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Human Growth Hormone Active Pharmaceutical Ingredient Gonadorelin 33515-09-2

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Human Growth Hormone Active Pharmaceutical Ingredient Gonadorelin 33515-09-2
 
Gonadorelin Basic Info.:
 
Product Name: Gonadorelin
Other Name: LH-RH, human, Gonadoreline
CAS: 33515-09-2
Purity (HPLC): 98.0%min.
Appearance: White powder
Molecular Formula: C59H83N17O17
Molecular Weight: 1302.39
Single Impurity (HPLC): 0.5%max
Amino Acid Composition: ±10% of theoretical
Peptide Content (N%): ≥80.0% 
Water Content(Karl Fischer): ≤8.0%
Acetate Content(HPIC): ≤10.0%
Specific Rotation (20/D): -55.0~-65.0°(c=1 1%HAc)
MS (ESI): Consistent
Mass Balance: 95.0~105.0%
 
Gonadorelin Description:
 
Gonadorelin is another name for gonadotropin-releasing hormone (GnRH). It is a synthetic decapeptide prepared using solid phase peptide synthesis. GnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary.
GnRH is available as gonadorelin hydrochloride(Factrel®)and gonadorelin diacetate tetrahydrate(Cystorelin®)for injectable use. Studies have described it being used via an infusion pump system to induce ovulation in patients with hypothalamic hypogonadism. It is also used in veterinary medicine as a treatment for cattle with cystic ovarian disease.
 
Gonadorelin Application:
 
Gonadorelin is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process that is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens. The pulsatility of GnRH secretion has been seen in all vertebrates, and it is necessary to ensure a correct reproductive function. Thus a single hormone, GnRH, controls a complex process of follicular growth, ovulation, and corpus luteum maintenance in the female, and spermatogenesis in the male. Its short half life requires infusion pumps for its clinical use.
 

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Mix Injectable Steroids Solution Oil Nandro Test Depot 450 For Body Building

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Mix Injectable Steroids Solution Oil Nandro Test Depot 450 For Body Building
 
Nandro Test Depot 450 Quick Detail:
 
Product Name: Nandro Test Depot 450
Active Ingredient: Testosterone Decanoate, Testosterone Enanthate, Nandrolone Decanoate
USP Grade Materials: Raw Powders, BA, BB, carrier oil
Carrier Oil: grapeseed oil, Ethyl Oleate, cottonseed oil. The ratio of oil can be adjusted as required.
MOQ: 100ml
Package: Sterilized bottle
Delivery time: Send parcel within 8hour after payment
Shipping courier: EMS, DHL, UPS, Fedex, etc.
Payment terms: western union, moneygram, bank transfer and bitcoin.
 
Nandro Test Depot 450 Recipe:
 
Nandro Test Depot 450mg each ml contains:
Test Decanoate 200mg
Test Enanthate 100mg
Nandrolone Decanoate 150mg
BA 2%, BB 20%
Grape seed oil q.s.            
 
Test Depot 450 mg/ml, as a new form of finished steroids oil, it is great welcomed by professional Athelets. Test Depot 450 mg/ml has a great effect on muscle gaining and weight loss.
 
Step:
 
Step 1: Put Steroid Powders into the beaker;
Step 2: Put BA into the beaker;
Step 3: Put BB into the beaker;
Step 4: Put the beaker on the heater, temperature is about 80 ºC. Use the glass rod to stir the liquid until the powder dissolves into the liquid totally, then it will be transparent yellow liquid;
Step 5: Get the beaker down from the heater, wait until the transparent yellow liquid is cool;
Step 6: Put the EO into the beaker, Use the glass rod to stir the liquid until it is transparent yellow liquid again;
Step 7: Filter the liquid with a sterile filter or a filtering machine.
 
Nandro Test Depot 450 Applications:
 
Test Deca combination of Testosterone and ester Decanoate is androgenic steroid with a pronounced anabolic effect.
Test E is a long-acting depot steroid that is used for ultimate mass and size gains, some consider it the best testosterone available .
Nandrolone Deca is a steroid.It is used to treat anemia in people with kidney failure and may be used for other purposes.
 
Tips :
1. All steroid powders, oil and solvents used to make steroid injections are USP/BP standard.
2. We only offer semi-finished steroid injections. You just need to buy some syringe filters to filter it before injection. Heating semi-finished steroid injections to 20º C will make filtering smoother.
 

