Pharmaceutical raw materials used in synthesizing new medications

chemical-categories

Heptapeptide-1

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Hexadrone USP 99%

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Legit Gear Anabolic Steroids 99% Purity Powder Hexadrone For Muscle Building Body Care

Hexadrone Basic Information:

Product Name: Hexadrone

Synonyms: 6-Chloro-Androst-4-Ene-3-One--17B-Ol

MF: C19H27ClO2

MW: 322.86948

Purity: 99%

Appearance: White Crystalline Powder

Place of Origin: China

Standard: USP

Certification: SGS, GMP, ISO 9001, USP, BP

Hexadrone Description:

Hexadrone (6-alpha-chloro-andro-4-ene-17 beta-ol-3-one) is not a curse, but a 6 carbon halogenated anabolic steroid marketed as a prohormone before it can be banned. It does not convert to estrogen so aromatase has no effect, as this makes it dry it is excellent for lean mass gains, recomposition, and cutting alike. If you really want a wet sloppy bulk then don't use this. It is supposed to have a pretty strong anti-estrogenic ability similar to 6 bromo. For this reason it will dry out your whole cycle so if you want to look like Shamu this winter don't use this awesome dry AAS.

Hexadrone Function:

Unlike the other steroids falsely marketed as prohormones, this one is non-methylated. Apparently the chlorine bound to the sixth carbon stops cytochrome p450 from chewing it up, and it does not need a methyl group bound to carbon 17 to protect it from the first pass liver metabolism. Since it is NOT a prohormone and is infact an active steroid it would be smarter to make this sublingual since it doesn't need to be activated by the liver.

Hexadrone Applications:

Hexadrone is one of the next generation of legal androgens. It is extremely effective, dry, and non-methylated, it stacks well with everything, and is more than adequate for using it as a stand alone prohormone as well. 

Hexadrone is a powerful anabolic, with a high anabolic to androgenic ratio. It can't convert to estrogen which reduces the potential for many side effects, and makes it immune to the effects of the aromatase enzyme. Also, it is an intrinsically active compound with no conversion required.

Hexadrone is non-methylated which makes it easier on the liver, yet it may be resistant to some aspects of CYP-mediated metabolism due to the Chloro group at C6. 

In terms of results, Hexadrone is equal to harsher androgens such as M1, 4ADD and Halodrol, although in terms of toxicity, Hexadrone cannot even be compared to them. It is much safer and much milder.

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Hexarelin Human Growth Peptide Human Growth Hormone Peptides 140703-51-1

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Hexarelin Human Growth Peptide Human Growth Hormone Peptides 140703-51-1
 
Hexarelin Basic Info.
 
Product Name: Hexarelin
Synonyms: Hexarelin Acetate, HEX, Examorelin
Sequence: His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2
CAS number: 140703-51-1
Molecular formula: C47H58N12O6
Molar Mass: 887.04022
PubChem: CID 5464109
Peptide purity: > 98.0%
Appearance: White powder
Related substance: Total Impurities(%) ≤ 2.0%
Acetate content:≤15.0%
Bacterial Endotoxins: ≤5 IU/mg
Packing: 2mg/vial
 
What is Hexarelin?
 
Hexarelin (HEX) may be a amide GH secretagogue with a potent ability to stimulate GH secretion and recently reportable cardioprotective actions. as a result of Hexarelin’s aminoalkanoic acid sequence might facilitate in promoting the body to provide a lot of hormone, it’ll not finish off the body’s own production. Hexarelin may be a artificial amide composed of vi amino acids creating it a hexaptide with a structure that has been thought of to push the discharge of hormone. Effects from GH embody raised bone mineral density, raised cellular division and meiosis that ends up in a lot of muscle mass, acylglycerol chemical reaction that causes distinguished fat loss, animal tissue strengthening, and improved skin physical property. as a result of Hexarelin’s aminoalkanoic acid sequence might facilitate in promoting the body to provide a lot of hormone, it’ll not finish off the body’s own production. this is often a really necessary issue and makes Hexarelin a pretty chain compared to hormone alone. For analysis functions solely. 
 
