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Erythropoietin

Erythropoietin is a glycoprotein hormone that controls erythropoiesis, or red blood cell production. It is a cytokine for erythrocyte (red blood cell) precursors in the bone marrow.It is produced by interstitial fibroblasts in the kidney in close association with peritubular capillary and tubular epithelial cells. It is also produced in perisinusoidal Ito cells in the liver.Erythropoietin is the hormone that regulates red blood cell production.It has its primary effect on red blood cells by promoting red blood cell survival through protecting these cells from apoptosis. It also cooperates with various growth factors involved in the development of precursor red cells.Erythropoietin is available as a therapeutic agent produced by recombinant DNA technology in mammalian cell culture. It is used in treating anemia resulting from chronic kidney disease and myelodysplasia, from the treatment of cancer (chemotherapy and radiation).

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Hydrocortisone

Hydrocortisone is a steroid hormone, or glucocorticoid, produced by the adrenal gland. It is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis, suppress the immune system, and aid in fat, protein and carbohydrate metabolism.Hydrocortisone counteracts insulin, contributes to hyperglycemia-causing hepatic gluconeogenesis and inhibits the peripheral utilization of glucose (insulin resistance) by decreasing the translocation of glucose transporters (especially GLUT4) to the cell membrane,stimulates gastric-acid secretion.It acts as a diuretic hormone, controlling one-half of intestinal diuresis.It reduces bone formation, favoring long-term development of osteoporosis. It transports potassium out of cells in exchange for an equal number of sodium ions,increases blood pressure by increasing the sensitivity of the vasculature to epinephrine and norepinephrine,inhibits secretion of corticotropin-releasing hormone.

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Norepinephrine

Norepinephrine a catecholamine, which is the principal neurotransmitter of postganglionic adrenergic neurons, having predominant α-adrenergic activity. It is a hormone secreted by certain nerve endings of the sympathetic nervous system, and by the medulla (center) of the adrenal glands. Its primary function is to help maintain a constant blood pressure by stimulating certain blood vessels to constrict when the blood pressure falls below normal. Norepinephrine is synthesized from dopamine by dopamine β-hydroxylase. It is released from the adrenal medulla into the blood as a hormone, and is also a neurotransmitter in the central nervous system and sympathetic nervous system. It affects parts of the brain, such as the amygdala, where attention and responses are controlled, triggering the release of glucose from energy stores, and increasing blood flow to skeletal muscle. It increases the brain's oxygen supply. Norepinephrine is synthesized from tyrosine as a precursor, and packed into synaptic vesicles. It stimulates the production of adrenaline, which makes our heart race, and the palms sweat, and increases the experience of joy and reduces appetite. In humans Norepinephrine prompts first attraction, first "sparks" in the air followed by falling in love.

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Phenethylamine

Phenethylamine is a natural monoamine alkaloid, trace amine, and psychoactive drug with stimulant effects. It is biosynthesized from the amino acid phenylalanine by enzymatic decarboxylation. Phenethylamine is an amine, consisting of a benzene ring and an aminoethyl group. Phenethylamine is a natural compound biosynthesized from the amino acid phenylalanine by enzymatic decarboxylation. It is also found in many foods such as chocolate. Phenethylamine releases norepinephrine and dopamine. Phenethylamine's half-life is 5-10 minutes. First attraction in humans causes to produce more phenethylamine which results in those dizzying feelings associated with romantic love. It increase both physical and emotional energy and at the same time releases more dopamine.

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Prostaglandins

Prostaglandins is any member of a group of lipid compounds that are derived enzymatically from fatty acids and have important functions in the animal body. Every prostaglandin contains 20 carbon atoms, including a 5-carbon ring.Prostaglandins are not endocrine hormones, but autocrine or paracrine, which are locally acting messenger molecules.Prostaglandins are highly potent substances that are not stored but are produced as needed by cell membranes in virtually every body tissue. Different prostaglandins have been found to raise or lower blood pressure and regulate smooth muscle activity and glandular secretion.Prostaglandins also control the substances involved in the transmission of nerve impulses, participate in the body's defenses against infection, and regulate the rate of metabolism in various tissues.It cause constriction or dilation in vascular smooth muscle cells, aggregation or disaggregation of platelets, sensitize spinal neurons to pain induce labor, decrease intraocular pressure, regulate inflammatory mediation, regulate calcium movement, control hormone regulation, cell growth, acts on thermoregulatory center of hypothalamus to produce fever, mesangial cells in the glomerulus of the kidney to increase glomerular filtration rate.

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Serilesine 1

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Thrombopoietin

Thrombopoietin is a glycoprotein hormone produced mainly by the liver and the kidney that regulates the production of platelets by the bone marrow. It stimulates the production and differentiation of megakaryocytes, the bone marrow cells that fragment into large numbers of platelets.Thrombopoietin is produced primarily in liver parenchymal cells with much smaller amounts being made in the kidney and bone marrow.It is synthesized as a 353 amino acid precursor protein with a molecular weight of 36 kDa.It has an unusual structure in that the first 153 amino acids of the mature protein are 23% homologous with human erythropoietin.

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Androstenedione

Androstenedione is a 19-carbon steroid hormone produced in the adrenal glands and the gonads as an intermediate step in the biochemical pathway that produces the androgen testosterone and the estrogens estrone and estradiol. Androstenedione is the common precursor of male and female sex hormones. Androstenedione can be synthesized in one of two ways. The primary pathway involves conversion of 17-hydroxypregnenolone to dehydroepiandrosterone by way of 17, 20-lyase, with subsequent conversion of dehydroepiandrosterone to androstenedione via the enzyme 3-β-hydroxysteroid dehydrogenase. The secondary pathway involves conversion of 17-hydroxyprogesterone, most often a precursor to cortisol, to androstenedione directly by way of 17,20-lyase. Androstenedione is further converted to either testosterone or estrogen. Androstenedione was manufactured as a dietary supplement. It has been shown to increase serum testosterone levels over an eight-hour period in men.

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Angiotensinogen

Angiotensinogen is an α-2-globulin that is produced constitutively and released into the circulation mainly by the liver. It is a member of the serpin family.Plasma angiotensinogen levels are increased by plasma corticosteroid, estrogen, thyroid hormone, and angiotensin II levels.It is also known as renin substrate.Human angiotensinogen is 452 amino acids long, but other species have angiotensinogen of varying sizes. The first 12 amino acids are the most important for activity.

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