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Prostaglandins

Prostaglandins is any member of a group of lipid compounds that are derived enzymatically from fatty acids and have important functions in the animal body. Every prostaglandin contains 20 carbon atoms, including a 5-carbon ring.Prostaglandins are not endocrine hormones, but autocrine or paracrine, which are locally acting messenger molecules.Prostaglandins are highly potent substances that are not stored but are produced as needed by cell membranes in virtually every body tissue. Different prostaglandins have been found to raise or lower blood pressure and regulate smooth muscle activity and glandular secretion.Prostaglandins also control the substances involved in the transmission of nerve impulses, participate in the body's defenses against infection, and regulate the rate of metabolism in various tissues.It cause constriction or dilation in vascular smooth muscle cells, aggregation or disaggregation of platelets, sensitize spinal neurons to pain induce labor, decrease intraocular pressure, regulate inflammatory mediation, regulate calcium movement, control hormone regulation, cell growth, acts on thermoregulatory center of hypothalamus to produce fever, mesangial cells in the glomerulus of the kidney to increase glomerular filtration rate.

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Purity 99% Female Hormone Chlormadinone Acetate CAS 302-22-7

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Purity 99% Female Hormone Chlormadinone Acetate CAS 302-22-7
 
Chlormadinone Acetate Basic Info.:
 
Product Name: Chlormadinone Acetate
CAS: 302-22-7
MF: C23H29ClO4
MW: 404.93
EINECS: 206-118-0
Mp: 212°C
Storage temp: -20°C Freezer
Appearance: Crystalline Solid
 
Chlormadinone Acetate Description:
 
Chlormadinone acetate (CMA) is a derivative of progesterone (17-acetoxy-6-chloro-4,6-pregnadiene-3,20-dione), first synthesized in 1961 and is used as an orally effective progestogen in hormone replacement therapy (HRT), and in combination with ethinyl estradiol (EE) in contraception since 1999. Chlormadinone acetate has a strong progestogenic effect about one-third higher than that of progesterone and may vary depending on the previous effect of an estrogen, i.e., estrogens may promote the formation of progesterone receptors and proliferation of the endometrium. Like progesterone, it is anti-estrogenic and has no partial androgenic effect (at the doses used for contraception and HRT). In contrast to progesterone, it has a slight glucocorticoid effect, a pronounced anti-androgenic effect and no anti-mineralocorticoid effect. No pregnancy-maintaining effect of CMA has been demonstrated in humans.
 
The anti-androgenic effect of CMA is presumed to be the result of both its binding to androgen receptors competitively inhibiting the effect of endogenous testosterone and dihydrotestosterone and the competitive inhibition of 5-reductase. In this respect, dosing of CMA is crucial; agonistic effects are observed when doses are increased from those optimal for an antagonistic effect.
 
Chlormadinone acetate has a strong anti-gonadotropic effect, through negative feedback on gonadotropin secretion, and has been used for more than 20 years alone for contraception in arterial risk patients. The clinical and metabolic tolerability of CMA has been demonstrated in numerous clinical studies with duration of treatment of up to 2.5 years.
The more recent application of CMA as an oral contraceptive in combination with EE (Neo Eunomin, Belara) has proven highly successful, with studies reporting excellent contraceptive efficacy, high tolerability and adherence due to a good side effect profile and positive effects on preexisting dysmenorrhea, skin and hair conditions.
 
Chlormadinone Acetate Application:
 
Chlormadinone acetate (CMA) is a derivative of naturally secreted progesterone that shows high affinity and activity at the progesterone receptor. It has an anti-estrogenic effect and, in contrast to natural progesterone, shows moderate anti-androgenic properties. CMA acts by blocking androgen receptors in target organs and by reducing the activity of skin 5alpha-reductase. It suppresses gonadotropin secretion and thereby reduces ovarian and adrenal androgen production. CMA shows high contraceptive efficacy by inhibiting ovulation due to its ability to suppress or disrupt endogenous gonadotropin secretion and, by this, inhibits follicular growth and maturation. In addition, it suppresses endometrial thickness and increases the viscosity of cervical mucus.
 

