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Androstenedione

Androstenedione is a 19-carbon steroid hormone produced in the adrenal glands and the gonads as an intermediate step in the biochemical pathway that produces the androgen testosterone and the estrogens estrone and estradiol. Androstenedione is the common precursor of male and female sex hormones. Androstenedione can be synthesized in one of two ways. The primary pathway involves conversion of 17-hydroxypregnenolone to dehydroepiandrosterone by way of 17, 20-lyase, with subsequent conversion of dehydroepiandrosterone to androstenedione via the enzyme 3-β-hydroxysteroid dehydrogenase. The secondary pathway involves conversion of 17-hydroxyprogesterone, most often a precursor to cortisol, to androstenedione directly by way of 17,20-lyase. Androstenedione is further converted to either testosterone or estrogen. Androstenedione was manufactured as a dietary supplement. It has been shown to increase serum testosterone levels over an eight-hour period in men.

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Androstenol

Androstenol is a steroidal pheromone and neurosteroid in humans and other mammals, notably pigs.It possesses a characteristic musk-like odor.In humans and boars, androstenol is biosynthesized in the testes.Androstenol may also be synthesized in the adrenal glands and the ovaries in humans.In addition, androstenol may be synthesized in the human nasal mucosa from androstenone, and likely also from androstadienol and androstadienone in this area.It has been proposed that this action may mediate the pheromone effects of androstenol.In animals, androstenol has been found to produce anxiolytic-like, antidepressant-like, and anticonvulsant effects.Androstenol has also been found to modify the behavioral and social responses of humans. In addition, androstenol has been found to decrease luteinizing hormone (LH) pulse frequency during the follicular phase of the human menstrual cycle.

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Androstenone

Androstenone is a steroid-like pheromone. It is found in boar's saliva, celery cytoplasm,and truffle fungus.Androstenone was the first mammalian pheromone to be identified. It is found in high concentrations in the saliva of male pigs, and, when inhaled by a female pig that is in heat, results in the female assuming the mating stance.

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Angiotensin

Angiotensin a peptide hormone, causes blood vessels to constrict, and drives blood pressure up. It is part of the renin-angiotensin system, which is a major target for drugs that lower blood pressure. Angiotensin also stimulates the release of aldosterone, another hormone, from the adrenal cortex. Aldosterone promotes sodium retention in the distal nephron, in the kidney, which also drives blood pressure up.It is an oligopeptide in the blood that causes vasoconstriction, increased blood pressure, and release of aldosterone from the adrenal cortex. It is a hormone and a powerful dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. It plays an important role in the renin-angiotensin system. Angiotensin was independently isolated in Indianapolis and Argentina in the late 1930s (as 'Angiotonin' and 'Hypertensin' respectively).

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Angiotensinogen

Angiotensinogen is an α-2-globulin that is produced constitutively and released into the circulation mainly by the liver. It is a member of the serpin family.Plasma angiotensinogen levels are increased by plasma corticosteroid, estrogen, thyroid hormone, and angiotensin II levels.It is also known as renin substrate.Human angiotensinogen is 452 amino acids long, but other species have angiotensinogen of varying sizes. The first 12 amino acids are the most important for activity.

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Anti-Aging Properties Thyrotropin TRH Peptide Thyroid Stimulating Hormone 24305-27-9

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Anti-Aging Properties Thyrotropin TRH Peptide Thyroid Stimulating Hormone 24305-27-9
 
Thyrotropin TRH Quick Details:
 
Product Name: Thyrotropin TRH
TRH (Thyrotropin Releasing Hormone) (Protirelin Acetate)
Synonyms:TRH;TRF;TRH,HUMAN;
Sequence: (pyro)Glu-His-Pro-NH2
CAS: 24305-27-9
MF: C16H22N6O4
MW: 362.38
EINECS: 246-143-4
Storage temp.: −20°C
Solubility: H2O: 10 mg/mL, clear, colorless
Appearance: Lyophilized Powder
PubChem: CID 439302
Product Categories: Peptide;Thypinone.
Usage: Prothyrotropin.
 
