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High Purity 99.5% Pharmaceutical Raw Materials Meldonium For Angina Treatment 76144-81-5

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High Purity 99.5% Pharmaceutical Raw Materials Meldonium For Angina Treatment 76144-81-5
 
Meldonium Basic Info.:
 
Product Name: Mildronate
Synonyms: 2-(2-carboxyethyl)-1,1,1-trimethylhydrazinium hydroxide inner salt;3-(2,2,2-trimethylhydrazine)propionate;MILDRONATE;Mildonate;3-(2,2,2-Trimethylhydrazinium)propionate;2-(2-Carboxyethyl)-1,1,1-trimethyl Hydrazinium Inner Salt;Meldomiun;MET88
CAS: 76144-81-5
MF: C6H14N2O2
MW: 146.18756
EINECS: N/A
Melting Point: 85-900°C
Storage Temp.: Refrigerator
Stability: Hygroscopic
Chemical Properties: White Crystalline Powder
Usage: A novel pharmaceutical composition based on a reverse transcriptase inhibitor and meldonium
Definition: ChEBI: An ammonium betaine that is beta-alaninate in which one of the amino hydrogens is replaced by a trimethylamino group. A clinically used cardioprotective drug that is used for treatment of heart failure, myocardial infarction, arrhythmia, a herosclerosis and diabetes.
Product Categories: Cardiovascular;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical intermediate;Pharma raw material.
 
Description Of Meldonium:
 
Meldonium,trade-named as Mildronate among others, is a limited-market pharmaceutical, developed in 1970 by Ivars Kalviņš, Latvian Institute of Organic Synthesis (USSR), and manufactured primarily by Grindeks of Latvia and several generic manufacturers. It is distributed in Eastern European countries as an anti-ischemia medication.Since 1 January 2016, it has been on the World Anti-Doping Agency (WADA) list of substances banned from use by athletes.However, there are debates over its use as an athletic performance enhancer. Some athletes are known to have been using it before it was banned. It is currently unscheduled in the US.
 
The chemical name of meldonium is 3-(2,2,2-trimethylhydraziniumyl) propionate.It is a structural analogue of γ-butyrobetaine, with an amino groupreplacing the C-4 methylene of γ-butyrobetaine.[citation needed] γ-Butyrobetaine is a precursor in the biosynthesis of carnitine.[better source needed][needs update] It has a molecular weight of 146.188. It is available as a white crystalline powder, as well as a capsule sold by Grindeks. The melting point is anywhere between 85-90 degrees Celsius
 
Application Of Meldonium:
 
Meldonium may be used to treat coronary artery disease.These heart problems may sometimes lead to ischemia, a condition where too little blood flows to the organs in the body, especially the heart. Because this drug is thought to expand the arteries, it helps to increase the blood flow as well as increase the flow of oxygen throughout the body.Meldonium has also been found to induce anticonvulsant and antihypnotic effects involving alpha 2-adrenergic receptors as well as nitric oxide-dependent mechanisms. This, in summary, shows that meldonium given in acute doses could be beneficial for the treatment of seizures and alcohol intoxication.It may also have some effect on decreasing the severity of withdrawal symptoms caused by the cessation of chronic alcohol use.
 
Meldonium Function:
 
Meldonium is believed to work through its ability to increase the size of blood vessels and therefore improve blood flow.Although initial reports suggested meldonium is a non-competitive and non-hydroxylatable analogue of gamma-butyrobetaine;[9][non-primary source needed] further studies have identified that meldonium is a substrate for gamma-butyrobetaine dioxygenase. X-ray crystallographic and in vitro biochemical studies suggest that meldonium binds to the substrate pocket of γ-butyrobetaine hydroxylase and acts as an alternative substrate ,and therefore a competitive inhibitor.[non-primary source needed] Normally, this enzyme's action on its substrates γ-butyrobetaine and 2-oxoglutarate gives, in the presence of the further substrate oxygen, the products L-carnitine, succinate, and carbon dioxide; in the presence of this alternate substrate, the reaction yields malonic acid semialdehyde, formaldehyde (akin to the action of histone demethylases), dimethylamine, and (1-methylimidazolidin-4-yl)acetic acid, "an unexpected product with an additional carbon-carbon bond resulting from N-demethylation coupled to oxidative rearrangement, likely via an unusual radical mechanism.
 

