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Parathyroid Hormone

Parathyroid Hormone is secreted by the chief cells of the parathyroid glands as a polypeptide containing 84 amino acids. It acts to increase the concentration of calcium (Ca2+) and phosphorous available in the blood. It acts to increase the concentration of calcium in the blood by acting upon the parathyroid hormone 1 receptor and the parathyroid hormone 2 receptor. Parathyroid Hormone reduces the reabsorption of phosphate from the proximal tubule of the kidney, increases the activity of 1-α-hydroxylase enzyme. Parathyroid hormone is closely linked to vitamin D, and both of these substances likely play a role in the long-term regulation of blood pressure.

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Parkinson Disease Treatment Pramipexole Dihydrochloride Monohydrate 104632-25-9

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Parkinson Disease Treatment Pramipexole Dihydrochloride Monohydrate 104632-25-9
 
Pramipexole Dihydrochloride Monohydrate Basic Info.:
 
Product Name: Pramipexole Dihydrochloride Monohydrate
CAS: 191217-81-9
Other Names: (S)-2-Amino-4,5,6,7-Tetrahyd
Mf: C10h17n3s.2(HCl).H2O
Mw: 302.26
Appearance: Appearance White Crystalline Powder
Purity: 99.5%
Grade: Medicine Grade
Quality Standard: Quality Standard Ep7.0/USP35
 
Product Function Of Pramipexole Dihydrochloride Monohydrate:
 
General introduction: Pramipexole dihydrochloride is a non-ergoline dopamine agonist indicated for treating early-stage Parkinson's disease (PD) andrestless legs syndrome (RLS). It is also sometimes used off-label as a treatment for cluster headache and to counteract the problems with sexual dysfunction experienced by some users of the selective serotonin reuptake inhibitor (SSRI) antidepressants. Pramipexole has shown robust effects on pilot studies in a placebo-controlled proof of concept study in bipolar disorder. It is also being investigated for the treatment of clinical depression and fibromyalgia.
 
Product Indications Of Pramipexole Dihydrochloride Monohydrate:
 
Parkinson's disease is a neurodegenerative disease affecting the substantia nigra, a component of the basal ganglia. The substantia nigra has a high quantity of dopaminergic neurons, which are nerve cells that release theneurotransmitter known as dopamine. When dopamine is released, it may activate dopamine receptors in the striatum, which is another component of the basal ganglia. When neurons of the substantia nigra deteriorate in Parkinson's disease, the striatum no longer properly receives dopamine signals. As a result, the basal ganglia can no longer regulate body movement effectively and motor function becomes impaired. By acting as an agonist for the D2, D3, and D4 dopamine receptors, pramipexole may directly stimulate the underfunctioning dopamine receptors in the striatum, thereby restoring the dopamine signals needed for proper functioning of the basal ganglia.
 

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Pentadecapeptide Bpc 157 Human Growth Hormone Supplements Peptide Peptide Drum 137525-51-0

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Pentadecapeptide Bpc 157 Human Growth Hormone Supplements Peptide Peptide Drum 137525-51-0
 
Pentadecapeptide Bpc 157 Basic Info.
 
Product Name: Pentadecapeptide Bpc 157
Alias: Booly Protection Compound 15, Pentadecapeptide, BPC 157;
Sequence: Gly-Glu-Pro-Pro-Pro-Gly- Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val 
CAS: 137525-51-0 
MF: C62H98N16O22 
MW: 1419.53552 
Purity: 99% 
Specification: 2mg/vial 
Appearance: White Lyophilized Powder 
Standard: USP 
Certification: SGS 
Method of Analysis: HPLC 
Storage: Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18°C. Upon reconstitution of the peptide it should be stored at 4°C between 2-21 days and for future use below -18°C. 
 
Pentadecapeptide Bpc 157 Description:
 
Pentadecapeptide BPC 157, composed of 15 amino acids, is a partial sequence of body protection
compound (BPC) Pentadecapeptide BPC 157, composed of 15 amino acids, is a partial sequence 
of body protection compound (BPC) that is discovered in and isolated from human gastric juice.
The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, 
cell survival, and cell migration
 
Stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W. 1419) may be the new drug stable in human gastric juice, effective both in the upper and lower GI tract, and free of side effects.
 
