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Tacrolimus FK-506 Pharmaceutical Intermediates Organ Transplant 104987-11-3

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Tacrolimus FK-506 Pharmaceutical Intermediates Organ Transplant  104987-11-3
 
Tacrolimus Basic info: 
 
Product Name: Tacrolimus
Synonyms: Tacrolimus;Fr900506;Prograf;Tsukubaenolide;FK-506;
CAS: 104987-11-3
MF: C44H69NO12
MW: 804.02
Purity: 99%
Melting Point: 113-115°C
Boiling Point: 871.7 °C at 760 mmHg
Solubility: DMSO: >3 mg/mL
Appearance: White Crystalline Powder
Storage temp.: −20°C
Storage: Store in a cool, dry place. Do not store in direct sunlight. Store in a tightly closed container.
Product Categories: Active Pharmaceutical Ingredients;Immunosuppressant.;Intermediates & Fine Chemicals;Pharmaceuticals;API;Chiral Reagents;Fujimycin, Prograf;antibiotic;Inhibitors.
Usage: FK-506 (Tacrolimus) is a macrolide immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system.
 
Tacrolimus Application: 
 
L Immunosuppression following transplantation It has similar immunosuppressive properties to ciclosporin, but is much more potent. Immunosuppression with tacrolimus was associated with a significantly lower rate of acute rejection compared with ciclosporin-based immunosuppression (30.7% vs 46.4%) in one study. Clinical outcome is better with tacrolimus than with ciclosporin during the first year of liver transplantation. Long term outcome has not been improved to the same extent. Tacrolimus is normally prescribed as part of a post-transplant cocktail including steroids, mycophenolate and IL-2 receptor inhibitors. Dosages are titrated to target blood levels. Typical starting doses for once daily tacrolimus are 0.15-0.20 mg/kg body weight.
 
Tacrolimus Interactions:
 
Also like cyclosporin it has a wide range of interactions, including that with grapefruit which increases plasma-tacrolimus concentration. Several of the newer class of antifungals, especially of the azole class (fluconazole, posaconazole) also increase drug levels by competing for degradative enzymes.
 
Ulcerative colitis: 
In recent years, tacrolimus has been used to suppress the inflammation associated with ulcerative colitis, a form of inflammatory bowel disease. Although almost exclusively used in trial cases only, tacrolimus has shown to be significantly effective in the suppression of outbreaks of UC.
 
Tacrolimus Dermatological Use: 
 
As an ointment, tacrolimus is used in the treatment of eczema, in particular atopic dermatitis. It suppresses inflammation in a similar way to steroids, and is equally as effective as a mid-potency steroid. An important advantage of tacrolimus is that, unlike steroids, it does not cause skin thinning (atrophy), or other steroid related side-effects.
 
It is applied on the active lesions until they heal off, but may also be used continuously in low doses (twice a week), and applied to the thinner skin over the face and eyelids[citation needed]. Clinical trials of up to one year have been conducted. Recently it has also been used to treat segmental vitiligo in children, especially in areas on the face.
 

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Tamoxifen Citrate

CAS: 54965-24-1 EINECS: 259-415-2 Assay: 99.5%. USP32 MF: C32H37NO8 MW: 563.64 Character: White crystalline powder. MP 140-144 degrees Tel:00862781331422 Fax:00862781685200 Cel:+8615337164625 Skype:leslie(at)carphetin(dot)com Email:leslie(at)carphetin(dot)com

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Tesamorelin Anabolic Androgenic Steroids Tesamorelin Intramuscular Injection 218949-48-5

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Tesamorelin Anabolic Androgenic Steroids Tesamorelin Intramuscular Injection 218949-48-5
 
Tesamorelin Basic Info.:
 
Product Name: Tesamorelin
Unit Size: 2 mg/vial 
Unit Quantity: 1 Vial 
C6H9O-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2
CAS: 218949-48-5
Molecular Formula: C211H366N72O67S1
Molecular Weight: 5135.89
Appearance: white powder
Purity (HPLC): ≥99.00%
Packing: According to every customer's requirement.
 