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High Purity Body Building Powder Growth Powder Dapoxetine Hydrochloride (129938-20-1) USP

Dapoxetine Hydrochloride

 

Product Description:

CAS: 129938-20-1                                             Assay: 98% min. 

Packing: 1kg net/foil bag or tin.                          Delivery: Express courier.

MF: C9H7ClN2O5                                             MW: 258.62 

HS Code:30012000

 

Character: White to Off-White Cyrstalline Solid, odorless, slight sweet taste, Mp 175-177°C, optical rotation +128°

 

Usage: Selective serotonin reuptake inhibitor (SSRI), pharmaceutical material, hormone.  

 

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Male Hormone Fitness Anabolic Steroids Powder Nandrolone Undecylate / Dynabolon 862-89-5

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Male Hormone Fitness Anabolic Steroids Powder Nandrolone Undecylate / Dynabolon 862-89-5
 
Nandrolone Undecylate Basic Info.:
 
Product Name: Nandrolone Undecylate
Synonyms: Nandrolone Undecanoate; Nandrolone 17β-Undecanoate;Dynabolon
CAS: 862-89-5
MF: C29H46O3
MW: 442.68
EIENCS: 212-729-3
Assay: 99% min.
Packing: foil bag or tin.
Delivery: Express courier.
Usage: pharmaceutical material, Tibolone intermediate.
Standard: Enterprise standard
 
Nandrolone Undecylate Description: 
 
Nandrolone undecylate is an effective compound that produces quality, long-lasting muscle gains. This is because of the relatively long half-life of the drug (around 8 days). Users report mild side effects, with the biggest side effect being water retention. 
 
Nandrolone Undecylate Applications:
 
Nandrolone is most commonly found with a cypionate, laurate, decanoate or plenylpropionate ester. Briefly explained, the ester determines how much of the given hormone is released over a period of time. Longer esters such as decanoate peak slowly and can keep stable blood plasma levels up to ten days, shorter esters such as the phenylpropionate peak more rapidly but the half-live is shorter. Shorter esters usually release much more active hormone per mg than longer esters, and of course, allow the drugs effects to leave your system more quickly.
 

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Natural Herb Sex Enhancer Icariin / Horny Goat Weed Extract / Epimedium Extract 489-32-7

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Natural Herb Sex Enhancer Icariin / Horny Goat Weed Extract / Epimedium Extract 489-32-7
 
Epimedium Extract Basic Info:
 
Product Name: Epimedium Extract (Icariin)
Synonyms: Horny Goat Weed Extract;Icariin;Icarrin;Epimedium Extract;Epimedium Herb Ext;Epimedium P.E;Epimedium Brevicornum P.E;Epimedim Brevicormum P.E
CAS: 489-32-7
MF: C33H40O15
MW: 676.66
Melting point: 223-225 ºC
Density: 1.55
Storage temp.: room temp
Chemical Properties: Light yellow to yellow solid
Usage: hepatoprotective
Product Categories: Flavones;Functional Products;Natural Plant Extract;The group of Epimedii;plant extract;Nutritional Ingredients;Plant extracts;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Standardized plant extract;Inhibitors;API
 
Epimedium Extract Description:
 
Epimedium as kidney tonifying herbs commonly used, can promote the effects of Epimedium on pituitary gonadal system function, can improve the male gonadal damage, increase the content of testosterone, but also promote the secretion of corticosterone and adrenal cortical cells. Reinforce the kidney yang effect of Herba Epimedii with its direct stimulation of target gland secretion of hormones involved. Epimedium can promote sexual function is due to hypersecretion of semen, seminal vesicle is filled, stimulation of sensory nerves, caused by indirect excited sexual desire.
 
Epimedium Extract Application:
 
Effect of Herba Epimedii from different aspects of aging mechanism, can delay the aging process and prevent the occurrence of senile disease. Such as the impact of cell passage, prolong the growth period, adjusting immunity and secretion system, improve metabolism and the function of various organs.
 