Hexarelin may be a non-natural (synthetic) hormone (GH)-releasing hexapeptide that belongs to the GHS family. This specific supermolecule has been found to act on each ductless gland and also the neural structure, however, its mechanisms of action within the human physiological system has not nonetheless been totally elucidated (Arvat et al. 1995).
 
This artificial amide has similar GH-secreting properties with its predecessors like the GHRP-6, GHRP-2 and GHRP-1. Hexarelin is GHRP analog during which the Trp was substituted with with chemicals a lot of table 2-Methyl-Trp (Denghenghi et al. 1994). The chemical structure of that is shown within the following: several studies on mice are disbursed double-geared towards deeper understanding of its chemical activity.
 
Hexarelin (HEX) may be a amide GH secretagogue with a potent ability to stimulate GH secretion and recently reportable cardioprotective actions. However, hexarelin (HEX) effects within the brain area unit mostly unknown, and also the aim of the current study was to look at the potential protecting impact of hexarelin (HEX) on the central systema nervosum once injury, also as on caspase-3, Akt, and animate thing signal-regulated supermolecule enzyme (ERK) signal cascades in an exceedingly rat model of babe hypoxia-ischemia.
 
The Functionality of Hexarelin:
 
Hexarelin (Hexarelin Acetate) is chemically designed as L-Histidyl-2-methyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide. Hexarelin (Hexarelin Acetate) is a potent GHRP-6 analog,
whose structure (His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2) creates a greater stability than GHRP-6 due to a substituted (2 Me)Trp. Hexarelin has a half-life of about 70 min, longer than that of GHRP-6. Replacement of the naturally occurring L-amino acids for the D-configuration results in these longer
half-lives.
 
Hexarelin has shown that it is highly stimulated at 30 minutes after being induced by rapid and sustained GH secretion. The pituitary gland produces GH in the brain, in children this hormone helps them to grow and in adults it helps to maintain muscle and burn fat. In one sixteen-week study, it has been shown that GH levels return to normal after stopping use after four weeks.
 

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High Purity 1,4-Butanediol (BDO) 110-63-4

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High Purity 1,4-Butanediol (BDO) 110-63-4
 
1,4-Butanediol Basic Info.:
 
Product Name: 1,4-Butanediol
CAS: 110-63-4
MF: C4H10O2
MW: 90.12
EINECS: 203-786-5
Water Solubility: Miscible
Sensitive: Hygroscopic
Stability: Stable. Combustible. Incompatible with strong oxidizing agents, mineral acids, acid chlorides, acid anhydrides.
 
1,4-Butanediol Usage:
 
1. 1,4 butanediol is an important raw materials for organic and refined. It is the basic material for producing PBT plastics and fiber, and PBT is one of the five most promising engineering plastics.
2. 1,4butanediol is the main raw material for producing THF, which is an important organic solvent. The polymeric compound PTMEG of THF forms the basic material for highly-elastic urethane elastic fiber, which is mainly used for producing high-grade sports wear and swimming suit that requir high elasticity.
3. 1,4-butanediol is the main material for producing γ-butyrolacton, which is widely used in pesticide, pharmaceuticals, cosmetics and other industries due to its ability to produce 2-pyrrolidone, NMP and their derivatives NVP and PVP etc. high add-ons products.
4. 1,4butanediol is the main material for producing polyurethane artificial leather, polyurethane, elastomer and polyurethane sole glue. polyurethane elastomer are widely used to manufacture elastic sole, auto solid fire, friction conveying belt and etc.
 