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No Side Effect Pharmaceutical Raw Materials Atorvastatin Calcium 134523-03-8

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No Side Effect Pharmaceutical Raw Materials Atorvastatin Calcium 134523-03-8
 
Atorvastatin Calcium Basic info:
 
Product Name: Atorvastatin Calcium
CAS: 134523-03-8
MF: C66H68CaF2N4O10
MW: 1155.36
Purity: 99%min.
FREE SAMPLES can be sent on request!
Storage: Stored in cool and dry place, keep away from strong light/heat.
Shelf Life: 2 years when properly stored.
Color:White crystalline powder
 
Atorvastatin Calcium Description:
 
Atorvastatin calcium is a white to off-white crystalline powder that is insoluble in aqueous solutions of pH 4 and below. Atorvastatin calcium is very slightly soluble in distilled water, pH 7.4 phosphate buffer, and acetonitrile, slightly soluble in ethanol, and freely soluble in methanol.
 
Atorvastatin Calcium Function:
 
Used for primary hypercholesterolemia, combined hyperlipidemia or diet control invalid for patients with familial hypercholesterolemia.
 

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Norandrostenedione For Male Muscle Building Steroid Sex Enhancement 734-32-7

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Norandrostenedione For Male Muscle Building Steroid Sex Enhancement 734-32-7
 
Norandrostenedione Basic Info.:
 
Product Name: Norandrostenedione
CAS NO: 734-32-7
EINECS: 211-995-8
Molecular Formula: C18H24O2
Molecular Weight: 272.38
Density: 1.13 g/cm3
Boiling Point: 433.4 °C at 760 mmHg
Melting Point: 169-172°C
Flash Point: 433.4 °C at 760 mmHg
Standard: Enterprise standard
Color: white powder
Assay: 99.3%
Package: 1kg/AL bag
 
Norandrostenedione Descriptions:
 
19-Norandrostenediones (4-estrene-3,17-dione, NOR) is a precursor of the anabolic steroid nandrolones. Until 2005 19-Norandrostenediones was available without prescription in United States, where it was marketed as a prohormone, but it is now classified as a Schedule III drug. It is also banned from use in many sports, including the Olympic Games, under the World Anti-Doping Code.19-Norandrostenediones is readily metabolized to nandroloe after oral administration, but its potency to transactivate the androgen receptor dependent reporter gene expression is 10 times lower as compared todihydrotestosterone (DHT).
 
Norandrostenedione Applications:
 
Scientific studies have shown that oral administration of 19-norandrostenediones is "a very ineffective strategy for stimulating skeletal muscle mass increases but may be associated with side effects".
In vivo experiments in castrated rats demonstrated that subcutaneous treatment with 19-norandrostenediones resulted only in a stimulation of the weight of the levator ani muscle, while the prostate and seminal vesicle weights remained completely unaffected. In contrast to its metabolite nandrolones, 19-norandrostenediones highly selectively stimulates the growth of the skeletal muscles but has only weak androgenic properties.
 
In the early 2000s, contamination of androstenedioe products with traces of 19-norandrostenediones caused false positives for doping tests for nandroloe because 19-norandrosterones is a metabolite of both nandrolones and 19-norandrostenedionse. In a randomized controlled trial trace contamination of androstenedion with 19-norandrostenedie was sufficient for users of androstendioe to test positive for nandrolones.This detail became less relevant after 19-norandrostenedie and androstenediones were banned by major sporting bodies.
 

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Oral Finasteride / Proscar Steroids Powder For Hairloss Treatment 98319-26-7

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Oral Finasteride / Proscar Steroids Powder For Hairloss Treatment 98319-26-7
 
Finasteride Basic Info.
 
Product Name: Finasteride
Synonyms: Finasteride;Proscar;Prostide;
CAS: 98319-26-7
Molecular Formula: C23H36N2O2
Molecular Weight: 372.5441
Assay: 99%
Appearance: White or off-white crystal powder
Density: 1.066g/cm3
Boiling Point: 576.61°C at 760 mmHg
Flash Point: 177.448°C
Vapour Pressure: 0mmHg at 25°C
Usage: It is 5 alpha - reductase inhibitor that can inhibit testosterone to convert into DHT. Also used for the treatment of Hyperplasia of prostate. Finasteride is a 4-- aza-steroid compound which is a specific inhibitor of the metabolism of testosterone within dihydro testosterone become stronger during the cell type-II enzyme 5a-reductase. The enlarged prostate called benign prostatic hyperplasia or prostate depends on the conversion of testosterone to dihydro-testosterone.
 
Finasteride Description:
 
Finasteride is a popular anti-androgen medication manufactured by Merck most commonly known as either Proscar or Propecia. Based on the progesterone skeleton, Finasteride belongs to a class of medications known as 5alpha-reductase inhibitors and as such is used for the treatment revolving around type 2 5-AR based occurrences.
 
This is important for performance enhancers as DHT based anabolic steroids have specific side-effects that may occur that can largely be remedied with the use of a 5-AR inhibitor such as Finasteride. As a type 2 5-AR inhibitor Finasteride was designed for the purpose of treating hair-loss, prostate enlargement, as well as prostate cancer.
 
