Pharmaceutical raw materials used in synthesizing new medications

chemical-categories

Pharmaceutical Raw Materials Elubiol Dichlorophenylimidazoldioxolan 67914-69-6

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Pharmaceutical Raw Materials Elubiol Dichlorophenylimidazoldioxolan 67914-69-6
 
Elubiol Basic Info.:
 
Product Name: Elubiol (Dichlorophenylimidazoldioxolan)
Synonyms: Elubiol; Dichlorophenylimidazoldioxolan
CAS: 67914-69-6
Molecular formula: C27H30Cl2N4O5
Molecular weight: 561.46
Quantity: 500Kgs stock inventory. 10 tons per month
Appearance white to off white crystalline powder
Identification of HPLC
Loss on drying 0.50%max
The heavy metal 20ppmmax
The purity of (HPLC) 99.00%min
Content (titrimetric) 99.0%-101.0%
Package: 25kg paperboard barrel
 
Elubiol Description:
 
New posaconazole is a novel imidazole fungicides could inhibit the fungal sterol biosynthesis, wheat, and other components of the changes of cell membrane lipid compounds. Killing of Candida albicans, Histoplasma, Blastomyces dermatitidis and Coccidioides immitis, to dandruff, sterilization and regulate the skin grease in the washing products.
 
The main structure and the new azole ketoconazole are exactly the same, only at the end of keto ester instead of ketoconazole in. The Pityrosporum ovale of dandruff, two is the most potent inhibitor. The new azole included in the INCI directory, list the EU cosmetics ingredients and the Ministry of "health standard Chinese names of raw materials of Cosmetics International Directory", can be legally used in cosmetics.
 

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Pharmaceutical Raw Materials Female Steroids Raw Hormone Powders Mifepristone 84371-65-3

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Pharmaceutical Raw Materials Female Steroids Raw Hormone Powders Mifepristone 84371-65-3
 
Mifepristone Basic Info.:
 
Product Name: Mifepristone (R38486)
Synonyms: 11-(4-(dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)-estra-9-dien-3-one;11beta-[4-(n,n-dimethylamino)phenyl]-17alpha-(prop-1-ynyl)-delta4,9-estradiene;r38486
CAS Number: 84371-65-3
Molecular Formula: C29H35NO2
Molecular Weight: 429.65
Assay: 99%
Melting Point: 195-198 °C
Storage temp.: 2-8°C
Appearance: Light yellowish powder
Product Categories: Steroids;Hormone;Acetylenes;Biochemistry;Functionalized Acetylenes;Hydroxyketosteroids;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Intracellular receptor;Nuclear Receptors;Steroid and Hormone;API;Hormone Drugs.
Uses: It is a novel anti-progestin and has anti-glucocorticoid activity without the activity of progesterone, estrogen, androgen and anti-estrogen. It has a progesterone receptor affinity five times as high as progesterone. It is used for anti-pregnancy, inducing menstruation and terminating pregnancy, intrauterine inducer labor for dead fetal.
 
Mifepristone Description:
 
Mifepristone is a synthetic steroid compound with both antiprogesterone and antiglucocorticoid properties. The compound is a 19-nor steroid with substitutions at positions C11 and C17 (17 beta-hydroxy-11 beta-[4-dimethylamino phenyl] 17 alpha-[1-propynyl]estra-4, 9-dien-3-one), which antagonizes cortisol action competitively at the receptor level.
 
Mifepristone is a progesterone receptor antagonist used as an abortifacient in the first months of pregnancy, and in smaller doses as an emergency contraceptive. It is also a powerful glucocorticoid receptor antagonist.
 
Mifepristone Applications:
 
Mifepristone is used alone or in combination with misoprostol (Cytotec) to end an early pregnancy. Early pregnancy means it has been 49 days or less since your last menstrual period began. Mifepristone is in a class of medications called antiprogestational steroids. It works by blocking the activity of progesterone, a substance your body makes to help continue pregnancy.
 
Mifepristone is also available as another product (Korlym), which is used to control hyperglycemia (high blood sugar) in people with a certain type of Cushing's Syndrome in which the body makes too much of the hormone cortisol. This monograph only gives information about mifepristone (Mifeprex), which is used alone or in combination with another medication to end an early pregnancy. If you are using mifepristone to control hyperglycemia caused by Cushing's syndrome, read the monograph entitled mifepristone (Korlym) that has been written about this product.
 
