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Phenacetin Pharmaceutical Intermediates BP Grade Antipyretic Analgesic 62-44-2

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Phenacetin Pharmaceutical Intermediates BP Grade Antipyretic Analgesic 62-44-2
 
1. Phenacetin Quick Detail:
 
Product Name: Phenacetin
CAS: 62-44-2
EINECS Number: 200-533-0
Formula: C10H13NO2
MW: 179.2157
Density: 1.099g / cm3
Melting point: 133-138 °C
Boiling point: 355.1 °C at 760 mmHg
Flash Point: 168.5 °C
Water-soluble: 0.076 g / 100 mL
Vapor Pressure: 3.21E-05mmHg at 25 °C
Uses: Anti-inflammatory drugs
Assay: 99%
Appearance: White or almost white crystalline powder
 
2. Phenacetin Descriptions:
 
Phenacetin is a pain-relieving and fever-reducing drug, widely used from its introduction in 1887 until banned in the US by the FDA in 1983. Its use has declined because of its adverse effects, which include increased risk of certain cancers and kidney damage. It is metabolized into paracetamol, which replaced it in some over-the-counter medications following the ban on phenacetin.
 
3. Applications of Phenacetin:
 
Phenacetin was widely used until the third quarter of the twentieth century, often in the form of an "A.P.C." or aspirin-phenacetin-caffeine compound analgesic, as a remedy for fever and pain. An early formulation (1919) was Vincent's APC in Australia. However the U.S. Food and Drug Administration ordered the withdrawal of drugs containing phenacetin in November 1983, owing to its carcinogenic and kidney-damaging properties (Federal Register of October 5, 1983 (48 FR 45466)).
 
It was also banned in India.As a result some branded, previously phenacetin-based preparations continued to be sold, but with the phenacetin replaced by safer alternatives. A popular brand of phenacetin was Roche's Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol and caffeine. Coricidin was also reformulated without phenacetin. Paracetamol is a metabolite of phenacetin with similar analgesic and antipyretic effects, but the new formulation has not been found to have phenacetin's carcinogenicity.
 
Phenacetin is now being used as a cutting agent to adulterate cocaine in the UK and Canada, owing to the similar physical features of the two drugs.Due to low cost phenacetin is used for research into the physical and refractive properties of crystals. It is an ideal compound for this type of research.
 

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T3 Fat Loss Steroid 98% Liothyronine Sodium Herbal Weight Loss Powders 55-06-1

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T3 Fat Loss Steroid 98% Liothyronine Sodium Herbal Weight Loss Powders 55-06-1
Organic Herbal Weight Loss Powders For Tablet / Capsule Liothyronine Sodium 
 
Liothyronine Sodium Basic Info.
 
Product Name: Liothyronine Sodium
Alias : T3 Sodium Salt; T3,Na; Liothyronine Sodium; Liothyronine Sodium Salt; Cytomel T3 
CAS NO: 55-06-1
MF: C15H11I3NNaO4
MW: 672.96
Einecs No: 200-223-5
Purity: 99%
Melting point: 205°C (dec.)(lit.)
Alpha: 20°(c=2,alcohol/1.2N HCl)
Storage temp.: 2-8°C
Solubility: 4 M NH4OH in methanol: 125 g/5mL, clear, yellow-brown
Appearance: white to beige powder, almost tasteless.
Product Categories: Amino Acids & Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;Steroid and Hormone;Isolabel;Other APIs.
Usage: 
(1)One of the hormones produced by the thyroid gland that is involved in the maintenance of metabolic homeostasis. Also produced in peripheral tissues as the active metabolite of Thyroxine.
(2)Cytochrome P450 inhibitor, Ca antagonist, anesthetic (local)Product 
 
Liothyronine Sodium Description :
 
Triiodothyronine, also known as T3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate.
 
Production of T3 and its prohormone thyroxine (T4) is activated by thyroid-stimulating hormone (TSH), which is released from the pituitary gland. This pathway is regulated via a closed-loop feedback process: Elevated concentrations of T3, and T4 in the blood plasma inhibit the production of TSH in the pituitary gland. As concentrations of these hormones decrease, the pituitary gland increases production of TSH, and by these processes, a feedback control system is set up to regulate the amount of thyroid hormones that are in the bloodstream.
 
