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Sarms Powder Steroids Pirfenidone 53179-13-8 Anti Fibrosis

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Sarms Powder Steroids Pirfenidone 53179-13-8 Anti Fibrosis 
 
Pirfenidone Basic information
 
Product Name: Pirfenidone
Synonyms: 5-methyl-1-phenyl-2(1h)-pyridon;amr-69;PIRFENIDONE;5-METHYL-1-PHENYL-1H-PYRIDIN-2-ONE;5-METHYL-1-PHENYL-2(1H)-PYRIDINONE;5-METHYL-1-PHENYL-2-(1H)-PYRIDONE;5-Methyl-N-phenyl-2-1H-pyridone;Pirfenidone also see 5-Methyl-1-Phenyl-2(1H)-Pyridinone
CAS: 53179-13-8
MF: C12H11NO
MW: 185.22
EINECS: N/A
Melting point: 96-97°C
Storage temp.: Store at RT
Solubility: DMSO: ≥10 mg/mL, Soluble
Chemical Properties: Off-White Solid
Usage: Pirfenidone has demonstrated activity in multiple fibrotic conditions, including those of the lung, kidney and liver
Product Categories: Aromatics Compounds;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Cytokine signaling;Inhibitors.
 
Pirfenidone Description:
 
Pirfenidone (INN, BAN) is an anti-fibrotic drug for the treatment of idiopathic pulmonary fibrosis (IPF). It works by reducing lung fibrosis through downregulation of the production of growth factors and procollagens I and II.
 
It is a drug developed by several companies worldwide, including InterMune Inc. (now part of Roche), Shionogi Ltd., and GNI Group Ltd. In 2008, it was first approved in Japan for the treatment of IPF after clinical trials, under the trade name of Pirespa by Shionogi & Co. In October 2010, the Indian Company Cipla launched it as Pirfenex. In 2011, it was approved for use in Europe for IPF; it was approved in Canada in 2012 ; and was approved in the United States in October 2014 under the same name. In September 2011, the Chinese State Food and Drug Administration provided GNI Group Ltd with new drug approval of pirfenidone in China, and later manufacture approval in 2013 under the trade name of Etuary.
 
In 2014 it was approved in Mexico under the name KitosCell LP, indicated for pulmonary fibrosis and liver fibrosis.There is also a topical form created for the treatment of abnormal wound healing processes.
 
Pirfenidone Application:
 
In vitro, pirfenidone can inhibit the uterine flesh tumour cells and leiomyoma cells proliferation. Pirfenidone can inhibit the TGF - beta - 1 inducing fibroblast collagen formation. Inhibition of PDGF, FGF and TGF - beta - 1 inducing fibroblast proliferation. In hamster model, pirfenidone, taken by mouth, that can the prevention and treatment of pulmonary fibrosis . Pirfenidone can prevent the sclerosing peritonitis in rats induced by chemical, can also be keloid grafting for the treatment of nude mice. Pirfenidone 0.01 1 mg/ml can suppress the matrix and dose dependent manner serum stimulate uterine fibroids and leiomyoma cell DNA synthesis, the compound has no cytotoxic effect, has no effect on collagen mRNA level also. Pirfenidone in hamster pulmonary fibrosis model can reduce the disease before the collagen I mRNA level enhancement, reduce the level of the lung hydroxyproline and malondialadehyde and lung preserved ammonia acyl hydroxylase activity.
 

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Serine/threonine-protein kinase B-raf (586-614) LAB GRADE 97%

Creative peptides is specialized in the process development and the manufacturing of bioactive peptides. We offer custom peptide synthesis, process development, GMP manufacturing as well as catalog products. We supply Serine/threonine-protein kinase B-raf (586-614).http://www.creative-peptides.com/product/serine-threonine-protein-kinase-b-raf-item-ta-189-13259.html

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Tau Peptide (255-314) (Repeat 2 Domain) (human) LAB GRADE 98%

Creative peptides is specialized in the process development and the manufacturing of bioactive peptides. We offer custom peptide synthesis, process development, GMP manufacturing as well as catalog products. We provide Tau Peptide (255-314) (Repeat 2 Domain) (human). More information please visit the website:http://www.creative-peptides.com/product/tau-peptide-repeat-domain-human-item-cad-055-33779.html

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39S ribosomal protein L34, mitochondrial (58-66) LAB GRADE 97%

Creative peptides is specialized in the process development and the manufacturing of bioactive peptides. We offer custom peptide synthesis, process development, GMP manufacturing as well as catalog products. We supply 39S ribosomal protein L34, mitochondrial (58-66).http://www.creative-peptides.com/product/39s-ribosomal-protein-l34-mitochondrial-item-ta-070-2982.html

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Cell division cycle protein 27 homolog (760-771) LAB GRADE 97%

