Pharmaceutical raw materials used in synthesizing new medications

chemical-categories

Protein SSX4 (51-70) LAB GRADE 97%

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Protein SSX4 (61-80) LAB GRADE 97%

Creative peptides is specialized in the process development and the manufacturing of bioactive peptides. We offer custom peptide synthesis, process development, GMP manufacturing as well as catalog products. We supply Protein SSX4 (61-80).http://www.creative-peptides.com/product/protein-ssx4-item-ta-527-31303.html

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Protein enabled homolog (443-451) LAB GRADE 97%

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Protein enabled homolog (502-510) LAB GRADE 97%

Creative peptides is specialized in the process development and the manufacturing of bioactive peptides. We offer custom peptide synthesis, process development, GMP manufacturing as well as catalog products. We supply Protein enabled homolog (502-510).http://www.creative-peptides.com/product/protein-enabled-homolog-item-ta-321-22350.html

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Protein phosphatase 1 regulatory subunit 3B (172-180) LAB GRADE 97%

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Protein timeless homolog (848-856) LAB GRADE 97%

Creative peptides is specialized in the process development and the manufacturing of bioactive peptides. We offer custom peptide synthesis, process development, GMP manufacturing as well as catalog products. We supply Protein timeless homolog (848-856).http://www.creative-peptides.com/product/protein-timeless-homolog-item-ta-059-1927.html

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Protirelin LAB GRADE 97%

We provide Protirelin. More information please visit the website:http://www.creative-peptides.com/product/protirelin-item-10-101-51-91.html

CAT#
10-101-51
Synonyms/Alias
TRH; Thyrotropin-releasing hormone; D00176; Antepan; Thypinone; Thyroliberin; Abbott-38579; Abbott38579; TRH Ferring; TRH Prem
CAS No.
24305-27-9
Sequence
Pyr-His-Pro-NH2
M.W/Mr.
362.41
Molecular Formula
C16H22N6O4
Source
Synthetic
Long-term Storage Conditions
−20°C
Application
TRH has been used clinically for the treatment of spinocerebellar degeneration and disturbance of consciousness in humans.
Description
Protirelin, also known as thyrotropin-releasing hormone (TRH), causes the secretion of thyroid-stimulating hormone (TSH) from the anterior pituitary gland. TSH acts on the thyroid gland to release the thyroid hormones thyroxine (T4) and triiodothyronine (T3).
Areas of Interest
Hormonal therapy

 

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Proto-oncogene PIM1 (191-199) LAB GRADE 97%

Creative peptides is specialized in the process development and the manufacturing of bioactive peptides. We offer custom peptide synthesis, process development, GMP manufacturing as well as catalog products. We supply Proto-oncogene PIM1 (191-199).http://www.creative-peptides.com/product/proto-oncogene-pim1-item-ta-006-257.html

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Purity 99% Female Hormone Chlormadinone Acetate CAS 302-22-7

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Purity 99% Female Hormone Chlormadinone Acetate CAS 302-22-7
 
Chlormadinone Acetate Basic Info.:
 
Product Name: Chlormadinone Acetate
CAS: 302-22-7
MF: C23H29ClO4
MW: 404.93
EINECS: 206-118-0
Mp: 212°C
Storage temp: -20°C Freezer
Appearance: Crystalline Solid
 
Chlormadinone Acetate Description:
 
Chlormadinone acetate (CMA) is a derivative of progesterone (17-acetoxy-6-chloro-4,6-pregnadiene-3,20-dione), first synthesized in 1961 and is used as an orally effective progestogen in hormone replacement therapy (HRT), and in combination with ethinyl estradiol (EE) in contraception since 1999. Chlormadinone acetate has a strong progestogenic effect about one-third higher than that of progesterone and may vary depending on the previous effect of an estrogen, i.e., estrogens may promote the formation of progesterone receptors and proliferation of the endometrium. Like progesterone, it is anti-estrogenic and has no partial androgenic effect (at the doses used for contraception and HRT). In contrast to progesterone, it has a slight glucocorticoid effect, a pronounced anti-androgenic effect and no anti-mineralocorticoid effect. No pregnancy-maintaining effect of CMA has been demonstrated in humans.
 
The anti-androgenic effect of CMA is presumed to be the result of both its binding to androgen receptors competitively inhibiting the effect of endogenous testosterone and dihydrotestosterone and the competitive inhibition of 5-reductase. In this respect, dosing of CMA is crucial; agonistic effects are observed when doses are increased from those optimal for an antagonistic effect.
 