Product Description Of Thyrotropin TRH:
 
Anti-Aging Properties of Thyrotropin Releasing Hormone TRH By DR WALTER PIERPAOLI MD 2012 THE YEAR OF THE FOUNTAIN OF YOUTH MOLECULE - TRH - DR WALER PIERPAOLI MD - SWITZERLAND AND ITALIAN RESEARCH LABS AND CLINICS .. A4M AMERICAN ACADEMY OF ANTIAGING MEDICINE Aging-Reversing Properties of Thyrotropin Releasing Hormone (TRH) Walter Pierpaoli, MD, PhD Interbion Foundation for Basic Biomedical Research (TRH Absrtact)
 
Product Application Of Thyrotropin TRH:
 
Previous work from our laboratory prompted us to study the effects of short-term, acute administration of TRH or its chronic oral administration, on organs, tissues and aging-related metabolic and hormonal markers, in order to acquire more knowledge on effects, dosage and timing of administration according to its circadian cyclicity. In addition, we wanted to verify its anti-aging effects on two most fundamental functions, namely gonadal- reproductive and kidney-urinary. The results demonstrate that both a short-term, acute or a chronic, long-term oral administration of TRH to old, aging mice, results into positive changes and rapid correction to more juvenile levels of most typical aging-related hormonal and metabolic alterations.
 
Thyrotropin TRH Function:
 
Store the kit at 4°C upon receipt.The kit should be equilibrat4ed to room temperature before the assay. Remove any unneeded strips from Human MUSK Antibody-Coated plate, reseal them in zip-lock foil and keep at 4°C.
Precipitates may appear in concentrated washing buffer. Please heat the buffer to dissolve all the precipitates, which will not affect the results.
Accurate pipette should be used to avoid experimental error. Samples should be added to the Microplate in less than 5 minutes. If a large number of samples are included, multiple channel pipette is recommended.
Standard curve should be included in every assay. Replicate wells are recommended. If the OD value of the sample is greater than the first well of standards, please dilute the sample (n times) before test. When calculating the original MUSK? concentration, please multiply the total dilution factor (XnX5).
 

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Anti-Estrogens Nolvadex Steroids Powder Tamoxifen Citrate For Breast Cancer 54965-24-1

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Anti-Estrogens Nolvadex Steroids Powder Tamoxifen Citrate For Breast Cancer 54965-24-1
 
Tamoxifen Citrate Basic Info.:
 
Product Name: Tamoxifen Citrate
Product name: Tamoxifen Citrate
Synonym: Nolvadex
CAS Registry Number: 54965-24-1
Molecular Formula: C32H37NO8
Molecular Weight: 563.64
Assay: 99%
Packing: 1kg/bag
Appearance: White crystalline powder
 
Tamoxifen Citrate Description:
 
1.This product is most often referred to as "Nolvadex" by bodybuilders. Nolvadex is not a steroid, rather a selective estrogen blocker. While Nolvadex doesn't prevent the buildup of estrogen in the body, it does prevent it from acting on certain receptors, most notably, those located in the nipples. This has obvious benefits to bodybuilders, because this is the area in which "gyno" occurs during the use of aromatizing steroids such as testosterones.
 
2.Nolvadex (tamoxifen citrate) is very comparable to Clomid, behaves in the same manner in all tissues, and is a mixed estrogen agonist/antagonist of the same type as Clomid. The two molecules are also very similar in structure. It is not correct that Nolvadex reduces levels of estrogen: rather, it blocks estrogen from estrogen receptors and, in those tissues where it is an antagonist, causes the receptor to do nothing.
 
The belief that it reduces gains seems to stem from the fact that the scientific literature reports a slight reduction in IGF-1 (individuals using anabolic steroids were not studied though) from use of Nolvadex.
 
Thus, Dan Duchaine reported that it reduces IGF-1 and therefore reduces gains. However, if this effect exists at all,
it must be very minor, due to the excellent gains that many have made, and from the fact that no one has noticed any such thing from Clomid, which has the same activity profile.
 
The fact that Nolvadex will reduce water retention may result in the user agreeing that gains are less, since weight gain is less, thus reinforcing the bias.
 
Tamoxifen Citrate Applications:
 
Commonly known as Nolvadex or Nolva, Tamoxifen Citrate generally serves two purposes for the anabolic steroid user .Tamoxifen Citrate is one of the most commonly used medications among performance enhancers but more often than not it is used for remedy rather than solution.
 
For on cycle side-effect prevention and more commonly for post cycle therapy (PCT) needs. Regardless of the purpose at hand Nolva is generally very well-tolerated by those who use it and this includes both men and women. Women will use it at a much lower dose and many women who supplement with Nolvadex will do so for more of an actual solution rather than remedy.
 
Beyond on cycle use the most common time in-which Tamoxifen Citrate is used by performance enhancers is during the PCT period; after anabolic steroid use is complete. Nolva has been shown to greatly increase testosteronse stimulation in part by largely increasing Luteinizing release.
 