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Purity 99% Medical Androsterone Androgenic Prohormone Steroids 53-41-8

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Purity 99% Medical Androsterone Androgenic Prohormone Steroids 53-41-8 
 
Androsterone Basic Info.:
 
Product Name: Androsterone
Synonyms: 3-alpha-hydroxy-17-androstanone;3alpha-Hydroxy-17-androstanone;3-alpha-hydroxy-5-alpha-androstan-17-on;3-Epihydroxyetioallocholan-17-one;3-hydroxy-,(3-alpha,5-alpha)-androstan-17-on;3-hydroxy-,(3alpha,5alpha)-androstan-17-on;5alpha-Androstan-17-one, 3alpha-hydroxy-;5alpha-Androstane-3alpha-ol-17-one
CAS: 53-41-8
MF: C19H30O2
MW: 290.44
EINECS: 200-173-4
Melting point: 181-184 °C(lit.)
Alpha: 96 º (c=1, C2H5OH)
Storage temp.: -20°C
Chemical Properties: white to light beige crystalline powder.
Usage: It was isolated from male urine after removed of the phenolic estrogen fraction. Antihypertensor.
Product Categories: Steroids;Steroids & Hormones - 13C & 2H;Intermediates & Fine Chemicals;Pharmaceuticals.
 
Androsterone Description:
 
Androsterone, or 3α-hydroxy-5α-androstan-17-one, is an endogenous steroid hormone, neurosteroid, and putative pheromone. It is a weak androgen with a potency that is approximately 1/7th that of testosterone. In addition, it can be converted to dihydrotestosterone (DHT) from 3α-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase, bypassing conventional intermediates such as androstenedione and testosterone, and as such, can be considered to be a metabolic intermediate in its own right. 
Androsterone is also known to be an inhibitory androstane neurosteroid, acting as a positive allosteric modulator of the GABAA receptor, and possesses anticonvulsant effects. The unnatural enantiomer of androsterone is more potent as a positive allosteric modulator of GABAA receptors and as an anticonvulsant than the natural form. Androsterone's 3β-isomer is epiandrosterone, and its 5β-epimer is etiocholanolone.
 
Androsterone Applications:
 
Androsterone is one of the androgens, which are steroid hormones that affect the masculinization of the fetus and child and that maintain or create masculine traits in adults. Testosterone is the most active and abundant of the androgens. Androsterone was originally isolated from male urine in very small amounts. Many scientists believe it to be a metabolic byproduct of the breakdown of testosterone, and many scientists who study pheromones think it might be active in human relations.
 
A molecule of androsterone is very similar to testosterone. It consists of three six-member carbon rings and one five member ring joined along common sides. The molecular formula is C19 H30 O2. It has a beta-isomer called epiandrosterone, in which an hydroxyl group occupies a different geometric position. 
 
The ratio of androsterone to epiandrosterone is thought to be important in how masculine behavior is interpreted by others Pheromones are well known in insect behavior. Their role in insect mating, navigation and nest protection has been studied, and active compounds have been isolated. Pheromones are the basis of some insect baits. Their effect on mammal behavior patterns is less well understood.
 

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Purtity 98.5% Androstenediol CAS No 521-17-5 For Muscle Gaining

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Purtity 98.5% Androstenediol CAS No 521-17-5 For Muscle Gaining
 
Androstenediol Basic Info.:
 
Product Name: Androstenediol
Synonym: Hermaphrodiol;5-Androstenediol;Androstendiol;
CAS No.: 521-17-5
M.F.: C19H30O2
M.W.: 290.44
Assays: 99%
Packing: foil bag
AndrostenediolAppearance: White crystalline powder.
 

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Quality Factory Price Anti-estrogen Tamoxifen 10540-29-1

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Quality Factory Price Anti-estrogen Tamoxifen 10540-29-1
 
Tamoxifen Basic Info.:
 
Product Name: Tamoxifen
Synonyms: Tamoxifen;Ici47699;Nolvadex-D;Tamoxifenz
CAS: 10540-29-1
MF: C26H29NO
MW: 371.51
EINECS: 234-118-0
Purity: 99%
Character: White Powder
Product Categories: Active Pharmaceutical Ingredients;Protein Kinase Inhibitors and Activators;Intermediates & Fine Chemicals;Pharmaceuticals;Isotope Labeled Compounds;Aromatics
 
Tamoxifen Application:
 
The goods to anti-estrogen fertility inducer, the objects in dysfunctional uterine bleeding, polycystic ovary, menstrual disorders and drug-induced amenorrhea and other gynecologic diseases; It is used as a first line defense against breast cancer. Nolvadex or Tamoxifen citrate, a non-steroidal antiestrogen for oral administration, is commonly by athletes as a post cycle therapy drug to reduce or prevent the formation of excess estrogens that can lead to oily skin, acne, fluid retention, and gynecomastia.
 
