assays: 99%
Melting point: 92°C
Boiling point: 310°C, 183-184°C (1.87×103Pa)
Density: 1.17
Stability: Stable. Combustible.
Chemical Properties: White odourless crystals.
Uses: 
(1)The goods are used to relieve pain for the local anesthetic, wounds, ulcers and hemorrhoids facial, also are cough suppressants retreat intermediates.
(2)Used in cosmetic ultraviolet absorption, local anesthetics and used to relieve pain in the wound, ulcer surface and Hemorrhoids.
 
Benzocaine HCL Description:
 
Benzocaine is also called amino ethyl benzoate, a colorless or white orthorhombic needle-like crystals or crystalline powder. Benzocaine hydrochloride salt is the hydrochloride salt form of the local anesthetic benzocaine, with the same pharmacological effects of benzocaine and weaker effect of anesthesia than procaine. Local absorption is slow with lasting effect. It cannot be used for anesthesia as a result of not being dissolved in water. It can be used for pain relief and anti-itch. Benzocaine hydrochloride is usually made into powder or oil paste and used to heal wounds, ulcers, burns, skin abrasions and hemorrhoids.
 
Benzocaine is commonly found, particularly in Britain, as an impurity in street cocaine. Whilst giving a numbing effect similar to cocaine on users' gums it does not actually produce the effects of cocaine. But in terms of an orally based saliva drug test benzocaine can and has been mistaken for a false positive for cocaine.
 
Benzocaine HCL Applications:
 
Benzocaine HCL works by creating a chemical barrier that halts the build-up of sodium, which accumulates as the nerve endings are stimulated by pain. When sodium builds up, electrical signals also build in the nerve endings. These are eventually transmitted to the brain, which interprets the signals as pain.
 
Benzocaine is a local anesthetic commonly used as a topical pain reliever or in cough drops. It is the active ingredient in many over-the-counter anesthetic ointments such as products for oral ulcers. It is also combined with antipyrine to form A/B otic drops to relieve ear pain and remove earwax
 
Benzocaine is used as a key ingredient in numerous pharmaceuticals:
Over the counter throat lozenges such as Cepacol.
Some glycerol-based ear medications for use in removing excess wax as well as relieving ear conditions such as otitis media and swimmers ear.
Some previous diet products such as Ayds.
Some condoms designed to prevent premature ejaculation. Benzocaine largely inhibits sensitivity on the penis, and can allow for an erection to be maintained longer (in a continuous act) by delaying ejaculation. Conversely, an erection will also fade faster if stimulus is interrupted.
Benzocaine mucoadhesive patches have been used in reducing orthodontic pain.
In Poland it is included, together with menthol and zinc oxide, in the liquid powder (not to be confused with the liquid face powder) used mainly after mosquito stings. Today's ready made Pudroderm was once used there as pharmaceutical compound.
 

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99% Benzocione Local Anesthetic Benzocaine For Anti-Paining 94-09-7

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99% Benzocione Local Anesthetic Benzocaine For Anti-Paining 94-09-7
 
Benzocaine Basic Info.:
 
Product Name: Benzocaine
Synonyms: Aethoform;Anesthesin;Akos Bbs-00003658;4-Aminobenzoic Acid Ethyl Ester;Labotest-Bb Ltbb000527;H-4-Abz-Oet;Ethyl 4-Aminobenzoate;Ethyl P-Aminobenzoate
CAS: 94-09-7
Molecular Formula: C9H11NO2
Molecular Weight: 166.1965
EINECS number: 202-303-5
Purity: 99%
Size: 40 mesh and 200 mesh
Melting point: 88-90°C
Boiling point: 172°C (12.7517 mmHg)
Density: 1.17
Flash Point: 164.2°C
Vapor Pressure: 0.000589mmHg at 25 °C
Fp: 172°C/13mm
Storage temp.: 0-6°C
Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
Chemical Properties: White odourless crystals.
Product Categories: Aromatic Esters;C8 to C9;Carbonyl Compounds;Esters;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Research Chemical;Pharmaceutical intermediate;API;Pharma materials;Intermediate of Tetracaine hydrochloride.
Uses: 
(1)The goods are used to relieve pain for the local anesthetic, wounds, ulcers and hemorrhoids facial, also are cough suppressants retreat intermediates.
(2)Used in cosmetic ultraviolet absorption, local anesthetics and used to relieve pain in the wound, ulcer surface and Hemorrhoids.
 
