chemical-categories

Streptozocin

Streptozocin is a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. It is used in medicine for treating certain cancers of the Islets of Langerhans and used in medical research to produce an animal model for Type 1 diabetes.It is an antibiotic that is produced by Stretomyces achromogenes.It is known to inhibit DNA synthesis, interfere with biochemical reactions of NAD and NADH, and inhibit some enzymes involved in gluconeogenesis. Its activity appears to occur as a result of formation of methylcarbonium ions, which alkylate or bind with many intracellular molecular structures including nucleic acids. Its cytotoxic action is probably due to cross-linking of strands of DNA, resulting in inhibition of DNA synthesis.

Cyclophosphamide

Cyclophosphamide is precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.It work by three different mechanisms attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA,DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and the induction of mispairing of the nucleotides leading to mutations.

Tcep HCl Purified 96%

Appearance: light yellow solid
Formula: C9H16O6PCl
Molecular Weight: 286.65
Storage conditions: sealed and dark storage
Uses: protein disulfide reductant

Application
Tcep HCl, also named Tris(2-carboxyethyl)phosphine hydrochloride is a protein disulfide bond reducing agent, it also has an antioxidant properties. One of the main purposes of the TCEP is reducing agent or deprotecting agent for thiolated DNA. It is often use to make reduction of disulfide bonds in protein, It could be prevented a intra or inter molecular link of disulfide bonds between cysteine in proteins or between the proteins.
TCEP reducing ability is stronger then beta-mercaptoethanol and DTT, its effect maintained for 2-3 weeks. Both in the acidic or alkaline conditions, TCEP is more stable, better then DTT.
TCEP is tasteless, non-toxic, water-soluble, easier operation. Unlike DTT, It could not make the Ni ionic reduction, It is better compatibility with other biological agents and produce an easy condition for further mass spectrometric analysis.

Inhibitor Library >98%

The inhibitors library contains over 2672 active compounds, variety structure. Most products have been reported with clear biological and pharmacological activity, which can be used in not only specific research but also high-throughput screening and high-content screening.

Clinical Compound Library LAB GRADE >98%

A unique collection of 480 compounds, all of which have been permitted into clinical phase. Every compound contains detailed information on pharmacological activities, sources and references etc.

http://targetmol.com/screening2/Clinical-Compound-Library.html

Nicotinamide Adenine Dinucleotide, Disodium Salt LAB GRADE 95%

NADH, Disodium Salt functions as a coenzyme of a large number of oxidoreductases.

NADH is the reduced form of nicotinamide adenine dinucleotide (NAD) that can donate electrons as part of a reducing reaction. In that process, NADH becomes oxidized to produce beta-NAD. A variety of enzymes use NADH plus Hydrogen ion to reduce substrates, generating beta-NAD as well as the reduced product. For example, NADH:ubiquinone oxidoreductase accepts two electrons from NADH and passes them to ubiquinone (coenzyme Q) as part of the mitochondrial electron transport chain.

NADH is a coenzyme that functions as a regenerating electron donor in catabolic processes including glycolysis, beta-oxidation and the citric acid cycle. As a reagent, NADH can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations.

β-Nicotinamide adenine dinucleotide (NAD) and β-Nicotinamide adenine dinucleotide, reduced (NADH) comprise a coenzyme redox pair (NAD:NADH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. In addition to its redox function, NAD/NADH is a donor of ADP-ribose units in ADP-ribosylaton (ADP-ribosyltransferases; poly(ADP-ribose) polymerases ) reactions and a precursor of cyclic ADP-ribose (ADP-ribosyl cyclases).
As a reagent, NADH can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations.

Molecular Formula: C21H29N7O14P2 • 2Na
Formula Weight: 711.4

tacrolimus fk-506 pharmaceutical intermediates organ transplant 104987-11-3 USP 102%

A white or almost white powder

Specific rotation:-82°~ -90°

Water≤3.0%

Residue on ignition≤0.2%

Heavy metals≤20 ppm

Related substances

Impurity A (Ascomycin) ≤0.5%

Impurity B(Dihydro tacrolimus)≤0.5%

Any individual unknown impurity ≤0.1 %

Total impurities ≤1.0%

Tautomers I+II≤1.0%

Assay:98.0% ~ 102.0%

An immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release.

For use after allogenic organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It was first approved by the FDA in 1994 for use in liver transplantation, this has been extended to include kidney, heart.