Tesamorelin Description:
 
Tesamorelin is a synthetic peptide consisting of all 44 amino acids of hGRF with the addition of a trans-3-Hexenoic acid group.Tesamorelin (also known as Egrifta) is a synthetic form of growth-hormone-releasing hormone which is used in the treatment of HIV-associated lipodystrophy.tendon fibroblasts in a dose-dependent manner as revealed by transwell filter migration assay. BPC 157 also dose dependently accelerated the spreading of tendon fibroblasts on culture dishes. The F-actin formation as detected by FITC-phalloidin staining was induced in BPC 157-treated fibroblasts. The protein expression and activation of FAK and paxillin were determined by Western blot analysis, and the phosphorylation levels of both FAK and paxillin were dose dependently increased by BPC 157 while the total amounts of protein was unaltered. In conclusion, BPC 157 promotes the ex vivo outgrowth of tendon fibroblasts from tendon explants, cell survival under stress, and the in vitro migration of tendon fibroblasts, which is likely mediated by the activation of the FAK-paxillin pathway.
 
Tesamorelin Applications:
 
1. Triptorelin raises testosterone levels by causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). 
 
2. Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty,estrogen-dependent conditions (such as endometriosis or uterine fibroids), and in assisted reproduction.
 

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Test Base tony@kafenbio.com USP 99%

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Muscle Body Building Anabolic Steroids Powder Testolent 58-22-0
 
Testolent Basic Info:
 
Chemical name: Testolent (Testosterones Base) 
Synonyms: Testosterones;Testosteron;Testred;Testex;Testoderm;Orquisteron;Oreton;Primoteston;Test Base 
CAS: 58-22-0
EINECS: 200-370-5
Assay: 99%
MF:C19H28O2
MW:288.43 
Packing: foil bag or tin.
Appearance: white or off-white crystalline powder
Product Categories: MI;TPI;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals;Intracellular receptor;Steroid and Hormone;API;testosterone;TESTIM;Inhibitors
Usage:to promote the development of male genitalia and maintain their normal function, for disease-free Testosterones replacement therapy, male menopause syndrome, impotence and other diseases Treatment, but also for women of functional uterine bleeding, dysmenorrhea, menorrhagia, aplastic anemia embolism.
 
Testolent Description:
 
Testosterones base is the undisputed king of steroids mainly because it is safe, elicits rapid mass and strength gains while maintaining libido, a sense of well being and energy. It's not uncommon for a first time user to gain 15-20lbs of LBM in a standard Testosterones cycle. Pure Testosterones comes in a water based aqueous form (Suspension) and also in a solvent/oil based form (Test Base).
 
Suspensions have tiny particles that are visible with the naked eye. If left on the shelf for a few days many times the particles will sink to the bottom leaving the clear solvents and water on the top. Depending on the manufacturer, particle sizes vary meaning some Suspension preparations can clog a 22 gauge needle. Ultra micronized Suspension can pass through a 25 gauge needle making injections more comfortable. Shake the suspension preparation vigorously before injecting.
 
Testosterones Base is the most common anabolic hormone that there is and is also considered the most basic. Due to this, bodybuilders often consider it the base steroid to most all cycles. Testosterones Base is both anabolic and androgenic in nature. Users of this steroid will notice a dramatic gain in muscle size and strength, as well as an overall sense of well being and increases libido and sex drive.
 
Testosterone Base Applications:
 
Testosterones Suspension is an injectable Testosterones hormone in a water base that was developed and used for decades, and is actually the first anabolic androgenic steroid made. For the purpose of building mass, Testosterones Suspension has never been surpassed since it was first developed in the 1930s. Many underground labs also suspend this product in propylene glycol or oil as well (which makes for a very painful injection). It has no ester attached; therefore no ester is calculated into the weight.
 

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Testosterone

Testosterone is a steroid hormone from the androgen group and is found in mammals, reptiles, birds, and other vertebrates. It is derived from cholesterol. It is primarily secreted in the testes of males and the ovaries of females. It is the principal male sex hormone and an anabolic steroid. In men, testosterone plays a key role in the development of male reproductive tissues such as the testis and prostate as well as promoting secondary sexual characteristics such as increased muscle, bone mass, and the growth of body hair, adequate levels of red blood cells, sense of well-being, and sexual and reproductive function. Testosterone can be used by an athlete in order to improve performance.