BPC 157, in addition to an antiulcer effect efficient in therapy of inflammatory bowel disease (IBD)(PL 14736) so far only tested in clinical phase II, has a very safe profile, and exhibited a particular wound healing effect. It also has shown to interact with the NO-saystem, providing endothelium protection and angiogenic effect, even in severely impaired conditions (i.e., it stimulated expression of early growth response 1 gene responsible for cytokine and factor generation and early extracellular matrix (collagen) formation (but also its repressor nerve factor 1- A binding protein-2)), important to counteract severe complications of advanced and poorly controlled IBD. Hopefully, the lessons from animal studies, particularly advanced intestinal anastomosis healing, reversed short bowel syndrome and fistula healing indicate BPC 157s high significance in further IBD therapy. Also, this supportive evidence (i.e., no toxic effect, limit test negative, LD1 not achieved, no side effect in trials) may counteract the problems commonly exercised in the use of peptidergic agents, particularly those used on a long-term basis
 
Pentadecapeptide Bpc 157 Application:
 
1. BPC 157 has a strong anti-inflammatory activity in both acute and chronic inflammation models. In fact, preliminary results in clinical trials suggest that BPC 157 may become an important therapeutic tool for the treatment of inflammatory bowel disease.
 
2. BPC 157 was shown to accelerate wound healing and to have a marked angiogenic effect. In addition, it significantly facilitates the healing of bone fracture in rats. This peptide also exhibits an osteogenic effect significantly improving the healing of segmental bone defect. BPC 157 accelerates the healing of transected rat Achilles tendon and transected rat quadriceps muscle.
 
3. FITC-phalloidin staining was able to demonstrate that BPC 157 induces F-actin formation in fibroblasts. Likewise, Western blot analysis was able to detect the production and activation of paxillin and FAK proteins. The western blot analysis also showed that BPC 157 increases the extent of phosphorylation of paxillin and FAK proteins without affecting the amounts produced.
 

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Peptides 170851-70-4 Weight Loss Steroids Ipamorelin For Muscle Gain

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Peptides 170851-70-4 Weight Loss Steroids Ipamorelin For Muscle Gain
 
Ipamorelin Basic Info.:
 
Product Name: Ipamorelin
Synonyms: IpoMarelin;IpaMorelin Acetate;Aib-His-D-2-Nal-D-Phe-Lys-NH2
Unit Size: 2 mg/vial
Unit Quantity: 1 Vial
CAS NO.: 170851-70-4
Molecular Formula: C38H49N9O5
Molecular Weight: 711.85
Sequence: H-Aib-His-D-2-Nal-D-Phe-Lys-NH2
Appearance: White Powder
Purity: 98.49%
Identity (ESI-MS) 711.85±0.5
Source Chemical Synthesis
Storage: Stable at room temperature for 90 days,however it should be stored in a freezer below -8°C for any extended period of time. After reconstituting Ipamorelin should be refrigerated at temperatures not to exceed 36°F.
 
Ipamorelin Description:
 
Ipamorelin is a fascinating new muscle building discovery that is getting a lot of attention in the bodybuilding world. It is a synthetic peptide that has powerful Growth Hormon releasing properties. And these GH releasing properties are what is of interest to athletes and bodybuilders since they can make a tremendous difference in the amount of muscle you can grow and how quickly you burn fat.
 
Ipamorelin is a penta-peptide. (Aib-His-D-2-Nal-D- Phe-Lys-NH2) And, the strength it displays may very well make regular old Growth Hormon (GH) obsolete. But what athletes and bodybuilders really want to know is what is this wonder peptide capable of doing, how is it used, and how does it compare to the other GHRP peptides?
 
Athletes are taking Ipamorelin in a 200mcg -300mcg dosage, two or three times daily, using a tiny insulin needle to inject. They usually start with the lower dose since side effects can include headaches or what feels like a head-rush. Ipamorelin can be taken at anytime but taking it about 30-45 minutes before a workout would seem ideal because of the pulse in Growth Hormon (GH) it creates allowing for maximum growth.
 
Studies on the effects of Ipamorelin on bone growth, body weight, and GH release showed some interesting conclusions.In one experiment, various doses were administered over the course of 15 days to test the group's reactions.
 
There was a distinct and dose-dependent effect on body weight gain however, the treatment group did not show a change in total IGF-I levels. Nor did the treatment group produce serum markers of bone development. For example, the number of cells in the wide portion of the tibia (the shinbone) did not change significantly. This is a good thing because it suggests muscle growth with less potential for deformity of bone or cartilage.
 
