chemical-categories

 

99% Purity Steroids Arimidex 120511-73-1 Anastrozole For Women Breast Cancer

 

Anastrozole Basic Info.:

 

Product Name: Anastrozole

Synonyms: Anastrozole;Arimidex

CAS No: 120511-73-1

Molecular formula: C17H19N5

Molecular weight: 293.37

Appearance: White powder.

Assay: 99%

Melting point: 81-82°C

Storage temp.: Store at RT

Minimum order: 10g

Quality standard: USP 32 

 

Anastrozole Descriptions:

 

Anastrozole will begin taking it the day they start their cycle, Anastrozole will run it throughout the duration of steroid administration. Anastrozole is also important to point out GP Anastrozole's ability to increase testosterone in the body. Some studies have shown that natural testosterone levels have increases as much as 60% after the use of this substance for 7 days. Because of this, bodybuilders find Anastrozole extremely effective during PCT where as they are trying to elevate natural levels as much as possible in order to avoid a post cycle "crash".

 

Anastrozole Applications:

 

High Purity Anastrozole/Arimidex/CAS No: 120511-73-1

The drug is appropriately used when using substantial amounts of aromatizing steroids, or when one is prone to gynecomastia and using moderate amounts of such steroids. Arimidex does not have the side effects of aminoglutethimide (Cytadren) and can achieve a high degree of estrogen blockade, much moreso than Cytadren. It is possible to reduce estrogen too much with Arimidex, and for this reason blood tests, or less preferably salivary tests, should be taken after the first week of use to determine if the dosing is correct.

 

 

Effective Legal Muscle Building Steroids Hormone Powder Mebolazine 3625-07-8

 

Mebolazine Basic Info.

 

Product Name: Mebolazine

Alias: Mebolazine; Diarethyl; Dimetazin; Dimetina; Dostalon; Roxilon; 2-alpha-Dimethyl-5-alpha-androstan-17-beta-ol-3

CAS No.: 3625-07-8

Molecular Formula: C42H68N2O2

Molecular Weight: 633.011

EINECS: 214-983-0

Density: 1.24

Purity: ≥99%

Appearance: White Powder

Usage: Diamethazine is an C17-alkylated, anabolic-androgenic steroid, that exhibits similar effects to Superdrol (M226010).

 

Mebolazine Description:

 

Mebolazine is really a variant of the Superdrol molecule with almost the exact same features. It is really just two superdrol molecules paired together and those molecules break apart in the body to form two Superdrol molecules.

 

Mebolazine is very similar in effects to Superdrol, but may be slightly milder on the liver, due to the bonding. No one knows where the molecule actually splits, so it is possible that the molecule makes it past the liver and misses the first pass, thus making it less liver stressful. That being said, Mebolazine has just about the same characteristics as superdrol, meaning it will likely be very supressive to natural androgen production and can’t convert to estrogen, making the need to stack it with something “wet” pretty common.

 

Mebolazine should have the same harsh effects on cholesterol and blood pressure as Superdrol, since it is a DHT compound that is very dry. Common side effects will be similar like extreme back pumps, the ability to gain 15-18lbs of dry mass in a 3 week period, aggressive moods and acne.

 

Mebolazine Application:

 

Dymethazine is really a variant of the Superdrol molecule with almost the exact same features. It is really just two superdrol molecules paired together and those molecules break apart in the body to form two Superdrol molecules.

 

Dymethazine is very similar in effects to Superdrol, but may be slightly milder on the liver, due to the bonding. No one knows where the molecule actually splits, so it is possible that the molecule makes it past the liver and misses the first pass, thus making it less liver stressful.

 

That being said, Dymethazine has just about the same characteristics as superdrol, meaning it will likely be very supressive to natural androgen production and can't convert to estrogen, making the need to stack it with something "wet" pretty common.

 

Dymethazine should have the same harsh effects on cholesterol and blood pressure as Superdrol, since it is a DHT compound that is very dry. Common side effects will be similar like extreme back pumps, the ability to gain 15-18lbs of dry mass in a 3 week period, aggressive moods and acne.

 

 

High Purity 99.5% Tetracaine White Fine Powder For Local Anaesthesia 94-24-6

 

Tetracaine Basic Info.:

 

Product Name: Tetracaine

Synonym: Anetain, Amethocaine, Pontocaine,Ametop,Dicaine

CAS: 94-24-6

MF: C15H24N2O2

MW: 264.36

EINECS: 202-316-6

Assay: 99%

Quality Standards: EnterpriseStandard/Pharma Grade

Appearance: White powder

Package: 25kg/Drum

Usage: Tetracaine is a topical local anesthetic for the eyes. Tetracaine works by interfering with entry of sodium ions into nerve cells. This reduces the ability of nerves to generate an impulse and send pain sensations.

