Pharmaceutical raw materials used in synthesizing new medications

chemical-categories

6-Bromoindolin-2-one USP > 98 %

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6-Chloro 2-Hexanone (1C5H) Purified Above 98

Synonyms
Chlorohexanone;6-Chloro-2-hexanol;1-CHLOROHEXAN-5-ONE;1-CHLORO-5-HEXANONE;6-CHLORO-2-HEXANONE;6-CHLOROHEXAN-2-ONE;1-Chlorohexane-5-one;2-Hexanone, 6-chloro-;6-CHLORO-2-HEXANONE,98%;6-Chloro-2-hexanone 97%

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6-Oxo Muscle Building Steroids 4-Androstene-3 to Increase Muscle Mass 2243-06-3

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6-Oxo Muscle Building Steroids 4-Androstene-3 to Increase Muscle Mass 2243-06-3
 
6-OXO Basic Info.
 
Product Name: 6-OXO
Alias: 4-androstene-3, 6, 17- trione; Androst-4-ene-3, 6, 17-trione; 4-Androstenetrione; 4-Androstenetriol
CAS: 2243-06-3
Molecular Weight: 300.39
Molecular Formula: C19H24O3
Melting Point: 223-224° C
Package: Foil bag or tin, or as you require
Properties: White powder
Usage: Steroid drug intermediates. Low Estrogen Levels. 
Payment: T/T, Western Union and Money Gram
Delivery: Within 12hours After Your Payment
Express: EMS, DHL, FedEx, etc(door-to-door) 
 
6-OXO Description:
 
6 OXO refer to the same chemical compound that is a steroidal testosterone booster/anti-aromatase agent. First identified in cow adrenal glands it was further found to be a natural metabolite of androstenedione metabolism in humans and most mammals. This makes 6 OXO a perfectly legal dietary supplement under the current DSHEA law and since it is not androgenic, not at all an anabolic steroid. What 6 OXO does is reduce an enzyme in the body that turns your testosterone into estrogen. By blocking this enzyme two major things happen, first it causes you to keep more of your testosterone and second, the body senses a lack of estrogen and causes the testes to release more testosterone.
 
6 OXO has been well studied in men and the original manufacturer of 6 OXO, Ergopharm Inc actually paid for quite a few studies in both men and rats. The most telling one was done by Incledon, which studied 6 OXO in doses of 300mg in healthy men, then measured the effects. The Incledon study found a boost of testosterone of about 200% with a slight reduction in estradiol, which means it was very effective at boosting testosterone while reducing estrogen. This was the first really well tested testosterone booster on the market.
 
Applications Of 6-OXO:
 
Study delivered a dose of 50 mg of 1-DHEA for 10 months with no serious adverse events reported.
1-DHEA was administered at a dose of 200 mg/day for 24 weeks with slight androgenic effects noted.
 

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60S ribosomal protein L30 (95-115) LAB GRADE 97%

Creative peptides is specialized in the process development and the manufacturing of bioactive peptides. We offer custom peptide synthesis, process development, GMP manufacturing as well as catalog products. We supply 60S ribosomal protein L30 (95-115).http://www.creative-peptides.com/product/60s-ribosomal-protein-l30-item-ta-109-5185.html

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7-ethyl-10-hydroxycamptothecine >99%

Product Name: 7-Ethyl-10-hydroxycamptothecin
CAS No.: 86639-52-3
Other Name: SN38
Formula: C22H20N2O5
Formula Weight: 392.4
Appearance: Pale yellow crystalline powder
Structure: structue of 7-Ethyl-10-hydroxycamptothecin sn38 CAS NO.:86639-52-3.
Assay: ≥ 99.0%
Storage Store at +4°C

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72 kDa type IV collagenase (560-568) LAB GRADE 97%

Creative peptides is specialized in the process development and the manufacturing of bioactive peptides. We offer custom peptide synthesis, process development, GMP manufacturing as well as catalog products. We supply 72 kDa type IV collagenase (560-568).http://www.creative-peptides.com/product/kda-type-iv-collagenase-item-ta-376-28387.html

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9-Fluorenone[486-25-9]

CAS号: 486-25-9
分子式: C13H8O
分子量: 180.2

 