Ipamorelin in theory may increase Acetylchloine or Cortisol when used in higher dosages. However, and increase in Acetylchloine or Cortisol is even more likely with GHRP-2 and GHRP-6. In fact, in the case of Ipamorelin, there was little to no rise in Acetylcholine and Cortisol blood plasma levels even at injections more than 200 times higher than the effective dosage for comparable GH release.
 
Ipamorelin Applications:
 
Ipamorelin is a selective growth hormon secretagogue and agonist of the ghrelin receptor. In pentobarbital anaesthetised rats, ipamorelin released GH with a potency and efficacy comparable to GHRP-6 (ED50 = 80±42 nmol/kg and Emax = 1545±250 ng GH/ml vs 115±36nmol/kg and 1167±120ng GH/ml). In conscious swine, ipamorelin released GH with an ED50 = 2.3±0.03 nmol/kg and an Emax = 65±0.2 ng GH/ml plasma. Again, this was very similar to GHRP-6 (ED50 = 3.9±1.4 nmol/kg and Emax = 74±7ng GH/ml plasma). GHRP-2 displayed higher potency but lower efficacy (ED50 = 0.6 nmol/kg and Emax = 56±6 ng GH/ml plasma). The specificity for GH release was studied in swine.
 

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Peptides Alarelin Acetate For Ovulation And Endmometriosis 79561-22-1

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Peptides Alarelin Acetate For Ovulation And Endmometriosis 79561-22-1 
 
Alarelin Acetate Basic Info.:
 
Product Name: Alarelin Acetate
Synonyms: Des-Gly10,[D-Ala6]-Lh-Rh Ethylamide Acetate Salt.
CAS: 79561-22-1
MF: C56H78N16O12
MW: 1167.32
Storage temp.: −20°C
Form: Powder
Product Categories: Amino Acid Derivatives;Peptide;LH-RH;LH-RHPeptides for Cell Biology;Neuropeptides;Releasing Factors;API.
 
Alarelin Acetate (79561-22-1) Description:
 
Alarelin acetate is a gondatrophin releasing hormone. Natural forms of alarelin found in animals are used to induce ovulation. Synthetic versions of this product are created using an LH-RH antagonist which is commonly set in larger doses than the natural LH-RH that is typically found in the rat hypophyseal stimulation or the gondatoropin secretions in induced ovulation or in vitro.
 
This chemical is the acetate form of the natural hypothalamic peptide which is used by an animal’s body to release LH and FSH from the pituitary gland. The peptide alarelin acetate has a single non-glycosylated polypeptide structure that is made up of nine amino acids. This has a molecular mass of 1167.3.
 
Alarelin is commonly used in research settings both to better understand this peptide’s effects on an animal’s body and to induce conditions that may assist with reproductive research. Samples of this chemical intended for research settings are typically stable for around three weeks at room temperature, and will need to be stored at temperatures below -18 degrees Celsius for long term use.
 
Most versions of this chemical are shipped as a lyophilized powder that can be reconstituted at a sterile temperature. This chemical may remain stable for up to three weeks at room temperature if it is kept sealed when it is not in use. If this product will be used for long periods of time is should be kept in a freezer with a waterproof sea.
 
If the mixture has already been reconstituted it can be kept at 40 degrees Celsius for 2-7 days but should be kept at -180 degrees Celsius for longer periods of time. Do not continually refreeze and thaw the product.
 

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Peptides Carbetocin Acetate Contracting Uterus Control Bleeding 37025-55-1

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Peptides Carbetocin Acetate Contracting Uterus Control Bleeding 37025-55-1
 
Carbetocin Acetate Basic Info.:
 
Product Name: Carbetocin Acetate
Synonyms: (Butyryl1,Tyr(Me)2)-1-Carbaoxytocin Trifluoroacetate Salt;Carbetocin;Carbetocin Trifluoroacetate Salt;
CAS: 37025-55-1
MF: C45H69N11O12S
MW: 988.17
EINECS: 253-312-6
Storage temp.: -15°C
Product Categories: Peptide;Vasopressin and Oxytocin receptor;Intermediates & Fine Chemicals;Pharmaceuticals;Other APIs
Usage: An obstetric drug used to control postpartum hemorrhaging.
 