As the true hormone, the effects of T3 on target tissues are roughly four times more potent than those of T4.Of the thyroid hormone that is produced, just about 20% is T3, whereas 80% is produced as T4. Roughly 85% of the circulating T3 is later formed in the thyroid by removal of the iodine atom from the carbon atom number five of the outer ring of T4. In any case, the concentration of T3 in the human blood plasma is about one-fortieth that of T4. This is observed in fact because of the short half-life of T3, which is only 2.5 days.This compares with the half-life of T4, which is about 6.5 days.
 
Liothyronine Sodium Application:
 
High Purity Liothyronine sodium/Cytomel T3/3,3',5´╝Źtriiodothyronine sodium/CAS No: 55-06-1 200-223-5 Weight Loss Powders
Liothyronine is the most potent form of thyroid hormone. Chemically, it is nearly identical to triiodothyronine (T3). As such, it acts on the body to increase the basal metabolic rate, affect protein synthesis and increase the body's sensitivity to catecholamines (such as adrenaline) by permissiveness. The thyroid hormones are essential to proper development and differentiation of all cells of the human body. These hormones also regulate protein, fat, and carbohydrate metabolism, affecting how human cells use energetic compounds.
In comparison to levothyroxine (T4), liothyronine has a faster onset of action as well as a shorter biological half-life, which may be due to less plasma protein binding to thyroxine-binding globulin and transthyretin.
 
Physicians can use this instead of or in addition to levothyroxine (T4) for patients undergoing thyroid withdrawal. When a patient has thyroid cancer or Graves' disease, ablation therapy with radioactive iodine can be used to remove any trace thyroid tissue. For 131I therapy to be effective, the trace thyroid tissue must be avid to iodine. The best method is to starve the tissue of iodine but this can lead to hypothyroid symptoms for the patient. Withdrawal from levothyroxine can be done but it takes six weeks of withdrawal for the remaining thyroid tissue to be completely starved. Six weeks is needed owing to levothyroxine's long half life. Six weeks can be inconvenient for the patient and delay treatment. Liothyronine instead can be taken and withdrawn from for two weeks to starve the thyroid tissue. This is much safer and more convenient than levothyroxine.
 

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6-Oxo Muscle Building Steroids 4-Androstene-3 to Increase Muscle Mass 2243-06-3

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6-Oxo Muscle Building Steroids 4-Androstene-3 to Increase Muscle Mass 2243-06-3
 
6-OXO Basic Info.
 
Product Name: 6-OXO
Alias: 4-androstene-3, 6, 17- trione; Androst-4-ene-3, 6, 17-trione; 4-Androstenetrione; 4-Androstenetriol
CAS: 2243-06-3
Molecular Weight: 300.39
Molecular Formula: C19H24O3
Melting Point: 223-224° C
Package: Foil bag or tin, or as you require
Properties: White powder
Usage: Steroid drug intermediates. Low Estrogen Levels. 
Payment: T/T, Western Union and Money Gram
Delivery: Within 12hours After Your Payment
Express: EMS, DHL, FedEx, etc(door-to-door) 
 
6-OXO Description:
 
6 OXO refer to the same chemical compound that is a steroidal testosterone booster/anti-aromatase agent. First identified in cow adrenal glands it was further found to be a natural metabolite of androstenedione metabolism in humans and most mammals. This makes 6 OXO a perfectly legal dietary supplement under the current DSHEA law and since it is not androgenic, not at all an anabolic steroid. What 6 OXO does is reduce an enzyme in the body that turns your testosterone into estrogen. By blocking this enzyme two major things happen, first it causes you to keep more of your testosterone and second, the body senses a lack of estrogen and causes the testes to release more testosterone.
 
6 OXO has been well studied in men and the original manufacturer of 6 OXO, Ergopharm Inc actually paid for quite a few studies in both men and rats. The most telling one was done by Incledon, which studied 6 OXO in doses of 300mg in healthy men, then measured the effects. The Incledon study found a boost of testosterone of about 200% with a slight reduction in estradiol, which means it was very effective at boosting testosterone while reducing estrogen. This was the first really well tested testosterone booster on the market.
 