 

Tetracaine Description:

 

Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia. It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.

(1) In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.

(2) Tetracaine is the T in Tac, a mixture of 5 to 12 per cent tetracaine, 5M(per myriad), a half per mille (0.5‰), or .05 per cent (1 part in 2000) , and 4 or 10 per cent hydrochloride used in ear, nose & throat surgery and in the emergemcy department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations.

(3) Tetracaine is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.

 

Tetracaine Applications:

 

Tetracaine is used in different parts of the body to cause numbness or loss of feeling in some patients before having a medical test or procedure.

 

 

Human Growth Hormone Active Pharmaceutical Ingredient Gonadorelin 33515-09-2

 

Gonadorelin Basic Info.:

 

Product Name: Gonadorelin

Other Name: LH-RH, human, Gonadoreline

CAS: 33515-09-2

Purity (HPLC): 98.0%min.

Appearance: White powder

Molecular Formula: C59H83N17O17

Molecular Weight: 1302.39

Single Impurity (HPLC): 0.5%max

Amino Acid Composition: ±10% of theoretical

Peptide Content (N%): ≥80.0% 

Water Content(Karl Fischer): ≤8.0%

Acetate Content(HPIC): ≤10.0%

Specific Rotation (20/D): -55.0~-65.0°(c=1 1%HAc)

MS (ESI): Consistent

Mass Balance: 95.0~105.0%

 

Gonadorelin Description:

 

Gonadorelin is another name for gonadotropin-releasing hormone (GnRH). It is a synthetic decapeptide prepared using solid phase peptide synthesis. GnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary.

GnRH is available as gonadorelin hydrochloride(Factrel®)and gonadorelin diacetate tetrahydrate(Cystorelin®)for injectable use. Studies have described it being used via an infusion pump system to induce ovulation in patients with hypothalamic hypogonadism. It is also used in veterinary medicine as a treatment for cattle with cystic ovarian disease.

 

Gonadorelin Application:

 

Gonadorelin is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process that is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens. The pulsatility of GnRH secretion has been seen in all vertebrates, and it is necessary to ensure a correct reproductive function. Thus a single hormone, GnRH, controls a complex process of follicular growth, ovulation, and corpus luteum maintenance in the female, and spermatogenesis in the male. Its short half life requires infusion pumps for its clinical use.

 

 

No Side Effect Pharmaceutical Raw Materials Atorvastatin Calcium 134523-03-8

 

Atorvastatin Calcium Basic info:

 

Product Name: Atorvastatin Calcium

CAS: 134523-03-8

MF: C66H68CaF2N4O10

MW: 1155.36

Purity: 99%min.

FREE SAMPLES can be sent on request!

Storage: Stored in cool and dry place, keep away from strong light/heat.

Shelf Life: 2 years when properly stored.

Color:White crystalline powder

 

Atorvastatin Calcium Description:

 

Atorvastatin calcium is a white to off-white crystalline powder that is insoluble in aqueous solutions of pH 4 and below. Atorvastatin calcium is very slightly soluble in distilled water, pH 7.4 phosphate buffer, and acetonitrile, slightly soluble in ethanol, and freely soluble in methanol.

 

Atorvastatin Calcium Function:

 

Used for primary hypercholesterolemia, combined hyperlipidemia or diet control invalid for patients with familial hypercholesterolemia.

 

 

Norandrostenedione For Male Muscle Building Steroid Sex Enhancement 734-32-7

 

Norandrostenedione Basic Info.:

 

Product Name: Norandrostenedione

CAS NO: 734-32-7

EINECS: 211-995-8

Molecular Formula: C18H24O2

Molecular Weight: 272.38

Density: 1.13 g/cm3

Boiling Point: 433.4 °C at 760 mmHg

Melting Point: 169-172°C

Flash Point: 433.4 °C at 760 mmHg

Standard: Enterprise standard

Color: white powder

Assay: 99.3%

Package: 1kg/AL bag

 

Norandrostenedione Descriptions:

 

19-Norandrostenediones (4-estrene-3,17-dione, NOR) is a precursor of the anabolic steroid nandrolones. Until 2005 19-Norandrostenediones was available without prescription in United States, where it was marketed as a prohormone, but it is now classified as a Schedule III drug. It is also banned from use in many sports, including the Olympic Games, under the World Anti-Doping Code.19-Norandrostenediones is readily metabolized to nandroloe after oral administration, but its potency to transactivate the androgen receptor dependent reporter gene expression is 10 times lower as compared todihydrotestosterone (DHT).

 

Norandrostenedione Applications:

 

Scientific studies have shown that oral administration of 19-norandrostenediones is "a very ineffective strategy for stimulating skeletal muscle mass increases but may be associated with side effects".