Product Description Of Benzocaine:
 
Benzocaine is used to relieve pain and itching caused by conditions such as sunburn or other minor burns, insect bites or stings, poison ivy, poison oak, poison sumac, minor cuts, or scratches.
 
Benzocaine belongs to a group of medicines known as topical local anesthetics. It deadens the nerve endings in the skin. This medicine does not cause unconsciousness like general anesthetics do when used for surgery.
 
This medicine is available without a prescription; However, your doctor may have special instructions on the proper use and dose for your medical condition.
 
Fat soluble surface anaesthetic. It's for the local anesthetic for wound, pain, ulcer and hemorrhoids, as well as cough suppressants retreat Benzocaine intermediates. Also can be used for ultraviolet absorption in cosmetic. Related product: Lidocaine. 
 
Benzocaine Applications: 
 
Benzocaine is a topical analgesic (meaning it is to be used on the body surface or in the mouth but should not be swallowed) that has a number of different uses in over-the-counter (OTC) medicines. Depending on the dose and form, the active ingredient benzocaine can be used to relieve throat and mouth pain; To alleviate external vaginal itching and burning; To stop pain and itching due to hemorrhoids; Or to relieve minor skin irritations, pain, and itching. Because benzocaine is available in different doses and forms, it is very important to read the Drug Facts label carefully to determine whether the medicine is intended to be used for the symptoms you are experiencing. 
 
Benzocaine can be the only active ingredient in oral treatments that relieve sore throat or address mouth pain caused by cold sores, canker sores, teething, and other issues. It also can be combined with other active ingredients in oral treatments that not only relieve mouth and throat pain, but also protect irritated areas, provide a soothing coating, or relieve dryness. 
 
While oral discomfort treatments containing benzocaine are intended to be used in and around the mouth, there are other topical benzocaine medicines that should only be used externally, or on the outer surface of the body (not near or in the mouth). For example, benzocaine can be found in vaginal medicines that contain more than one external analgesic ingredient or in single active ingredient hemorrhoid treatments. Benzocaine also is available in topical pain relievers that not only relieve skin irritations, pain, and itching, but also contain other active ingredients that kill germs and help prevent infection. 
 
Benzocaine is approved by the U. S. Food and Drug Administration (FDA) and is safe and effective when used according to label directions. Some oral discomfort treatments can be used to temporarily relieve pain due to toothaches; However, these medicines are not intended for long-term treatment. If your toothache pain is severe or lasts for more than seven days, you should talk to your dentist.
 
Benzocaine may not be contained in all products sold under these brands. Please read the OTC Drug Facts label carefully for active ingredient information for specific products.
 

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99% Female Steroids Hormone Flibanserin For Gaining Women Sexy-Enhancement 167933-07-5

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99% Female Steroids Hormone Flibanserin For Gaining Women Sexy-Enhancement 167933-07-5
 
Flibanserin Basic Info:
 
Product Name: Flibanserin
Chemical Name: Centrophenoxine HCL
CAS Number: 167933-07-5
EINECS Number: 222-975-3
Molecular Formula: C20H21F3N4O
Molecular Weight: 294.17
Melting Point: 139-143°C
Assay: 99.5%
Appearance: White powder
 
Flibanserin Description:
 
Flibanserin is a novel, non-hormonal drug that has been studied in clinical trials for the treatment of HSDD in premenopausal and postmenopausal women. The application submitted to the FDA is for premenopausal women. Flibanserin is believed to work on key neurotransmitters, or chemicals, in the brain that affect sexual desire. More specifically, it is thought that flibanserin corrects an imbalance of levels of these neurotransmitters by increasing dopamine and norepinephrine (both responsible for sexual excitement) and decreasing serotonin (responsible for sexual inhibition). In clinical studies, flibanserin was evaluated for its ability to increase the frequency of satisfying sexual events, increase the intensity of sexual desire and decrease the associated distress women feel from its loss.
 
