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Cortisol is a hormone that belongs to a family of steroid hormones known as glucocorticoids. It’s secreted by the adrenal cortex, which is located in your adrenal glands that sit atop your kidneys. Cortisol is the main glucocorticoid in humans.Cortisol is a life sustaining adrenal hormone essential to the maintenance of homeostasis. Called “the stress hormone,” cortisol influences, regulates or modulates many of the changes that occur in the body in response to stress.Cortisol levels normally fluctuate throughout the day and night in a circadian rhythm that peaks at about 8 AM and reaches it lowest around 4 AM. While it is vital to health for the adrenals to secret more cortisol in response to stress, it is also very important that bodily functions and cortisol levels return to normal following a stressful event.Cortisol is produced in the human body by the adrenal gland in the zona fasciculata,the second of three layers comprising the adrenal cortex.Cortisol prevents the release of substances in the body that cause inflammation. It is used to treat conditions resulting from over activity of the B-cell-mediated antibody response.Cortisol plays an important role in glycogenolysis, the breaking down of glycogen to glucose-1-phosphate and glucose, in liver and muscle tissue. Glycogenolysis is stimulated by epinephrine and/or norepinephrine. Cortisol facilitates the activation of glycogen phosphorylase, which is necessary for epinephrine to have an effect on glycogenolysis.Cortisol is released in response to stress, sparing available glucose for the brain, generating new energy from stored reserves, and diverting energy from low-priority activities (such as the immune system) in order to survive immediate threats or prepare for the exertion of rising to a new day.
Similar to testosterone and Anadrol 50, Dianabol is a potent steroid, but also one which brings about noticeable side effects. For starters methandrostenolone is quite estrogenic. Gynecomastia is often a concern during treatment, and may present itself quite early into a cycle (particularly when higher doses are used). At the same time water retention can become a pronounced problem, causing a notable loss of muscle definition as both subcutaneous water and fat build. Sensitive individuals may therefore want to keep the estrogen under control with the addition of an anti-estrogen such as Nolvadex and/or Proviron. The stronger drugs Arimidex, Femara, or Aromasin (antiaromatase) would be a better choice if available. Methandrostenolone is a derivative of testosterone, exhibiting strong anabolic and moderate androgenic properties. This compound was first made available in 1960, and it quickly became the most favored and widely used anabolic steroid in all forms of athletics. This is likely due to the fact that it is both easy to use and extremely effective. In the U.S. Dianabol production had meteoric history, exploding for quite some time, then quickly dropping out of sight. Many were nervous in the late 80?s when the last of the U.S. generics were removed from pharmacy shelves, the medical community finding no legitimate use for the drug anymore. But the fact that Dianabol has been off the U.S. market for over 10 years now has not cut its popularity. It remains the most commonly used black market oral steroid in the U.S. As long as there are countries manufacturing this steroid, it will probably remain so. Tel:00862781331422 Fax:00862781331422 Cel:+8615337164625 Skype:leslie(at)carphetin(dot)com Email:leslie(at)carphetin(dot)com
Dopamine is a neurotransmitter that serves as a chemical messenger in the nervous system and permits individual nerve fibers (neurons) to communicate with each other. It belongs to the class of compounds known as monoamines, and more specifically to a subclass of chemicals called catecholamines. Dopamine can act either as an inhibitory mechanism or an excitatory mechanism in the nervous system, depending on the location of dopamine neurons, and the receiving characteristics of the next neuron in the chain. Dopamine is biosynthesized in the body (mainly by nervous tissue and the medulla of the adrenal glands) first by the hydroxylation of the amino acid L-tyrosine to L-DOPA via the enzyme tyrosine 3-monooxygenase, also known as tyrosine hydroxylase, and then by the decarboxylation of L-DOPA by aromatic L-amino acid decarboxylase. Dopamine is a brain chemical which produces feelings of satisfaction and pleasure. It is heavily secreted while falling in love and commonly found during the attraction phase of a relationship. It has many functions in the brain, including important roles in behavior and cognition, voluntary movement, motivation, punishment and reward, inhibition of prolactin production (involved in lactation and sexual gratification), sleep, mood, and attention, working memory, and learning. Dopaminergic neurons (i.e., neurons whose primary neurotransmitter is dopamine) are present chiefly in the ventral tegmental area (VTA) of the midbrain, the substantia nigra pars compacta, and the arcuate nucleus of the hypothalamus.