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High Purity 99.5% Lincomycin Hydrochloride Pharmaceutical Raw Materials Lincomycin HCl For Antibacterial

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High Purity 99.5% Lincomycin Hydrochloride Pharmaceutical Raw Materials Lincomycin HCl For Antibacterial 
 
Lincomycin HCL Basic Info.:
 
Product Name: Lincomycin Hcl
Synonyms: Lincomycin Hydrochloride
CAS: 859-18-7
MF: C18H35ClN2O6S
MW: 443
EINECS: 212-726-7
Assay: 99%
Standard: EP7.0/BP/USP
Packing: 20Bou/cardboard drum
Character: White crystalline powder. MP 156-158°C, PH3.5~5.5, Optical rotation +135~+150°. Solubility: H2O: 50 mg/mL, clear, colorless.
 
Lincomycin HCL Description:
 
Lincomycin kills bacteria by interfering with the ability of bacteria to produce important proteins necessary for them to survive. Lincomycin is effective against many types of bacteria including Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Propionibacterium acnes, and others. Use of lincomycin is reserved for penicillin-allergic patients or when penicillin-based treatment is not appropriate. This antibiotic should only be used to treat serious infections because of rare but sometimes fatal intestinal problems have occurred. The specific infections for which LINCOCIN is used include: Ear, throat and lung infections; Skin infections; Bone and joint infections; And infections of the blood. LINCOCIN will not work against viral infections such as colds or flu.
 
Lincomycin HCL Usage:
 
An antibiotic produced by Streptomyces lincolnensis. Lincomycin is a lincosamide antibiotic .An antibiotic produced by Streptomyces lincolnensis. Lincomycin is a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of the 23S rRNA. Inhibits bacterial protein synthesis. Antibacterial.
Lincomycin (hereinafter referred to as LCM) biosynthesis, in addition to produce LCM, but under certain conditions, also produced the LCM B, C, D, K, S and other analogues, thus refining process more difficult and costly.
LD50 acute toxicity test showed that mice injected 1000mg/kg, rat oral greater than 4000mg/kg, toxicity is low.
Indications: Effect as erythromycin, do not have to do skin test, the product of Gram-positive bacteria and gram-negative bacteria is stronger for osteomyelitis, sepsis, respiratory and soft tissue infections. This product is very strong penetration of bone, is the medicine of choice for osteomyelitis.
 

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High Purity 99.5% Pharmaceutical Raw Materials Meldonium For Angina Treatment 76144-81-5

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High Purity 99.5% Pharmaceutical Raw Materials Meldonium For Angina Treatment 76144-81-5
 
Meldonium Basic Info.:
 
Product Name: Mildronate
Synonyms: 2-(2-carboxyethyl)-1,1,1-trimethylhydrazinium hydroxide inner salt;3-(2,2,2-trimethylhydrazine)propionate;MILDRONATE;Mildonate;3-(2,2,2-Trimethylhydrazinium)propionate;2-(2-Carboxyethyl)-1,1,1-trimethyl Hydrazinium Inner Salt;Meldomiun;MET88
CAS: 76144-81-5
MF: C6H14N2O2
MW: 146.18756
EINECS: N/A
Melting Point: 85-900°C
Storage Temp.: Refrigerator
Stability: Hygroscopic
Chemical Properties: White Crystalline Powder
Usage: A novel pharmaceutical composition based on a reverse transcriptase inhibitor and meldonium
Definition: ChEBI: An ammonium betaine that is beta-alaninate in which one of the amino hydrogens is replaced by a trimethylamino group. A clinically used cardioprotective drug that is used for treatment of heart failure, myocardial infarction, arrhythmia, a herosclerosis and diabetes.
Product Categories: Cardiovascular;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical intermediate;Pharma raw material.
 
Description Of Meldonium:
 
Meldonium,trade-named as Mildronate among others, is a limited-market pharmaceutical, developed in 1970 by Ivars Kalviņš, Latvian Institute of Organic Synthesis (USSR), and manufactured primarily by Grindeks of Latvia and several generic manufacturers. It is distributed in Eastern European countries as an anti-ischemia medication.Since 1 January 2016, it has been on the World Anti-Doping Agency (WADA) list of substances banned from use by athletes.However, there are debates over its use as an athletic performance enhancer. Some athletes are known to have been using it before it was banned. It is currently unscheduled in the US.
 