Flibanserin Application:
 
Flibanserin is being hailed as "Viagra for women." The experimental drug - designed for post-menopausal women with low sex drives - has now won approval from an advisory panel for the Food and Drug Administration (FDA).
 
Flibanserin is an antidepressant that failed to help depression in clinical trials, but was noted to have improved sexual health outcomes. It's not uncommon for a drug to be developed for one purpose, then approved for another. Sildenafil (Viagra) was originally developed to lower blood pressure, but failed those trials. The benefit of both of these drugs was discovered by accident. However, flibanserin has now been studied for its effects on sexual health for nearly a decade.
 
Flibanserin doesn't have any interactions with hormonal medications, Thorp says. It does seem to interact with the original libido helper, though: some panelists recommended a warning against drinking alcohol while taking it, Reuters reported. (Interested in natural alternatives to hormone replacement therapy? The Natural Menopause Solution has everything you need to tame symptoms and trigger rapid, healthy weight loss in menopausal women.)
 
HSDD is the most commonly reported form of female sexual dysfunction. HSDD is defined as a persistent or recurrent deficiency or absence of sexual fantasies and desire for sexual activity that causes marked distress or interpersonal difficulty, and which is not better accounted for by a medical, substance-related, psychiatric (e.g., depression) or other sexual condition. The cause of HSDD is believed to involve a multitude of social, psychological and biological factors and may be attributed to
a complex interplay of these factors.
 
Flibanserin Function:
 
A new drug designed to boost sexual desire in women is controversial for some and eagerly awaited by others, but it's hit a potentially serious snag. The drug didn't boost women's desire any more than a placebo in two clinical trials. The Food and Drug Administration posted the clinical trial results on its website today in advance of a committee meeting on Friday, when a panel of experts will vote whether or not to recommend approval of the drug called flibanserin.(The FDA usually follows the recommendations of its expert panels.) Although there was a slight increase in the number of sexually satisfying events flibanserin users had each month, the FDA staff who reviewed the results said the so-called response rate isn't "particularly compelling."
 

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99% High Purity Articaine Hydrochloride/Articaine HCl 23964-57-0

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99% High Purity Articaine Hydrochloride/Articaine HCl 23964-57-0
 
Articaine HCL Basic Info.:
 
Product Name: Articaine HCL
CAS No.: 23964-57-0
Packing: 25kg/drum
M.F.: C13H21ClN2O3S
M.W.: 320.8354
Appearance: White crystalline powder
Model NO.:23964-57-0
Assay:99.5%
CAS:23964-57-0
Grade Standard:USP/BP
Market:Global
 
Articaine HCL Description:
 
Articaine hydrochloride, its CAS NO. is 23964-57-0, the synonyms are 2-Thiophenecarboxylic acid,4-methyl-3-((1-oxo-2-(propylamino)propyl)amino)-, methyl ester, monohydrochloride ; 4-Methyl-3-(2-(propylamino)propionamido)-2-thiophenecarboxylic acid methyl ester HCl ; Articaine HCl ; Methyl4-methyl-3-(2-(propylamino)propionamido)-2-thiophenecarboxylate, monohydrochloride ; Septanest ; Septocaine. Articaine is a dental local anesthetic. It is the most widely used local anesthetic in a number of European countries and is available in many countries around the world.
 