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Testosterone Cypionate

CAS No.:58-20-8 Molecular Formula: C27H40O3 Molecular Weight: 412.61 Purity: 98% Description: white or off-white crystalline powder Usage: Testosterone Cypionate is a synthetic androgen, mainly used for treatment of testosterone or class clinically free of testosterone syndrome, cryptorchidism, dysfunctional uterine bleeding, menorrhagia, ectopic endometriosis, uterine fibroid, menopause syndrome, metastatic breast cancer, and ovarian cancer, pituitary dwarfism, senile osteoporosis, such as aplastic anemia. Tel:00862781331422 Fax:00862781331422 Cel:+8615337164625 Skype:leslie(at)carphetin(dot)com Email:leslie(at)carphetin(dot)com

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Testosterone Decanoate

EINECS:227-226-4 MW: 442.67 CAS No.:5721-91-5 Chemical Name: 4-Androsten-17beta-ol-3-one Decanoate Chemical Formula: C29H46O3 Description: white or yellow white crystalline powder Purity: 99%, pharmaceutical grade Package: 20g-1kg/bag,1 kg /tin or foil bag; 5kg/cardboard drum,or as reqiurement Usage: can be used as pharmaceutical material. Its main function is to promote metabolism. Anabolic effects include growth of muscle mass and strength, increased bone density and strength, and stimulation of linear growth and bone maturation. Tel:00862781331422 Fax:00862781331422 Cel:+8615337164625 Skype:leslie(at)carphetin(dot)com Email:leslie(at)carphetin(dot)com

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Testosterone Enanthate

Primoteston is one of the most popular used testosterone products on the market today. It is very effective in building muscle, burning fat and gaining strength. It is also cheap and easy to obtain. Testosterone is the male sex hormone responsible for many of the physical and emotional traits of men. It creates the deeper voices, sex drive, aggression and, of coarse, larger muscles in men. Testosterone makes the muscles retain more nitrogen, which in turn makes the muscle synthesize proteins better, producing larger muscles. The downside to testosterone steroids is that they aromatize, or turn into estrogen, in the body. When the body has too much estrogen it begins to take on female characteristics gynocomastia, water retention, fat gain, loss of sex drive and testicular shrinkage are all most certain side effects of taking testosterone and letting it aromatize in the body. Testosterone enanthate is an oil based injectable steroid, designed to slowly release testosterone from the injection site (depot). Once administered, serum concentrations of this hormone will rise for several days, and remain markedly elevated for approximately two weeks. It may actually take three weeks for the action of this drug to fully diminish. For medical purposes this is the most widely prescribed testosterone, used regularly to treat cases of hypogonadism and other disorders related to androgen deficiency. Since patients generally do not selfadminister such injections, a long acting steroid like this is a very welcome item. Therapy is clearly more comfortable in comparison to an ester like propionate, which requires a much more frequent dosage schedule. Testosterone is a powerful hormone with notably prominent side effects. Much of which stem from the fact that testosterone exhibits a

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Testosterone Enanthate USP 99%

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Safe Raw Steroid Testosterone Enanthate For Bodybuilding Muscle 315-37-7
 
Testosterone Enanthate Basic Info.:
 
Product Name: Testosterone Enanthate
Synonyms: Testosterone Enantate;Primoteston Depot;Atlatest;Testosterone Enthanoate;Androtardyl;Everone;Testate;Atlates;Delatest;Testinon;NSC-17591;reposotmd;Testenate;Exten Test; Test E;
CAS: 315-37-7
MF: C26H40O3
MW: 400.59
EINECS: 206-253-5
Melting point: 34-39°C
Assay: 98%
Appearance: white crystalline powder
Product Categories: Steroids;Steroid and Hormone;Finished Steroid and Hormone;API;testosterone series;estosterone.
Uses: Clinical application in diseases such as male hypofunction, aplastic anemia, etc.
 
Description of Testosterone Enanthate:
 
Testosterone is an anabolic steroid that plays an integral role in overall health of both males and females. With aging there is tendency of decreasing the levels of testosterone. Testosterone enanthate is a steroid used to treat confirmed testosterone deficiency in males. It is an androgen replacement therapy that improves the symptoms of low testosterone levels. It is important to make the necessary blood tests in order to confirm the testosterone deficiency and get prescription of the right amount of drug. Consult a doctor before starting to use testosterone enanthate and follow all the indications of use and dosage.
 