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Oral or Injection Trenbolones Steroids 6-Bronmandrostenedione For Gain Muscle 38632-00-7

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Oral or Injection Trenbolones Steroids 6-Bronmandrostenedione For Gain Muscle 38632-00-7
 
6-Bronmandrostenedione Basic Info.:
 
Product Name: 6-Bronmandrostenedione
Synonyms: (6b)-6-Bromoandrost-4-ene-3,17-dione; (6beta)-6-bromoandrost-4-ene-3,17-dione; 6-Bromoandrost-4-ene-3,17-dione
CAS RN.: 38632-00-7
Molecular Weight: 365.3046
Molecular Formula: C19H25BrO2
Density: 1.35g/cm3
Boiling Point(ºC): 467°C at 760 mmHg
Flash Point(ºC): 100.3°C
refractive_index: 1.577
Chemical Properties: Pale Yellow Solid
Usage: 6-Bronmandrostenedione analog, an aromatase inhibitor.
 
6-Bronmandrostenedione Description:
 
6-Bromodione is a fast acting competitive inhibitor of the aromatase enzyme. It works by binding to the aromatase enzyme to prevent it from aromatizing androgens. This is not a permanent binding and later acts to normalize aromatase (and thus estrogen levels) as hormone production returns to normal. It specifically targets aromatase and does not act as a central anti-androgen like some other post cycle products can. This means that your libido and mood will not be negatively affected.
 
6-Bronmandrostenedione Application:
 
6-beta-Bromodione works in a similar way but has an irreversible and permanent effect. This works well to mediate the excess aromatase that was produced while on cycle, while the alpha isomer works to normalize the natural levels. The goal is again to transition into normal production levels for all hormones affected by the anabolic cycle.
 

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Pharma Antiviral Agents Tenofovir Disoproxil Fumarate 202138-50-9 For Medicine Ingredients

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Pharma Antiviral Agents Tenofovir Disoproxil Fumarate 202138-50-9 For Medicine Ingredients

 

Tenofovir Basic Info.:

 

Product Name: Tenofovir

CAS:147127-20-6

MF: C9H14N5O4P

MW:287.21

mp:276-280°C

storage temp. Store at -20°C

Water Solubility :13.4 mg/mL (25 ºC)

Chemical Properties:White Crystalline Solid

Usage:Acyclic phosphonate nucleotide analogue. Used as an anti-HIV agent

Usage:Acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.

Usage:Tenofovir blocks reverse transcriptase and hepatitis B virus infections.

Biological Activity Selectively inhibits HIV reverse transcriptase (RNA-dependent DNA polymerase). Prevents cytotoxicity in SIV-infected C-8166 cells in vitro (IC 50 = 1.5 μ M). Antiviral agent.

 

Tenofovir Usage And Synthesis:

 

1. Antiviral drugs, Tenofovir is an acyclic nucleoside antiviral reverse transcriptase inhibitor. The active substance is Tenofovir disoproxil, while tenofovir is a prodrug that is used because of its better absorption in the gut.

2. Tenofovir can inhibit viral polymerase through direct competitively combine with natural deoxyribose or by insertion to terminate chain of human DNA. It is the first nucleotide analogs to treat HIV-1 infection that approved by the US Food and Drug Administration (FDA).

3. Tenofovir is a main medicine in AIDS cocktail therapy, researches has shown that it can effectively improve the monkeys` ability on prevention of immunodeficiency virus (similar to the human AIDS virus).

 

Tenofovir Pharmacokinetics:

 

Tenofovir is hardly absorbed through the gastrointestinal tract, for this reason, prodrug of Tenofovir has been developed by esterification, and then to make tenofovir fumarate ester. Tenofovir ester is water-soluble, can be rapidly absorbed and degraded into the active tenofovir, and then was metabolized to the active Tenofovir disoproxil. Tenofovir will reach the peak of plasma Concentration within 1-2 h after administration. When combined with food service, the bioavailability of Tenofovir can be increased by 40%. Intracellular half-life of Tenofovir disoproxil is about 10 h, it needs dosing everyday. Because Tenofovir is not a CYP-450 substrate, this may decrease the possibility of interactions with other drugs caused by CYP450. Elimination of Tenofovir is by glomerular filtration and active tubular secretion. Approximately 70% to 80% is recovered in urine as unchanged drug. Elimination half-life is approximately 17 h.

 

Indications: Tenofovir is indicated for the treatment of HIV, HBV infection. This product also can cooperated with other reverse transcriptase inhibitors for HIV-1 infection and hepatitis B treatment.

