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Prohormones Steroids White Powder Misoprostol For Terminate Pregnancy 59122-46-2

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Prohormones Steroids White Powder Misoprostol For Terminate Pregnancy 59122-46-2
 
Misoprostol Basic Info.
 
Product Name: Misoprostol
Synonyms: Misoprostol;Cytotec;SC-29333
CAS: 59122-46-2
Molecular Formula: C22H38O5
Molecular Weight: 382.60
Assay: 99%
Chemical Properties: White Solid
Solubility: Soluble to 100 mM in Ethanol
Safety: Poison by ingestion, intramuscular, and intraperitoneal routes. When heated to decomposition it emits acrid smoke and irritating fumes.
Package: Aluminium foil bag packing 
Storage: Keep in cool and dry place, away from light
 
Misoprostol Description:
 
Misoprostol is a medication used to start labor, induce abortions, prevent and treat stomach ulcers, and treat postpartum bleeding due to insufficient contraction of the uterus. For abortions it is used with mifepristone or methotrexate. It is a synthetic prostaglandin E1 (PGE1).
 
Common side effects include diarrhea and abdominal pain. It is pregnancy category X meaning that it is known to result in negative fetal outcomes if taken during pregnancy. Uterine rupture may occur.
 
It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. Misoprostol was invented and marketed by G.D. Searle & Company under the trade name Cytotec, but other trade names and generic formulations are available.
 
Misoprostol Usage
 
Misoprostol is approved for use in the prevention of NSAID-induced gastric ulcers. It acts upon gastric parietal cells, inhibiting the secretion of gastric acid by G-protein coupled receptor-mediated inhibition of adenylate cyclase, which leads to decreased intracellular cyclic AMP levels and decreased proton pump activity at the apical surface of the parietal cell. Because other classes of drugs, especially H2-receptor antagonists and proton pump inhibitors, are more effective for the treatment of acute peptic ulcers, misoprostol is only indicated for use by people who are both taking NSAIDs and are at high risk for NSAID-induced ulcers, including the elderly and people with ulcer complications. Misoprostol is sometimes coprescribed with NSAIDs to prevent their common adverse effect of gastric ulceration (e.g. with diclofenac in Arthrotec).
 
Misoprostol has other protective actions, but is only clinically effective at doses high enough to reduce gastric acid secretion. For instance, at lower doses, misoprostol may stimulate increased secretion of the protective mucus that lines the gastrointestinal tract and increase mucosal blood flow, thereby increasing mucosal integrity. However, these effects are not pronounced enough to warrant prescription of misoprostol at doses lower than those needed to achieve gastric acid suppression.
However, even in the treatment of NSAID-induced ulcers, omeprazole proved to be at least as effective as misoprostol,but was significantly better tolerated, so misoprostol should not be considered a first-line treatment. Misoprostol-induced diarrhea and the need for multiple daily doses (typically four) are the main issues impairing compliance with therapy.
 
The most commonly reported adverse effect of taking a misoprostol orally for the prevention of stomach ulcers is diarrhea. In clinical trials, an average 13% of patients reported diarrhea, which was dose-related and usually developed early in the course of therapy (after 13 days) and was usually self-limiting (often resolving within 8 days), but sometimes (in 2% of patients) required discontinuation of misoprostol.
 
The next most commonly reported adverse effects of taking misoprostol orally for the prevention of gastric ulcers are: abdominal pain, nausea, flatulence, headache, dyspepsia, vomiting, and constipation, but none of these adverse effects occurred significantly more often than when taking placebos. In practice, fever is almost universal when multiple doses are given every 4 to 6 hours.
 
Misoprostol should not be taken by pregnant women to reduce the risk of NSAID-induced gastric ulcers because it increases uterine tone and contractions in pregnancy, which may cause partial or complete abortions, and because its use in pregnancy has been associated with birth defects.
 

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Propargylamine

Propargylamine is widely used an pharmaceutical intermediate.

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Propylene Imine

Propylene imine is used as an intermediate in the paper, textile, rubber, and pharmaceutical industries.