Mifepristone (or RU-486) is a synthetic steroid compound with both antiprogesterone and antiglucocorticoid properties. The compound is a 19-nor steroid with substitutions at positions C11 and C17 (17 beta-hydroxy-11 beta-[4-dimethylamino phenyl] 17 alpha-[1-propynyl]estra-4, 9-dien-3-one), which antagonizes cortisol action competitively at the receptor level.
 
Mifepristone is a progesterone receptor antagonist used as an abortifacient in the first months of pregnancy, and in smaller doses as an emergency contraceptive. It is also a powerful glucocorticoid receptor antagonist, and has occasionally been used in refractory Cushing's syndrome (due to ectopic/neoplastic ACTH/cortisol secretion).
Mifepristone was the first antiprogestin to be developed and it has been evaluated extensively for its use as an abortifacient.
 

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Pharmaceutical Raw Materials Guaifenesin CAS 93-14-1

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Pharmaceutical Raw Materials Guaifenesin CAS 93-14-1 
 
Guaifenesin Basic Info.:
 
Product Name: Guaifenesin 
Synonyms:3-(2-Methoxyphenoxy)-1,2-propanediol; Guaiacol glyceryl ether; Glycerol guaiacolate 
Molecular Formula:C10H14O4 
Molecular Weight:198.22 
CAS Registry Number:93-14-1 
EINECS: 202-222-5 
Melting point:77-81 ºC 
Boiling point:215 ºC (19 mmHg) 
Water solubility:5 g/100 mL (25 ºC)
 
Guaifenesin Usage: 
 
Expectorant cough, phlegm cough for chronic bronchitis, bronchiectasis and other illnesses
Guaifenesin or guaiphenesin (former BAN), also glyceryl guaiacolate,is an expectorant drugsold 
over the counter and usually taken orally to assist the bringing up (expectoration) of phlegm from 
the airways in acute respiratory tract infectiion.
 
 
Effect and mechanism of Action:
 
Guaifenesin is thought to act as an expectorant by increasing the volume and reducing the viscosity of secretions in the trachea and bronchi. It also stimulates the flow of respiratory tract secretions, allowing ciliary movement to carry the loosened secretions upward toward the pharynx.Thus, it may increase the efficiency of the cough reflex and facilitate removal of the secretions; however, objective evidence for this is limited and conflicting.
 

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Pharmaceutical Raw Materials Hyaluronic Acid 9004-61-9 For Beauty Food and Cosmetic Grade

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Pharmaceutical Raw Materials Hyaluronic Acid 9004-61-9 For Beauty Food and Cosmetic Grade
 
Hyaluronic Acid Basic Info.:
 
Product Name: Hyaluronic acid
Synonyms: [beta-sodium-gluconate-(1,3)-beta-n-acetyl-d-glucosamine-1,4-]n;Hyaluronic acid sodium;Hyaluronic acid human sodium salt
CAS: 9004-61-9
MF: C14h22nnao11
MW:403.31
Einecs: 232-678-0
Hyaluronic acid 25mg/ml
Application: Filling For Cosmetic Surgery
Spec: 1ml/syringe
Hyaluronate Acid -Filling For Cosmetic Surgery Injecting Gel
Major components:
hyaluronic acid: 25mg/ml
PH7.2 phosphate buffer: 1ml
Has been filling the syringe: 1ml
 
Product Introduction of Hyaluronic Acid:
 
Hyaluronic Acid Gel is a non animal origin cross-linked hyaluronic acid gel which is sterile, apyrogenic with physiological pH and osmolarity. It is packed in a 1ml pre-filled glass syringe and sterlised by moist heat autoclaving. Hyaluronic Acid Gel is for single use product. The commercial ha is commonly a sodium salt, called sodium hyaluronate, habitually called hyaluronic acid. Ha is a new biological at home and abroad. Its molecular weight is from several ten thousand to several million. It's aqueous solution has outstanding moisture keeping ability, high viscoelasticity and lubricity.
 
Product Avail of Hyaluronic Acid:
 
Hyaluronic Acid Gel is an injectable implant indicated for filling deep to very deep wrinkles and/or for volume restoration (cheeks, contours of the face, cheekbones) by deep dermal injection in the face. Hyaluronic acid(ha) is a straight chain macromolecular mucopolysaccharide composed of repeat disaccharide units of glucuronic acid and n-acetylglucosamine. It widely consists in the extracellular space of human and animal tissue, vitreum, umbilical cord, skin joints synovia and cockscomb etc.
 