 

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Pharmaceutical Raw Materials Female Steroids Raw Hormone Powders Mifepristone 84371-65-3

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Pharmaceutical Raw Materials Female Steroids Raw Hormone Powders Mifepristone 84371-65-3
 
Mifepristone Basic Info.:
 
Product Name: Mifepristone (R38486)
Synonyms: 11-(4-(dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)-estra-9-dien-3-one;11beta-[4-(n,n-dimethylamino)phenyl]-17alpha-(prop-1-ynyl)-delta4,9-estradiene;r38486
CAS Number: 84371-65-3
Molecular Formula: C29H35NO2
Molecular Weight: 429.65
Assay: 99%
Melting Point: 195-198 °C
Storage temp.: 2-8°C
Appearance: Light yellowish powder
Product Categories: Steroids;Hormone;Acetylenes;Biochemistry;Functionalized Acetylenes;Hydroxyketosteroids;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Intracellular receptor;Nuclear Receptors;Steroid and Hormone;API;Hormone Drugs.
Uses: It is a novel anti-progestin and has anti-glucocorticoid activity without the activity of progesterone, estrogen, androgen and anti-estrogen. It has a progesterone receptor affinity five times as high as progesterone. It is used for anti-pregnancy, inducing menstruation and terminating pregnancy, intrauterine inducer labor for dead fetal.
 
Mifepristone Description:
 
Mifepristone is a synthetic steroid compound with both antiprogesterone and antiglucocorticoid properties. The compound is a 19-nor steroid with substitutions at positions C11 and C17 (17 beta-hydroxy-11 beta-[4-dimethylamino phenyl] 17 alpha-[1-propynyl]estra-4, 9-dien-3-one), which antagonizes cortisol action competitively at the receptor level.
 
Mifepristone is a progesterone receptor antagonist used as an abortifacient in the first months of pregnancy, and in smaller doses as an emergency contraceptive. It is also a powerful glucocorticoid receptor antagonist.
 
Mifepristone Applications:
 
Mifepristone is used alone or in combination with misoprostol (Cytotec) to end an early pregnancy. Early pregnancy means it has been 49 days or less since your last menstrual period began. Mifepristone is in a class of medications called antiprogestational steroids. It works by blocking the activity of progesterone, a substance your body makes to help continue pregnancy.
 
Mifepristone is also available as another product (Korlym), which is used to control hyperglycemia (high blood sugar) in people with a certain type of Cushing's Syndrome in which the body makes too much of the hormone cortisol. This monograph only gives information about mifepristone (Mifeprex), which is used alone or in combination with another medication to end an early pregnancy. If you are using mifepristone to control hyperglycemia caused by Cushing's syndrome, read the monograph entitled mifepristone (Korlym) that has been written about this product.
 
Mifepristone (or RU-486) is a synthetic steroid compound with both antiprogesterone and antiglucocorticoid properties. The compound is a 19-nor steroid with substitutions at positions C11 and C17 (17 beta-hydroxy-11 beta-[4-dimethylamino phenyl] 17 alpha-[1-propynyl]estra-4, 9-dien-3-one), which antagonizes cortisol action competitively at the receptor level.
 
Mifepristone is a progesterone receptor antagonist used as an abortifacient in the first months of pregnancy, and in smaller doses as an emergency contraceptive. It is also a powerful glucocorticoid receptor antagonist, and has occasionally been used in refractory Cushing's syndrome (due to ectopic/neoplastic ACTH/cortisol secretion).
Mifepristone was the first antiprogestin to be developed and it has been evaluated extensively for its use as an abortifacient.
 

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Pharmaceutical Safe Organic Solvents Grape Seed Oil For Cooking Cosmetics CAS 85594-37-2

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Pharmaceutical Safe Organic Solvents Grape Seed Oil For Cooking Cosmetics CAS 85594-37-2
 
Grape Seed Oil Basic Info.:
 
Product Name: Grape seed oil
Synonyms: Grapeseed Oil; Oils, grape; Grape stem extract; VITIS VINIFERA (GRAPE) SEED OIL; Traubenkernoel; Grape seed oil;
CAS No.: 85594-37-2
Purity: 99%
Appearance: Pale yellow liquid
Standard: Enterprise Standard
Packing: 200KG/Drum or as per your requirements
Application: Natural Plant Extract; Flavors & Fragrances
 