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Propylene glycol n-butyl ether 97%

CAS: 10215-33-5         Propylene glycol n-butyl ether

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Purity 99% Female Hormone Chlormadinone Acetate CAS 302-22-7

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Purity 99% Female Hormone Chlormadinone Acetate CAS 302-22-7
 
Chlormadinone Acetate Basic Info.:
 
Product Name: Chlormadinone Acetate
CAS: 302-22-7
MF: C23H29ClO4
MW: 404.93
EINECS: 206-118-0
Mp: 212°C
Storage temp: -20°C Freezer
Appearance: Crystalline Solid
 
Chlormadinone Acetate Description:
 
Chlormadinone acetate (CMA) is a derivative of progesterone (17-acetoxy-6-chloro-4,6-pregnadiene-3,20-dione), first synthesized in 1961 and is used as an orally effective progestogen in hormone replacement therapy (HRT), and in combination with ethinyl estradiol (EE) in contraception since 1999. Chlormadinone acetate has a strong progestogenic effect about one-third higher than that of progesterone and may vary depending on the previous effect of an estrogen, i.e., estrogens may promote the formation of progesterone receptors and proliferation of the endometrium. Like progesterone, it is anti-estrogenic and has no partial androgenic effect (at the doses used for contraception and HRT). In contrast to progesterone, it has a slight glucocorticoid effect, a pronounced anti-androgenic effect and no anti-mineralocorticoid effect. No pregnancy-maintaining effect of CMA has been demonstrated in humans.
 
The anti-androgenic effect of CMA is presumed to be the result of both its binding to androgen receptors competitively inhibiting the effect of endogenous testosterone and dihydrotestosterone and the competitive inhibition of 5-reductase. In this respect, dosing of CMA is crucial; agonistic effects are observed when doses are increased from those optimal for an antagonistic effect.
 
Chlormadinone acetate has a strong anti-gonadotropic effect, through negative feedback on gonadotropin secretion, and has been used for more than 20 years alone for contraception in arterial risk patients. The clinical and metabolic tolerability of CMA has been demonstrated in numerous clinical studies with duration of treatment of up to 2.5 years.
The more recent application of CMA as an oral contraceptive in combination with EE (Neo Eunomin, Belara) has proven highly successful, with studies reporting excellent contraceptive efficacy, high tolerability and adherence due to a good side effect profile and positive effects on preexisting dysmenorrhea, skin and hair conditions.
 
Chlormadinone Acetate Application:
 
Chlormadinone acetate (CMA) is a derivative of naturally secreted progesterone that shows high affinity and activity at the progesterone receptor. It has an anti-estrogenic effect and, in contrast to natural progesterone, shows moderate anti-androgenic properties. CMA acts by blocking androgen receptors in target organs and by reducing the activity of skin 5alpha-reductase. It suppresses gonadotropin secretion and thereby reduces ovarian and adrenal androgen production. CMA shows high contraceptive efficacy by inhibiting ovulation due to its ability to suppress or disrupt endogenous gonadotropin secretion and, by this, inhibits follicular growth and maturation. In addition, it suppresses endometrial thickness and increases the viscosity of cervical mucus.
 

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Purity 99% Medical Androsterone Androgenic Prohormone Steroids 53-41-8

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Purity 99% Medical Androsterone Androgenic Prohormone Steroids 53-41-8 
 
Androsterone Basic Info.:
 
Product Name: Androsterone
Synonyms: 3-alpha-hydroxy-17-androstanone;3alpha-Hydroxy-17-androstanone;3-alpha-hydroxy-5-alpha-androstan-17-on;3-Epihydroxyetioallocholan-17-one;3-hydroxy-,(3-alpha,5-alpha)-androstan-17-on;3-hydroxy-,(3alpha,5alpha)-androstan-17-on;5alpha-Androstan-17-one, 3alpha-hydroxy-;5alpha-Androstane-3alpha-ol-17-one
CAS: 53-41-8
MF: C19H30O2
MW: 290.44
EINECS: 200-173-4
Melting point: 181-184 °C(lit.)
Alpha: 96 º (c=1, C2H5OH)
Storage temp.: -20°C
Chemical Properties: white to light beige crystalline powder.
Usage: It was isolated from male urine after removed of the phenolic estrogen fraction. Antihypertensor.
Product Categories: Steroids;Steroids & Hormones - 13C & 2H;Intermediates & Fine Chemicals;Pharmaceuticals.
 