The chemical name of meldonium is 3-(2,2,2-trimethylhydraziniumyl) propionate.It is a structural analogue of γ-butyrobetaine, with an amino groupreplacing the C-4 methylene of γ-butyrobetaine.[citation needed] γ-Butyrobetaine is a precursor in the biosynthesis of carnitine.[better source needed][needs update] It has a molecular weight of 146.188. It is available as a white crystalline powder, as well as a capsule sold by Grindeks. The melting point is anywhere between 85-90 degrees Celsius
 
Application Of Meldonium:
 
Meldonium may be used to treat coronary artery disease.These heart problems may sometimes lead to ischemia, a condition where too little blood flows to the organs in the body, especially the heart. Because this drug is thought to expand the arteries, it helps to increase the blood flow as well as increase the flow of oxygen throughout the body.Meldonium has also been found to induce anticonvulsant and antihypnotic effects involving alpha 2-adrenergic receptors as well as nitric oxide-dependent mechanisms. This, in summary, shows that meldonium given in acute doses could be beneficial for the treatment of seizures and alcohol intoxication.It may also have some effect on decreasing the severity of withdrawal symptoms caused by the cessation of chronic alcohol use.
 
Meldonium Function:
 
Meldonium is believed to work through its ability to increase the size of blood vessels and therefore improve blood flow.Although initial reports suggested meldonium is a non-competitive and non-hydroxylatable analogue of gamma-butyrobetaine;[9][non-primary source needed] further studies have identified that meldonium is a substrate for gamma-butyrobetaine dioxygenase. X-ray crystallographic and in vitro biochemical studies suggest that meldonium binds to the substrate pocket of γ-butyrobetaine hydroxylase and acts as an alternative substrate ,and therefore a competitive inhibitor.[non-primary source needed] Normally, this enzyme's action on its substrates γ-butyrobetaine and 2-oxoglutarate gives, in the presence of the further substrate oxygen, the products L-carnitine, succinate, and carbon dioxide; in the presence of this alternate substrate, the reaction yields malonic acid semialdehyde, formaldehyde (akin to the action of histone demethylases), dimethylamine, and (1-methylimidazolidin-4-yl)acetic acid, "an unexpected product with an additional carbon-carbon bond resulting from N-demethylation coupled to oxidative rearrangement, likely via an unusual radical mechanism.
 

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High Purity 99.5% Tetracaine White Fine Powder For Local Anaesthesia 94-24-6

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High Purity 99.5% Tetracaine White Fine Powder For Local Anaesthesia 94-24-6
 
Tetracaine Basic Info.:
 
Product Name: Tetracaine
Synonym: Anetain, Amethocaine, Pontocaine,Ametop,Dicaine
CAS: 94-24-6
MF: C15H24N2O2
MW: 264.36
EINECS: 202-316-6
Assay: 99%
Quality Standards: EnterpriseStandard/Pharma Grade
Appearance: White powder
Package: 25kg/Drum
Usage: Tetracaine is a topical local anesthetic for the eyes. Tetracaine works by interfering with entry of sodium ions into nerve cells. This reduces the ability of nerves to generate an impulse and send pain sensations.
 
Tetracaine Description:
 
Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia. It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.
(1) In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
(2) Tetracaine is the T in Tac, a mixture of 5 to 12 per cent tetracaine, 5M(per myriad), a half per mille (0.5‰), or .05 per cent (1 part in 2000) , and 4 or 10 per cent hydrochloride used in ear, nose & throat surgery and in the emergemcy department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations.
(3) Tetracaine is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.
 
Tetracaine Applications:
 
Tetracaine is used in different parts of the body to cause numbness or loss of feeling in some patients before having a medical test or procedure.
 