Articaine HCL Application:
 
Articaine HCL Structure And Metabolism:
 
The amide structure of articaine is similar to that of other local anesthetics, but its molecular structure differs through the presence of a thiophene ring instead of a benzene ring. Articaine is exceptional because it contains an additional ester group that is metabolized by esterases in blood and tissue. The elimination of articaine is exponential with a half-life of 20 minutes. Since articaine is hydrolized very quickly in the blood, the risk of systemic intoxication seems to be lower than with other anesthetics, especially if repeated injection is performed.
 
Articaine is a local anaesthetic that has been approved overseas for several years. Like other amide anaesthetics, articaine blocks nerve conduction when it is infiltrated around a nerve. This action is prolonged by combining the drug with a vasoconstrictor such as adrenaline.
The combination of articaine and adrenaline can be used for local or regional anaesthesia for dental procedures. Anaesthesia begins within six minutes and lasts for an hour. The half-life of articaine is approximately 1.8 hours. It is metabolised and then mainly excreted in the urine.
 
Articaine HCL Clinical Use:
 
(1) Articaine is used for pain control. Like other local anesthetic drugs, articaine causes a transient and completely reversible state of anesthesia (loss of sensation) during (dental) procedures.
(2) In dentistry, articaine is used both for infiltration and block injections, with the block technique yielding the greatest duration of anesthesia.
(3) In people with hypokalemic sensory overstimulation, lidocaine is not very effective, but articaine works well.
 

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99% High Purity Local Anesthetic Tetracaine Hydrochloride/Tetracaine HCL 136-47-0

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99% High Purity Local Anesthetic Tetracaine Hydrochloride/Tetracaine HCL 136-47-0
 
Tetracaine HCL Basic Info.:
 
Product Name: Tetracaine hydrochloride
Synonyms: Tetracaine HCL
CAS: 136-47-0
MF: C15H25ClN2O2
MW: 300.82
EINECS: 205-248-5
mp: 149°C
storage temp: Refrigerator
Appearance: White Solid
Usage: Local anesthetic; Mainly used in mucosa anesthetic.The function is stronger than Procaine and Lidocaine.
 
Tetracaine HCL Description:
 
Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.
 
Tetracaine HCL Applications:
 
Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
 
In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
 

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99% High Purity Prohormones Steroids Raw Powder Estriol 50-27-1

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99% High Purity Prohormones Steroids Raw Powder Estriol 50-27-1
 
Estriol Basic Info.:
 
Product Name: Estriol
CAS No.: 50-27-1
Formula: C18H24O3
Molecular Weight: 288.39
EINECS: 200-022-2
Density: 1.255 g/cm3
Melting Point: 280-282 °C(lit. )
Boiling Point: 469 °C at 760 mmHg
Flash Point: 220.8 °C
Purity: 99%
Appearance: White crystalline powder
 
Estriol Description:
 
Estradiol, or more precisely, 17β-estradiol, is a human sex hormone and steroid, and the primary female sex hormone. It is named for and is important in the regulation of the estrous and menstrual female reproductive cycles. Estradiol is essential for the development and maintenance of female reproductive tissues but it also has important effects in many other tissues including bone. While estrogen levels in men are lower compared to women, estrogens have essential functions in men as well. Estradiol is found in most vertebrates as well as many crustaceans, insects, fish, and other animal species.
 
Estradiol or oestradiol (American or British English usages), derives from estra-, Gk. οστρο? (oistros, literally meaning "verve or inspiration") and -diol, a chemical name and suffix indicating that this form of steroid and sex hormone is a type of alcohol bearing two hydroxyl groups.
 
Estradiol is produced especially within the follicles of female ovaries, but also in other endocrine (i.e., hormone-producing) and non-endocrine tissues (e.g., including fat, liver, adrenal, breast, and neural tissues). Estradiol is biosynthesized from progesterone (arrived at in two steps from cholesterol, via intermediate pregnenolone). One principle pathway then converts progesterone to its 17-hydroxy-derivative, and then to androstenedione via sequential cytochrome P450-catalyzed oxidations.Action of aromatase on this dione generates estrone, and action of a dehydrogenase on this gives the title compound, 17β-estradiol.
 