Applications Of 6-OXO:
 
Study delivered a dose of 50 mg of 1-DHEA for 10 months with no serious adverse events reported.
1-DHEA was administered at a dose of 200 mg/day for 24 weeks with slight androgenic effects noted.
 

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Carcinoembryonic antigen-related cell adhesion molecule 5 (691-699) LAB GRADE 97%

Creative peptides is specialized in the process development and the manufacturing of bioactive peptides. We offer custom peptide synthesis, process development, GMP manufacturing as well as catalog products. We supply Carcinoembryonic antigen-related cell adhesion molecule 5 (691-699).http://www.creative-peptides.com/product/carcinoembryonic-antigen-related-cell-adhesion-molecule-item-ta-240-16190.html

 

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Cleavage and polyadenylation specificity factor subunit 1 (250-258) LAB GRADE 97%

Creative peptides is specialized in the process development and the manufacturing of bioactive peptides. We offer custom peptide synthesis, process development, GMP manufacturing as well as catalog products. We supply Cleavage and polyadenylation specificity factor subunit 1 (250-258).http://www.creative-peptides.com/product/cleavage-and-polyadenylation-specificity-factor-subunit-item-ta-316-21538.html

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High Quality Local Anesthetic Prilocaine Hydrochloride Prilocaine HCl 1786-81-8

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High Quality Local Anesthetic Prilocaine Hydrochloride Prilocaine HCl 1786-81-8
 
Prilocaine HCL Basic Info.:
 
Product Name: Prilocaine HCL
CAS: 1786-81-8
English name: Propitocaine hydrochloride
Other name: Prilocaine hydrochloride; 2 - propylamine base - o C amide toluene hydrochloride; Prilocaine hydrochloride; Prilocaine hydrochloride
Molecular formula: C13H21ClN2O
EINECS: 217-244-0
Molecular Weight: 256.7716
 
Prilocaine HCL Description:
 
Propitocaine hydrochloride is a local anesthetic of the amino amide type first prepared by Claes Tegner and Nils Lö Fgren. In its injectable form, it is often used in dentistry. It is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia. As it has low cardiac toxicity, it is commonly used forintravenous regional anaesthesia.
 
In some patients, a metabolite of prilocaine may cause the unusual side effect of methemoglobinemia, which may be treated with methylene blue.
 
Local anesthetic is a substance that causes loss of sensation only to the area to which it is applied without affecting consciousness. Most local anesthetics structures have amino-ester or an amino-amide group which are linked to hydrophilic (secondary or tertiary amine) and to hydrophobic group (aromatics) on the other side.
 
Local anesthetics, long duration, lower toxicity, chemicals that are also small Suitable for epidural anesthesia, block anesthesia and infiltration anesthesia, etc.
 

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Parkinson Disease Treatment Pramipexole Dihydrochloride Monohydrate 104632-25-9

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Pharmaceutical Raw Materials Cabergoline 81409-90-7 Used To Parkinson's Disease

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Pharmaceutical Raw Materials Cabergoline 81409-90-7 Used To Parkinson's Disease
 
Cabergoline Basic Info.:
 
Product Name: Cabergoline
Synonyms: Cabergoline;Cabaser;Dostinex;Dostine;FCE-21336
CAS: 81409-90-7
MF: C26H37N5O2
MW: 451.6
Purity: 99%
Melting Point: 102-104°C
Storage temp.: Store at +4°C
Chemical Properties: White Crystalline Solid
Product Categories: Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals;API.
Usage: A dopamine D2-receptor agonist.Receptor stimulant.
Packing: Foil bag or as requirments.
 
Cabergoline Description:
 
Cabergoline is a dopamine agonist designed to reduce prolactin. In medical circles it is commonly used to combat prolactinomas, a benign tumor of the pituitary gland that may cause an excess production of prolactin. It is also used by athletes who supplement with anabolic steroids that may increase prolactin levels 
 
Cabergoline, most commonly sold under the brand name Dostinex, is not a new drug as it was first developed in 1981 by the Italian drug manufacture Farmitalia-Carlo Erba Spa. The drug was later acquired by Pharmacia and then found its resting place with Pfizer in 2002.
 