Finasteride is very common among those who supplement with anabolic steroids yet fear hair-loss but there are important things you need to understand before you consider Finasteride use. As an androgen suppressor Finasteride can seriously inhibit the gains made while on cycle, severely and on that basis it is not highly recommended for on-cycle hair preservation.
 
Finasteride Applications:
 
Propecia (finasteride) is used to treat male pattern baldness (androgenic alopecia) in men. Oral use though will reduce DHT levels systemically, which may adversely affect training and sex drive.
 
It is also used in combination with doxazosin in the treatment of benign prostatic hyperplasia (BPH).] Finasteride is an orally active testosterone Type II 5-alpha reductase inhibitor, inhibiting the enzyme that converts testosterone to dihydrotestosterone (DHT).
Topically (on the scalp itself) it is of some effect in minimizing further hair loss. In combination with Nizoral and spironolactone (which smells awful, by the way) it can actually reverse loss moderately.
 
For use in cycles with testosterone, I don't think it is bad at all. One simply doesn't want less DHT than normal. As the amount of testosterone in the system increases, the amount of finasteride needed to keep levels down to normal increases. I consider 5 mg/day reasonable at the gram per week level, and proportionally less at lower dosages of testosterone.
 

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Pharmaceutical Grade Reducing Fat Mass Chemicals Sr9011 SR-9011 1379686-29-9

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Pharmaceutical Grade Reducing Fat Mass Chemicals Sr9011 SR-9011 1379686-29-9
 
SR9011 Basic Info:
 
Product Name: SR9011
Synonyms: 3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)-N-pentylpyrrolidine-1-carboxamide
CAS No: 1379686-29-9
Molucelar Formula: C23H31ClN4O3S
Molucelar Weight: 479.03524
Solubility: DMSO up to 100 mM
 
Sr9011 Description:
 
SR9011 is a trifunctional methacrylate monomer that provides exceptional adhesion to metal substrates.
SR9011 is recommended for use in peroxide cured coatings, sealants, and PVC-based plastisols. Usage levels of 5% to 10% by weight are recommended.
 
SR9011 is a potent and specific synthetic REV-ERB agonist that binds to REV ERB α with an EC50 ~790 nM and REV-ERB-β with EC50 ~560 nM. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.
 
Sr9011 Application:
 
In vitro: SR9011 was used at 5-10 μM concentration in vitro and in cellular assays.
In vivo: IP administration of SR9011 was used at 100 mg/kg once or twice per day for 12-30 days in different mouse models.
 

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Pharmaceutical Raw Materials Vinblastine Sulfate For Antineoplastic 143-67-9

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Pharmaceutical Raw Materials Vinblastine Sulfate For Antineoplastic 143-67-9
 
Vinblastine Sulfate Basic Info.:
 
Product Name: Vinblastine Sulfate
Synonyms: 29060LE;EXAL;NSC49842;Rozevinsulfate;Velban;Velbe;Vincaleukoblastine,Sulfate(1:1)(Salt);Vinblastine Sulfate Salt;
CAS: 143-67-9
MF: C46H60N4O13S
MW: 909.05
EINECS: 205-606-0
Purity: 99.5%
Melting point: 267 °C (dec.)(lit.)
Alpha: -21.7 º (c=2, CH3OH 21 ºC)
Storage temp.: 2-8°C
Solubility: H2O: 10 mg/mL
Water Solubility: >=1 g/100 mL at 24.5 ºC
Standard: USP /EP /BP 
Appearance: White to slightly yellow crystalline powder.
Usage: Antitumor alkaloid isolated from periwinkle, Vinca rosea Linn., Apocynaceae; inhibits microtubule assembly. An antineoplastic.
 
Vinblastine Sulfate Introduction:
 
Mainly used for the treatment of solid tumor. For malignant lymphoma, testicular neoplasm and choriocarcinoma curative effect is better. For lung, breast, ovarian, skin cancer, renal mother cell tumor and monocytes leukaemia also have certain curative effect.
Pharmacology: Vinblastine Vinca plants for the oleander extract has anti-cancer activity of an alkaloid. Major inhibition of tubulin polymerization, preventing the formation of spindle microtubules, so stop in MID-mitosis. Role in the cell membrane can also interfere with membrane transport of amino acids, protein synthesis was inhibited, also inhibited RNA synthesis.
 