Carbetocin Acetate it is used to control bleeding after giving birth. Like oxytocin, it causes contraction of the uterus.
 

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Pharmaceutical Grade Reducing Fat Mass Chemicals Sr9011 SR-9011 1379686-29-9

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Pharmaceutical Grade Reducing Fat Mass Chemicals Sr9011 SR-9011 1379686-29-9
 
SR9011 Basic Info:
 
Product Name: SR9011
Synonyms: 3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)-N-pentylpyrrolidine-1-carboxamide
CAS No: 1379686-29-9
Molucelar Formula: C23H31ClN4O3S
Molucelar Weight: 479.03524
Solubility: DMSO up to 100 mM
 
Sr9011 Description:
 
SR9011 is a trifunctional methacrylate monomer that provides exceptional adhesion to metal substrates.
SR9011 is recommended for use in peroxide cured coatings, sealants, and PVC-based plastisols. Usage levels of 5% to 10% by weight are recommended.
 
SR9011 is a potent and specific synthetic REV-ERB agonist that binds to REV ERB α with an EC50 ~790 nM and REV-ERB-β with EC50 ~560 nM. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.
 
Sr9011 Application:
 
In vitro: SR9011 was used at 5-10 μM concentration in vitro and in cellular assays.
In vivo: IP administration of SR9011 was used at 100 mg/kg once or twice per day for 12-30 days in different mouse models.
 

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Pharmaceutical Grade Treatment Of Prostate Cancer Peptide Deslorelin Acetate 57773-65-6

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Pharmaceutical Grade Treatment Of Prostate Cancer Peptide Deslorelin Acetate 57773-65-6
 
Deslorelin Basic Info.:
 
Product Name: Deslorelin
Specification: 50mg*50vials/kit
Synonyms: GLP-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-NHET;Desorelin;Deslorelin; Deslorelin Acetate; Deslorelin (Human);
CAS: 57773-65-6
MF: C64H83N17O12
MW: 1282.45
Purity: 98%
Storage temp.: −20°C
Product Categories: Peptide;Hormones
Usage: Biochemical research;Clinical used in the treatment of prostate cancer.
 
Deslorelin Description:
 
Deslorelin acetate is an injectable gonadotropin releasing hormone super-agonist (GnRH agonist) also known as an LHRH agonist. It stops the production of sex hormones (and oestrogen). Deslorelin Acetate is marketed by Peptech with the brand name Ovuplant. It is currently approved for use in veterinary medicine and is used to induce ovulation in mares as part of the artificial insemination process. It is also used to stabilize high-risk pregnancies, mainly of livestock. Unlike other GnRH agonists, which are mainly used to inhibit uteinizing hormone and follicle-stimulating hormone by their ultimate downregulation of the pituitary gland, Deslorelin is primarily used for the initial flare effect upon the pituitary, and its associated surge of LH secretion.
 
Deslorelin Application:
 
Deslorelin was successfully trialed in the US and was approved for veterinary use under certain  circumstances. In Europe, it was approved for use in equine assisted reproduction. It is also being trialed in humans to study its efficacy in treatment of breast cancer in women,and in treating  precocious puberty and congenital adrenal hyperplasia in male and female children.
 

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Pharmaceutical Human Growth Hormone Peptide TB-500 Anti Inflammatory

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Pharmaceutical Human Growth Hormone Peptide TB-500 Anti Inflammatory
 
TB 500 Basic Info.:
 
Product Name: TB 500 
Synonyms:TB 500;TB500;Thymosin Beta 500
TB500 Appearance: White powder
TB500 CAS No.: 77591-33-4
TB500 MF: C212H350N56O78S
TB500 MW: 4963.49
TB500 Specification: 2mg/vial,10vials/kit
TB500 Purity (HPLC): 95%min
TB500 Amino Acid Composition: ± 10% of theoretical
TB500 Peptide Content (N%): ≥ 80.0%
TB500 Water Content(Karl Fischer): ≤ 5.0%
TB500 Acetate Content (HPIC): ≤ 15.0%
TB500 Single Impurity (HPLC): 2.0%max
TB500 MS(ESI): Consistent
 
TB 500 Description:
 
TB-500 is a synthetic fraction of the protein thymosin beta-4, which is present in virtually all human 
and animal cells. The main purpose of this peptide is to promote healing. It also promotes creation 
of new blood and muscle cells. The healing effects of TB-500 have been observed in tendons,
ligaments, muscle, skin, heart, and the eyes. Thymosin beta-4 is naturally produced in higher 
concentration where tissue has been damaged. This peptide is also a very potent anti-inflamatory 
agent. 
 