Applications and Effects of Testosterone Enanthate Muscle Bulk Steroids:
 
Testosterone Enanthate - Clinical Pharmacology
Endogenous androgens are responsible for the normal growth and development of the male sex organs and for maintenance of secondary sex characteristics. 
Androgens also cause retention of nitrogen, sodium, potassium, and phosphorus, and decreased urinary excretion of calcium. Androgens have been reported to increase protein anabolism and decrease protein catabolism. 
Androgens have been reported to stimulate the production of red blood cells by enhancing the production of erythropoietic stimulating factor.
 

 

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Testosterone Propionate USP 99%

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Agovirin Muscle Building Steroids Powder Testosterone Propionate 57-85-2
 
Testosterone Propionate Basic Info:
 
Product Name: Testosterone Propionate
Synonyms: Agovirin
CAS: 57-85-2
MF: C22H32O3
MW: 344.49
EINECS: 200-351-1
Melting point: 118-123 °C
Solubility Ethanol: 10 mg/mL
Water Solubility: <0.1 g/100 mL at 24.5 ºC
General Description: Odorless white or yellowish-white crystals or a white or creamy-white crystalline powder.
Air & Water Reactions: Insoluble in water.
Uses:
1.It is used for the treatment of breast cancer, ovarian cancer, uterine fibroids, multiple myeloma and kidney cancer.
2.Anabolic steroid. Androgen. Controlled substance. Antineoplastic.
Product Categories: Steroids;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Steroid and Hormone;Finished Steroid and Hormone;API;testosterone;Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals, Steroids;VIRORMONE;Hormone Drugs;Inhibitors
 
Testosterone Propionate Description:
 
Testosterone propionate is a commonly manufactured, oil-based injectable testosterone compound. The added propionate ester will slow the rate in which the steroid is released from the injection site, but only for a few days. Testosterone propionate is therefore comparatively much faster acting than other testosterone esters such as cypionate or enanthate, and requires a much more frequent dosing schedule. While cypionate and enanthate are injected on a weekly basis, propionate is generally administered (at least) every third day. Figure one illustrates a typical release pattern after injection. As you can see, levels peak and begin declining quickly with this ester of testosterone. To make this drug even more uncomfortable to use, the propionate ester can be very irritating to the site of injection. In fact, many sensitive individuals choose to stay away from this steroid completely, their body reacting with a pronounced soreness and low-grade fever that may last for a few days. Even the mild soreness that is experienced by most users can be quite uncomfortable, especially when taking multiple pharmacokinetics of Testosterone propionate injections each week. The "standard" esters like in ection enanthate and cypionate, which are clearly easier to use, are therefore much more popular among athletes.
 
Testosterone Propionate Function:
 
Testosterone is responsible for promoting health and well-being through enhanced libido, energy, immunity, increased fat loss, gaining and maintaining lean muscle mass, preventing Osteoporosis (loss of bone density) and possible protection against heart disease. Testosterone is also responsible for normal growth and development of male sex organs and maintenance of secondary sex characteristics. Secondary sex characteristics are specific traits that separate the two sexes, but are not directly part of the reproductive system, for example: chest and facial hair, a distinguished jaw line, broad shoulders and increased muscle mass. Testosterone binds to the Androgen Receptors (AR), which thus causes accelerated muscle gain, fat loss, and muscle repair and growth. These mechanisms are stimulated by activation of the Androgen Receptors (either directly or indirectly as DHT).
 
Testosterone Propionate Side effects:
 
There are many possible side-effects associated with Testosterone Propionate use. This product has a high level of aromatization into estrogen and coverts to DHT (dihydrotestosterone) as well. Testosterone can convert to estrogen, the female sex hormone, creating a high risk of gynecomastia (formation of breast tissue in males). Also, supplementing Testosterone to your body will result in the shutting down of the body's natural production of the hormone. The severity of side effects depend mostly on the dose and duration of circulating free testosterone and it's conversion to estrogen and DHT. Testosterone's anabolic/androgenic effects are dependant upon also dosage; the higher the dose the higher the muscle building effect. Testosterone typically promotes aggressive and dominant behavior.
 
Testosterone Propionate User Notes:
 
Testosterone Propionate is actually my favorite form of injectable testosterone. Anecdotally, this is because in myself as well as other users, this short acting ester would seem to produce far less water retention and a quicker onset of gains. The only down side to this particular form of testosterone is that it must be injected frequently, with many users (myself included) preferring to inject it every day or every other day at a dose of around 100 mg.
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