Creative peptides is specialized in the process development and the manufacturing of bioactive peptides. We offer custom peptide synthesis, process development, GMP manufacturing as well as catalog products. We supply Cell division cycle protein 27 homolog (760-771).http://www.creative-peptides.com/product/cell-division-cycle-protein-homolog-item-ta-193-13494.html

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Global Hot Sell Anti Aging Coenzyme Q10 / Ubiquinol 303-98-0

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Global Hot Sell Anti Aging Coenzyme Q10 / Ubiquinol 303-98-0

Coenzyme Q10 Basic Info.:

Product Name: Coenzyme Q10

Synonyms: LABOTEST-BB LT00244787;COQ10;COENZYME Q10;Q-10;Q10 COENZYME;UBIDECARENONE;UBIQUINONE;UBIQUINONE-10 

CAS: 303-98-0 

MF: C59H90O4 

MW: 863.34 

EINECS: 206-147-9 

Chemical Properties Yellow-Orange Crystalline Powder 

Usage antioxidant, cardiovascular agent 

Usage Antibacterial and antioxidant for preventing and treating cancer. 

Usage Antibacterial, antioxidant 

Biological Activity Component of the mitochondrial transporter chain that behaves as a powerful antioxidant. Displays neuroprotective activity.

Ubidecarenone Details Of Coenzyme Q10:

Coenzyme Q10 (CoQ10 or ubiquinone) has a low risk of side effects and it is an essential vitamin-like substance with many health benefits. 

It is proven helpful in treating heart-related problems such as congestive heart failure and to lower high blood pressure. 

Coenzyme Q10 is a quinone, which is a substance that helps provide energy to cells in all oxygen-breathing organisms. Researchers first discovered coenzyme Q10 in 1957, and first named it ubiquinone, 

Because it was a quinone that was found in every cell of the body (the prefix ubi means everywhere). 

Later studies showed that ubiquinone acts as a coenzyme in the body, without which the three enzymes that provide energy to the body cannot function. 

Coenzyme Q10 Benefits: 

1. Anti-Aging As a strong antioxidant Q10 protects cells from chemicals and other harmful factors. 

2. Anti-oxidant Q10 naturally prevents our body and cells from free radicals damage and works as a shield against harmful effects. 

3. Muscles are also in need of this enzyme, due to its energy boosting quality. Experiments proved that people who had a balanced Q10 level were more energetic and vigorous 

4. Heart-related problems It is proven helpful in treating heart-related problems such as congestive heart failure and to lower high blood pressure. 

5. Improves immunity and can dramatically slow tumor growth. 

Coenzyme Q10 Application: 

1. Applied in pharmaceutical field, it can be used for treating cardiovascular disease. 

2. Applied in Cosmetics, it can be sued for skin whitening, removing wrinkling and slowing down ageing. 

 

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High Purity Dutasteride Avodart For Bodybuilding 164656-23-9

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Microtubule-Associated Protein (142-161) (human) LAB GRADE 98%

Creative peptides is specialized in the process development and the manufacturing of bioactive peptides. We offer custom peptide synthesis, process development, GMP manufacturing as well as catalog products. We provide Microtubule-Associated Protein (142-161) (human). More information please visit the website:http://www.creative-peptides.com/product/microtubule-associated-protein-human-item-cad-046-33770.html

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Nicotinamide Adenine Dinucleotide, Disodium Salt LAB GRADE 95%

NADH, Disodium Salt functions as a coenzyme of a large number of oxidoreductases.

NADH is the reduced form of nicotinamide adenine dinucleotide (NAD) that can donate electrons as part of a reducing reaction. In that process, NADH becomes oxidized to produce beta-NAD. A variety of enzymes use NADH plus Hydrogen ion to reduce substrates, generating beta-NAD as well as the reduced product. For example, NADH:ubiquinone oxidoreductase accepts two electrons from NADH and passes them to ubiquinone (coenzyme Q) as part of the mitochondrial electron transport chain.

NADH is a coenzyme that functions as a regenerating electron donor in catabolic processes including glycolysis, beta-oxidation and the citric acid cycle. As a reagent, NADH can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations.

β-Nicotinamide adenine dinucleotide (NAD) and β-Nicotinamide adenine dinucleotide, reduced (NADH) comprise a coenzyme redox pair (NAD:NADH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. In addition to its redox function, NAD/NADH is a donor of ADP-ribose units in ADP-ribosylaton (ADP-ribosyltransferases; poly(ADP-ribose) polymerases ) reactions and a precursor of cyclic ADP-ribose (ADP-ribosyl cyclases).
As a reagent, NADH can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations.

Molecular Formula: C21H29N7O14P2 • 2Na
Formula Weight: 711.4

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