In vivo experiments in castrated rats demonstrated that subcutaneous treatment with 19-norandrostenediones resulted only in a stimulation of the weight of the levator ani muscle, while the prostate and seminal vesicle weights remained completely unaffected. In contrast to its metabolite nandrolones, 19-norandrostenediones highly selectively stimulates the growth of the skeletal muscles but has only weak androgenic properties.

 

In the early 2000s, contamination of androstenedioe products with traces of 19-norandrostenediones caused false positives for doping tests for nandroloe because 19-norandrosterones is a metabolite of both nandrolones and 19-norandrostenedionse. In a randomized controlled trial trace contamination of androstenedion with 19-norandrostenedie was sufficient for users of androstendioe to test positive for nandrolones.This detail became less relevant after 19-norandrostenedie and androstenediones were banned by major sporting bodies.

 

 

Oral Finasteride / Proscar Steroids Powder For Hairloss Treatment 98319-26-7

 

Finasteride Basic Info.

 

Product Name: Finasteride

Synonyms: Finasteride;Proscar;Prostide;

CAS: 98319-26-7

Molecular Formula: C23H36N2O2

Molecular Weight: 372.5441

Assay: 99%

Appearance: White or off-white crystal powder

Density: 1.066g/cm3

Boiling Point: 576.61°C at 760 mmHg

Flash Point: 177.448°C

Vapour Pressure: 0mmHg at 25°C

Usage: It is 5 alpha - reductase inhibitor that can inhibit testosterone to convert into DHT. Also used for the treatment of Hyperplasia of prostate. Finasteride is a 4-- aza-steroid compound which is a specific inhibitor of the metabolism of testosterone within dihydro testosterone become stronger during the cell type-II enzyme 5a-reductase. The enlarged prostate called benign prostatic hyperplasia or prostate depends on the conversion of testosterone to dihydro-testosterone.

 

Finasteride Description:

 

Finasteride is a popular anti-androgen medication manufactured by Merck most commonly known as either Proscar or Propecia. Based on the progesterone skeleton, Finasteride belongs to a class of medications known as 5alpha-reductase inhibitors and as such is used for the treatment revolving around type 2 5-AR based occurrences.

 

This is important for performance enhancers as DHT based anabolic steroids have specific side-effects that may occur that can largely be remedied with the use of a 5-AR inhibitor such as Finasteride. As a type 2 5-AR inhibitor Finasteride was designed for the purpose of treating hair-loss, prostate enlargement, as well as prostate cancer.

 

Finasteride is very common among those who supplement with anabolic steroids yet fear hair-loss but there are important things you need to understand before you consider Finasteride use. As an androgen suppressor Finasteride can seriously inhibit the gains made while on cycle, severely and on that basis it is not highly recommended for on-cycle hair preservation.

 

Finasteride Applications:

 

Propecia (finasteride) is used to treat male pattern baldness (androgenic alopecia) in men. Oral use though will reduce DHT levels systemically, which may adversely affect training and sex drive.

 

It is also used in combination with doxazosin in the treatment of benign prostatic hyperplasia (BPH).] Finasteride is an orally active testosterone Type II 5-alpha reductase inhibitor, inhibiting the enzyme that converts testosterone to dihydrotestosterone (DHT).

Topically (on the scalp itself) it is of some effect in minimizing further hair loss. In combination with Nizoral and spironolactone (which smells awful, by the way) it can actually reverse loss moderately.

 

For use in cycles with testosterone, I don't think it is bad at all. One simply doesn't want less DHT than normal. As the amount of testosterone in the system increases, the amount of finasteride needed to keep levels down to normal increases. I consider 5 mg/day reasonable at the gram per week level, and proportionally less at lower dosages of testosterone.

 

 

Pharmaceutical Grade Reducing Fat Mass Chemicals Sr9011 SR-9011 1379686-29-9

 

SR9011 Basic Info:

 

Product Name: SR9011

Synonyms: 3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)-N-pentylpyrrolidine-1-carboxamide

CAS No: 1379686-29-9

Molucelar Formula: C23H31ClN4O3S

Molucelar Weight: 479.03524

Solubility: DMSO up to 100 mM

 

Sr9011 Description:

 

SR9011 is a trifunctional methacrylate monomer that provides exceptional adhesion to metal substrates.

SR9011 is recommended for use in peroxide cured coatings, sealants, and PVC-based plastisols. Usage levels of 5% to 10% by weight are recommended.

 

SR9011 is a potent and specific synthetic REV-ERB agonist that binds to REV ERB α with an EC50 ~790 nM and REV-ERB-β with EC50 ~560 nM. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.

 

Sr9011 Application:

 

In vitro: SR9011 was used at 5-10 μM concentration in vitro and in cellular assays.