Androsterone Description:
 
Androsterone, or 3α-hydroxy-5α-androstan-17-one, is an endogenous steroid hormone, neurosteroid, and putative pheromone. It is a weak androgen with a potency that is approximately 1/7th that of testosterone. In addition, it can be converted to dihydrotestosterone (DHT) from 3α-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase, bypassing conventional intermediates such as androstenedione and testosterone, and as such, can be considered to be a metabolic intermediate in its own right. 
Androsterone is also known to be an inhibitory androstane neurosteroid, acting as a positive allosteric modulator of the GABAA receptor, and possesses anticonvulsant effects. The unnatural enantiomer of androsterone is more potent as a positive allosteric modulator of GABAA receptors and as an anticonvulsant than the natural form. Androsterone's 3β-isomer is epiandrosterone, and its 5β-epimer is etiocholanolone.
 
Androsterone Applications:
 
Androsterone is one of the androgens, which are steroid hormones that affect the masculinization of the fetus and child and that maintain or create masculine traits in adults. Testosterone is the most active and abundant of the androgens. Androsterone was originally isolated from male urine in very small amounts. Many scientists believe it to be a metabolic byproduct of the breakdown of testosterone, and many scientists who study pheromones think it might be active in human relations.
 
A molecule of androsterone is very similar to testosterone. It consists of three six-member carbon rings and one five member ring joined along common sides. The molecular formula is C19 H30 O2. It has a beta-isomer called epiandrosterone, in which an hydroxyl group occupies a different geometric position. 
 
The ratio of androsterone to epiandrosterone is thought to be important in how masculine behavior is interpreted by others Pheromones are well known in insect behavior. Their role in insect mating, navigation and nest protection has been studied, and active compounds have been isolated. Pheromones are the basis of some insect baits. Their effect on mammal behavior patterns is less well understood.
 

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Purtity 98.5% Androstenediol CAS No 521-17-5 For Muscle Gaining

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Purtity 98.5% Androstenediol CAS No 521-17-5 For Muscle Gaining
 
Androstenediol Basic Info.:
 
Product Name: Androstenediol
Synonym: Hermaphrodiol;5-Androstenediol;Androstendiol;
CAS No.: 521-17-5
M.F.: C19H30O2
M.W.: 290.44
Assays: 99%
Packing: foil bag
AndrostenediolAppearance: White crystalline powder.
 

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Pyrimidine

Pyrimidine is used for pharmaceutical intermediates, raw materials of photosensitive agent.etc

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Pyrogallole aldehyde CP 98.00%

【Appearance】
white to off-white crystalline powder
【Density】
1.598 g/cm3
【Melting Point】
159-162℃
【Boiling Point】
301.9 °C at 760 mmHg
【Vapour】
0.000573mmHg at 25°C
【Refractive Index】
1.734????
【Flash Point】
112 °C
【Stability】
Stable under normal temperatures and pressures.
【HS Code】
2912499000
【Storage temp】
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
【Computed Properties】
Molecular Weight:154.12014 [g/mol]
Molecular Formula:C7H6O4
XLogP3-AA:0.9
H-Bond Donor:3
H-Bond Acceptor:4
Rotatable Bond Count:1
Tautomer Count:26
Exact Mass:154.026609
MonoIsotopic Mass:154.026609
Topological Polar Surface Area:77.8
Heavy Atom Count:11
Formal Charge:0
Complexity:147
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Feature 3D Acceptor Count:1
Feature 3D Donor Count:3
Feature 3D Ring Count:1
Effective Rotor Count:1
Conformer Sampling RMSD:0.4
CID Conformer Count:2

Safety and Handling

【Hazard Codes】
Xi:Irritant
【Risk Statements】
R36/37/38
【Safety Statements 】
S26;S37/39
【Sensitive】
Air Sensitive
【Transport】
OTH

 

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