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96-48-0 GBL Intermediate GBL Wheel Cleaner Gamma Butyrolactone

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96-48-0 GBL Intermediate GBL Wheel Cleaner Gamma Butyrolactone
 
Gamma Butyrolactone Basic Info.:
 
Product Name: Gamma-Butyrolactone
Alias: Gamma Butyrolactone, 1, 4- Butyrolactone, γ -Butyroladone, GBL, BLO
CAS: 96-48-0
MF: C4H6O2
MW: 86.09
Einecs: 202-509-5
Purity : 99.5%
Melting Point:-44°C
Boiling Point:206°C
Flash Point:99.2°C
Ignition temperature:455°C
Refractive Index:nd20 :1.434~1.440
Density 1.12 g/mL at 25 °C(lit. )
Storage temp. 2-8°C
Chemical Properties: Colorless clear oily liquid with acetone-like odor
 
Gamma Butyrolactone Description:
 
Gamma-Butyrolactone (γ-butyrolactone or GBL) is a hygroscopic colorless liquid with a weak characteristic odor which is soluble in water. GBL is a common solvent and reagent in chemistry as well as being used as a flavouring, as a cleaning solvent, as a superglue remover, and as a solvent in some wet aluminium electrolytic capacitors. In humans it acts as a prodrug for GHB, and it is used as a recreational intoxicant with effects similar to alcohol.
 
GBL has been found in extracts from samples of unadulterated wines. This finding indicates that GBL is a naturally occurring component in some wines and may be present in similar products. The concentration detected was approximately 5 μg/mL and was easily observed using a simple extraction technique followed by GC/MS analysis. GBL can be found in cheese flavourings but typically results in a content of 0.0002% GBL in the final foodstuff.
 
GBL is a lactone. It is hydrolyzed under basic conditions, for example in a sodium hydroxide solution into sodium gamma-hydroxybutyrate, the sodium salt of gamma-hydroxybutyric acid. Under acidic conditions it forms an equilibrium mixture of both compounds. These compounds then may go on to form a polymer. When treated with a non-nucleophilic base, like lithium diisopropylamide, GBL can become an alpha-carbon nucleophile. The related compound caprolactone can be used to make a polyester in this manner.
GBL is not active in its own right; its mechanism of action stems from its identity as a prodrug of GHB. The hypnotic effect of GHB is enhanced by combination with alcohol. A 2003 rat study showed that GBL in combination with ethanol showed a potentiated hypnotic effect, as the sleep-timing measure was longer than both of the individual components combined.
 
GBL is rapidly converted into GHB by paraoxonase (lactonase) enzymes, found in the blood. Animals which lack these enzymes exhibit no effect from GBL. GBL is more lipophilic (fat soluble) than GHB, and so is absorbed faster and has higher bioavailability. Because of these pharmacokinetic differences, GBL tends to be more potent and faster-acting than GHB, but has a shorter duration; whereas the related compound 1,4-butanediol (1,4-B) tends to be slightly less potent, slower to take effect but longer-acting than GHB.
 
Gamma Butyrolactone Uses:
 
(1) GBL can be used to produce a-pyrrolidone, 1-Methyl-2-pyrrolidinone , polyvinyl pyrrolidone, and α-Acetyl-γ-butyrolactone, etc.
(2) GBL can be used as anaesthetic and tranquilizer, used to produce ciprofloxacin and interferon, as the intermediate of vitamin and rolicyprine;
(3) GBL is the intermediate of plant growth stimulator and insecticide.
(4) GBL is a good antioxidant, plasticizer, extractant, adsorbent, dispersant, fixative and curing agent; Moreover, it can also be used in battery, capacitor and development of color film.
 

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98% Androstene Safe Steroids 11-Oxo For Muscle Building 382-45-6

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98% Androstene Safe Steroids 11-Oxo For Muscle Building 382-45-6
 
11-Oxo Basic Info.:
 
Product Name: 11-Oxo
Synonyms: Androst-4-ene-3,11,17-trione 
CAS Number: 382-45-6
Molecular Formula: C19H24O3
Molecular Weight: 300.3921
Density: 1.18g/cm3
Appearance: white crystalline powder
Package: 1kg/ Aluminum foil bag
Payment: T/T, Western Union and Money Gram
Delivery: Within 12hours After Your Payment
Express: EMS, DHL, FedEx, etc(door-to-door) 
 
11-Oxo Description:
 
Adrenosterone is a steroid hormone with weak androgenic effect first isolated in 1936 from the adrenal cortex. Adrenosterone occurs in trace amounts in humans as well as most mammals and in larger amounts in fish, where it is a precursor to the primary androgen, 11-ketotestosterone. Adrenosterone has shown to be converted into 11-ketotestosterone in humans, which contributes to adrenosterone's androgenic effects.
 