Chlormadinone acetate has a strong anti-gonadotropic effect, through negative feedback on gonadotropin secretion, and has been used for more than 20 years alone for contraception in arterial risk patients. The clinical and metabolic tolerability of CMA has been demonstrated in numerous clinical studies with duration of treatment of up to 2.5 years.
The more recent application of CMA as an oral contraceptive in combination with EE (Neo Eunomin, Belara) has proven highly successful, with studies reporting excellent contraceptive efficacy, high tolerability and adherence due to a good side effect profile and positive effects on preexisting dysmenorrhea, skin and hair conditions.
 
Chlormadinone Acetate Application:
 
Chlormadinone acetate (CMA) is a derivative of naturally secreted progesterone that shows high affinity and activity at the progesterone receptor. It has an anti-estrogenic effect and, in contrast to natural progesterone, shows moderate anti-androgenic properties. CMA acts by blocking androgen receptors in target organs and by reducing the activity of skin 5alpha-reductase. It suppresses gonadotropin secretion and thereby reduces ovarian and adrenal androgen production. CMA shows high contraceptive efficacy by inhibiting ovulation due to its ability to suppress or disrupt endogenous gonadotropin secretion and, by this, inhibits follicular growth and maturation. In addition, it suppresses endometrial thickness and increases the viscosity of cervical mucus.
 

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Purity 99% Medical Androsterone Androgenic Prohormone Steroids 53-41-8

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Purity 99% Medical Androsterone Androgenic Prohormone Steroids 53-41-8 
 
Androsterone Basic Info.:
 
Product Name: Androsterone
Synonyms: 3-alpha-hydroxy-17-androstanone;3alpha-Hydroxy-17-androstanone;3-alpha-hydroxy-5-alpha-androstan-17-on;3-Epihydroxyetioallocholan-17-one;3-hydroxy-,(3-alpha,5-alpha)-androstan-17-on;3-hydroxy-,(3alpha,5alpha)-androstan-17-on;5alpha-Androstan-17-one, 3alpha-hydroxy-;5alpha-Androstane-3alpha-ol-17-one
CAS: 53-41-8
MF: C19H30O2
MW: 290.44
EINECS: 200-173-4
Melting point: 181-184 °C(lit.)
Alpha: 96 º (c=1, C2H5OH)
Storage temp.: -20°C
Chemical Properties: white to light beige crystalline powder.
Usage: It was isolated from male urine after removed of the phenolic estrogen fraction. Antihypertensor.
Product Categories: Steroids;Steroids & Hormones - 13C & 2H;Intermediates & Fine Chemicals;Pharmaceuticals.
 
Androsterone Description:
 
Androsterone, or 3α-hydroxy-5α-androstan-17-one, is an endogenous steroid hormone, neurosteroid, and putative pheromone. It is a weak androgen with a potency that is approximately 1/7th that of testosterone. In addition, it can be converted to dihydrotestosterone (DHT) from 3α-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase, bypassing conventional intermediates such as androstenedione and testosterone, and as such, can be considered to be a metabolic intermediate in its own right. 
Androsterone is also known to be an inhibitory androstane neurosteroid, acting as a positive allosteric modulator of the GABAA receptor, and possesses anticonvulsant effects. The unnatural enantiomer of androsterone is more potent as a positive allosteric modulator of GABAA receptors and as an anticonvulsant than the natural form. Androsterone's 3β-isomer is epiandrosterone, and its 5β-epimer is etiocholanolone.
 
Androsterone Applications:
 
Androsterone is one of the androgens, which are steroid hormones that affect the masculinization of the fetus and child and that maintain or create masculine traits in adults. Testosterone is the most active and abundant of the androgens. Androsterone was originally isolated from male urine in very small amounts. Many scientists believe it to be a metabolic byproduct of the breakdown of testosterone, and many scientists who study pheromones think it might be active in human relations.
 
A molecule of androsterone is very similar to testosterone. It consists of three six-member carbon rings and one five member ring joined along common sides. The molecular formula is C19 H30 O2. It has a beta-isomer called epiandrosterone, in which an hydroxyl group occupies a different geometric position. 
 
The ratio of androsterone to epiandrosterone is thought to be important in how masculine behavior is interpreted by others Pheromones are well known in insect behavior. Their role in insect mating, navigation and nest protection has been studied, and active compounds have been isolated. Pheromones are the basis of some insect baits. Their effect on mammal behavior patterns is less well understood.
 

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