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High Purity Body Supplement Kola Nut Extract Cola Acuminata Powder 68916-19-8

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High Purity Body Supplement Kola Nut Extract Cola Acuminata Powder 68916-19-8
 
Kola Nut Extract Basic Info.:
 
Product Name: Kola Nut Extract
Cola Acuminata 
Latin Name: Cola acuminata
CAS No.: 68916-19-8
Active Ingredient: Caffeine theobromine
Specifications: 1-99%
Test Method: HPLC
 
Kola Nut Extract Description:
 
Kola Nut is also known as Cola Nut and Cola. Kola Nut is the seed kernel of a large African tree grown commercially around the world. It is extremely popular in the tropics as a caffeine-containing stimulant. The properties of Kola are the same as caffeine, modified only by the astringents present.
Kola nut extract is a natural supplement from the seeds of the tree Kola vera, also known as Cola nitida and Cola acuminate. The Kola vera tree is a member of the Sterculiaceae family of evergreens, which grow in Africa and South America and can reach 60 feet tall.
 
Kola Nut Extract Application:
 
You can find kola nut extract as an ingredient in energy drinks or sold separately as an energy supplement or weight-loss aid. According to the "Encyclopedia of Natural Medicine," kola nut contains high quantities of caffeine, which is why manufacturers.
market the extract for weight loss and as an energy supplement. Additionally, you can use kola nut extract as a diuretic. Further uses have been as a remedy for headaches, rheumatism, whooping cough and asthma.
 

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High Purity Dutasteride Avodart For Bodybuilding 164656-23-9

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High Purity Estrogen Raw Female Steroid Powders Ethynyl Estradiol 57-63-6

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High Purity Estrogen Raw Female Steroid Powders Ethynyl Estradiol 57-63-6
 
Ethynyl Estradiol Basic Info.:
 
Ethynyl estradiol Basic information
Product Name: Ethynyl estradiol
CAS: 57-63-6
MF: C20H24O2
MW: 296.4
EINECS: 200-342-2
Chemical Properties: Off-White to Light-Yellow Crystalline Powder
Usage: A metabolite of 17A-Ethynylestradiol
Usage: A synthetic steroid with high oral estrogenic potency
Usage estrogen, plus progestogen as oral contraceptive
Standard: USP28
 
Ethynyl Estradiol Description:
 
Ethinylestradiol is a man-made form of the naturally occurring female hormone called oestrogen.
It is prescribed to treat period (menstrual) problems, and also to help ease menopausal symptoms. It is usually prescribed alongside another female hormone called a progestogen.
 
Ethinyl estradiol also sometimes written as ethinylestradiol, ethynyl estradiol, or ethinyl? Stradiol, is a derivative of 17β -estradiol (E2), the major endogenous estrogen in humans. EE is an orally bioactive estrogen used in many formulations of combined oral contraceptive pills. It is one of the most commonly used medications for this purpose.
 
Estinyl was a preparation of EE alone that was used for the management of menopausal symptoms and female hypogonadism.
EE is released into the environment as a xenoestrogen from the urine and feces of people who take it as a medication.
 
Ethynyl Estradiol Application:
 
When estrogen is prescribed for a woman with a uterus, progestin should also be initiated to reduce the risk of endometrial cancer. A woman without a uterus does not need progestin. Use of estrogen, alone or in combination with a progestin, should be with the lowest effective dose and for the shortest duration consistent with treatment goals and risks for the individual woman. Patients should be reevaluated periodically as clinically appropriate (e.g., 3-month to 6-month intervals) to determine if treatment is still necessary. For women who have a uterus, adequate diagnostic measures, such as endometrial sampling, when indicated, should be undertaken to rule out malignancy in cases of undiagnosed persistent or recurring abnormal vaginal bleeding.
Short-term cyclic use for treatment of moderate to severe vasomotor symptoms, vulval and vaginal atrophy associated with the menopause, the lowest dose and regimen that will control symptoms should be chosen and medication should be discontinued as promptly as possible.
Attempts to discontinue or taper medication should be made at 3- to 6-month intervals. The usual dosage range is 1 to 5 mg injected every 3 to 4 weeks.
For treatment of female hypoestrogenism due to hypogonadism 1.5 to 2 mg injected at monthly intervals.
 

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