It is widely used in cosmetics, pharmacy and health and beauty food. In intradermal, subcutaneous and intramuscular high biocompatibility; Anti-degradation, anti-migration, difficult to absorb, a long half-life; After implantation, no inflammation, immune response or foreign body reaction; In the soft tissue has a relatively The stability and biocompatibility; Without skin test, rapid, safe and effective; Of good moisture.
 

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Pharmaceutical Raw Materials Hydrocortisone For Anti-Inflammatory Allergy 50-23-7

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Pharmaceutical Raw Materials Hydrocortisone For Anti-Inflammatory Allergy 50-23-7
 
Hydrocortisone Basic Info.:
 
Product Name: Hydrocortisone
CAS: 50-23-7
MF: C21H30O5
MW: 362.46
EINECS: 200-020-1
Assay: 98%
Appearance: white powder
Package: 1kg/foil bag
Grade:Medicine grade
 
Description About Hydrocortisone:
 
Suitable for contact dermatitis, lichen planus, etc. It is currently the most important supplementary glucocorticoid drugs, extensive drug effects, versatile, indispensable clinical drugs. Adrenal crisis in the rescue, anaphylactic shock, status asthmaticus critically ill played an important role. In systemic lupus erythematosus, rheumatism, autoimmune vasculitis treatment of autoimmune diseases is an important and indispensable therapy.
The advantage of this drug is its ethanol and hydrocortisone sodium succinate intravenously directly and quickly to play a role for the rescue of critically ill patients and shock therapy for certain diseases, generally do not cause peptic ulcers, purpura and spirit symptoms, but the row of potassium and sodium retention is stronger. Short-term large doses of hydrocortisone (24h infusion 2000 ~ 4000mg, once every 2 to 3 days) for some critically ill with the rescue, to receive good results, such as the rescue of septic shock, status asthmaticus , adult respiratory distress syndrome, short-term application, generally no adverse reactions.
 
Hydrocortisone Application:
 
1. Biochemical studies, adrenal cortical hormone drugs.
2. Glucocorticoids have anti-inflammatory, anti allergic, anti toxin, anti shock four role.
3. Adrenal corticoids
 
Hydrocortisone Pharmacological Action:
 
Anti-inflammatory effects: anti-inflammatory effects of hydrocortisone cortisone 1.25 times, in the pharmacological doses of infectious and non-infectious inflammation are inhibited. Hydrocortisone increases vascular tone, alleviate congestion, reducing capillary permeability, and therefore reduce the exudation, edema; by inhibition of inflammatory cells (including macrophages and leukocytes) aggregation at sites of inflammation, and inhibit phagocytosis cell function, lysosomal membrane stability, prevent complement chemical involved in inflammation and inflammatory mediators (such as prostaglandins, thromboxane, leukotriene) synthesis and release to relieve redness, swelling, heat, pain and other symptoms.
 

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Pharmaceutical Raw Materials Indometacin Powder 53-86-1 For Pain Killer Anti Inflammatory

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Pharmaceutical Raw Materials Indometacin Powder 53-86-1 For Pain Killer Anti Inflammatory
 
Indometacin Basic Info.:
 
Product Name: Indometacin
Synonyms: Amuno; Chrono-Indocid 75; Confortid; Dolovin; Elmetacin; Flam; Indo-Rectolmin; Indo-Tablinen; IndoRich; Indocid
CAS: 53-86-1
MF: C19H16ClNO4
MW: 357.79
Appearance: White crystalline powder
EINECS: 200-186-5
Density: 1.327 g/cm3
Melting Point: 155-162°C
Boiling Point: 499.363°C at 760 mmHg
Storage: Store in cool and dry places, keep away from light
Indometacin or indomethacin is a non-steroidal anti-inflammatory drug (NSAID), to reduce fever, pain, stiffness, and swelling.
 
Product Description Of Indometacin: 
 
Indometacin (INN) or indomethacin (USAN and former BAN) is a non-steroidal anti-inflammatory drug (NSAID) commonly used as a prescription medication to reduce fever, pain, stiffness, and swelling. It works by inhibiting the production of prostaglandins, molecules known to cause these symptoms. It is marketed under more than seventy different trade names. 
 
Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that reduces fever, pain and inflammation. It is similar to ibuprofen (Motrin) and naproxen (Naprosyn, Aleve). Indomethacin works by reducing the production of prostaglandins. Prostaglandins are chemicals that the body produces and which cause the fever and pain that are associated with inflammation. Indomethacin blocks the enzymes that make prostaglandins (cyclooxygenase 1 and 2) and thereby reduces the levels of prostaglandins. As a result, fever, pain and inflammation are reduced. Indomethacin is available in an extended release form. 
 
Indomethacin is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Indomethacin works by reducing hormones that cause inflammation and pain in the body. 
Indomethacin is used to treat pain or inflammation caused by many conditions such as arthritis, gout, ankylosing spondylitis, bursitis, or tendinitis. 
 
Indomethacin may also be used for other purposes not listed in this medication guide. 
Ndomethacin is a medication that is often used to relieve pain caused by various types of arthritis and other painful conditions. Sold under the brand name Indocin, the medication is also available in generic form. Indomethacin belongs to a class of drugs known as NSAIDs and is commonly used to treat symptoms of conditions such as osteoarthritis, rheumatoid arthritis, and gout. The medicine is available in capsule, oral suspension, and suppository form. 
 
Indomethacin is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Indomethacin works by reducing hormones that cause inflammation and pain in the body. 
Indomethacin is used to treat pain or inflammation caused by many conditions such as arthritis, gout, ankylosing spondylitis, bursitis, or tendinitis. 
Indomethacin may also be used for other purposes not listed in this medication guide.
 
Indometacin Application: 
 
This product has obvious effect on anti-inflammation and antipyretic, can be easily absorbed and excreted. It can be fully absorbed after taken orally in the gastrointestinal tract, and in 1-4 hours the plasma concentration will reach a peak; It will be excreted by liver metabolism, with the urine. Analgesic effects on inflammatory pain there, and its mechanism of inhibiting prostaglandin synthesis. Salicylic acid is mainly used on the efficacy of drugs difficult to tolerate, or not significant rheumatoid arthritis, ankylosing spondylitis, osteoarthritis and so on. Can also be used for acute gout and cancer, fever, or other difficult to control fever.
 

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Pharmaceutical Raw Materials Lipoic Acid For Fat-Metabolism Stimulator 1077-28-7

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Pharmaceutical Raw Materials Lipoic Acid For Fat-Metabolism Stimulator 1077-28-7
 
Lipoic Acid Basic Info.:
 
Product Name: Lipoic Acid
Purity: 99.5%
CAS: 1077-28-7
MF: C8H14O2S2
MW: 206.33
Appearance: Yellow crystalline powder,no obvious odor.
Melting point: 60.0-62.0 degree centigrade 
Drying loss: Not more than 0.2%  
Usage: Lipoic acid is a vitamin drugs, limited physical activity in its dextral, basically no physical activity in its Lipoic acid, and no side effects. It is always used for acute and chronic hepatitis, liver cirrhosis, hepatic coma, fatty liver, diabetes, Alzheimer's disease, and applies as an antioxidant health products
 
Lipoic Acid Function:
 
Lipoic acid is a vitamin drugs, limited physical activity in its dextral, basically no physical activity in its Lipoic acid, and no side effects. It is always used for acute and chronic hepatitis, liver cirrhosis, hepatic coma, fatty liver, diabetes, Alzheimer's disease, and applies as an antioxidant health products
 
Lipoic Acid Applications:
 
1.Lipoic Acid is a good antioxidant. Taken internally, it is a water  and fat soluble antioxidant that is capable of regenerating other antioxidants, such as vitamins C and E; it also can help prevent cellular damage via its antioxidant properties. 
2.Usually it  is used for diabetes, peripheral neuropathy, cardiac autonomic neuropathy, retinopathy, cataracts, and glaucoma. Alpha-lipoic acid is also used orally for dementia, chronic fatigue syndrome, HIV/AIDS, cancer, liver disease, cardiovascular disease, peripheral arterial disease, intermittent claudication, Lyme disease, and lactic acidosis caused by inborn errors of metabolism.
3.It also has anti-inflammatory effects.
4.Topically, alpha-lipoic acid is used to reduce facial wrinkles, lines, and sun damage.
but it is extremely vulnerable to degradation by sunlight, and 5% or higher alpha lipoic acid are capable of causing burning or stinging sensations or a mild rash on skin.
 