Cabergoline Functions and Traits:
 
As a dopamine agonist, Cabergoline directly correlates with the long acting D2 receptor thereby inhibiting the secretion of prolactin in the body and in turn lowering serum prolactin levels. As a dopamine agnonist, Cabergoline is used to treat Parkinson's disease, hyperprolactinaemia (abnormally high levels of prolactin in the blood), Cushing's disease and as mentioned prolactinomas.
 
Cabergoline's direct function (specifics) is in that it inhibits prolactin secretion in the pituitary's lactotroph cells. It really is a very simple drug and what's simpler or perhaps interesting is that the simple medication was discovered almost accidently during experiments with ergot alkaloids.
 
Uses in Medicine:
 
There are many uses that the medical world is discovering for dostinex. They include hyperprolactinemia, prolactin producing tumors, Parkinson's disease, Cushing's disease, and a myriad of other ailments.
 
One of the best known uses for cabergoline is in tumors and cancers related to high prolactin levels. In fact, it's been an industry leading drug when it comes to shrinking prolactin-secreting macroadenomas.
 
Bodybuilding Uses:
 
There are several ways we can use caber in bodybuilding. Since it is a dopamine agonist, some athletes believe they can take it to give themselves an adrenaline rush during a sporting event. Also, the addition of dopamine can improve motor skills and give you an edge over your competition. In theory, you will be able to workout much harder and be able to ignore pain pushing your muscles to the limit.
 
The main way bodybuilders use cabergoline is when they run a compound which increases prolactin levels in the body. Trenbolone will turn into prolactin, and, when abused, you can get prolactin based gynecomastia. In addition, a spike in prolactin can cripple your sex drive. Even when you do not run a compound that increases prolactin, caber can still help normalize your libido when you are playing with your hormones.
 
Another way caber can be used in bodybuilding is by its mechanism of mimicking dopamine being produced from food intake. Ever had a craving for New York style greasy pizza, oreo ice cream or some other treat you know you shouldn't have? Well, when you take cabergoline, the dopamine being released can act as the pleasure chemical, which can make a bite of that pizza satisfy you rather than eating the whole pie. This aids weight loss goals and helps you stay lean.
 
And finally, sleep! Many bodybuilders who take cabergoline report improved sleep thanks to the dopamine mimic. This allows you to sleep more, deeper and longer.
 

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Women Prohormones Steroids Progestone Progesterone Hormon Altrenogest 850-52-2

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Women Prohormones Steroids Progestone Progesterone Hormon Altrenogest 850-52-2 
 
Altrenogest Basic Info.
 
Product Name: Altrenogest 
CAS No.: 850-52-2  
Formula: C21H26O2  
Molecular Weight: 310.47  
EINECS: 212-703-1  
Density: 1.15 g/cm3  
Boiling Point: 495.6 °C at 760 mmHg  
Flash Point: 210.1 °C    
Storage: store in cool, dry, ventilated place.
PackAge: Foil Bag or According to Your Requirements.
 
Altrenogest Application:
 
Altrenogest is indicated (labeled) to suppress estrus in mares to allow a more predictable occurrence of estrus following withdrawal of the drug. It is used clinically to assist mares to establish normal cycles during the transitional period from anestrus to the normal breeding season often in conjunction with an artificial photoperiod. It is more effective in assisting in pregnancy attainment later in the transition period. One group of authors (Squires et al. 1983) suggest selecting mares with considerable follicular activity (mares with one or more follicles 20 mm or greater in size) for treatment during the transitional phase. Mares that have been in estrus for 10 days or more and have active ovaries are also considered to be excellent candidates for progestin treatment.
 
Altrenogest is effective in normally cycling mares for minimizing the necessity for estrus detection, for the synchronization of estrus and permitting scheduled breeding. Estrus will ensue 2-5 days after treatment is completed and most mares ovulate between 8-15 days after withdrawal. Altrenogest is also effective in suppressing estrus expression in show mares or mares to be raced. Although the drug is labeled as contraindicated during pregnancy, it has been demonstrated to maintain pregnancy in oophorectomized mares and may be of benefit in mares who abort due to sub-therapeutic progestin levels.
 