11-Oxo Applications:
 
Adrenosterone's main action is it lowers cortisol levels. Cortisol is the main catabolic (muscle-eating) hormone and it also promotes fat gain. Cortisol and testosterone also work in an inverse relationship, so high cortisol levels lower testosterone. Adrenosterone acts as a competitive inhibitor, preventing cortisone from attaching to the 11b-hydroxysteroid dehydrogenase type I reductase. By competing at the receptor, it keeps cortisone from attaching and converting to cortisol through the enzyme. Adrenosterone is found naturally in the body and is released by the adrenal glands. The body uses it as a way to help regulate cortisol levels.
 

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98% Injectable Polypeptide Hormones Eptifibatide Raw Steroid Powders 148031-34-9

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98% Injectable Polypeptide Hormones Eptifibatide Raw Steroid Powders 148031-34-9
 
Eptifibatide Basic Info.
 
Product Name: Eptifibatide
Synonyms: Human Eptifibatide; Eptifitide
Sequence: Mpr-Har-Gly-Asp-Trp-Pro-Cys-NH2
Cas No.: 148031-34-9
Molecular Formula: C35H49N11O9S2
Molecular Weight: 831.96
Appearance: White slightly yellwish powder.
Specific Rotation[20/D]: -75.0~-95.0°(C=1,1%HAc)
Amino Acids composition: ± 10%
Peptide Purity (By HPLC): >98% by area integration.
Related Substance (By HPLC): Total Impurities (%)<2.0%;Largest Single Impurity (%)< 1.0%
Water Content (Karl Fischer): <8.0%
Peptide Content(N determination): >80%
Acetate Content: <15%
IR spectrum: in accordance
Grade : Pharmaceutical Grade
Storage: Closed, below 2 ~ 8ºC preservation
Usage : Platelet glycoprotein receptor antagonist model, the third generation of antiplatelet drugs. For acute coronary syndrome (including unstable angina or non Q wave myocardial infarction) or percutaneous coronary interventional therapy (including angioplasty or atheromatous plaque excision).
 
Description Of Eptifibatide:
 
Eptifibatide (Integrilin, Millennium Pharmaceuticals, also co-promoted by Schering-Plough/Essex), is an antiplatelet drug of the glycoprotein IIb/IIIa inhibitor class.[1] Eptifibatide is a cyclic heptapeptide derived from a protein found in the venom of the southeastern pygmy rattlesnake (Sistrurus miliarius barbouri). It belongs to the class of the so-called arginin-glycin-aspartat-mimetics and reversibly binds to platelets. Eptifibatide has a short half-life. The drug is the third inhibitor of GPIIb/IIIa that has found broad acceptance after the specific antibody abciximab and the non-peptide tirofiban entered the global market.
Integrilin is sold in two strengths, globally: vials containing 2 mg/ml (20 mg totally) and 0.75 mg/ml (75 mg totally).
 
Application Of Eptifibatide:
 
Eptifibatide is used to reduce the risk of acute cardiac ischemic events (death and/or myocardial infarction) in patients with unstable angina or non-ST-segment-elevation (e.g., non-Q-wave) myocardial infarction (i.e., non-ST-segment elevation acute coronary syndromes) both in patients who are to receive non surgery (conservative) medical treatment and those undergoing percutaneous coronary intervention (PCI).
 
The drug is usually applied together with aspirin or clopidogrel and (low molecular weight or unfractionated) heparin. Additionally, the usual supportive treatment consisting of applications of nitrates, beta-blockers, opioid analgesics and/or benzodiazepines should be employed as indicated. Angiographic evaluation and other intensive diagnostic procedures may be considered a first line task before initiating therapy with eptifibatide.
 

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