Tamoxifen Citrate is also used in medical practice to combat breast cancer.
 

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Antiandrogen 427-51-0 Cyproterone Acetate For Prostate Cancer

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Antiandrogen 427-51-0 Cyproterone Acetate For Prostate Cancer
 
Cyproterone Acetate Basic Info.:
 
Product Name: Cyproterone acetate
CAS: 427-51-0
MF: C24H29ClO4
MW: 416.94
EINECS: 207-048-3
Melting Point: 200-201°C
Boiling Point: 525.9oC at 760 mmHg
Flash Point: 177.6°C
Storage Temp.: 2-8°C
Appearance: Crystalline Solid
Manufacturer: Kafen
Product Categories: Antibiotics;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals;Intracellular receptor;Steroid and Hormone;VETRANAL;Hormone Drugs.
Usage: The free alcohol is an anti-androgen; The acetate is both an anti-androgen and a progestogen. Combined with estrogen it is used in the treatment of acne. 
 
Cyproterone Acetate Description:
 
Cyproterone acetate (INN, USAN, BAN, JAN), sometimes abbreviated asnCPA, and sold under brand names such as Androcur and Cyprostat, isna synthetic steroidal antiandrogen drug with additional progestogennand antigonadotropic.
The main therapeutic indications ofncyproterone acetate are prostate cancer, benign prostaticnhyperplasia, priapism, hypersexuality (e.g., as a form of chemicalncastration), and other conditions in which androgen actionnmaintains the disease process.
 
Cyproterone Acetate Application:
 
CPA has been in use as an antiandrogen since 1964, and was the first antiandrogen introduced for clinical use.It is widely used throughout Europe, and is also used in Canada, Mexico, and other countries. It is not FDA-approved for use in the United States.
due to concerns about hepatotoxicity;medroxyprogesterone acetate has been used in this country instead.CPA has been approved for the treatment of prostate cancer, precocious puberty, androgen-related dermatological conditions (such as acne, seborrhea, hirsutism, and androgenic alopecia), and to reduce sex drive in sex offenders.
Combination formulations of CPA with ethinyl estradiol (a formulation sometimes referred to as co-cyprindiol) have been available as contraceptives since 1997.Other uses of CPA include the treatment of benign prostatic hyperplasia, priapism, hypersexuality, paraphilias, hot flashes, and hyperandrogenism in women. In addition, with the exception of the United States (where CPA is not available and spironolactone is generally employed instead), CPA is widely used as a component of hormone replacement therapy.
 

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Antifungal Pharmaceutical Raw Materials Ketoconazole / Nizoral 65277-42-1

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Antifungal Pharmaceutical Raw Materials Ketoconazole / Nizoral 65277-42-1
 
Ketoconazole Basic Info.:
 
Product Name: Ketoconazole
Synonyms: Ketoconazole; Nizoral
CAS: 65277-42-1
EINECS: 265-667-4  
MF: C26H28Cl2N4O4 
MW: 531.43 
Assay: 99.5%
Standard: USP34
Package: 25 kilogram/cardboard drum
Appearance: White Powder 
Usage: Inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic. 
 
Ketoconazole Introduction:
 
Ketoconazole is an antifungal medication that fights infections caused by fungus.
Ketoconazole is not for use in treated fungal infections of the fingernails or toenails. This medicine is also not for use in treating prostate cancer or Cushing syndrome.
 
This medicine should be used only when you cannot use other antifungal medications. Ketoconazole can cause serious harm to your liver that may result in liver transplant or cause death.
Ketoconazole may also be used for purposes not listed in this medication guide.
 
Ketoconazole Employ:
 
This medicine should be used only when you cannot use other antifungal medications. Ketoconazole can cause serious harm to your liver that may result in liver transplant or cause death.
 

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Antimullerian Hormone

Antimullerian Hormone is a substance that is produced by granulosa cells in ovarian follicles.It is encoded by the AMH gene.It is first made in primary follicles that advance from the primordial follicle stage.Its production is highest in preantral and small antral stages (less than 4mm diameter) of follicle development.It is secreted by Sertoli cells of the testes during embryogenesis of the fetal male.It is a protein hormone structurally related to inhibin and activin, and a member of the transforming growth factor-β (TGF-β) family. It is a dimeric glycoprotein.It is present in fish, reptiles, birds, marsupials, and placental mammals.It is used in the treatment of a variety of medical conditions including endometriosis, adenomyosis, and uterine cancer.

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