Altrenogest Adverse Effects/Warnings:
 
Adverse effects of altrenogest appear to be minimal when used at labeled dosages. One study (Shideler et al. 1983) found negligible changes in hematologic and most "standard" laboratory tests after administering altrenogest to 4 groups of horses (3 dosages, 1 control) over 86 days. Occasionally, slight changes in Ca++, K+, alkaline phosphatase and AST were noted in the treatment group, but values were only slightly elevated and only noted sporadically. No pattern or definite changes could be attributed to altrenogest. No outward adverse effects were noted in the treatment group during the trial.
 
The following people should not handle the product:
1).Women who are or suspect that they are pregnant
2).Anyone with thrombophlebitis or thromboembolic disorders or with a history of these events
3).Anyone having cerebrovascular or coronary artery disease
4).Women with known or suspected carcinoma of the breast
5).People with known or suspected estrogen-dependent neoplasia
6).Women with undiagnosed vaginal bleeding
7).People with benign or malignant tumor which developed during the use of oral contraceptives or other estrogen containing products.
 

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98% Injectable Polypeptide Hormones Eptifibatide Raw Steroid Powders 148031-34-9

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98% Injectable Polypeptide Hormones Eptifibatide Raw Steroid Powders 148031-34-9
 
Eptifibatide Basic Info.
 
Product Name: Eptifibatide
Synonyms: Human Eptifibatide; Eptifitide
Sequence: Mpr-Har-Gly-Asp-Trp-Pro-Cys-NH2
Cas No.: 148031-34-9
Molecular Formula: C35H49N11O9S2
Molecular Weight: 831.96
Appearance: White slightly yellwish powder.
Specific Rotation[20/D]: -75.0~-95.0°(C=1,1%HAc)
Amino Acids composition: ± 10%
Peptide Purity (By HPLC): >98% by area integration.
Related Substance (By HPLC): Total Impurities (%)<2.0%;Largest Single Impurity (%)< 1.0%
Water Content (Karl Fischer): <8.0%
Peptide Content(N determination): >80%
Acetate Content: <15%
IR spectrum: in accordance
Grade : Pharmaceutical Grade
Storage: Closed, below 2 ~ 8ºC preservation
Usage : Platelet glycoprotein receptor antagonist model, the third generation of antiplatelet drugs. For acute coronary syndrome (including unstable angina or non Q wave myocardial infarction) or percutaneous coronary interventional therapy (including angioplasty or atheromatous plaque excision).
 
Description Of Eptifibatide:
 
Eptifibatide (Integrilin, Millennium Pharmaceuticals, also co-promoted by Schering-Plough/Essex), is an antiplatelet drug of the glycoprotein IIb/IIIa inhibitor class.[1] Eptifibatide is a cyclic heptapeptide derived from a protein found in the venom of the southeastern pygmy rattlesnake (Sistrurus miliarius barbouri). It belongs to the class of the so-called arginin-glycin-aspartat-mimetics and reversibly binds to platelets. Eptifibatide has a short half-life. The drug is the third inhibitor of GPIIb/IIIa that has found broad acceptance after the specific antibody abciximab and the non-peptide tirofiban entered the global market.
Integrilin is sold in two strengths, globally: vials containing 2 mg/ml (20 mg totally) and 0.75 mg/ml (75 mg totally).
 
Application Of Eptifibatide:
 
Eptifibatide is used to reduce the risk of acute cardiac ischemic events (death and/or myocardial infarction) in patients with unstable angina or non-ST-segment-elevation (e.g., non-Q-wave) myocardial infarction (i.e., non-ST-segment elevation acute coronary syndromes) both in patients who are to receive non surgery (conservative) medical treatment and those undergoing percutaneous coronary intervention (PCI).
 
The drug is usually applied together with aspirin or clopidogrel and (low molecular weight or unfractionated) heparin. Additionally, the usual supportive treatment consisting of applications of nitrates, beta-blockers, opioid analgesics and/or benzodiazepines should be employed as indicated. Angiographic evaluation and other intensive diagnostic procedures may be considered a first line task before initiating therapy with eptifibatide.
 

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