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Pharmaceutical Raw Materials Mitotan Used to Antineoplastic Agent 53-19-0

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Pharmaceutical Raw Materials Mitotan Used to Antineoplastic Agent 53-19-0
 
Mitotane Basic Info.:
 
Product Name: Mitotane
CAS:53-19-0
MF:C14H10Cl4
MW:320.04
EINECS:200-166-6
Air & Water Reactions:Insoluble in water.
Chemical Properties:White Crystalline Solid
Usage:insecticide, antineoplastic. treatment of osteoporosis and Paget's bone disease. Used as an adrenolytic agent
 
Mitotane Description:
 
Mitotane Simple aromatic halogenated organic compounds are very unreactive; halogenated aliphatic compounds are moderately or very reactive. For both subgroups, reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Materials in this group are incompatible with strong oxidizing and reducing agents. Also, they are incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.
 
Mitotane Avail:
 
Mitotane structure and pharmacological action insecticide DDT (DDT) and DDD similar, it selectively adrenal zona fasciculata and reticularis cells atrophy, necrosis, but does not affect the zona, aldosterone secretion and therefore will not be affected. Blood and urine cortisol and its metabolites rapidly reduced after treatment, the body adrenocorticotropic hormone and metabolism products decreased rapidly, for the treatment of inoperable, functional and non-functional adrenal cortical carcinoma, adrenal tumor, adrenal gland cruzi induced hyperplasia syndrome, adrenal hyperplasia, cortical cancer adjuvant therapy and tumor-induced Cushing's syndrome.
 

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Pharmaceutical Raw Materials Natural Steroid Hormones Powder Methyldienedione 5173-46-6

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Pharmaceutical Raw Materials Natural Steroid Hormones Powder Methyldienedione 5173-46-6
 
Methyldienedione Basic Info.:
 
Product Name: Methyldienedione
Alias: Estra-4,9-diene-3,17-dione
CAS register number: 5173-46-6
Molecular Formula: C18H22O2
Molecular Weight: 270.37
Melting Point: 131-134°C
Assay: 98%min
Grade: Pharmaceutical Grade
Storage: Shading, confined preservation
Packing: 1kg/foil bag. 25kg/drum
Character: White crystalline powder.
Usage: A potential metabolitie of STS 557 (Dienogest). A steroid with antiglucocorticoid activity.
 
Methyldienedione Description:
 
Estra-4,9-diene-3,17-dione is a powerful pro-steroid chemically similar to the anabolic agent Trenbolone.
When in the body, estra-4,9-diene-3,17-dione completes the conversion to Trenbolone. Trenbolone is a potent anabolic steroid, which binds to specific receptors present in reproductive tissue, muscle and fat.
 
Estra Diene Dione (estra-4,9-diene-3,17-dione) is an anabolic steroid and a precursor to Estra Diene Dione. It became a controlled substance in the US on January 4, 2010, and is classified as a Schedule III anabolic steroid under the United States Controlled Substances Act. Previous to this, it was sold as a bodybuilding supplement within the United States, and often mistakenly marketed as a prohormone for trenbolone, a veterinary steroid. Prior to its scheduling, it was part of a number of supplements that were seized during FDA enforcement for selling unapproved new drugs. The actual target steroid, Estra Diene Dione has some structural similarity to trenbolone, but lacks the 11-carbon -ene bond.
 
Methyldienedione Applications:
 
1. Protection from gynomastia,
2. Increased sex drive/libido,
3. Enhanced intensity & focus,
4. Estrogen control,
5. Positive effects on strength & lean mass.
 

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Pharmaceutical Raw Materials Prednisolone 50-24-8

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Pharmaceutical Raw Materials Prednisolone 50-24-8
 
Prednisolone Basic Info.:
 
Product Name: Prednisolone
Synonyms:
Hydrodeltalone Hydrodeltisone Hydroretrocortin Metacortandralone Meticortelone Meti-Derm Paracortol Paracotol Precortancyl Precortisyl Predne-dome Prednelan Prednis Predonin
Usage: Synthetic corticosteroid; metabolically interconvertible with prednisone
Molecular formula: C21H28O5
Cas no.: 50-24-8
Appearance: Crystalline Solid
Assay: 99%
Melting Point: 240ºC
Boiling Point: 570.6 ºC at mmHg
Water Solubility: 223 mg/L at 25 ºC in water
Refractive index: 1.587
Flash point: 313 ºC
 
Prednisolone Description:
 
Prednisolone API Intermediate 99%min USP BP Cas 50-24-8
 
Prednisolone Applications:
 
Synthetic corticosteroid; metabolically interconvertible with prednisone.
 

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