Tamoxifen Uses:
 
1. Treatment for Women with metastatic breast cancer recurrence. 
2. Used as adjuvant therapy after surgery for breast cancer metastasis, and relapse prevention. 
3. For the treatment of ovarian cancer, endometrial cancer and endometriosis.
 

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Raloxifene Hydrochloride Anti Estrogen Supplements 82640-04-8 Raloxifene HCL Anti Cancer Steroid

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Raloxifene Hydrochloride Anti Estrogen Supplements 82640-04-8 Raloxifene HCL Anti Cancer Steroid
 
Raloxifene HCL Basic Info.:
 
Product Name: Raloxifene HCL (Raloxifene Hydrochloride)
Synonyms: Raloxifene HCL;Raloxifene hydrochloride;Ly156758;Keoxifene;Keoxifene hydrochloride;Ly 139481;Akos 92138;
CAS: 82640-04-8 
MF: C28H28ClNO4S 
MW: 510.04 
Assay:99%
Standard:USP32
Chemical Properties: Light-Yellow Solid 
Usage: amino acid, nutrient. A nonsteroidal, selective estrogen receptor modulator (SERM). Antiosteoporotic. 
Packing: 1kg/foil bag or as required.
 
Raloxifene HCL Description:
 
Raloxifene hydrochloride (HCl) has the empirical formula C28H27NO4SHCl, which corresponds to a molecular weight of 510.05 g/mol. Raloxifene HCl is an off-white to pale-yellow solid that is slightly soluble in water.SERMs mimic estrogen in some tissues and have anti-estrogen activity in others. Other SERMs, such as Pfizer's lasofoxifene and Wyeth's bazedoxifene are in the later development phases.
 
Evista (Raloxifene Hydrochloride) is an estrogen agonist/antagonist, referred to as a selective estrogen receptor modulator (SERM) and belongs to the benzothiophene class of compounds. The biological actions of Raloxifene are largely mediated through binding to estrogen receptors. This binding results in activation of estrogenic pathways in some tissues (Agonism) and and the blockade of estrogenic pathways in other tissues (Antagonism).
 
Raloxifene HCL Usage:
 
Evista is specifically approved for the treatment and prevention of osteoporosis in postmenopausal women, the reduction in risk of invasive breast cancer in postmenopausal women with osteoporosis and the reduction in risk of invasive breast cancer in postmenopausal women at high risk of invasive breast cancer. Evista is supplied as a 60 mg tablet designed for oral administration. The recommended initial dose of the drug is one 60 mg tablet daily, which may be administered any time of day without regard to meals.
 

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Raw Medical Material Powder Priligy / Dapoxetine 119356-77-3

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Raw Medical Material Powder Priligy / Dapoxetine 119356-77-3
 
Dapoxetine Basic Info:
 
Product Name: Dapoxetine 
Synonyms: Priligy;Dapoxetine;Dapoxetine hydrochloride;Dapoxetine base;D-Dapoxetine HCL
CAS: 119356-77-3
MF: C21H23NO.ClH
MW: 341.88
EINECS: N/A
Purity: 99%
Appearance: White powder, odorless, slightly sweet, soluble in water and alcohol.
Product Categories: Erectile Dysfunction;API;Dapoxetine hydrochloride
  
Dapoxetine Description:
 
Premature ejaculation (PE) is the most common male sexual dysfunction. Dapoxetine hydrochloride, belonging to a class of drugs known as selective serotonin reuptake inhibitors or, was the first drug originally approved for the on-demand treatment of men with PE. We aimed to compare the intravaginal ejaculatory latency time (IELT), patient-reported global impression of change (PGIC), and adverse effect (AE) incidence associated with the use of dapoxetine (30 mg and 60 mg) versus placebo, and evaluate the differences in administering 60 mg versus 30 mg as on-demand medical oral therapy for the treatment of PE via a literature review and meta-analysis. Relevant randomized controlled trials (RCTs) were identified from PubMed, EMBASE, and Cochrane Central Register of Controlled Trials (Cochrane Library) databases. Ultimately, a total of seven RCTs with 8039 patients were included. Our meta-analysis demonstrated that dapoxetine (in the 30 mg and 60 mg subgroup) resulted in significantly higher IELT, PGIC, and AE incidence relative to the placebo, with higher proportions observed for 60 mg versus 30 mg of dapoxetine administration. The most common AEs were mild and tolerable. We conclude that dapoxetine (particularly the 60 mg dosage) may be considered a safe and effective drug for patients with PE.
 