TB-500 is different from other repair factors (growth hormone, IGF-1), because it promotes 
endothelial and keratinocyte migration. It also does not bind to the extracellular matrix and has 
a very low molecular weight. Because of this it can travel long distances through the tissues in the 
human body. 
 
One of TB-500 key mechanisms of action is its ability to regulate the cell-building protein - Actin. 
Of the thousands of proteins present within human cells, actin represents roughly 10% of the total.
It is thus a vital component of cell structure and movement.
 
TB-500 was identified as a gene that was up-regulated four-to-six fold during early blood vessel
formation and found to promote the growth of new blood cells from the existing vessels. This peptide is present in wound fluid and when administered subcutaneously, it promotes wound healing, muscle building and speeds up recovery time of muscles fibres and their cells. An additional key factor of
TB-500 is that it promotes cell migration through a specific interaction with actin in the cell cytoskeleton.
It has been demonstrated that a central small amino acid long-actin binding domain has both blood cell reproduction and wound healing characteristics. These characteristics are uncovered by accelerating
the migration of endothelial cells and keratinocytes. It also increases the production of extracellular matrix-degrading enzymes.
 
TB 500 Application:
 
TB-500 is different from other repair factors because it promotes endothelial and keratinocyte migration. It also does not bind to the extracellular matrix and has a very low molecular weight.Because of this it can travel long distances through the tissues in the human body. 
 
TB-500 is a synthetic fraction of the protein thymosin beta-4, which is present in virtually all human and animal cells. The main purpose of this peptide is to promote healing. It also promotes creation of new blood and muscle cells. The healing effects of TB-500 have been observed in tendons, ligaments, muscle, skin, heart, and the eyes. Thymosin beta-4 is naturally produced in higher concentration where tissue has been damaged. This peptide is also a very potent anti-inflamatory agent.
 

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Pharmaceutical Intermediate Anti-Estrogen Clomiphene Citrate Steroid Hormone Powder Clomid 50-41-9

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Pharmaceutical Intermediate Anti-Estrogen Clomiphene Citrate Steroid Hormone Powder Clomid 50-41-9
Male Anti Estrogenic Clomid for Steroid Cycle Clomiphene
 
Clomid Basic Info.:
 
Product Name: Clomid (Clomiphene Citrate)
Alias: Clomid;Clomifen;Clomiphene;Clomiphene Citrate;Serophene;Pergotime;Clomphid;Clomiphene Citrate Salt.
CAS No: 50-41-9
MF: C32H36ClNO8
MW: 598.09
Einecs No: 200-035-3
Purity: 99%
Melting point: 116.5-118°C
Storage temp.: 2-8°C
Appearance: Crystalline Solid; Odourless.
Product Categories: API;Intermediates & Fine Chemicals;Pharmaceuticals;Amines;Aromatics;Peptides;CLOMID
Usage:
(1)An unducer of ovulation. A gonad-stimulating principle
(2)Synthetic estrogen agonist-antagonist. Gonad-stimulating principle.
(3)A selective estrogen receptor modulator
 
Clomid Description:
 
Clomid is a mixed estrogen agonist/antagonist (activator/blocker) which, when bound to the estrogen receptor, puts it in a somewhat different conformation (shape) than does estradiol. The estrogen receptor requires binding of an estrogen or drug at its binding site and also the binding of any of several cofactors at different sites. Without the binding of the cofactor, the estrogen receptor is inactive. Different tissues use different cofactors. Some of these cofactors are able to bind to the estrogen receptor/Clomid complex, but others are blocked due to the change in shape. The result is that in some tissues Clomid acts as an antagonist - the cofactor used in that tissue cannot bind and so the receptor remains inactive - and in others Clomid acts as an agonist (activator), because the cofactors used in that tissue are able to bind. 
 
Clomid Applications:
 
Steroids Hormone Clomiphene Citrate/Clomid powders/CAS No: 50-41-9
Clomid is the anti-estrogen of choice for improving recovery of natural testosterone production after a cycle, improving testosterone production of endurance athletes, and is also effective in reducing risk of gynecomastia during a cycle employing aromatizable steroids. 
 

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