In vivo: IP administration of SR9011 was used at 100 mg/kg once or twice per day for 12-30 days in different mouse models.

 

 

Tacrolimus FK-506 Pharmaceutical Intermediates Organ Transplant  104987-11-3

 

Tacrolimus Basic info: 

 

Product Name: Tacrolimus

Synonyms: Tacrolimus;Fr900506;Prograf;Tsukubaenolide;FK-506;

CAS: 104987-11-3

MF: C44H69NO12

MW: 804.02

Purity: 99%

Melting Point: 113-115°C

Boiling Point: 871.7 °C at 760 mmHg

Solubility: DMSO: >3 mg/mL

Appearance: White Crystalline Powder

Storage temp.: −20°C

Storage: Store in a cool, dry place. Do not store in direct sunlight. Store in a tightly closed container.

Product Categories: Active Pharmaceutical Ingredients;Immunosuppressant.;Intermediates & Fine Chemicals;Pharmaceuticals;API;Chiral Reagents;Fujimycin, Prograf;antibiotic;Inhibitors.

Usage: FK-506 (Tacrolimus) is a macrolide immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system.

 

Tacrolimus Application: 

 

L Immunosuppression following transplantation It has similar immunosuppressive properties to ciclosporin, but is much more potent. Immunosuppression with tacrolimus was associated with a significantly lower rate of acute rejection compared with ciclosporin-based immunosuppression (30.7% vs 46.4%) in one study. Clinical outcome is better with tacrolimus than with ciclosporin during the first year of liver transplantation. Long term outcome has not been improved to the same extent. Tacrolimus is normally prescribed as part of a post-transplant cocktail including steroids, mycophenolate and IL-2 receptor inhibitors. Dosages are titrated to target blood levels. Typical starting doses for once daily tacrolimus are 0.15-0.20 mg/kg body weight.

 

Tacrolimus Interactions:

 

Also like cyclosporin it has a wide range of interactions, including that with grapefruit which increases plasma-tacrolimus concentration. Several of the newer class of antifungals, especially of the azole class (fluconazole, posaconazole) also increase drug levels by competing for degradative enzymes.

 

Ulcerative colitis: 

In recent years, tacrolimus has been used to suppress the inflammation associated with ulcerative colitis, a form of inflammatory bowel disease. Although almost exclusively used in trial cases only, tacrolimus has shown to be significantly effective in the suppression of outbreaks of UC.

 

Tacrolimus Dermatological Use: 

 

As an ointment, tacrolimus is used in the treatment of eczema, in particular atopic dermatitis. It suppresses inflammation in a similar way to steroids, and is equally as effective as a mid-potency steroid. An important advantage of tacrolimus is that, unlike steroids, it does not cause skin thinning (atrophy), or other steroid related side-effects.

 

It is applied on the active lesions until they heal off, but may also be used continuously in low doses (twice a week), and applied to the thinner skin over the face and eyelids[citation needed]. Clinical trials of up to one year have been conducted. Recently it has also been used to treat segmental vitiligo in children, especially in areas on the face.

 

 

99% High Quality Anesthetic CAS 61-12-1 Dibucaine Hydrochloride Dibucaine HCl

 

Dibucaine HCL Basic Info.:

 

Product Name: Dibucaine hydrochloride

Dibucaine hydrochloride Synonyms: 2-butoxy-n-(2-(diethylamino)ethyl)-4-quinolinecarboxamidmonohydrochlorid;butoxycinchoninicaciddiethylethylenediamidehydrochloride;c3225

CAS: 61-12-1

MF: C20H30ClN3O2

MW: 379.92

EINECS: 200-498-1

Product Categories: Heterocycles;Intermediates & Fine Chemicals;PharmaceuticalsDibucaine hydrochloride  Chemical Properties:whitepowder Dibucaine hydrochloride  Usage Anesthetic (local).

 

Dibucaine HCL Description:

 

Dibucaine hydrochloride is a local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted. The drug blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade.

 

In combination sodium dibucaine hydrochloride is administered to dogs to induce rapid, humane, painless euthanasia. The euthanasia solution is toxic to wildlife. Euthanized animals must be properly disposed of by deep burial, incineration or other method in compliance with state and local laws.

 

Dibucaine HCL Applications:

 

Spinal anesthesia (high, low, saddle block) and topically to produce surface anesthesia. Eye: To anesthetize conjunctiva and cornea prior to superficial procedures (including tonometry, gonioscopy, removal of foreign bodies or sutures, corneal scraping).

 

Nose and Throat: To abolish laryngeal and esophageal reflexes prior to bronchoscopy, esophagoscopy.

Skin: To relieve pruritus, pain, burning.