Dapoxetine Application:
 
Dapoxetine hydrochloride is a drug that is used to treat premature ejaculation in men. It is available by prescription and is taken orally, prior to sexual intercourse. The drug belongs to the class called serotonin reuptake inhibitors (SSRIs), which have mainly been used to treat depression.
 
Sexual dysfunction, including premature ejaculation, is an extremely common condition worldwide. The cause of premature ejaculation has not been fully elucidated, but may include both psychological and physiological factors. Premature ejaculation refers to a short ejaculation time, which can affect the satisfaction of both partners during sexual intercourse.
 

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Relaxin

Relaxin a hormone produced by the ovaries during pregnancy that causes pelvic and cervical expansion and relaxation. It is a heterodimer of two peptide chains of 24 and 29 amino acids linked by disulfide bridges, and it appears related to insulin. In the female, it is produced by the corpus luteum of the ovary, the breast and, during pregnancy, also by the placenta, chorion, and decidua. In the male, it is produced in the prostate and is present in human semen. Relaxin works by simultaneously cutting collagen production and increasing collagen breakdown. It stimulates the growth of the glands in the breasts that are responsible for milk production, and increases the amount of water in the uterus. Relaxin affects collagen metabolism, inhibiting collagen synthesis and enhancing its breakdown by increasing matrix metalloproteinases.

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Renin

Renin is a protein (enzyme) released by special kidney cells when you have decreased salt (sodium levels) or low blood volume.Renin also plays a role in the release of aldosterone, a hormone that helps control the body's salt and water balance.It participates in the body's renin-angiotensin system.The primary structure of renin precursor consists of 406 amino acids with a pre- and a pro-segment carrying 20 and 46 amino acids.Mature renin contains 340 amino acids and has a mass of 37 kDa.It that acts upon a circulating substrate, angiotensinogen, that undergoes proteolytic cleavage to from the decapeptide angiotensin I,which is further converted into angiotensin II by ACE, the angiotensin-converting enzyme primarily within the capillaries of the lungs.Renin is secreted from kidney cells, which are activated via signaling from the macula densa, which responds to the rate of fluid flow through the distal tubule, by decreases in renal perfusion pressure, and by sympathetic nervous stimulation, mainly through beta-1 receptor activation.Renin is usually measured as the plasma renin activity.

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Ropivacaine Hydrochloride Ropivacaine Hcl 132112-35-7 Local Anesthetic Raw Material

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Ropivacaine Hydrochloride Ropivacaine Hcl 132112-35-7 Local Anesthetic Raw Material
 
Ropivacaine HCL Basic Info.:
 
Product Name: Ropivacaine hydrochloride
Synonyms: S-ROPIVACAINE HCL;
CAS: 132112-35-7
MF: C17H26N2O.ClH.H2O
MW: 328.88
EINECS: N/A
Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
use:anesthetic (local),Pharmaceutical raw materials
Packing:Foil bag or as requirments
 
Ropivacaine HCL Description:
 
Ropivacaine is a local anaesthetic drug belonging to the amino amide group. The name ropivacaine refers to both the racemate and the marketed S-enantiomer. 
 
Ropivacaine is an anesthetic (numbing medicine) that blocks the nerve impulses that send pain signals to your brain. 
Ropivacaine is used as a local (in only one area) anesthesia for a spinal block, also called an epidural. The medication is used to provide anesthesia during a surgery or C-section, or to ease labor pains. 
Ropivacaine may also be used for purposes not listed in this medication guide.
 
Ropivacaine HCL Applications:
 
(1) Surgical anesthesia:Epidural anesthesia (including epidural anesthesia during cesarean section);Local infiltration anesthesia.
(2) Acute pain control:For postoperative or labor analgesia continuous epidural infusion can be used can also be intermittent medication;Local infiltration anesthesia.
 

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