Estriol Application:
 
Hormonal contraception:
A chemical derivative of estradiol, ethinyl estradiol with maximum dosage 200 µg, is a major component of hormonal contraceptive devices. Combined forms of hormonal contraception contain ethinyl estradiol and a progestin, which both contribute to the inhibition of GnRH, LH, and FSH, which accounts for the ability of these birth control methods to prevent ovulation and thus prevent pregnancy. Other types of hormonal birth control contain only progestins and no ethinyl estradiol.
 
Hormone replacement therapy:
If severe side effects of low levels of estradiol in a woman's blood are experienced (commonly at the beginning of menopause or after oophorectomy), hormone replacement therapy may be prescribed. Such therapy is usually combined with a progestin to reduce the risk of endometrial cancer.
 
Estrogen therapy may be used in treatment of infertility in women when there is a need to develop sperm-friendly cervical mucus or an appropriate uterine lining. This is often prescribed in combination with clomifene.
 
Estrogen therapy can also be used to treat advanced prostate cancer, as well as to relieve symptoms of breast cancer.
Not all products are available worldwide. Estradiol is also part of conjugated estrogen preparations, such as Premarin, though it is not the major ingredient. (Premarin consists of a large number of estrogen derivatives. As the name indicates, it comes from pregnant mares' urine.
 
Hormone replacement therapy in transgender women:
Main article: Hormone replacement therapy (male-to-female)
Estrogen therapy is also used as part of the hormone replacement therapy for trans women. Either oral or transdermal estradiol is used in higher concentrations during initial treatment and transition; estradiol is continued in lower doses to maintain female-level hormones following gender reassignment surgery.
 
Estriol Blocking Estrogens:
Inducing a state of hypoestrogenism may be beneficial in certain situations where estrogens are contributing to unwanted effects, e.g., certain forms of breast cancer, gynecomastia, premature closure of epiphyses, and inhibiting feminization in female-to-male transsexual hormone treatment. Estrogen levels can be reduced by inhibiting production using gonadotropin-releasing factor agonists (GnRH agonists) or blocking the aromatase enzyme using an aromatase inhibitor, or with an estrogen receptor antagonist.
 

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99% High Quality Anesthetic CAS 61-12-1 Dibucaine Hydrochloride Dibucaine HCl

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99% High Quality Anesthetic CAS 61-12-1 Dibucaine Hydrochloride Dibucaine HCl
 
Dibucaine HCL Basic Info.:
 
Product Name: Dibucaine hydrochloride
Dibucaine hydrochloride Synonyms: 2-butoxy-n-(2-(diethylamino)ethyl)-4-quinolinecarboxamidmonohydrochlorid;butoxycinchoninicaciddiethylethylenediamidehydrochloride;c3225
CAS: 61-12-1
MF: C20H30ClN3O2
MW: 379.92
EINECS: 200-498-1
Product Categories: Heterocycles;Intermediates & Fine Chemicals;PharmaceuticalsDibucaine hydrochloride  Chemical Properties:whitepowder Dibucaine hydrochloride  Usage Anesthetic (local).
 
Dibucaine HCL Description:
 
Dibucaine hydrochloride is a local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted. The drug blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade.
 
In combination sodium dibucaine hydrochloride is administered to dogs to induce rapid, humane, painless euthanasia. The euthanasia solution is toxic to wildlife. Euthanized animals must be properly disposed of by deep burial, incineration or other method in compliance with state and local laws.
 
Dibucaine HCL Applications:
 
Spinal anesthesia (high, low, saddle block) and topically to produce surface anesthesia. Eye: To anesthetize conjunctiva and cornea prior to superficial procedures (including tonometry, gonioscopy, removal of foreign bodies or sutures, corneal scraping).
 
Nose and Throat: To abolish laryngeal and esophageal reflexes prior to bronchoscopy, esophagoscopy.
Skin: To relieve pruritus, pain, burning.
 

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