Vinblastine Sulfate Function:
 
1. Mainly used in the treatment of Hodgkin's disease, lymphatic reticulum cell sarcoma, chorionic carcinoma, testicular tumor. Is also effective for other malignant lymphoma.
2. For acute leukemia, mononuclear cell leukemia, lung cancer, breast cancer, ovarian cancer, kidney tumor, oral cancer, malignant melanoma, skin cancer have certain curative effect.
3. Treatment of idiopathic thrombocytopenic purpura.
4. Treatment of rheumatoid arthritis.
 

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Safety Benzyl Benzoate Safe Organic Solvents Insoluble In Water Cas 120-51-4

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Safety Benzyl Benzoate Safe Organic Solvents Insoluble In Water Cas 120-51-4
 
Benzyl Benzoate Basic Info.:
 
Product name: Benzyl benzoate
CAS NO: 120-51-4
MF: C14H12O2
MW:  212.24
EINECS: 204-402-9
Purity: 99%
Package: 250kg/plastic bucket
Appearance: Colorless liquid
 
Benzyl Benzoate Description:
 
Benzyl benzoate is the organic compound with the formula C6H5CH2O2CC6H5. It is the ester of benzyl alcohol and benzoic acid. It forms either a viscous liquid or solid flakes and has a weak, sweet-balsamic odor. It occurs in a number of blossoms (e.g. Tuberose, hyacinth) and is a component of Balsam of Peru and Tolu balsam.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.
 
Benzyl Benzoate Application:
 
Benzyl benzoate is used as an acaricide, scabicide, and pediculicide in veterinary hospitals. It is also a repellent for chiggers, ticks, and mosquitoes. It is an effective and inexpensive topical treatment for human scabies. It has vasodilating and spasmolytic effects and is present in many asthma and whooping cough drugs.
Other uses of benzyl benzoate are dye carrier, solvent for cellulose derivatives, plasticizer, and fixative in the perfume industry.
 

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Tacrolimus FK-506 Pharmaceutical Intermediates Organ Transplant 104987-11-3

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Tacrolimus FK-506 Pharmaceutical Intermediates Organ Transplant  104987-11-3
 
Tacrolimus Basic info: 
 
Product Name: Tacrolimus
Synonyms: Tacrolimus;Fr900506;Prograf;Tsukubaenolide;FK-506;
CAS: 104987-11-3
MF: C44H69NO12
MW: 804.02
Purity: 99%
Melting Point: 113-115°C
Boiling Point: 871.7 °C at 760 mmHg
Solubility: DMSO: >3 mg/mL
Appearance: White Crystalline Powder
Storage temp.: −20°C
Storage: Store in a cool, dry place. Do not store in direct sunlight. Store in a tightly closed container.
Product Categories: Active Pharmaceutical Ingredients;Immunosuppressant.;Intermediates & Fine Chemicals;Pharmaceuticals;API;Chiral Reagents;Fujimycin, Prograf;antibiotic;Inhibitors.
Usage: FK-506 (Tacrolimus) is a macrolide immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system.
 
Tacrolimus Application: 
 
L Immunosuppression following transplantation It has similar immunosuppressive properties to ciclosporin, but is much more potent. Immunosuppression with tacrolimus was associated with a significantly lower rate of acute rejection compared with ciclosporin-based immunosuppression (30.7% vs 46.4%) in one study. Clinical outcome is better with tacrolimus than with ciclosporin during the first year of liver transplantation. Long term outcome has not been improved to the same extent. Tacrolimus is normally prescribed as part of a post-transplant cocktail including steroids, mycophenolate and IL-2 receptor inhibitors. Dosages are titrated to target blood levels. Typical starting doses for once daily tacrolimus are 0.15-0.20 mg/kg body weight.
 
Tacrolimus Interactions:
 
Also like cyclosporin it has a wide range of interactions, including that with grapefruit which increases plasma-tacrolimus concentration. Several of the newer class of antifungals, especially of the azole class (fluconazole, posaconazole) also increase drug levels by competing for degradative enzymes.
 
Ulcerative colitis: 
In recent years, tacrolimus has been used to suppress the inflammation associated with ulcerative colitis, a form of inflammatory bowel disease. Although almost exclusively used in trial cases only, tacrolimus has shown to be significantly effective in the suppression of outbreaks of UC.
 
Tacrolimus Dermatological Use: 
 
As an ointment, tacrolimus is used in the treatment of eczema, in particular atopic dermatitis. It suppresses inflammation in a similar way to steroids, and is equally as effective as a mid-potency steroid. An important advantage of tacrolimus is that, unlike steroids, it does not cause skin thinning (atrophy), or other steroid related side-effects.
 
It is applied on the active lesions until they heal off, but may also be used continuously in low doses (twice a week), and applied to the thinner skin over the face and eyelids[citation needed]. Clinical trials of up to one year have been conducted. Recently it has also been used to treat segmental vitiligo in children, especially in areas on the face.
 

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