Grape Seed Oil Description:
 
Appearance: pale green to pale yellow oily liquid
Relative Density: (20 °C) 0.915 ~ 0.925
Refractive index: (20 °C) 1.4700 ~ 1.4750
Linoleic acid: (%) 70 ~ 76
 
Grape Seed Oil Application:
 
1. Grape seed through the most advanced cold pressing method and refined, is one of the very popular in the base oil and the effect is outstanding varieties. Grape seed oil is a natural non-toxic properties, so children, pregnant women, the elderly and athletes are applicable.
2. Atioxidant, dilute the stain.
3. Endocrine disorders caused by dry skin, reduce melanin, whitening skin, removing chloasma.
4. To stimulate cell division and tissue regeneration, activation of the surface cells, reduce wrinkles, delay aging.
5. Inhibit and remove the body of free radicals, anti-cancer anti allergic effect.
6. Anti prostate cancer, the role of anti liver tumor, but also against damage to the nervous system.
 

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Safe Human Growth Hormone Peptide PT 141 Bremelanotide For Peptide Drum PT141 32780-32-8

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Safe Human Growth Hormone Peptide PT 141 Bremelanotide For Peptide Drum PT141 32780-32-8
 
PT 141 Basic Info.
 
Product Name: PT-141; PT141
CAS: 32780-32-8
MF: C50H69N15O10
MW: 1040.17736
Appearance: White powder
Water Content(Karl Fischer): ≤ 5.0%
Acetate Content(by HPLC): ≤ 15.0%
Amino Acid Composition: ± 10% of theoretical
Purity(by HPLC): ≥ 97.0%
Single Impurity(by HPLC): ≤ 1.0%
Peptide Content(by %N): ≥ 80%
Assay(By Anhydrous, Acetic Acid-free): 95.0~105.0%
Bacterial Endotoxins: ≤ 5EU/mg
Grade: Pharmceutical Grade
Storage: Shading, confined preservation
 
PT 141 Description:
 
PT-141 is a synthetic amino acid protein discovered during clinical trials using the Melanotan 2 for sunless tanning, photo-protection results from melanotans. Participants were documented as having experienced aphrodisiac reactions, leading to the further development PT-141. The melanocortin system targets receptors associated with desire through the melanocyte stimulating hormone paths that cross the blood-brain-barrier. Potentially the powerful sex-drug results feeling an aphrodisiac experience amplifying arousal pt141 reviews have shown the ability to increase libido effects of both men and women.
 
PT 141 Application:
 
PT-141 functions by activating the melanocortin receptor and MC4R namely. Bremelanotide originally was tested for nasal spray delivery but was discontinued after concerns about side effects. Bremelanotide PT141, as Melanotan II, may cause spontaneous arousal enhancing effect. Unlike other supplements, PT-141 results do not act on the vascular body, but directly increases desires through the nervous system.
 

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Sell Pharmaceutical Grade Plant Extract Glabridin Powder In Cosmetic Industry 59870-68-7

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Sell Pharmaceutical Grade Plant Extract Glabridin Powder In Cosmetic Industry 59870-68-7
 
Glabridin Basic Info.:
 
Product name: Glabridin
CAS No.: 59870-68-7
Molecular Formula: C20H20O4
Molecular Weight: 324.37
Appearance: Light-yellow powder
Package: 5kg/drum, or at customer's requirements
Storage: Store in a cool, dry place and keep away from direct strong light.
Shelf Life: 2 years
 
Product Functions Of Glabridin:
 
Glabridin is a chemical compound that is found in the root extract of licorice (Glycyrrhiza glabra). It is used as an ingredient in cosmetics and is listed in International Nomenclature of Cosmetic Ingredients (INCI). Glabridin is a flavonoid molecule, this product is a larger family of plant-derived phenols.
 
Glabridin (glycyrrhiza glabra extract) in its main function as a potent, natural skin-whitening agent It is known for its beneficial effects on the skin due to its anti-inflammatory and antioxidant properties. In addition, glabridin inhibits melanogenesis. Some researchers have established that this effect may be due to the inhibition of tyrosinase activity. Glabridin whitens skin without being cytotoxic (destruction of pigment cells).
 

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