Musculoskeletal drugs usd in treating musculoskeletal disorders, muscle pain, tendons, joints



Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and fever reducer effects. It is a derivative of oxicam, closely related to piroxicam, and falls in the enolic acid group of NSAIDs.It was developed by Boehringer-Ingelheim. It inhibits cyclooxygenase (COX), the enzyme responsible for converting arachidonic acid into prostaglandin H2-the first step in the synthesis of prostaglandins, which are mediators of inflammation and leads to a decrease of the synthesis of prostaglandins, therefore, inflammation is reduced.

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Oxaceprol is an atypical inhibitor of inflammation. It is an established drug for joint disease without serious side-effects. Oxaceprol has a clearly different spectrum of action to NSAIDs such as indomethacin and may act by inhibiting leucocyte infiltration and late connective tissue changes during inflammatory joint disease. It is used in the treatment of osteoarthritis.

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Oxaprozin is a non-steroidal anti-inflammatory drug (NSAID),used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. Chemically, it is a propionic acid derivative.Anti-inflammatory effects of Oxaprozin are believed to be due to inhibition of cylooxygenase in platelets which leads to the blockage of prostaglandin synthesis. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.Oxaprozin is 95% absorbed after oral administration. Food may reduce the rate of absorption of oxaprozin, but the extent of absorption is unchanged.

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Piroxicam is a non-steroidal anti-inflammatory drug of the oxicam class used to relieve the symptoms of rheumatoid and osteoarthritis, primary dysmenorrhoea, postoperative pain,and act as an analgesic.It is also used in veterinary medicine to treat certain neoplasias expressing cyclooxygenase (COX) receptors, such as bladder, colon, and prostate cancers.

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Rofecoxib is a nonsteroidal anti-inflammatory drug.It selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, which is important for the mediation of inflammation and pain.It is used for the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and primary dysmenorrhea, as well as acute treatment of migraine attacks with or without auras.

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Tenoxicam is a non-steroidal anti-inflammatory drug (NSAID).It belongs to the class of NSAIDs known as oxicams. It is used to relieve inflammation, swelling, stiffness, and pain associated with rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, tendinitis,bursitis,and periarthritis of the shoulders or hips.

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Diclofenac is a non-steroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. It is often used to treat pain, dysmenorrhea, ocular inflammation, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and actinic keratosis.

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Etofylline is acts as an inhibitor of 3',5'-Cyclic nucleotide phosphodiesterase. It has diuretic, muscle relaxant, bronchial dilation and CNS stimulant activities.

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Fenoprofen is an anti-inflammatory analgesic and antipyretic highly bound to plasma proteins. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding.It inhibits prostaglandin synthesis by decreasing the enzyme needed for biosynthesis.It is used for relief of the signs and symptoms of rheumatoid arthritis and osteoarthritis.Fenoprofen's overdose appear within several hours and generally involve the gastrointestinal and central nervous systems.They include dyspepsia, nausea, vomiting, abdominal pain, dizziness, headache, ataxia, tinnitus, tremor, drowsiness, and confusion.

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Ketoprofen is a is one of the propionic acid class of non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic effects.It acts by inhibiting the body's production of prostaglandin.Ketoprofen can also be used for treatment of some pain, especially nerve pain like sciatica, post-herpetic neuralgia and referred pain for radiculopathy, in the form of a cream, ointment, liquid, spray, or gel which also contains ketamine and lidocaine, along with other agents which may be useful such as cyclobenzaprine, amitryptiline, acyclovir, gabapentin, orphenadrine and other drugs used as NSAIDs or adjuvant, atypical or potentiators for pain treatment.

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