Estrogen is the general name for a group of hormone compounds. It is the main sex hormone in women and is essential to the menstrual cycle.It is also an essential part of a woman’s reproductive process. Estrogen regulates the menstrual cycle and prepares the uterus for pregnancy by enriching and thickening the endometrium.Estrogen is manufactured mostly in the ovaries, by developing egg follicles. It is also produced by the corpus luteum in the ovaries, as well as by the placenta.Estrogens are used as part of some oral contraceptives, in estrogen replacement therapy for postmenopausal women, and in hormone replacement therapy for trans women.
Glucagon a hormone secreted by the pancreas, raises blood glucose levels.It is a 29-amino acid polypeptide.Its effect is opposite that of insulin, which lowers blood glucose levels.It causes the liver to convert stored glycogen into glucose, which is released into the bloodstream.It is synthesized and secreted from alpha cells (α-cells) of the islets of Langerhans, which are located in the endocrine portion of the pancreas.Glucagon helps maintain the level of glucose in the blood,also regulates the rate of glucose production through lipolysis.Glucagon is used to treat insulin coma or insulin reaction resulting from severe hypoglycemia (low blood sugar).
Inhibin is an endocrine hormone produced in the ovaries and the testes.Inhibin levels in women being linked to the menstrual cycle and playing a role in fetal development.It is secreted by the granulosa cells in the ovaries of women that acts primarily to inhibit the secretion of follicle-stimulating hormone by the anterior pituitary gland.It was purified from bovine and porcine follicular fluid and identified first as a gonadal hormone that potently inhibits pituitary synthesis and secretion of FSH.Inhibins are related to TGF-beta.Inhibin is produced in two forms through dimeric assembly of an alpha subunit and one of two closely related beta subunits.
CAS: 521-12-0 MF: C23H36O3 MW: 360.53 EINECS: 208-303-1 Assay: 99% min. Usage: can be used as pharmaceutical material. Its main function is to promote metabolism. Anabolic effects include growth of muscle mass and strength, increased bone density and strength, and stimulation of linear growth and bone maturation. Tel:00862781331422 Fax:00862781685200 Cel:+8615337164625 Skype:leslie(at)carphetin(dot)com Email:leslie(at)carphetin(dot)com
Oxytocin is a mammalian hormone that acts primarily as a neuromodulator in the brain.It is best known for its roles in female reproduction. It is released in large amounts after distension of the cervix and uterus during labor, facilitating birth, and after stimulation of the nipples, facilitating breastfeeding.Oxytocin is a peptide of nine amino acids (a nonapeptide). Its systematic name is cysteine-tyrosine-isoleucine-glutamine-asparagine-cysteine-proline-leucine-glycine-amine.Oxytocin is a very abundant neuropeptide exerting a wide spectrum of central and peripheral effects as neurohormone, neurotransmitter, or neuromodulator.
Secretin is a hormone that controls the secretions into the duodenum, and also separately, water homeostasis throughout the body. It is produced in the S cells of the duodenum in the crypts of Lieberkuhn.Its effect is to regulate the pH of the duodenal contents via the control of gastric acid secretion and buffering with bicarbonate from the centroacinar cells of the pancreas as well as intercalated ducts.Secretin is released into circulation and/or intestinal lumen in response to low duodenal pH that ranges between 2 and 4.5 depending on species.It increases watery bicarbonate solution from pancreatic duct epithelium,counteracts blood glucose concentration spikes by triggering increased insulin release from pancreas, following oral glucose intake.Secretin has been widely used in medical field especially in pancreatic functioning test because it increases pancreatic secretions.Secretin modulates water and electrolyte transport in pancreatic duct cells,liver cholangiocytes,and epididymis epithelial cells. It has also been recently been found to play a role in the vasopressin-independent regulation of renal water reabsorption.
Calcidiol is a prehormone that is produced in the liver by hydroxylation of vitamin D3 by the enzyme cholecalciferol 25-hydroxylase. Calcifediol is then converted in the kidneys (by the enzyme 25(OH)D-1α-hydroxylase) into calcitriol.Calcitriol binds to intracellular receptors that then function as transcription factors to modulate gene expression.It is produced in the liver and is the best indicator of the body's vitamin D stores. It is effective in the treatment of rickets and osteomalacia, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties.It is also used in conjunction with calcium in the management and prevention of primary or corticosteroid-induced osteoporosis.
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